Disrupting the circTNC/miR-582-5p/MAPK8 axis alleviates oxidative stress-induced trophoblast dysfunction in preeclampsia

Ali M et al (2024) Preeclampsia: a comprehensive review. Clin Chim Acta 563:119922

Article  PubMed  CAS  Google Scholar 

Brooker IA et al (2024) Understanding the impact of placental oxidative and nitrative stress in pregnancies complicated by fetal growth restriction. Placenta 158:318–328

Article  PubMed  CAS  Google Scholar 

Cao M et al (2023) Reversal of H(2)O(2)-induced cell death by knockdown of HOTAIR in HTR-8/SVneo cells by mediation of miR-106b-5p/ACSL4 axis. Funct Integr Genomics 23(2):161

Article  PubMed  CAS  Google Scholar 

Chen Z et al (2022) Ferroptosis and its emerging role in pre-eclampsia. Antioxid (Basel) 11(7):1282

Cunningham MW Jr. et al (2018) AT1-AA (angiotensin II type 1 receptor agonistic autoantibody) blockade prevents preeclamptic symptoms in placental ischemic rats. Hypertension 71(5):886–893

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fox R et al (2019) Preeclampsia: risk factors, diagnosis, management, and the cardiovascular impact on the offspring. J Clin Med 8(10):1625

Fuchs Wightman F et al (2024) Influence of RNA circularity on target RNA-directed MicroRNA degradation. Nucl Acids Res 52(6):3358–3374

Article  PubMed  PubMed Central  Google Scholar 

Gehi BR et al (2022) Intrinsic disorder in proteins associated with oxidative stress-induced JNK signaling. Cell Mol Life Sci 79(4):202

Article  PubMed  PubMed Central  CAS  Google Scholar 

Guindi C et al (2023) Inhibition of PI3K/C/EBPβ axis in tolerogenic bone marrow-derived dendritic cells of NOD mice promotes Th17 differentiation and diabetes development. Transl Res 255:37–49

Article  CAS  Google Scholar 

Guo YJ et al (2020) ERK/MAPK signalling pathway and tumorigenesis. Exp Ther Med 19(3):1997–2007

PubMed  PubMed Central  Google Scholar 

Gusella A, Martignoni G, Giacometti C (2024) Behind the curtain of abnormal placentation in pre-eclampsia: from molecular mechanisms to histological hallmarks. Int J Mol Sci 25(14):7886

Article  PubMed  PubMed Central  CAS  Google Scholar 

He P et al (2025) Amomum villosum Lour. alleviates pre-eclampsia by inducing enrichment of Bifidobacterium bifidum through vanillic acid to inhibit placental ferroptosis. J Ethnopharmacol 340:119217

Article  PubMed  CAS  Google Scholar 

Huang X et al (2019) Genetic polymorphism in DGCR8 is associated with late onset of preeclampsia. BMC Med Genet 20(1):151

Article  PubMed  PubMed Central  Google Scholar 

Huang Y, Bai Z, Sui S (2024) miR-224-5p alleviates preeclampsia-like mouse symptoms by targeting PANX1 to inhibit ferroptosis in trophoblast cells. Placenta 158:113–125

Article  PubMed  CAS  Google Scholar 

Ives CW et al (2020) Preeclampsia—pathophysiology and clinical presentations. JACC 76(14):1690–1702

Article  PubMed  CAS  Google Scholar 

Jaszczuk I et al (2022) The role of miRNA-210 in pre-eclampsia development. Ann Med 54(1):1350–1356

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kornacki J et al (2024) Pathophysiology of pre-eclampsia—two theories of the development of the disease. Int J Mol Sci 25(1):307

Article  CAS  Google Scholar 

Lai W, Yu L, Deng Y (2024) PPARγ alleviates preeclampsia development by regulating lipid metabolism and ferroptosis. Commun Biol 7(1):429

