Collaborators GLBP (2023) Global, regional, and national burden of other musculoskeletal disorders, 1990–2020, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021.[J]. Lancet Rheumatol. 5(11)
Nikolay LM et al (2016) Genetic alterations in intervertebral disc disease.[J]. Front Surg 3:59
Humzah MD et al (1988) Human intervertebral disc: structure and function. Anat Rec 220(4):337–356
Article CAS PubMed Google Scholar
Eyre DR et al (1976) Types I and II collagens in intervertebral disc. Interchanging radial distributions in annulus fibrosus. Biochem J 157(1):267
Article CAS PubMed PubMed Central Google Scholar
Nam VV et al (2013) Expression and regulation of metalloproteinases and their inhibitors in intervertebral disc aging and degeneration.[J]. Spine J 13(3):331–341
Chen F et al (2020) Melatonin activates autophagy via the NF-κB signaling pathway to prevent extracellular matrix degeneration in intervertebral disc.[J]. Osteoarthr Cartil 28(8):1121–1132
Xi Y et al (2020) PTEN promotes intervertebral disc degeneration by regulating nucleus pulposus cell behaviors.[J]. Cell Biol Int 44(2):583–592
Article CAS PubMed Google Scholar
Ge Q et al (2021) Chlorogenic Acid retards cartilaginous endplate degeneration and ameliorates intervertebral disc degeneration via suppressing NF-κB signaling.[J]. Life Sci 274:119324
Article CAS PubMed Google Scholar
Zhang TW et al (2021) Decorin inhibits nucleus pulposus apoptosis by matrix-induced autophagy via the mTOR pathway.[J]. J Orthop research: official publication Orthop Res Soc 39(8):1777–1788
Chen Z et al (2024) Dysfunction of STING autophagy degradation in senescent nucleus pulposus cells accelerates intervertebral disc degeneration.[J]. Int J Biol Sci 20(7):2370–2387
Article CAS PubMed PubMed Central Google Scholar
Das DN et al (2017) Elimination of dysfunctional mitochondria through mitophagy suppresses benzo[a]pyrene-induced apoptosis. Free Radic Biol Med 112:452–463
Article CAS PubMed Google Scholar
Jurkuvenaite A et al (2015) Upregulation of autophagy decreases chlorine-induced mitochondrial injury and lung inflammation. Free Radic Biol Med 85:83–94
Article CAS PubMed PubMed Central Google Scholar
Matsumoto G et al (2011) Serine 403 phosphorylation of p62/SQSTM1 regulates selective autophagic clearance of ubiquitinated proteins.[J]. Mol Cell 44(2):279–289
Article CAS PubMed Google Scholar
Metaxakis A et al (2018) Autophagy in age-associated neurodegeneration.[J]. Cells 7(5):2–24
Fîlfan M et al (2017) Autophagy in aging and disease. Romanian J morphology Embryol = Revue roumaine de morphologie et embryologie 58(1):27–31
Thu-Huyen P et al (2017) Fargesin exerts anti-inflammatory effects in THP-1 monocytes by suppressing PKC-dependent AP-1 and NF-ĸB signaling. Phytomedicine 24:96–103
Young-Sil L et al (2012) Fargesin improves lipid and glucose metabolism in 3T3-L1 adipocytes and high-fat diet-induced obese mice. BioFactors 38(4):300–308
Xin W et al (2015) Fargesin as a potential β₁ adrenergic receptor antagonist protects the hearts against ischemia/reperfusion injury in rats via attenuating oxidative stress and apoptosis. Fitoterapia 105:16–25
Wang G et al (2020) Fargesin alleviates atherosclerosis by promoting reverse cholesterol transport and reducing inflammatory response.[J]. Biochimica et biophysica acta. Mol cell biology lipids 1865(5):158633
Lu J et al (2021) Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways. Arthritis Res therapy 23(1):142
