EpCAM as a novel target of MARCH8: implications for esophageal squamous cell carcinoma progression

Bano A, Suyal G, Saraya A, Sharma R (2024) miR-335-5p Inhibits EMT and PI3K/AKT Pathways via MARCH8. Ind J Clin Biochem. https://doi.org/10.1007/s12291-023-01175-8

Article  Google Scholar 

Bartee E, Mansouri M, Hovey Nerenberg B, Gouveia K, Früh K (2004) Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. J Virol 78:1109–1120. https://doi.org/10.1128/JVI.78.3.1109-1120.2004

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bartee E, Eyster CA, Viswanathan K, Mansouri M, Donaldson JG, Früh K (2010) Membrane Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes. PLoS ONE 5(12):e15132. https://doi.org/10.1371/journal.pone.0015132

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bray F, Laversanne M, Sung H, Ferlay J, Siegel RL, Soerjomataram I, Jemal A (2024) Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 74(3):229–263. https://doi.org/10.3322/caac.21834

Article  PubMed  Google Scholar 

Chen R, Li M, Zhang Y, Zhou Q, Shu HB (2012) The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation. Proc Natl Acad Sci U S A 109:14128–14133. https://doi.org/10.1073/pnas.1205246109

Article  PubMed  PubMed Central  Google Scholar 

Chen W, Patel D, Jia Y, Yu Z, Liu X, Shi H, Liu H (2018) Sh-MARCH8 Inhibits Tumorigenesis via PI3K Pathway in Gastric Cancer. Cell Physiol Biochem 49(1):306–321. https://doi.org/10.1159/000492882

Article  CAS  Google Scholar 

Chen HN, Liang KH, Lai JK, Lan CH, Liao MY, Hung SH, Chuang YT, Chen KC, Tsuei WW, Wu HC (2020) EpCAM Signaling Promotes Tumor Progression and Protein Stability of PD-L1 through the EGFR Pathway. Cancer Res 80(22):5035–5050. https://doi.org/10.1158/0008-5472.CAN-20-1264

Article  CAS  PubMed  Google Scholar 

Chen W, Patel D, Jia Y, Yu Z, Liu X, Shi H, Liu H (2021) MARCH8 Suppresses Tumor Metastasis and Mediates Degradation of STAT3 and CD44 in Breast Cancer Cells. Cancers (Basel) 13(11):2550. https://doi.org/10.3390/cancers13112550

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen C, Wang Y, Zhao Q, Li GD, Wang YH, Xu LC, Huang HZ, Song G, Li WT, He XH (2023) E3 Ubiquitin Ligase MARCH8 Promotes Pancreatic Cancer Growth and Metastasis by Activating STAT3 via Degradation of PTPN4. Pancreas 52(4):e224–e234. https://doi.org/10.1097/MPA.0000000000002244

Article  CAS  PubMed  Google Scholar 

Chen W, Zhai Y, Yang X, Zhang W, Gao D, Zhao X, Zhao N, Zhang Y, Yuan Q, Zhao Z, Wu Q, Xie Y, Zhao J, Dong Z, Liu K, Jiang Y (2025) CERS6 promotes esophageal squamous cell carcinoma proliferation by increasing the stability of RPN1. Cell Death Discov 11(1):512. https://doi.org/10.1038/s41420-025-02727-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui Y, Li J, Liu X, Gu L, Lyu M, Zhou J, Zhang X, Liu Y, Zhu H, Zhang T, Sun F (2022) Dynamic Expression of EpCAM in Primary and Metastatic Lung Cancer Is Controlled by Both Genetic and Epigenetic Mechanisms. Cancers (Basel) 14(17):4121. https://doi.org/10.3390/cancers14174121

Article  CAS  PubMed  PubMed Central  Google Scholar 

Driemel C, Kremling H, Schumacher S, Will D, Wolters J, Lindenlauf N, Mack B, Baldus SA, Hoya V, Pietsch JM, Panagiotidou P, Raba K, Vay C, Vallböhmer D, Harréus U, Knoefel WT, Stoecklein NH, Gires O (2014) Context-dependent adaption of EpCAM expression in early systemic esophageal cancer. Oncogene 33(41):4904–4915. https://doi.org/10.1038/onc.2013.441

