Du Z, Lovly CM. Mechanisms of receptor tyrosine kinase activation in cancer. Mol Cancer. 2018;17:58.

Article  PubMed  PubMed Central  Google Scholar 

Sudhesh Dev S, Zainal Abidin SA, Farghadani R, Othman I, Naidu R. Receptor tyrosine kinases and their signaling pathways as therapeutic targets of curcumin in cancer. Front Pharmacol. 2021;12:772510.

Article  PubMed  PubMed Central  Google Scholar 

Neben CL, Lo M, Jura N, Klein OD. Feedback regulation of RTK signaling in development. Dev Biol. 2019;447:71–89.

Article  CAS  PubMed  Google Scholar 

Cohen S. Epidermal growth factor (nobel lecture). Angew Chemie Int Ed English. 1987;26:717–22.

Article  Google Scholar 

O’Leary C, Gasper H, Sahin KB, Tang M, Kulasinghe A, Adams MN, et al. Epidermal growth factor receptor (EGFR)-mutated non-small-cell lung cancer (NSCLC). Pharmaceuticals. 2020;13:273.

Article  PubMed  PubMed Central  Google Scholar 

Sigismund S, Avanzato D, Lanzetti L. Emerging functions of the <scp>EGFR</scp> in cancer. Mol Oncol. 2018;12:3–20.

Article  PubMed  Google Scholar 

Zubair T, Bandyopadhyay D. Small molecule EGFR inhibitors as anti-cancer agents: discovery, mechanisms of action, and opportunities. Int J Mol Sci. 2023;24:2651.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh B, Carpenter G, Coffey RJ. EGF receptor ligands: recent advances. F1000Research. 2016;5:2270.

Article  Google Scholar 

Rosenkranz AA, Slastnikova TA. Epidermal growth factor receptor: key to selective intracellular delivery. Biochem. 2020;85:967–93.

CAS  Google Scholar 

Gagliardi PA, Dobrzyński M, Jacques M-A, Dessauges C, Ender P, Blum Y, et al. Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival. Dev Cell. 2021;56:1712-1726.e6.

Article  CAS  PubMed  Google Scholar 

Freed DM, Bessman NJ, Kiyatkin A, Salazar-Cavazos E, Byrne PO, Moore JO, et al. EGFR ligands differentially stabilize receptor dimers to specify signaling kinetics. Cell. 2017;171:683-695.e18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pascarelli S, Merzhakupova D, Uechi G-I, Laurino P. Binding of single-mutant epidermal growth factor (EGF) ligands alters the stability of the EGF receptor dimer and promotes growth signaling. J Biol Chem. 2021;297: 100872.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang Y, Ognjenovic J, Karandur D, Miller K, Merk A, Subramaniam S, et al. A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife. 2021;10: e73218.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin S, Hirayama D, Maryu G, Matsuda K, Hino N, Deguchi E, et al. Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration. Life Sci Alliance. 2022;5: e202101206.

Article  CAS  PubMed  Google Scholar 

Wang Z. Transactivation of epidermal growth factor receptor by G protein-coupled receptors: recent progress, challenges and future research. Int J Mol Sci. 2016;17:95.

Article  PubMed  PubMed Central  Google Scholar 

Forrester SJ, Kawai T, O’Brien S, Thomas W, Harris RC, Eguchi S. Epidermal growth factor receptor transactivation: mechanisms, pathophysiology, and potential therapies in the cardiovascular system. Annu Rev Pharmacol Toxicol. 2016;56:627–53.

