Hipp, M. S., Kasturi, P. & Hartl, F. U. The proteostasis network and its decline in ageing. Nat. Rev. Mol. Cell Biol. 20, 421–435 (2019).

Article  PubMed  CAS  Google Scholar 

Rosenzweig, R., Nillegoda, N. B., Mayer, M. P. & Bukau, B. The Hsp70 chaperone network. Nat. Rev. Mol. Cell Biol. 20, 665–680 (2019).

Article  PubMed  CAS  Google Scholar 

Horwich, A. L. & Fenton, W. A. Chaperonin-assisted protein folding: a chronologue. Q. Rev. Biophys. 53, e4 (2020).

Article  PubMed  Google Scholar 

Juszkiewicz, S. & Hegde, R. S. Quality control of orphaned proteins. Mol. Cell 71, 443–457 (2018).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Schulte, U. et al. Mitochondrial complexome reveals quality-control pathways of protein import. Nature 614, 153–159 (2023).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Morgenstern, M. et al. Definition of a high-confidence mitochondrial proteome at quantitative scale. Cell Rep. 19, 2836–2852 (2017).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Vögtle, F.-N. et al. Landscape of submitochondrial protein distribution. Nat. Commun. 8, 290 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Morgenstern, M. et al. Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Cell Metab. 33, 2464–2483.e18 (2021).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rath, S. et al. MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations. Nucleic Acids Res. 49, D1541–D1547 (2021).

Article  PubMed  CAS  Google Scholar 

Wrobel, L. et al. Mistargeted mitochondrial proteins activate a proteostatic response in the cytosol. Nature 524, 485–488 (2015).

Article  PubMed  CAS  Google Scholar 

Wang, X. & Chen, X. J. A cytosolic network suppressing mitochondria-mediated proteostatic stress and cell death. Nature 524, 481–484 (2015).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhao, Q. et al. A mitochondrial specific stress response in mammalian cells. EMBO J. 21, 4411–4419 (2002).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yoneda, T. et al. Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J. Cell Sci. 117, 4055–4066 (2004).

Article  PubMed  CAS  Google Scholar 

Song, J., Herrmann, J. M. & Becker, T. Quality control of the mitochondrial proteome. Nat. Rev. Mol. Cell Biol. 22, 54–70 (2021).

Article  PubMed  CAS  Google Scholar 

Maruszczak, K. K., Ayyamperumal, S. & Chacinska, A. Defective mitochondrial import as a challenge for cellular protein homeostasis. FEBS Lett. 597, 1555–1568 (2023).

Article  PubMed  CAS  Google Scholar 

Rödl, S. & Herrmann, J. M. The role of the proteasome in mitochondrial protein quality control. IUBMB Life 75, 868–879 (2023).

Article  PubMed  Google Scholar 

Becker, T., Song, J. & Pfanner, N. Versatility of preprotein transfer from the cytosol to mitochondria. Trends Cell Biol. 29, 534–548 (2019).

Article  PubMed  CAS  Google Scholar 

Bykov, Y. S., Rapaport, D., Herrmann, J. M. & Schuldiner, M. Cytosolic events in the biogenesis of mitochondrial proteins. Trends Biochem. Sci. 45, 650–667 (2020).

Article  PubMed  CAS  Google Scholar 

Busch, J. D., Fielden, L. F., Pfanner, N. & Wiedemann, N. Mitochondrial protein transport: versatility of translocases and mechanisms. Mol. Cell 83, 890–910 (2023).

Article  PubMed  CAS  Google Scholar 

Drwesh, L. & Rapaport, D. Biogenesis pathways of α-helical mitochondrial outer membrane proteins. Biol. Chem. 401, 677–686 (2020).

Article  PubMed  CAS  Google Scholar 

Eaglesfield, R. & Tokatlidis, K. Targeting and insertion of membrane proteins in mitochondria. Front. Cell Dev. Biol. 9, 803205 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Araiso, Y., Imai, K. & Endo, T. Role of the TOM complex in protein import into mitochondria: structural views. Annu. Rev. Biochem. 91, 679–703 (2022).

Article  PubMed  CAS  Google Scholar 

Araiso, Y. et al. Structure of the mitochondrial import gate reveals distinct preprotein paths. Nature 575, 395–401 (2019).

Article  PubMed  CAS  Google Scholar 

Tucker, K. & Park, E. Cryo-EM structure of the mitochondrial protein-import channel TOM complex at near-atomic resolution. Nat. Struct. Mol. Biol. 26, 1158–1166 (2019).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bausewein, T. et al. Cryo-EM structure of the TOM core complex from Neurospora crassa. Cell 170, 693–700.e7 (2017).

Article  PubMed  CAS  Google Scholar 

Wiedemann, N., Pfanner, N. & Ryan, M. T. The three modules of ADP/ATP carrier cooperate in receptor recruitment and translocation into mitochondria. EMBO J. 20, 951–960 (2001).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shiota, T. et al. Molecular architecture of the active mitochondrial protein gate. Science 349, 1544–1548 (2015).

Article  PubMed  CAS  Google Scholar 

Zhou, X. et al. Molecular pathway of mitochondrial preprotein import through the TOM–TIM23 supercomplex. Nat. Struct. Mol. Biol. 30, 1996–2008 (2023).

Article  PubMed  CAS  Google Scholar 

Yamano, K. et al. Tom20 and Tom22 share the common signal recognition pathway in mitochondrial protein import. J. Biol. Chem. 283, 3799–3807 (2008).

Article  PubMed  CAS  Google Scholar 

Yamamoto, H. et al. Roles of Tom70 in import of presequence-containing mitochondrial proteins. J. Biol. Chem. 284, 31635–31646 (2009).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Backes, S. et al. The chaperone-binding activity of the mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress. Cell Rep. 35, 108936 (2021).

Article  PubMed  PubMed Central  CAS  Google Scholar