Cao L, Liu GW, Gan YK, Fan QM, Yang F, Zhang XL, Tang TT, Dai KR (2012) The use of autologous enriched bone marrow MSCs to enhance osteoporotic bone defect repair in long-term estrogen deficient goats. Biomaterials 33(20):5076–5084. https://doi.org/10.1016/j.biomaterials.2012.03.069

Article  CAS  PubMed  Google Scholar 

Chen Q, Shou P, Zheng C, Jiang M, Cao G, Yang Q, Cao J, Xie N, Velletri T, Zhang X, Xu C, Zhang L, Yang H, Hou J, Wang Y, Shi Y (2016) Fate decision of mesenchymal stem cells: adipocytes or osteoblasts? Cell Death Differ 23(7):1128–1139. https://doi.org/10.1038/cdd.2015.168

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen C, Guo YY, Guo YX, Wu XK, Si CH, Xu YX, Kang QZ, Sun ZQ (2021a) m6A modification in non-coding RNA: the role in cancer drug resistance. Front Oncol. https://doi.org/10.3389/fonc.2021.746789

Article  PubMed  PubMed Central  Google Scholar 

Chen L, Luo W, Wang YZ, Song XB, Li SL, Wu J, Sun L (2021b) Directional homing of glycosylation-modified bone marrow mesenchymal stem cells for bone defect repair. J Nanobiotechnology. https://doi.org/10.1186/s12951-021-00969-3

Article  PubMed  PubMed Central  Google Scholar 

Cotts KG, Cifu AS (2018) Treatment of osteoporosis. JAMA 319(10):1040–1041. https://doi.org/10.1001/jama.2017.21995

Article  PubMed  Google Scholar 

Crane JL, Cao X (2014) Bone marrow mesenchymal stem cells and TGF-β signaling in bone remodeling. J Clin Invest 124(2):466–472. https://doi.org/10.1172/jci70050

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong X, Liao B, Zhao J, Li XX, Yan K, Ren K, Zhang XP, Bao XM, Guo WD (2023) METTL14 mediates m6a modification on osteogenic proliferation and differentiation of bone marrow mesenchymal stem cells by regulating the processing of pri-miR-873. Mol Med Rep. https://doi.org/10.3892/mmr.2023.13053

Article  PubMed  PubMed Central  Google Scholar 

He MY, Lei H, He XQ, Liu Y, Wang A, Ren ZJ, Liu XY, Yan GG, Wang WB, Wang Y, Li GH, Wang T, Pu JY, Shen ZH, Wang YQ, Xie JJ, Du WJ, Yuan Y, Yang L (2022) METTL14 regulates osteogenesis of bone marrow mesenchymal stem cells via inducing autophagy through m6A/IGF2BPs/Beclin-1 signal axis. Stem Cells Transl Med 11(9):987–1001. https://doi.org/10.1093/stcltm/szac049

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang TB, Yu Z, Yu Q, Wang Y, Jiang ZW, Wang HM, Yang GL (2020) Inhibition of osteogenic and adipogenic potential in bone marrow-derived mesenchymal stem cells under osteoporosis. Biochem Biophys Res Commun 525(4):902–908. https://doi.org/10.1016/j.bbrc.2020.03.035

Article  CAS  PubMed  Google Scholar 

Huang BY, Xie L, Ke M, Fan YH, Tan J, Ran JH, Zhu CH (2023) Programmed release METTL3-14 inhibitor microneedle protects myocardial function by reducing Drp1 m6A modification-mediated mitochondrial fission. ACS Appl Mater Interfaces 15(40):46583–46597. https://doi.org/10.1021/acsami.3c06318

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin Y, Wu A, Bian SS, Teng JW (2024) Icariin upregulates methyltransferase-like 14-mediated prolyl 4-hydroxy-lase beta subunit m6A modification to promote osteogenic differentiation of bone marrow stem cells. Exp Cell Res. https://doi.org/10.1016/j.yexcr.2024.114138

Article  PubMed  Google Scholar 

Kokabu S, Lowery JW, Jimi E (2016) Cell fate and differentiation of bone marrow mesenchymal stem cells. Stem Cells Int. https://doi.org/10.1155/2016/3753581

Article  PubMed  PubMed Central  Google Scholar 

Lee AR, Moon DK, Siregar A, Moon SY, Jeon RH, Son YB, Kim BG, Hah YS, Hwang SC, Byun JH, Woo DK (2019) Involvement of mitochondrial biogenesis during the differentiation of human periosteum-derived mesenchymal stem cells into adipocytes, chondrocytes and osteocytes. Arch Pharm Res 42(12):1052–1062. https://doi.org/10.1007/s12272-019-01198-x

Article  CAS  PubMed  Google Scholar 

Li HX, Xiao ZS, Quarles LD, Li W (2021) Osteoporosis: mechanism, molecular target and current status on drug development. Curr Med Chem 28(8):1489–1507. https://doi.org/10.2174/0929867327666200330142432

