Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. Lancet. 2006;367:1618–25.

Article  PubMed  Google Scholar 

Mazda Y, Jadin S, Kahn JS. Postoperative pain management. Can J Gen Intern Med. 2021;16:5–17.

Article  Google Scholar 

Glare P, Aubrey KR, Myles PS. Transition from acute to chronic pain after surgery. Lancet. 2019;393:1537–46.

Article  PubMed  Google Scholar 

Matsuda M, Huh Y, Ji RR. Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain. J Anesth. 2019;33:131–9.

Article  PubMed  Google Scholar 

Borsook D, Kussman BD, George E, Becerra LR, Burke DW. Surgically induced neuropathic pain: understanding the perioperative process. Ann Surg. 2013;257:403–12.

Article  PubMed  Google Scholar 

Pogatzki-Zahn EM, Gomez-Varela D, Erdmann G, Kaschube K, Segelcke D, Schmidt M. A proteome signature for acute incisional pain in dorsal root ganglia of mice. Pain. 2021;162:2070–86.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mitsui K, Hishiyama S, Jain A, Kotoda Y, Abe M, Matsukawa T, et al. Role of macrophage autophagy in postoperative pain and inflammation in mice. J Neuroinflammation. 2023;20:102.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji RR, Chamessian A, Zhang YQ. Pain regulation by non-neuronal cells and inflammation. Science. 2016;354:572–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pogatzki-Zahn EM, Segelcke D, Schug SA. Postoperative pain-from mechanisms to treatment. Pain Rep. 2017;2:e588.

Article  PubMed  PubMed Central  Google Scholar 

Guha A, Waris S, Nabors LB, Filippova N, Gorospe M, Kwan T, et al. The versatile role of HuR in glioblastoma and its potential as a therapeutic target for a multi-pronged attack. Adv Drug Deliv Rev. 2022;181:114082.

Article  CAS  PubMed  Google Scholar 

Guha A, Husain MA, Si Y, Nabors LB, Filippova N, Promer G, et al. RNA regulation of inflammatory responses in glia and its potential as a therapeutic target in central nervous system disorders. Glia. 2023;71:485–508.

Article  CAS  PubMed  Google Scholar 

Barreau C, Paillard L, Osborne HB. AU-rich elements and associated factors: are there unifying principles? Nucleic Acids Res. 2005;33:7138–50.

Article  CAS  PubMed  Google Scholar 

Brooks SA, Blackshear PJ. Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action. Biochim Biophys Acta. 2013;1829:666–79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Patial S, Blackshear PJ. Tristetraprolin as a therapeutic target in inflammatory disease. Trends Pharmacol Sci. 2016;37:811–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Snyder BL, Blackshear PJ. Clinical implications of tristetraprolin (TTP) modulation in the treatment of inflammatory diseases. Pharmacol Ther. 2022. https://doi.org/10.1016/j.pharmthera.2022.108198.

Article  PubMed  PubMed Central  Google Scholar 

Anderson P. Post-transcriptional regulons coordinate the initiation and resolution of inflammation. Nat Rev Immunol. 2010;10:24–35.

Article  CAS  PubMed  Google Scholar 

Sorge RE, Si Y, Norian LA, Guha A, Moore GE, Nabors LB, et al. Inhibition of the RNA regulator HuR by SRI-42127 attenuates neuropathic pain after nerve injury through suppression of neuroinflammatory responses. Neurotherapeutics. 2022;19:1649–61.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Borgonetti V, Galeotti N. Intranasal delivery of an antisense oligonucleotide to the RNA-binding protein HuR relieves nerve injury-induced neuropathic pain. Pain. 2021;162:1500–10.

Article  CAS  PubMed  Google Scholar 

Filippova N, Yang X, Ananthan S, Calano J, Pathak V, Bratton L, et al. Targeting the HuR oncogenic role with a new class of cytoplasmic dimerization inhibitors. Cancer Res. 2021;81:2220–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Husain MA, Smith R, Sorge RE, Kaimari A, Si Y, Hassan AZ, et al. Inhibition of the RNA regulator HuR mitigates spinal cord injury by potently suppressing post-injury neuroinflammation. FASEB J. 2025;39:e70588.

Article  CAS  PubMed  Google Scholar 

Qiu LQ, Stumpo DJ, Blackshear PJ. Myeloid-specific tristetraprolin deficiency in mice results in extreme lipopolysaccharide sensitivity in an otherwise minimal phenotype. J Immunol. 2012;188:5150–9.

Article  CAS  PubMed  Google Scholar 

Patial S, Curtis AD 2nd, Lai WS, Stumpo DJ, Hill GD, Flake GP, et al. Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies. Proc Natl Acad Sci U S A. 2016;113:1865–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sharma RK, Goswami B, Das Mandal S, Guha A, Willard B, Ray PS. Quorum sensing by gelsolin regulates Programmed Cell Death 4 expression and a density-dependent phenotype in macrophages. J Immunol. 2021;207:1250–64.

Article  CAS  PubMed  Google Scholar 

Chellappan R, Guha A, Si Y, Kwan T, Nabors LB, Filippova N, et al. SRI-42127, a novel small molecule inhibitor of the RNA regulator HuR, potently attenuates glial activation in a model of lipopolysaccharide-induced neuroinflammation. Glia. 2022;70:155–72.

Article  CAS  PubMed  Google Scholar 

Khan M, Gasser S. Generating Primary Fibroblast Cultures from Mouse Ear and Tail Tissues. Journal of visualized experiments: JoVE 2016.

Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994;53:55–63.

Article  CAS  PubMed  Google Scholar 

Rowland MB, Moore PE, Bui C, Correll RN. Assessing wound closure in mice using skin-punch biopsy. STAR Protoc. 2023;4:101989.

Article  PubMed  PubMed Central  Google Scholar 

Vanburen CS, Norman DB, Fröbisch NB. Examining the relationship between sexual dimorphism in skin anatomy and body size in the white-lipped treefrog, Litoria infrafrenata (Anura: Hylidae). Zool J Linn Soc. 2019;186:491–500.

Article  PubMed  PubMed Central  Google Scholar 

Gui WS, Wei X, Mai CL, Murugan M, Wu LJ, Xin WJ, et al. Interleukin-1beta overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents. Molecul Pain 2016; 12

Svensson CI. Interleukin-6: a local pain trigger? Arthritis Res Ther. 2010;12:145.

Article  PubMed  PubMed Central  Google Scholar 

Prudhomme M, Legras A, Delorme C, Lansaman T, Lanteri-Minet M, Medioni J, et al. Management of neuropathic pain induced by surgery: review of the literature by a group of experts specialized in pain management, anesthesia and surgery. J Visc Surg. 2020;157:43–52.

Article  CAS  PubMed  Google Scholar 

Ji R-R, Nackley A, Huh Y, Terrando N, Maixner W. Neuroinflammation and central sensitization in chronic and widespread pain. Anesthesiology. 2018;129:343–66.

Article  PubMed  Google Scholar 

Ni Choileain N, Redmond HP. Cell response to surgery. Arch Surg. 2006;141:1132–40.

Article