Alhenc-Gelas F, Bouby N, Girolami J-P. Kallikrein/K1, Kinins, and ACE/Kininase II in homeostasis and in disease insight from human and experimental genetic Studies, therapeutic implication. Front Med. 2019;6:136. https://doi.org/10.3389/fmed.2019.00136.
Marceau F, Bachelard H, Bouthillier J, Fortin J-P, Morissette G, Bawolak M-T, et al. Bradykinin receptors: Agonists, antagonists, expression, signaling, and adaptation to sustained stimulation. Int Immunopharmacol. 2020;82:106305. https://doi.org/10.1016/j.intimp.2020.106305.
Article CAS PubMed Google Scholar
Leeb-Lundberg LMF. 3 Kinin receptor signaling and regulation. In: Bader M, editor. Kinins [Internet]. DE GRUYTER; 2011 [cited 2025 May 27]. pp. 33–50. https://doi.org/10.1515/9783110252354.33
Nauroy P, Nyström A, Kallikreins. Essential epidermal messengers for regulation of the skin microenvironment during homeostasis, repair and disease. Matrix Biol Plus. 2020;6–7:100019. https://doi.org/10.1016/j.mbplus.2019.100019.
Article CAS PubMed Google Scholar
Mella C, Figueroa CD, Otth C, Ehrenfeld P. Involvement of Kallikrein-Related peptidases in nervous system disorders. Front Cell Neurosci. 2020;14:166. https://doi.org/10.3389/fncel.2020.00166.
Article CAS PubMed PubMed Central Google Scholar
Karakosta TD, Soosaipillai A, Diamandis EP, Batruch I, Drabovich AP. Quantification of human Kallikrein-Related peptidases in biological fluids by multiplatform targeted mass spectrometry assays. Mol Cell Proteom. 2016;15:2863–76. https://doi.org/10.1074/mcp.M115.057695.
Azizi M, Boutouyrie P, Bissery A, Agharazii M, Verbeke F, Stern N, et al. Arterial and renal consequences of partial genetic deficiency in tissue Kallikrein activity in humans. J Clin Invest. 2005;115:780–7. https://doi.org/10.1172/JCI23669.
Article CAS PubMed PubMed Central Google Scholar
Ji M, Ran X, Zuo H, Zhang Q. Novel insights into the Kallikrein–Kinin system in fulminant myocarditis: physiological basis and potential therapeutic advances. J Inflamm Res 2024;Volume 17:7347–60. https://doi.org/10.2147/JIR.S488237
Rex DAB, Deepak K, Vaid N, Dagamajalu S, Kandasamy RK, Flo TH, et al. A modular map of Bradykinin-mediated inflammatory signaling network. J Cell Commun Signal. 2022;16:301–10. https://doi.org/10.1007/s12079-021-00652-0.
Article CAS PubMed Google Scholar
Duchene J, Lecomte F, Ahmed S, Cayla C, Pesquero J, Bader M, et al. A novel inflammatory pathway involved in leukocyte recruitment: role for the Kinin B1 receptor and the chemokine CXCL5. J Immunol Baltim Md 1950. 2007;179:4849–56. https://doi.org/10.4049/jimmunol.179.7.4849.
Brechter AB, Persson E, Lundgren I, Lerner UH. Kinin B1 and B2 receptor expression in osteoblasts and fibroblasts is enhanced by interleukin-1 and tumour necrosis factor-alpha. Effects dependent on activation of NF-kappaB and MAP kinases. Bone. 2008;43:72–83. https://doi.org/10.1016/j.bone.2008.02.003.
Article CAS PubMed Google Scholar
Motta G, Juliano L, Chagas JR. Human plasma kallikrein: roles in coagulation, fibrinolysis, inflammation pathways, and beyond. Front Physiol. 2023;14:1188816. https://doi.org/10.3389/fphys.2023.1188816.
Article PubMed PubMed Central Google Scholar
Sasiadek L, Bielecka E, Falkowski K, Kulczycka M, Bereta G, Maksylewicz A, et al. Human tissue Kallikrein 14 induces the expression of IL -6, IL ‐8, and CXCL1 in skin fibroblasts through protease‐activated receptor 1 signaling. FEBS J. 2025. https://doi.org/10.1111/febs.70170. febs.70170.
Article PubMed PubMed Central Google Scholar
Briot A, Deraison C, Lacroix M, Bonnart C, Robin A, Besson C, et al. Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome. J Exp Med. 2009;206:1135–47. https://doi.org/10.1084/jem.20082242.
Article CAS PubMed PubMed Central Google Scholar
Ribas-Latre A, Hoffmann A, Gebhardt C, Weiner J, Arndt L, Raulien N, et al. The Serine protease KLK7 promotes immune cell infiltration in visceral adipose tissue in obesity. Metabolism. 2025;168:156239. https://doi.org/10.1016/j.metabol.2025.156239.
