Voacangine targeting of PI3K/Akt/ERK via the knockdown of inflammation in DEN-induced liver cancer: in vivo and in silico approach

Abdu S, Juaid N, Amin A, Moulay M, Miled N (2022) Therapeutic effects of Crocin alone or in combination with Sorafenib against hepatocellular carcinoma: in vivo & in vitro insights. Antioxid (Basel) 11:1645. https://doi.org/10.3390/antiox11091645

Article  CAS  Google Scholar 

Abuthakir MHS, Al-Dosary MA, Hatamleh AA, Alodaini HA, Perumal P, Jeyam M (2022) Platyphylloside, a potential inhibitor from epicarp of B. aegyptiaca against CYP450 protein in T. rubrum - In in vitro and in Silico approaches. Saudi J Biol Sci 29:3899–3910. https://doi.org/10.1016/j.sjbs.2022.03.017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahmed OM, Fahim HI, Mohamed EE, Abdel-Moneim A (2022) Protective effects of persea Americana fruit and seed extracts against chemically induced liver cancer in rats by enhancing their antioxidant, anti-inflammatory, and apoptotic activities. Environ Sci Pollut Res Int 29:43858–43873. https://doi.org/10.1007/s11356-022-18902-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alturki NA, Mashraqi MM, Alzamami A, Alghamdi YS, Alharthi AA, Asiri SA, Ahmad S, Alshamrani S (2022) In-Silico screening and molecular dynamics simulation of drug bank experimental compounds against SARS-CoV-2. Molecules 27:4391. https://doi.org/10.3390/molecules27144391

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arboatti AS, Lambertucci F, Sedlmeier MG, Pisani G, Monti J, Álvarez ML, Francés DEA, Ronco MT, Carnovale CE (2018) Diethylnitrosamine increases proliferation in early stages of hepatic carcinogenesis in Insulin-Treated type 1 diabetic mice. Biomed Res Int 2018:9472939. https://doi.org/10.1155/2018/9472939

Article  CAS  PubMed  PubMed Central  Google Scholar 

Assar DH, Mokhbatly AA, Ghazy EW, Ragab AE, Abou Asa S, Abdo W, Elbialy ZI, Mohamed NE, El-Far AH (2021) Ameliorative effects of Aspergillus Awamori against the initiation of hepatocarcinogenesis induced by diethylnitrosamine in a rat model: regulation of Cyp19 and p53 gene expression. Antioxidants 10:922. https://doi.org/10.3390/antiox10060922

Article  CAS  Google Scholar 

Blessy JJ, Sharmila DJ (2015) Molecular simulation of N-acetylneuraminic acid analogs and molecular dynamics studies of cholera toxin-Neu5Gc complex. J Biomol Struct Dyn 33:1126–1139. https://doi.org/10.1080/07391102.2014.931825

Article  CAS  PubMed  Google Scholar 

Chen Z, Xie H, Hu M, Huang T, Hu Y, Sang N, Zhao Y (2020) Recent progress in treatment of hepatocellular carcinoma. Am J Cancer Res 10:2993–3036

CAS  PubMed  PubMed Central  Google Scholar 

Childers MC, Daggett V (2018) Validating molecular dynamics simulations against experimental observables in light of underlying conformational ensembles. J Phys Chem B 122:6673–6689. https://doi.org/10.1021/acs.jpcb.8b02144

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clark AJ, Tiwary P, Borrelli K, Feng S, Miller EB, Abel R, Friesner RA, Berne BJ (2016) Prediction of Protein–Ligand binding poses via a combination of induced fit Docking and metadynamics simulations. J Chem Theory Comput 12:2990–2998. https://doi.org/10.1021/acs.jctc.6b00201

Article  CAS  PubMed  Google Scholar 

Ding YF, Wu ZH, Wei YJ, Shu L, Peng YR (2017) Hepatic inflammation-fibrosis-cancer axis in the rat hepatocellular carcinoma induced by diethylnitrosamine. J Cancer Res Clin Oncol 143:821–834. https://doi.org/10.1007/s00432-017-2364-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang D, Xiong Z, Xu J, Yin J, Luo R (2019) Chemopreventive mechanisms of Galangin against hepatocellular carcinoma. Rev Biomed Pharmacother 109:2054–2061. https://doi.org/10.1016/j.biopha.2018.09.154

Article  CAS  Google Scholar 

Galluzzi L, Vitale I, Aaronson SA et al (2018) Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018. Cell Death Differ 25:486–541. https://doi.org/10.1038/s41418-017-0012-4

Article  PubMed  PubMed Central  Google Scholar 

Ganesan K, Xu B (2017) Polyphenol-Rich lentils and their health promoting effects. Int J Mol Sci 18:2390. https://doi.org/10.3390/ijms18112390

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gani SA, Muhammad SA, Kura AU, Barahuie F, Hussein MZ, Fakurazi S (2019) Effect of Protocatechuic acid-layered double hydroxide nanoparticles on diethylnitrosamine/phenobarbital-induced hepatocellular carcinoma in mice. PLoS ONE 14:e0217009. https://doi.org/10.1371/journal.pone.0217009