Zhou Y et al (2019) BRD4 suppression alleviates cerebral ischemia-induced brain injury by blocking glial activation via the inhibition of inflammatory response and pyroptosis. Biochem Biophys Res Commun 519(3):481–488
Article CAS PubMed Google Scholar
Zhang G et al (2025) BRD4/MAP2K7/PGF signaling axis promotes senescence and extracellular matrix metabolism of nucleus pulposus cells in intervertebral disk degeneration. Aging Cell 24(6):e70034
Article PubMed PubMed Central Google Scholar
Li Y et al (2020) Inhibition of Brd4 by JQ1 promotes functional recovery from spinal cord injury by activating autophagy. Front Cell Neurosci 14:555591
Article CAS PubMed PubMed Central Google Scholar
Xu YD et al (2024) Apoptotic body-inspired nanotherapeutics efficiently attenuate osteoarthritis by targeting BRD4-regulated synovial macrophage polarization.[J]. Biomaterials 306:122483
Article CAS PubMed Google Scholar
Lin S et al (2020) The therapeutic potential of BRD4 in cardiovascular disease.[J]. Hypertens research: official J Japanese Soc Hypertens 43(10):1006–1014
Zhang GZ et al (2022) BRD4 inhibition suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy during intervertebral disc degeneration: an in vitro and in vivo study. Oxidative medicine and cellular longevity. 9181412
Wang J et al (2019) BRD4 inhibition regulates MAPK, NF-κB signals, and autophagy to suppress MMP-13 expression in diabetic intervertebral disc degeneration. FASEB journal: official publication Federation Am Soc Experimental Biology 33(10):11555–11566
Bin H et al (2008) A simple disc degeneration model induced by percutaneous needle puncture in the rat tail.[J]. Spine (Phila Pa 1976). 33(18): 1925-1934
Jian C et al (2018) Sirt6 overexpression suppresses senescence and apoptosis of nucleus pulposus cells by inducing autophagy in a model of intervertebral disc degeneration. Cell Death Dis 9(2):56
Rebecca K et al (2024) Impact of autophagy inhibition on intervertebral disc cells and extracellular matrix. JOR Spine. 7(1),e1286
Yousof F et al (2024) Adipokines as potential pharmacological targets for immune inflammatory rheumatic diseases: Focus on rheumatoid arthritis, osteoarthritis, and intervertebral disc degeneration. Pharmacol Res 205:107219
Azril et al (2023) Correlation of the degenerative stage of a disc with magnetic resonance imaging, chemical content, and biomechanical properties of the nucleus pulposus. J Biomed Mater Res A 111(7):1054–1066
Article CAS PubMed Google Scholar
Brook IM et al (2018) Trends in lumbar fusion procedure rates and associated hospital costs for degenerative spinal diseases in the united states, 2004 to 2015. Spine (Phila Pa 1976). 44(5), 369-376
Guang-Zhi Z et al (2020) Sirtuins and intervertebral disc degeneration: Roles in inflammation, oxidative stress, and mitochondrial function. Clin Chim Acta 508:33–42
Wei Q et al (2024) BRD4: an effective target for organ fibrosis.[J]. Biomark Res 12(1):92
Article PubMed PubMed Central Google Scholar
Rebecca LO et al (2019) JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk. J Neuroinflammation 16(1):148
Zhan S et al (2020) lncRNA HOTAIR upregulates autophagy to promote apoptosis and senescence of nucleus pulposus cells.[J]. J Cell Physiol 235(3):2195–2208
Article CAS PubMed Google Scholar
Ma Y et al (2018) Autophagy controls mesenchymal stem cell properties and senescence during bone aging. Aging Cell 17(1), e12709
Junmin H et al (2020) Bromodomain-containing protein 4 inhibition alleviates matrix degradation by enhancing autophagy and suppressing NLRP3 inflammasome activity in NP cells. J Cell Physiol 235(7–8):5736–5749
Comments (0)