Akundi RS, Huang Z, Eason J, Pandya JD, Zhi L, Cass WA, Sullivan PG, Bueler H (2011) Increased mitochondrial calcium sensitivity and abnormal expression of innate immunity genes precede dopaminergic defects in Pink1-deficient mice. PLoS ONE 6:e16038

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, Mori H, Mann D, Tsuchiya K, Yoshida M, Hashizume Y et al (2006) TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun 351:602–611

Article  CAS  PubMed  Google Scholar 

Bai D, Yin P, Zhang Y, Sun F, Chen L, Lin L, Yan S, Li S, Li X-J (2021) Lack of association of somatic CAG repeat expansion with striatal neurodegeneration in HD knock-in animal models. Hum Mol Genet 30:1497–1508

Article  CAS  PubMed  Google Scholar 

Bakken TE, Miller JA, Ding S-L, Sunkin SM, Smith KA, Ng L, Szafer A, Dalley RA, Royall JJ, Lemon T et al (2016) A comprehensive transcriptional map of primate brain development. Nature 535:367–375

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bates GP, Dorsey R, Gusella JF, Hayden MR, Kay C, Leavitt BR, Nance M, Ross CA, Scahill RI, Wetzel R et al (2015) Huntington disease. Nat Rev Dis Prim 1:15005

Article  PubMed  Google Scholar 

Baxa M, Hruska-Plochan M, Juhas S, Vodicka P, Pavlok A, Juhasova J, Miyanohara A, Nejime T, Klima J, Macakova M et al (2013) A transgenic minipig model of Huntington’s disease. J Huntingtons Dis 2:47–68

Article  CAS  PubMed  Google Scholar 

Bernard A, Lubbers LS, Tanis KQ, Luo R, Podtelezhnikov AA, Finney EM, McWhorter MME, Serikawa K, Lemon T, Morgan R et al (2012) Transcriptional architecture of the primate neocortex. Neuron 73:1083–1099

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chan KY, Jang MJ, Yoo BB, Greenbaum A, Ravi N, Wu W-L, Sánchez-Guardado L, Lois C, Mazmanian SK, Deverman BE et al (2017) Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems. Nat Neurosci 20:1172–1179

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen B, Niu Y, Wang H, Wang K, Yang H, Li W (2020) Recent advances in CRISPR research. Protein Cell 11:786–791

Article  PubMed  PubMed Central  Google Scholar 

Chen Z-Z, Wang J-Y, Kang Y, Yang Q-Y, Gu X-Y, Zhi D-L, Yan L, Long C-Z, Shen B, Niu Y-Y (2021) PINK1 gene mutation by pair truncated sgRNA/Cas9-D10A in cynomolgus monkeys. Zool Res 42:469–477

Article  PubMed  PubMed Central  Google Scholar 

Chen-Plotkin AS, Lee VM-Y, Trojanowski JQ (2010) TAR DNA-binding protein 43 in neurodegenerative disease. Nat Rev Neurol 6:211–220

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chieppa MN, Perota A, Corona C, Grindatto A, Lagutina I, Vallino Costassa E, Lazzari G, Colleoni S, Duchi R, Lucchini F et al (2014) Modeling amyotrophic lateral sclerosis in hSOD1 transgenic swine. Neurodegener Dis 13:246–254

Article  CAS  PubMed  Google Scholar 

Corti O, Lesage S, Brice A (2011) What genetics tells us about the causes and mechanisms of Parkinson’s disease. Physiol Rev 91:1161–1218

Article  CAS  PubMed  Google Scholar 

Crook ZR, Housman D (2011) Huntington’s disease: can mice lead the way to treatment? Neuron 69:423–435

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cummins N, Gotz J (2018) Shedding light on mitophagy in neurons: what is the evidence for PINK1/Parkin mitophagy in vivo? Cell Mol Life Sci 75:1151–1162

Article  CAS  PubMed  Google Scholar 

Damier P, Hirsch EC, Agid Y, Graybiel AM (1999) The substantia nigra of the human brain. II. Patterns of loss of dopamine-containing neurons in Parkinson’s disease. Brain 122(8):1437–1448

Article  PubMed  Google Scholar 

Darmanis S, Sloan SA, Zhang Y, Enge M, Caneda C, Shuer LM, Hayden Gephart MG, Barres BA, Quake SR (2015) A survey of human brain transcriptome diversity at the single cell level. Proc Natl Acad Sci U S A 112:7285–7290

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davies SW, Turmaine M, Cozens BA, DiFiglia M, Sharp AH, Ross CA, Scherzinger E, Wanker EE, Mangiarini L, Bates GP (1997) Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation. Cell 90:537–548

Article  CAS  PubMed  Google Scholar 

Dawson TM, Golde TE, Lagier-Tourenne C (2018) Animal models of neurodegenerative diseases. Nat Neurosci 21:1370–1379

Article  CAS  PubMed  PubMed Central  Google Scholar 

Defelipe J (2011) The evolution of the brain, the human nature of cortical circuits, and intellectual creativity. Front Neuroanat 5:29

Article  PubMed  PubMed Central  Google Scholar 

Deng HX, Siddique T (2000) Transgenic mouse models and human neurodegenerative disorders. Arch Neurol 57:1695–1702

Article  CAS  PubMed  Google Scholar 

Deng H, Wang P, Jankovic J (2018) The genetics of Parkinson disease. Ageing Res Rev 42:72–85

Article  CAS  PubMed  Google Scholar 

Dugger BN, Perl DP, Carlson GA (2017) Neurodegenerative disease transmission and transgenesis in mice. Cold Spring Harb Perspect Biol 9(11):a023549

Article  PubMed  PubMed Central  CAS  Google Scholar 

Farshim PP, Bates GP (2018) Mouse models of Huntington’s disease. Methods Mol Biol 1780:97–120

Article  CAS  PubMed  Google Scholar 

Ferraiuolo L, Kirby J, Grierson AJ, Sendtner M, Shaw PJ (2011) Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis. Nat Rev Neurol 7:616–630

Article  CAS  PubMed  Google Scholar 

Forsberg K, Andersen PM, Marklund SL, Brännström T (2011) Glial nuclear aggregates of superoxide dismutase-1 are regularly present in patients with amyotrophic lateral sclerosis. Acta Neuropathol 121:623–634

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gao P, Postiglione MP, Krieger TG, Hernandez L, Wang C, Han Z, Streicher C, Papusheva E, Insolera R, Chugh K et al (2014) Deterministic progenitor behavior and unitary production of neurons in the neocortex. Cell 159:775–788

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gautier CA, Kitada T, Shen J (2008) Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc Natl Acad Sci U S A 105:11364–11369

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geschwind DH, Rakic P (2013) Cortical evolution: judge the brain by its cover. Neuron 80:633–647

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM-Y (2002) Neuronal alpha-synucleinopathy with severe movement disorder in mice ex