Aliyu M, Zohora FT, Anka AU, Ali K, Maleknia S, Saffarioun M, Azizi G (2022) Interleukin-6 cytokine: an overview of the immune regulation, immune dysregulation, and therapeutic approach. Int Immunopharmacol 111:109130. https://doi.org/10.1016/j.intimp.2022.109130
Article CAS PubMed Google Scholar
Azaria C, Nabila BZ, Sumiwi YAA, Susilowati R, Purnomosari D (2025) Inflammatory and morphological changes in the colon reflect early aging induced by d-galactose in rats. Sci Rep 15(1):35726. https://doi.org/10.1038/s41598-025-19437-1
Article CAS PubMed PubMed Central Google Scholar
Azman KF, Zakaria R (2019) d-Galactose-induced accelerated aging model: an overview. Biogerontology 20(6):763–782. https://doi.org/10.1007/s10522-019-09837-y
Baixauli-Martín J, Aliena-Valero A, Castelló-Ruiz M, Burguete MC, López-Morales MA, Muñoz-Espín D, Torregrosa G, Salom JB (2022) Brain cell senescence: a new therapeutic target for the acute treatment of ischemic stroke. J Neuropathol Exp Neurol 81(8):614–620. https://doi.org/10.1093/jnen/nlac048
Article CAS PubMed Google Scholar
Capparelli C, Chiavarina B, Whitaker-Menezes D, Pestell TG, Pestell RG, Hulit J, Andò S, Howell A, Martinez-Outschoorn UE, Sotgia F, Lisanti MP (2012) CDK inhibitors (p16/p19/p21) induce senescence and autophagy in cancer-associated fibroblasts, fueling tumor growth via paracrine interactions, without an increase in neo-angiogenesis. Cell Cycle 11(19):3599–3610. https://doi.org/10.4161/cc.21884
Article CAS PubMed PubMed Central Google Scholar
Cheng X, Yao H, Xiang Y, Chen L, Xiao M, Wang Z, Xiao H, Wang L, Wang S, Wang Y (2019) Effect of Angelica polysaccharide on brain senescence of Nestin-GFP mice induced by D-galactose. Neurochem Int 122:149–156. https://doi.org/10.1016/j.neuint.2018.09.003
Article CAS PubMed Google Scholar
Chia CW, Egan JM, Ferrucci L (2018) Age-related changes in glucose metabolism, hyperglycemia, and cardiovascular risk. Circ Res 123(7):886–904. https://doi.org/10.1161/circresaha.118.312806
Article CAS PubMed PubMed Central Google Scholar
Clay DE, Fox DT (2021) DNA damage responses during the cell cycle: insights from model organisms and beyond. Genes (Basel) 12(12):1882. https://doi.org/10.3390/genes12121882
Article CAS PubMed PubMed Central Google Scholar
Cowley MJ, Cotsapas CJ, Williams RBH, Chan EKF, Pulvers JN, Liu MY, Luo OJ, Nott DJ, Little PFR (2009) Intra- and inter-individual genetic differences in gene expression. Mamm Genome 20(5):281–295. https://doi.org/10.1007/s00335-009-9181-x
Article CAS PubMed PubMed Central Google Scholar
Engeland K (2022) Cell cycle regulation: p53-p21-RB signaling. Cell Death Differ 29(5):946–960. https://doi.org/10.1038/s41418-022-00988-z
Article CAS PubMed PubMed Central Google Scholar
Faget DV, Ren Q, Stewart SA (2019) Unmasking senescence: context-dependent effects of SASP in cancer. Nat Rev Cancer 19(8):439–453. https://doi.org/10.1038/s41568-019-0156-2
Article CAS PubMed Google Scholar
Fernández A, Quintana E, Velasco P, Moreno-Jimenez B, de Andrés B, Gaspar ML, Liste I, Vilar M, Mira H, Cano E (2021) Senescent accelerated prone 8 (SAMP8) mice as a model of age dependent neuroinflammation. J Neuroinflamm 18(1):75. https://doi.org/10.1186/s12974-021-02104-3
Galluzzi L, Yamazaki T, Kroemer G (2018) Linking cellular stress responses to systemic homeostasis. Nat Rev Mol Cell Biol 19(11):731–745. https://doi.org/10.1038/s41580-018-0068-0
Article CAS PubMed Google Scholar
García-Domínguez M (2025) Pathological and inflammatory consequences of aging. Biomolecules 15(3):404. https://doi.org/10.3390/biom15030404