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gnanaraj C, Shah MD, Makki JS, Iqbal M (2016) Hepatoprotective effects of flagellaria indica are mediated through the suppression of pro-inflammatory cytokines and oxidative stress markers in rats. Pharm Biol 54:1420–1433. https://doi.org/10.3109/13880209.2015.1104697

Article  CAS  PubMed  Google Scholar 

Goyal A, Daneshpajouhnejad P, Hashmi MF, Bashir K (2023) Acute kidney injury. In: StatPearls. StatPearls Publishing, Treasure Island

Hadi S, Desy Ratnasari B, Septiyana M, Priyambodo S, Sudarma IM (2019) Antibacterial assay and alkaloid lombine distribution study of Voacangafoetida (BI) Rolfe from Lombok island, Oriental. J Chem 35. https://doi.org/10.13005/ojc/350133

Hou A, Zhen H, Qiao X, Dang H, Shen Y (2023) Voacangine mitigates human nasopharyngeal carcinoma cells HK-1 proliferation and triggers apoptosis through the suppression of NF-κB facilitated PI3K/AKT/mTOR pathway. Pharmacogn Mag 1012–1020. https://doi.org/10.1177/09731296231197

Jayakumar S, Madankumar A, Asokkumar S, Raghunandhakumar S, Gokula dhas K, Kamaraj S, Divya MG, Devaki T (2012) Potential preventive effect of carvacrol against diethylnitrosamine-induced hepatocellular carcinoma in rats. Mol Cell Biochem 360:51–60. https://doi.org/10.1007/s11010-011-1043-7

Article  CAS  PubMed  Google Scholar 

Jiang D, Xu J, Liu S, Nasser MI, Wei W, Mao T, Liu X, Zou X, Li J, Li X (2021) Rosmanol induces breast cancer cells apoptosis by regulating PI3K/AKT and STAT3/JAK2 signaling pathways. Oncol Lett 22:631. https://doi.org/10.3892/ol.2021.12892

Kumar V, Rahman M, Gahtori P, Al-Abbasi F, Anwar F, Kim HS (2021) Current status and future directions of hepatocellular carcinoma-targeted nanoparticles and nanomedicine. Expert Opin Drug Deliv 18:673–694. https://doi.org/10.1080/17425247.2021.1860939

Article  CAS  PubMed  Google Scholar 

Kurma K, Manches O, Chuffart F, Sturm N, Gharzeddine K, Zhang J, Mercey-Ressejac M, Rousseaux S, Millet A, Lerat H, Marche PN, Macek Jilkova Z, Decaens T (2021) DEN-Induced rat model reproduces key features of human hepatocellular carcinoma. Cancers 13:4981. https://doi.org/10.3390/cancers13194981

Article  CAS  PubMed  Google Scholar 

Ledda C, Loreto C, Zammit C, Marconi A, Fago L, Matera S, Costanzo V, Fuccio Sanzà G, Palmucci S, Ferrante M, Costa C, Fenga C, Biondi A, Pomara C, Rapisarda V (2017) Noninfective occupational risk factors for hepatocellular carcinoma: a review (Review). Mol Med Rep 15:511–533. https://doi.org/10.3892/mmr.2016.6046

Article  CAS  PubMed  Google Scholar 

Li G, Liu D, Cooper TK, Kimchi ET, Qi X, Avella DM, Li N, Yang QX, Kester M, Rountree CB, Kaifi JT, Cole DJ, Rockey DC, Schell TD, Staveley, Carroll KF (2017) Successful chemoimmunotherapy against hepatocellular cancer in a novel murine model. J Hepatol 66:75–85

CAS  PubMed  Google Scholar 

Li S, Yao J, Xie M, Liu Y, Zheng M (2018) Exosomal MiRNAs in hepatocellular carcinoma development and clinical responses. J Hematol Oncol 11:54. https://doi.org/10.1186/s13045-018-0579-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu J, Fan L, Yu H, Zhang J, He Y, Feng D, Wang F, Li X, Liu Q, Li Y, Guo Z, Gao B, Wei W, Wang H, Sun G (2017a) Endoplasmic reticulum stress causes liver cancer cells to release Exosomal miR-23a-3p and upregulate programmed death ligand 1 expression in macrophages. Hepatology 70:241–258. https://doi.org/10.1002/hep.30607

Article  CAS  Google Scholar 

Liu M, Du L, He Z, Yan L, Shi Y, Shang J, Tang H (2017b) Increased ERp57 expression in HBV-Related hepatocellular carcinoma: possible correlation and prognosis. Biomed Res Int 2017:1252647. https://doi.org/10.1155/2017/1252647

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mair CE, de Miranda Silva C, Grienke U, Kratz JM, Carreño F, Zimmermann ES, de Araújo BV, Dalla Costa T, Rollinger JM (2016) Pharmacokinetics of hERG channel blocking Voacangine in Wistar rats applying a validated LC–ESI–MS/MS method. Planta Med 82:1030–1038. https://doi.org/10.1055/s-0042-107800

Article  CAS  PubMed  Google Scholar 

Mak LY, Wong DK, Pollicino T, Raimondo G, Hollinger FB, Yuen MF (2020) Occult hepatitis B infection and hepatocellular carcinoma: epidemiology, virology, hepatocarcinogenesis and clinical significance. J Hepatol 73:952–964.

Comments (0)

No login
gif