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li L, Ma L (2018) Upregulation of miR-582-5p regulates cell proliferation and apoptosis by targeting AKT3 in human endometrial carcinoma. Saudi J Biol Sci 25(5):965–970

Article  PubMed  PubMed Central  Google Scholar 

Liu J et al (2022) circ_0085296 inhibits the biological functions of trophoblast cells to promote the progression of preeclampsia via the miR-942-5p/THBS2 network. Open Med (Wars) 17(1):577–588

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lopes ACS et al (2025) Changes in microRNA expression associated with preeclampsia: a systematic review. Braz J Med Biol Res 58:e13988

Article  PubMed  PubMed Central  CAS  Google Scholar 

Malik A, Pal R, Gupta SK (2020) EGF-mediated reduced miR-92a-1-5p controls HTR-8/SVneo cell invasion through activation of MAPK8 and FAS which in turn increase MMP-2/-9 expression. Sci Rep 10(1):12274

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nalbant E, Akkaya-Ulum YZ (2024) Exploring regulatory mechanisms on miRNAs and their implications in inflammation-related diseases. Clin Exp Med 24(1):142

Article  CAS  Google Scholar 

Ortega MA et al (2024) Oxidative stress, lipid peroxidation and ferroptosis are major pathophysiological signatures in the placental tissue of women with late-onset preeclampsia. Antioxid (Basel) 13(5):591

Pong SK, Gullerova M (2018) Noncanonical functions of microRNA pathway enzymes - Drosha, DGCR8, Dicer and Ago proteins. FEBS Lett 592(17):2973–2986

Article  PubMed  CAS  Google Scholar 

Qiu M et al (2025) Hyperlipidemia exacerbates acute pancreatitis via interactions between P38MAPK and oxidative stress. Cell Signal 125:111504

Article  PubMed  CAS  Google Scholar 

Shan Y et al (2023) Impact of ferroptosis on preeclampsia: a review. Biomed Pharmacother 167:115466

Article  PubMed  CAS  Google Scholar 

Shi F, Li L (2022) Hsa_circ_0088196 suppresses trophoblast migration and invasion by the miR-525-5p/ABL1 axis and the PI3K/AKT signaling pathway. J Biochem Mol Toxicol 36(10):e23150

Article  PubMed  CAS  Google Scholar 

Shi Y et al (2022) Downregulation of Circ_0088196 contributes to the development of trophoblastic cells through miR-133b sponging function to affect the AHNAK expression. Gynecol Obstet Invest 87(5):305–315

Article  PubMed  CAS  Google Scholar 

Shu Z, Chen L, Ding D (2016) miR-582-5P induces colorectal cancer cell proliferation by targeting adenomatous polyposis coli. World J Surg Oncol 14(1):239

Article  PubMed  PubMed Central  Google Scholar 

Su MT et al (2017) miR-346 and miR-582-3p-regulated EG-VEGF expression and trophoblast invasion via matrix metalloproteinases 2 and 9. Biofactors 43(2):210–219

Tian X et al (2024) Circ_0030042 inhibits trophoblast cell growth, invasion and epithelial-mesenchymal transition process in preeclampsia via miR-942-5p/LITAF. J Reprod Immunol 162:104205

Article  PubMed  CAS  Google Scholar 

Tobita T, Kiyozumi D, Ikawa M (2017) Placenta-specific gene manipulation using lentiviral vector and its application. Placenta 59:S37–S43

Article  PubMed  CAS  Google Scholar 

Torres-Torres J et al (2024) A narrative review on the pathophysiology of preeclampsia. Int J Mol Sci 25(14):7569

Wang W, Liu J, Pan E (2022) CircHIPK3 contributes to human villous trophoblast growth, migration and invasion via modulating the pathway of miR-346/KCMF1. Placenta 118:46–54

Article  PubMed  CAS  Google Scholar 

Wang X et al (2023) The emerging roles of MAPK-AMPK in ferroptosis regulatory network. Cell Commun Signal 21(1):200

Article  PubMed  PubMed Central 

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