Article CAS PubMed PubMed Central Google Scholar
García-Trejo SS, Gómez-Sierra T, Eugenio-Pérez D, Medina-Campos ON, Pedraza-Chaverri J (2024) Protective effect of curcumin on d-galactose-induced senescence and oxidative stress in LLC-PK1 and HK-2 cells. Antioxid (Basel) 13(4):415. https://doi.org/10.3390/antiox13040415
Ghanbari A, Danaie Fard P, Azarmehr N, Mahmoudi R, Roozbehi A, Zibara K, Hosseini E (2025) D-galactose induces senescence in adult mouse neural stem cells by imbalanced oxidant and antioxidant activity and differential expression of specific hub genes. Mol Neurobiol 62(4):4250–4263. https://doi.org/10.1007/s12035-024-04546-1
Article CAS PubMed Google Scholar
González-Gualda E, Baker AG, Fruk L, Muñoz-Espín D (2021) A guide to assessing cellular senescence in vitro and in vivo. FEBS J 288(1):56–80. https://doi.org/10.1111/febs.15570
Article CAS PubMed Google Scholar
Grebenciucova E, VanHaerents S (2023) Interleukin 6: at the interface of human health and disease. Front Immunol 14:1255533. https://doi.org/10.3389/fimmu.2023.1255533
Article CAS PubMed PubMed Central Google Scholar
Hernandez-Segura A, de Jong TV, Melov S, Guryev V, Campisi J, Demaria M (2017) Unmasking transcriptional heterogeneity in senescent cells. Curr Biol 27(17):2652–2660e2654. https://doi.org/10.1016/j.cub.2017.07.033
Article CAS PubMed PubMed Central Google Scholar
Hinkal GW, Gatza CE, Parikh N, Donehower LA (2009) Altered senescence, apoptosis, and DNA damage response in a mutant p53 model of accelerated aging. Mech Ageing Dev 130(4):262–271. https://doi.org/10.1016/j.mad.2009.01.001
Article CAS PubMed PubMed Central Google Scholar
Imerb N, Thonusin C, Pratchayasakul W, Arunsak B, Nawara W, Ongnok B, Aeimlapa R, Charoenphandhu N, Chattipakorn N, Chattipakorn SC (2022) D-galactose-induced aging aggravates obesity-induced bone dyshomeostasis. Sci Rep 12(1):8580. https://doi.org/10.1038/s41598-022-12206-4
Article CAS PubMed PubMed Central Google Scholar
Jung WK, Park SB, Kim HR, Ryu HY, Kim YH, Kim J (2021) Advanced glycation end products increase salivary gland hypofunction in d-galactose-induced aging rats and its prevention by physical exercise. Curr Issues Mol Biol 43(3):2059–2067. https://doi.org/10.3390/cimb43030142
Article CAS PubMed PubMed Central Google Scholar
Kiela PR, Ghishan FK (2016) Physiology of intestinal absorption and secretion. Best Pract Res Clin Gastroenterol 30(2):145–159. https://doi.org/10.1016/j.bpg.2016.02.007
Article CAS PubMed PubMed Central Google Scholar
Kim Y (2023) The impact of altered lamin B1 levels on nuclear lamina structure and function in aging and human diseases. Curr Opin Cell Biol 85:102257. https://doi.org/10.1016/j.ceb.2023.102257
Article CAS PubMed Google Scholar
Körholz JC, Zocher S, Grzyb AN, Morisse B, Poetzsch A, Ehret F, Schmied C, Kempermann G (2018) Selective increases in inter-individual variability in response to environmental enrichment in female mice. Elife 7. https://doi.org/10.7554/eLife.35690
Lamech LT, Haynes CM (2015) The unpredictability of prolonged activation of stress response pathways. J Cell Biol 209(6):781–787. https://doi.org/10.1083/jcb.201503107
Article CAS PubMed PubMed Central Google Scholar
Lee SJ, Trostel A, Le P, Harinarayanan R, Fitzgerald PC, Adhya S (2009) Cellular stress created by intermediary metabolite imbalances. PNAS 106(46):19515–19520. https://doi.org/10.1073/pnas.0910586106
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