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang B, Burley G, Lin S, Shi YC (2022) Osteoporosis pathogenesis and treatment: existing and emerging avenues. Cell Mol Biol Lett. https://doi.org/10.1186/s11658-022-00371-3

Article  PubMed  PubMed Central  Google Scholar 

Lin YH, Chen CY, Chou LY, Chen CH, Kang L, Wang CZ (2017) Enhancement of bone marrow-derived mesenchymal stem cell osteogenesis and new bone formation in rats by Obtusilactone A. Int J Mol Sci. https://doi.org/10.3390/ijms18112422

Article  PubMed  PubMed Central  Google Scholar 

Lin ZY, He HB, Wang M, Liang JY (2019) MicroRNA-130a controls bone marrow mesenchymal stem cell differentiation towards the osteoblastic and adipogenic fate. Cell Prolif. https://doi.org/10.1111/cpr.12688

Article  PubMed  PubMed Central  Google Scholar 

Liu FX, Dong J, Zhang P, Zhou DS, Zhang QY (2022) Transcriptome sequencing reveals key genes in three early phases of osteogenic, adipogenic, and chondrogenic differentiation of bone marrow mesenchymal stem cells in rats. Front Mole Biosci. https://doi.org/10.3389/fmolb.2021.782054

Article  Google Scholar 

Mei ZQ, Mou YH, Zhang N, Liu XY, He ZS, Gu SY (2023) Emerging mutual regulatory roles between m6A modification and microRNAs. Int J Mol Sci. https://doi.org/10.3390/ijms24010773

Article  PubMed  PubMed Central  Google Scholar 

Sikora M, Smieszek A, Marycz K (2021) Bone marrow stromal cells (BMSCs CD45-/CD44+/CD73+/CD90+) isolated from osteoporotic mice SAM/P6 as a novel model for osteoporosis investigation. J Cell Mol Med 25(14):6634–6651. https://doi.org/10.1111/jcmm.16667

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song SS, Guo YY, Yang YH, Fu DH (2022) Advances in pathogenesis and therapeutic strategies for osteoporosis. Pharmacol Therapeut. https://doi.org/10.1016/j.pharmthera.2022.108168

Article  Google Scholar 

Sun ZY, Wang H, Wang YX, Yuan GD, Yu X, Jiang H, Wu Q, Yang BK, Hu ZB, Shi F, Cao XS, Zhang S, Guo T, Zhao JN (2021) MiR-103-3p targets the m6A methyltransferase METTL14 to inhibit osteoblastic bone formation. Aging Cell. https://doi.org/10.1111/acel.13298

Article  PubMed  PubMed Central  Google Scholar 

Sun KY, Chen L, Li YW, Huang B, Yan Q, Wu CJ, Lai QH, Fang YX, Cai JQ, Liu YF, Chen JS, Wang XK, Zhu YX, Dong SY, Tan JY, Li AM, Liu SD, Zhang Y (2023) METTL14-dependent maturation of pri-miR-17 regulates mitochondrial homeostasis and induces chemoresistance in colorectal cancer. Cell Death Dis. https://doi.org/10.1038/s41419-023-05670-x

Article  PubMed  PubMed Central  Google Scholar 

Tao ZB, Wang JP, Wen KC, Yao RQ, Da W, Zhou SM, Meng Y, Qiu S, Yang KD, Zhu Y, Tao L (2021) Pyroptosis in osteoblasts: a novel hypothesis underlying the pathogenesis of osteoporosis. Front Endocrinol. https://doi.org/10.3389/fendo.2020.548812

Article  Google Scholar 

Wang FS, Wu RW, Chen YS, Ko JY, Jahr H, Lian WS (2021a) Biophysical modulation of the mitochondrial metabolism and redox in bone homeostasis and osteoporosis: how biophysics converts into bioenergetics. Antioxidants. https://doi.org/10.3390/antiox10091394

Article  PubMed  PubMed Central  Google Scholar 

Wang HT, Wei P, Zhang Y, Li YB, Yin L (2021b) LncRNA TCONS_00023297 regulates the balance of osteogenic and adipogenic differentiation in bone marrow mesenchymal stem cells and the coupling process of osteogenesis and angiogenesis. Front Cell Develop Biol. https://doi.org/10.3389/fcell.2021.697858

Article  Google Scholar 

Wang S, Lv W, Li T, Zhang S, Wang H, Li X, Wei W (2022) Dynamic regulation and functions of mRNA m6A modification. Cancer Cell Int 22(1):48

Article  PubMed  PubMed Central  Google Scholar 

Wang W, Yan J, Han L, Zou ZL, Xu AL (2024) Silencing METTL14 alleviates liver injury in non-alcoholic fatty liver disease by regulating mitochondrial homeostasis. Biomol Biomed 24(3):505–519. https://doi.org/10.17305/bb.2023.9698

Article