Article  CAS  PubMed  Google Scholar 

Eyster CA, Cole NB, Petersen S, Viswanathan K, Früh K, Donaldson JG (2011) MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation. Mol Biol Cell 22:3218–3230. https://doi.org/10.1091/mbc.E10-11-0874

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan W, Tang Z, Chen D, Moughon D, Ding X, Chen S, Zhu M, Zhong Q (2010) Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy. Autophagy 6(5):614–621. https://doi.org/10.4161/auto.6.5.12189

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan J, Tian L, Li M, Huang SH, Zhang J, Zhao B (2017) MARCH8 is associated with poor prognosis in non-small cell lung cancers patients. Oncotarget 8(64):108238–108248. https://doi.org/10.18632/oncotarget.22602

Article  PubMed  PubMed Central  Google Scholar 

Ferri F (2013) Ferri’s clinical advisor 5 books in 1, 1st edn. Elsevier, St. Louis, Mo.

Google Scholar 

Goto E, Ishido S, Sato Y, Ohgimoto S, Nagano-Fujii M, Hotta H (2003) c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. J Biol Chem 278:14657–14668. https://doi.org/10.1074/jbc.M211285200

Article  CAS  PubMed  Google Scholar 

Hasan MR, Sharma R, Saraya A, Chattopadhyay TK, DattaGupta S, Walfish PG, Chauhan SS, Ralhan R (2013) Slug is a predictor of poor prognosis in esophageal squamous cell carcinoma patients. PLoS One 2013 8(12):e82846. https://doi.org/10.1371/journal.pone.0082846

Article  CAS  Google Scholar 

Hershko A, Ciechanover A (1998) The ubiquitin system. Annu Rev Biochem 67:425–479. https://doi.org/10.1146/annurev.biochem.67.1.425

Article  CAS  PubMed  Google Scholar 

Holzerlandt R, Orengo C, Kellam P, Albà MM (2002) Identification of new herpesvirus gene homologs in the human genome. Genome Res 12(11):1739–1748. https://doi.org/10.1101/gr.334302

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hyun KA, Koo GB, Han H, Sohn J, Choi W, Kim SI, Jung HI, Kim YS (2016) Epithelial-to-mesenchymal transition leads to loss of EpCAM and different physical properties in circulating tumor cells from metastatic breast cancer. Oncotarget 7(17):24677–24687

Article  PubMed  PubMed Central  Google Scholar 

Kim MH, Rebbert ML, Ro H, Won M, Dawid IB (2014) Cell adhesion in zebrafish embryos is modulated by March 8. PLoS ONE 9:e94873. https://doi.org/10.1371/journal.pone.0094873

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kimura H, Kato H, Faried A, Sohda M, Nakajima M, Fukai Y, Miyazaki T, Masuda N, Fukuchi M, Kuwano H (2007) Prognostic significance of EpCAM expression in human esophageal cancer. Int J Oncol 30(1):171–179. https://doi.org/10.3892/ijo.30.1.171

Article  CAS  PubMed  Google Scholar 

Lee CC, Su YJ, Panda SS, Chiu CY, Wu CH, Lu TM, Li PC, Huang YL, Hong RL, Hung SH, Yee C, Lai SY, Wu HC (2025) EpCAM activates the ERK-EGR1 signaling axis and promotes TNF-α-induced the progression of anaplastic thyroid cancer. J Transl Med. https://doi.org/10.1186/s12967-025-07575-zEpub ahead of print

Article  PubMed  PubMed Central  Google Scholar 

Li K, Wang Q, Bian H (2023) USP45 acts as an oncogene to regulate the proliferation of esophageal cancer cells. Genes Dis 11(5):101135. https://doi.org/10.1016/j.gendis.2023.101135

Article  CAS  PubMed  PubMed Central  Google Scholar 

Litvinov SV, Velders MP, Bakker HA, Fleuren GJ, Warnaar SO (1994) Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. J Cell Biol 125(2):437–446. https://doi.org/10.1083/jcb.125.2.437

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu H, Jain R, Guan J, Vuong V, Ishido S, La Gruta NL, Gray DH, Villadangos JA, Mintern JD (2016) Ubiquitin ligase MARCH 8 cooperates with CD83 to control surface MHC II expression in thymic epithelium and CD4 T cell selection. J Exp Med 213(9):1695–1703. https://doi.org/10.1084/jem.20160312

Article  CAS  PubMed 

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