Bano A, Suyal G, Saraya A, Sharma R (2024) miR-335-5p Inhibits EMT and PI3K/AKT Pathways via MARCH8. Ind J Clin Biochem. https://doi.org/10.1007/s12291-023-01175-8
Bartee E, Mansouri M, Hovey Nerenberg B, Gouveia K, Früh K (2004) Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. J Virol 78:1109–1120. https://doi.org/10.1128/JVI.78.3.1109-1120.2004
Article CAS PubMed PubMed Central Google Scholar
Bartee E, Eyster CA, Viswanathan K, Mansouri M, Donaldson JG, Früh K (2010) Membrane Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes. PLoS ONE 5(12):e15132. https://doi.org/10.1371/journal.pone.0015132
Article CAS PubMed PubMed Central Google Scholar
Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229–263. https://doi.org/10.3322/caac.21834
Chen R, Li M, Zhang Y, Zhou Q, Shu HB (2012) The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation. Proc Natl Acad Sci U S A 109:14128–14133. https://doi.org/10.1073/pnas.1205246109
Article PubMed PubMed Central Google Scholar
Chen W, Patel D, Jia Y, Yu Z, Liu X, Shi H, Liu H (2018) Sh-MARCH8 Inhibits Tumorigenesis via PI3K Pathway in Gastric Cancer. Cell Physiol Biochem 49(1):306–321. https://doi.org/10.1159/000492882
Chen HN, Liang KH, Lai JK, Lan CH, Liao MY, Hung SH, Chuang YT, Chen KC, Tsuei WW, Wu HC (2020) EpCAM Signaling Promotes Tumor Progression and Protein Stability of PD-L1 through the EGFR Pathway. Cancer Res 80(22):5035–5050. https://doi.org/10.1158/0008-5472.CAN-20-1264
Article CAS PubMed Google Scholar
Chen W, Patel D, Jia Y, Yu Z, Liu X, Shi H, Liu H (2021) MARCH8 Suppresses Tumor Metastasis and Mediates Degradation of STAT3 and CD44 in Breast Cancer Cells. Cancers (Basel) 13(11):2550. https://doi.org/10.3390/cancers13112550
Article CAS PubMed PubMed Central Google Scholar
Chen C, Wang Y, Zhao Q, Li GD, Wang YH, Xu LC, Huang HZ, Song G, Li WT, He XH (2023) E3 Ubiquitin Ligase MARCH8 Promotes Pancreatic Cancer Growth and Metastasis by Activating STAT3 via Degradation of PTPN4. Pancreas 52(4):e224–e234. https://doi.org/10.1097/MPA.0000000000002244
Article CAS PubMed Google Scholar
Chen W, Zhai Y, Yang X, Zhang W, Gao D, Zhao X, Zhao N, Zhang Y, Yuan Q, Zhao Z, Wu Q, Xie Y, Zhao J, Dong Z, Liu K, Jiang Y (2025) CERS6 promotes esophageal squamous cell carcinoma proliferation by increasing the stability of RPN1. Cell Death Discov 11(1):512. https://doi.org/10.1038/s41420-025-02727-y
Article CAS PubMed PubMed Central Google Scholar
Cui Y, Li J, Liu X, Gu L, Lyu M, Zhou J, Zhang X, Liu Y, Zhu H, Zhang T, Sun F (2022) Dynamic Expression of EpCAM in Primary and Metastatic Lung Cancer Is Controlled by Both Genetic and Epigenetic Mechanisms. Cancers (Basel) 14(17):4121. https://doi.org/10.3390/cancers14174121
Article CAS PubMed PubMed Central Google Scholar
Driemel C, Kremling H, Schumacher S, Will D, Wolters J, Lindenlauf N, Mack B, Baldus SA, Hoya V, Pietsch JM, Panagiotidou P, Raba K, Vay C, Vallböhmer D, Harréus U, Knoefel WT, Stoecklein NH, Gires O (2014) Context-dependent adaption of EpCAM expression in early systemic esophageal cancer. Oncogene 33(41):4904–4915. https://doi.org/10.1038/onc.2013.441
Article CAS PubMed Google Scholar
Eyster CA, Cole NB, Petersen S, Viswanathan K, Früh K, Donaldson JG (2011) MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation. Mol Biol Cell 22:3218–3230. https://doi.org/10.1091/mbc.E10-11-0874
Article CAS PubMed PubMed Central Google Scholar
Fan W, Tang Z, Chen D, Moughon D, Ding X, Chen S, Zhu M, Zhong Q (2010) Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy 6(5):614–621. https://doi.org/10.4161/auto.6.5.12189
Article CAS PubMed PubMed Central Google Scholar
Fan J, Tian L, Li M, Huang SH, Zhang J, Zhao B (2017) MARCH8 is associated with poor prognosis in non-small cell lung cancers patients. Oncotarget 8(64):108238–108248. https://doi.org/10.18632/oncotarget.22602
Article PubMed PubMed Central Google Scholar
Ferri F (2013) Ferri’s clinical advisor 5 books in 1, 1st edn. Elsevier, St. Louis, Mo.