Article CAS PubMed Google Scholar
Engin A. Lipid Storage, Lipolysis, and lipotoxicity in obesity. In: Engin AB, Engin A, editors. Obes lipotoxicity [Internet]. Cham: Springer International Publishing; 2024. pp. 97–129. [cited 2025 May 27]. https://doi.org/10.1007/978-3-031-63657-8_4.
Engin A. The mechanism of leptin resistance in obesity and therapeutic perspective. In: Engin AB, Engin A, editors. Obes lipotoxicity [Internet]. Cham: Springer International Publishing; 2024. pp. 463–87. [cited 2025 May 27]. https://doi.org/10.1007/978-3-031-63657-8_16.
Yu J, Qiu J, Zhang Z, Cui X, Guo W, Sheng M, et al. Redox biology in adipose tissue physiology and obesity. Adv Biol. 2023;7:2200234. https://doi.org/10.1002/adbi.202200234.
Audano M, Pedretti S, Caruso D, Crestani M, De Fabiani E, Mitro N. Regulatory mechanisms of the early phase of white adipocyte differentiation: an overview. Cell Mol Life Sci. 2022;79:139. https://doi.org/10.1007/s00018-022-04169-6.
Article CAS PubMed PubMed Central Google Scholar
Kim H-Y, Jang H-J, Muthamil S, Shin UC, Lyu J-H, Kim S-W, et al. Novel insights into regulators and functional modulators of adipogenesis. Biomed Pharmacother. 2024;177:117073. https://doi.org/10.1016/j.biopha.2024.117073.
Article CAS PubMed Google Scholar
Blüher M. Understanding adipose tissue dysfunction. J Obes Metab Syndr. 2024;33:275–88. https://doi.org/10.7570/jomes24013.
Article PubMed PubMed Central Google Scholar
Dahdah N, Tercero-Alcázar C, Malagón MM, Garcia-Roves PM, Guzmán-Ruiz R. Interrelation of adipose tissue macrophages and fibrosis in obesity. Biochem Pharmacol. 2024;225:116324. https://doi.org/10.1016/j.bcp.2024.116324.
Article CAS PubMed Google Scholar
Bilson J, Hydes TJ, McDonnell D, Buchanan RM, Scorletti E, Mantovani A, et al. Impact of metabolic syndrome traits on kidney disease risk in individuals with MASLD: A UK biobank study. Liver Int Off J Int Assoc Study Liver. 2025;45:e16159. https://doi.org/10.1111/liv.16159.
Turner L, Wanasinghe AI, Brunori P, Santosa S. Is adipose tissue inflammation the culprit of Obesity-Associated comorbidities? Obes Rev. 2025. https://doi.org/10.1111/obr.13956. e13956.
Article PubMed PubMed Central Google Scholar
Blaes N, Girolami J-P. Targeting the Janus face of the B2-bradykinin receptor. Expert Opin Ther Targets. 2013;17:1145–66. https://doi.org/10.1517/14728222.2013.827664.
Article CAS PubMed Google Scholar
Talbot S, Dias JP, El Midaoui A, Couture R. Beneficial effects of Kinin B1 receptor antagonism on plasma fatty acid alterations and obesity in Zucker diabetic fatty rats. Can J Physiol Pharmacol. 2016;94:752–7. https://doi.org/10.1139/cjpp-2016-0063.
Article CAS PubMed Google Scholar
Mori MA, Araújo RC, Reis FCG, Sgai DG, Fonseca RG, Barros CC, et al. Kinin B1 receptor deficiency leads to leptin hypersensitivity and resistance to obesity. Diabetes. 2008;57:1491–500. https://doi.org/10.2337/db07-1508.
Article CAS PubMed Google Scholar
Mori MA, Sales VM, Motta FL, Fonseca RG, Alenina N, Guadagnini D et al. Kinin B1 Receptor in Adipocytes Regulates Glucose Tolerance and Predisposition to Obesity. Ho PL, editor. PLoS ONE. 2012;7:e44782. https://doi.org/10.1371/journal.pone.0044782
Freitas-Lima LC, Budu A, Estrela GR, Alves-Silva T, Perilhão MS, Arruda AC, et al. Metabolic fasting stress is ameliorated in Kinin B1 receptor-deficient mice. Life Sci. 2022;294:120007. https://doi.org/10.1016/j.lfs.2021.120007.
Article CAS PubMed Google Scholar
Barros CC, Haro A, Russo FJVP, Schadock I, Almeida SS, Ribeiro RA et al. NOS Câmara editor 2012 Altered glucose homeostasis and hepatic function in obese mice deficient for both Kinin receptor genes. PLoS ONE 7 e40573 https://doi.org/10.1371/journal.pone.0040573.
Article CAS PubMed PubMed Central Google Scholar
Reis FCG, Haro AS, Bacurau AVN, Hirabara SM, Wasinski F, Ormanji MS et al. JA Chowen editor 2015 Deletion of Kinin B2 receptor alters muscle metabolism and exercise performance. PLoS ONE 10 e0134844 https://doi.org/10.1371/journal.pone.0134844.
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