Article  CAS  PubMed  Google Scholar 

Chi S, Cao H, Wang Y, McNiven MA. Recycling of the epidermal growth factor receptor is mediated by a novel form of the clathrin adaptor protein Eps15. J Biol Chem. 2011;286:35196–208.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen PH, Bendris N, Hsiao YJ, Reis CR, Mettlen M, Chen HY, et al. Crosstalk between CLCb/Dyn1-mediated adaptive clathrin-mediated endocytosis and epidermal growth factor receptor signaling increases metastasis. Dev Cell. 2017;40:278–88.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crotchett BLM, Ceresa BP. Knockout of c-Cbl slows EGFR endocytic trafficking and enhances EGFR signaling despite incompletely blocking receptor ubiquitylation. Pharmacol Res Perspect. 2021;9: e00756.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pinilla-Macua I, Sorkin A. Cbl and Cbl-b independently regulate EGFR through distinct receptor interaction modes. Mol Biol Cell. 2023;34:ar134.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Caldieri G, Barbieri E, Nappo G, Raimondi A, Bonora M, Conte A, et al. Reticulon 3–dependent ER-PM contact sites control EGFR nonclathrin endocytosis. Science (80-). 2017;356:617–24.

Article  CAS  Google Scholar 

Tito C, Genovese I, Giamogante F, Benedetti A, Miglietta S, Barazzuol L, et al. Sorcin promotes migration in cancer and regulates the EGF-dependent EGFR signaling pathways. Cell Mol Life Sci. 2023;80:202.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Battista T, Fiorillo A, Chiarini V, Genovese I, Ilari A, Colotti G. Roles of sorcin in drug resistance in cancer: one protein, many mechanisms, for a novel potential anticancer drug target. Cancers (Basel). 2020;12:887.

Article  CAS  PubMed  Google Scholar 

Lonic A, Gehling F, Belle L, Li X, Schieber NL, Nguyen EV, et al. Phosphorylation of PKCδ by FER tips the balance from EGFR degradation to recycling. J Cell Biol. 2021;220: e201902073.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tanaka T, Ozawa T, Oga E, Muraguchi A, Sakurai H. Cisplatin-induced non-canonical endocytosis of EGFR via p38 phosphorylation of the C-terminal region containing Ser-1015 in non-small cell lung cancer cells. Oncol Lett. 2018;15:9251–6.

PubMed  PubMed Central  Google Scholar 

Tanaka T, Zhou Y, Ozawa T, Okizono R, Banba A, Yamamura T, et al. Ligand-activated epidermal growth factor receptor (EGFR) signaling governs endocytic trafficking of unliganded receptor monomers by non-canonical phosphorylation. J Biol Chem. 2018;293:2288–301.

Article  CAS  PubMed  Google Scholar 

Perez Verdaguer M, Zhang T, Paulo JA, Gygi S, Watkins SC, Sakurai H, et al. Mechanism of p38 MAPK–induced EGFR endocytosis and its crosstalk with ligand-induced pathways. J Cell Biol. 2021;220: e202102005.

Article  PubMed  PubMed Central  Google Scholar 

Grassi ML, de Palma CS, Thomé CH, Lanfredi GP, Poersch A, Faça VM. Proteomic analysis of ovarian cancer cells during epithelial-mesenchymal transition (EMT) induced by epidermal growth factor (EGF) reveals mechanisms of cell cycle control. J Proteomics. 2017;151:2–11.

Article  CAS  PubMed  Google Scholar 

Schelch K, Vogel L, Schneller A, Brankovic J, Mohr T, Mayer RL, et al. EGF induces migration independent of EMT or invasion in A549 lung adenocarcinoma cells. Front Cell Dev Biol. 2021;9: 634371.

Article  PubMed  PubMed Central  Google Scholar 

Wee P, Wang Z. Epidermal growth factor receptor cell proliferation signaling pathways. Cancers (Basel). 2017;9:52.

Article  PubMed  Google Scholar 

Ayuso-Sacido A, Moliterno JA, Kratovac S, Kapoor GS, O’Rourke DM, Holland EC, et al. Activated EGFR signaling increases proliferation, survival, and migration and blocks neuronal differentiation in post-natal neural stem cells. J Neurooncol. 2010;97:323–37.

Article  CAS