Goto E, Ishido S, Sato Y, Ohgimoto S, Nagano-Fujii M, Hotta H (2003) c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. J Biol Chem 278:14657–14668. https://doi.org/10.1074/jbc.M211285200
Article CAS PubMed Google Scholar
Hasan MR, Sharma R, Saraya A, Chattopadhyay TK, DattaGupta S, Walfish PG, Chauhan SS, Ralhan R (2013) Slug is a predictor of poor prognosis in esophageal squamous cell carcinoma patients. PLoS One 2013 8(12):e82846. https://doi.org/10.1371/journal.pone.0082846
Hershko A, Ciechanover A (1998) The ubiquitin system. Annu Rev Biochem 67:425–479. https://doi.org/10.1146/annurev.biochem.67.1.425
Article CAS PubMed Google Scholar
Holzerlandt R, Orengo C, Kellam P, Albà MM (2002) Identification of new herpesvirus gene homologs in the human genome. Genome Res 12(11):1739–1748. https://doi.org/10.1101/gr.334302
Article CAS PubMed PubMed Central Google Scholar
Hyun KA, Koo GB, Han H, Sohn J, Choi W, Kim SI, Jung HI, Kim YS (2016) Epithelial-to-mesenchymal transition leads to loss of EpCAM and different physical properties in circulating tumor cells from metastatic breast cancer. Oncotarget 7(17):24677–24687
Article PubMed PubMed Central Google Scholar
Kim MH, Rebbert ML, Ro H, Won M, Dawid IB (2014) Cell adhesion in zebrafish embryos is modulated by March 8. PLoS ONE 9:e94873. https://doi.org/10.1371/journal.pone.0094873
Article CAS PubMed PubMed Central Google Scholar
Kimura H, Kato H, Faried A, Sohda M, Nakajima M, Fukai Y, Miyazaki T, Masuda N, Fukuchi M, Kuwano H (2007) Prognostic significance of EpCAM expression in human esophageal cancer. Int J Oncol 30(1):171–179. https://doi.org/10.3892/ijo.30.1.171
Article CAS PubMed Google Scholar
Lee CC, Su YJ, Panda SS, Chiu CY, Wu CH, Lu TM, Li PC, Huang YL, Hong RL, Hung SH, Yee C, Lai SY, Wu HC (2025) EpCAM activates the ERK-EGR1 signaling axis and promotes TNF-α-induced the progression of anaplastic thyroid cancer. J Transl Med. https://doi.org/10.1186/s12967-025-07575-zEpub ahead of print
Article PubMed PubMed Central Google Scholar
Li K, Wang Q, Bian H (2023) USP45 acts as an oncogene to regulate the proliferation of esophageal cancer cells. Genes Dis 11(5):101135. https://doi.org/10.1016/j.gendis.2023.101135
Article CAS PubMed PubMed Central Google Scholar
Litvinov SV, Velders MP, Bakker HA, Fleuren GJ, Warnaar SO (1994) Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. J Cell Biol 125(2):437–446. https://doi.org/10.1083/jcb.125.2.437
Article CAS PubMed PubMed Central Google Scholar
Liu H, Jain R, Guan J, Vuong V, Ishido S, La Gruta NL, Gray DH, Villadangos JA, Mintern JD (2016) Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection. J Exp Med 213(9):1695–1703. https://doi.org/10.1084/jem.20160312
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