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Ether-lipids accumulation promotes hepatocellular carcinoma progression linked to PPARα deficiency
Ether-lipids accumulation promotes hepatocellular carcinoma progression linked to PPARα deficiency
While the Warburg effect links glycolysis to de novo lipid synthesis in carcinogenesis, the roles of lipids in cancer prog...
PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region
PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region
PPM1D (protein phosphatase Mg2⁺/Mn2⁺ dependent 1D) is a Ser/Thr phosphatase that negatively regulates p53 and ...
The impacts of different dietary restriction regimens on aging and longevity: from yeast to humans
The impacts of different dietary restriction regimens on aging and longevity: from yeast to humans
Dietary restriction (DR) refers to a broad set of interventions that limit the intake of specific nutrients or overall foo...
EGF receptor in organ development, tissue homeostasis and regeneration
EGF receptor in organ development, tissue homeostasis and regeneration
The epidermal growth factor receptor (EGFR) is a protein embedded in the outer membrane of epithelial and mesenchymal cell...
miR-193b-3p suppresses lung cancer cell migration and invasion through PRNP targeting
miR-193b-3p suppresses lung cancer cell migration and invasion through PRNP targeting
Tumor metastasis is responsible for approximately 90% of mortality in lung cancer. Understanding the molecular mechanisms ...
The zinc finger protein ZFP36L2 inhibits flavivirus infection via the 5′-3′ XRN1-mediated RNA decay pathway in the replication complexes
The zinc finger protein ZFP36L2 inhibits flavivirus infection via the 5′-3′ XRN1-mediated RNA decay pathway in the replication complexes
The zinc finger protein 36-like (ZFP36L) family is a CCCH-type group consisting of RNA-binding proteins, i.e., ZFP36L1 and...
A non-structural protein 1 substitution of dengue virus enhances viral replication by interfering with the antiviral signaling pathway
A non-structural protein 1 substitution of dengue virus enhances viral replication by interfering with the antiviral signaling pathway
The largest dengue virus 2 (DENV2) outbreak occurred in Taiwan in 2015, resulting in many fatalities. We therefore aim to ...
Treating neuromuscular diseases: unveiling gene therapy breakthroughs and pioneering future applications
Treating neuromuscular diseases: unveiling gene therapy breakthroughs and pioneering future applications
In this review, we highlight recent advancements in adeno-associated virus (AAV)-based gene therapy for genetic neuromuscu...
ARID1A loss activates MAPK signaling via DUSP4 downregulation
ARID1A loss activates MAPK signaling via DUSP4 downregulation
ARID1A, a tumor suppressor gene encoding BAF250, a protein participating in chromatin remodeling, is frequently m...
SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer
SCEL regulates switches between pro-survival and apoptosis of the TNF-α/TNFR1/NF-κB/c-FLIP axis to control lung colonization of triple negative breast cancer
Patients with metastatic triple-negative breast cancer (mTNBC) have a higher probability of developing visceral metastasis...
Butterflies in the gut: the interplay between intestinal microbiota and stress
Butterflies in the gut: the interplay between intestinal microbiota and stress
Psychological stress is a global issue that affects at least one-third of the population worldwide and increases the risk ...
The ‘speck’-tacular oversight of the NLRP3-pyroptosis pathway on gastrointestinal inflammatory diseases and tumorigenesis
The ‘speck’-tacular oversight of the NLRP3-pyroptosis pathway on gastrointestinal inflammatory diseases and tumorigenesis
The NLRP3 inflammasome is an intracellular sensor and an essential component of the innate immune system involved in dange...
Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA
Spatiotemporal roles of AMPK in PARP-1- and autophagy-dependent retinal pigment epithelial cell death caused by UVA
Although stimulating autophagy caused by UV has been widely demonstrated in skin cells to exert cell protection, it remain...
Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies
Complete spectrum of adverse events associated with chimeric antigen receptor (CAR)-T cell therapies
Chimeric antigen receptor (CAR)-T cell therapies have been approved by FDA to treat relapsed or refractory hematological m...
Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges
Small interfering RNA (siRNA)-based therapeutic applications against viruses: principles, potential, and challenges
RNA has emerged as a revolutionary and important tool in the battle against emerging infectious diseases, with roles exten...
Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission
Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission
Human angiotensin-converting enzyme 2 (hACE2) is the receptor mediating severe acute respiratory syndrome coronavirus 2 (S...
Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis
Mitochondrial mass and quality are tightly regulated by two essential and opposing mechanisms, mitochondrial biogenesis (m...
Extracellular release in the quality control of the mammalian mitochondria
Extracellular release in the quality control of the mammalian mitochondria
Mammalian cells release a wealth of materials to their surroundings. Emerging data suggest these materials can even be mit...
Clinical trials of new drugs for Alzheimer disease: a 2020–2023 update
Clinical trials of new drugs for Alzheimer disease: a 2020–2023 update
Alzheimer's disease (AD) is the leading cause of dementia, presenting a significant unmet medical need worldwide. The ...
mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications
mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications
mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class...
Interaction of the AKT and β-catenin signalling pathways and the influence of photobiomodulation on cellular signalling proteins in diabetic wound healing
Interaction of the AKT and β-catenin signalling pathways and the influence of photobiomodulation on cellular signalling proteins in diabetic wound healing
The induction of a cells destiny is a tightly controlled process that is regulated through communication between the matri...
Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations
Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations
Mitochondria are essential organelles for cellular metabolism and physiology in eukaryotic cells. Human mitochondria have ...
LncRNA SLCO4A1-AS1 suppresses lung cancer progression by sequestering the TOX4-NTSR1 signaling axis
LncRNA SLCO4A1-AS1 suppresses lung cancer progression by sequestering the TOX4-NTSR1 signaling axis
Metastasis is a multistep process involving the migration and invasion of cancer cells and is a hallmark of cancer maligna...
Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery
Expanding applications of allogeneic platelets, platelet lysates, and platelet extracellular vesicles in cell therapy, regenerative medicine, and targeted drug delivery
Platelets are small anucleated blood cells primarily known for their vital hemostatic role. Allogeneic platelet concentrat...
Long noncoding RNA SNHG16 regulates TLR4-mediated autophagy and NETosis formation in alveolar hemorrhage associated with systemic lupus erythematosus
Long noncoding RNA SNHG16 regulates TLR4-mediated autophagy and NETosis formation in alveolar hemorrhage associated with systemic lupus erythematosus
Dysregulated long noncoding RNA (lncRNA) expression with increased apoptosis has been demonstrated in systemic lupus eryth...
Platelet-derived biomaterial with hyaluronic acid alleviates temporal-mandibular joint osteoarthritis: clinical trial from dish to human
Platelet-derived biomaterial with hyaluronic acid alleviates temporal-mandibular joint osteoarthritis: clinical trial from dish to human
Bioactive materials have now raised considerable attention for the treatment of osteoarthritis (OA), such as knee OA, rheu...
Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post stroke
Structural changes in perineuronal nets and their perforating GABAergic synapses precede motor coordination recovery post stroke
Stroke remains one of the leading causes of long-term disability worldwide, and the development of effective restorative t...
A novel phage carrying capsule depolymerase effectively relieves pneumonia caused by multidrug-resistant Klebsiella aerogenes
A novel phage carrying capsule depolymerase effectively relieves pneumonia caused by multidrug-resistant Klebsiella aerogenes
Klebsiella aerogenes can cause ventilator-associated pneumonia by forming biofilms, and it is frequently associated with m...
Harnessing cell reprogramming for cardiac biological pacing
Harnessing cell reprogramming for cardiac biological pacing
Electrical impulses from cardiac pacemaker cardiomyocytes initiate cardiac contraction and blood pumping and maintain life...
5ʹ-Ectonucleotidase CD73/NT5E supports EGFR-mediated invasion of HPV-negative head and neck carcinoma cells
5ʹ-Ectonucleotidase CD73/NT5E supports EGFR-mediated invasion of HPV-negative head and neck carcinoma cells
Epithelial-to-mesenchymal transition (EMT) of malignant cells is a driving force of disease progression in human papilloma...
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