Cx43 modulates malignant phenotypes in bladder cancer cells via the c-Src/PTEN/FAK axis

Ai XL, Chi Q, Qiu Y, Li HY, Li DJ, Wang JX, Wang ZY (2017) Gap junction protein connexin43 deregulation contributes to bladder carcinogenesis via targeting MAPK pathway. Mol Cell Biochem 428:109–118. https://doi.org/10.1007/s11010-016-2921-9

Article  CAS  PubMed  Google Scholar 

Ashrafizadeh M, Zarrabi A, Samarghandian S, Najafi M (2020) PTEN: what we know of the function and regulation of this onco-suppressor factor in bladder cancer? Eur J Pharmacol 881:173226. https://doi.org/10.1016/j.ejphar.2020.173226

Article  CAS  PubMed  Google Scholar 

Busby M, Hallett MT, Plante I (2018) The complex subtype-dependent role of connexin 43 (GJA1) in breast cancer. Int J Mol Sci. https://doi.org/10.3390/ijms19030693

Article  PubMed  PubMed Central  Google Scholar 

Carneiro BA, Meeks JJ, Kuzel TM, Scaranti M, Abdulkadir SA, Giles FJ (2015) Emerging therapeutic targets in bladder cancer. Cancer Treat Rev 41:170–178. https://doi.org/10.1016/j.ctrv.2014.11.003

Article  CAS  PubMed  Google Scholar 

Chi Q, Wang ZY, Li HY, Song DB, Xu H, Ma G, Wang ZM, Li XM (2019) Tumor-suppressor microRNA-139-5p restrains bladder cancer cell line ECV-304 properties via targeting Connexin 43. Chin Med J (Engl) 132:2354–2361. https://doi.org/10.1097/cm9.0000000000000455

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dawson JC, Serrels A, Stupack DG, Schlaepfer DD, Frame MC (2021) Targeting FAK in anticancer combination therapies. Nat Rev Cancer 21:313–324. https://doi.org/10.1038/s41568-021-00340-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dobruch J, Oszczudłowski M (2021) Bladder cancer: current challenges and future directions. Medicina (Kaunas). https://doi.org/10.3390/medicina57080749

Article  PubMed  PubMed Central  Google Scholar 

Dong C, Li X, Yang J, Yuan D, Zhou Y, Zhang Y, Shi G, Zhang R, Liu J, Fu P, Sun M (2021) PPFIBP1 induces glioma cell migration and invasion through FAK/Src/JNK signaling pathway. Cell Death Dis 12:827. https://doi.org/10.1038/s41419-021-04107-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dyrskjøt L, Hansel DE, Efstathiou JA, Knowles MA, Galsky MD, Teoh J, Theodorescu D (2023) Bladder cancer. Nat Rev Dis Primers 9:58. https://doi.org/10.1038/s41572-023-00468-9

Article  PubMed  PubMed Central  Google Scholar 

Egawa H, Jingushi K, Hirono T, Ueda Y, Kitae K, Nakata W, Fujita K, Uemura M, Nonomura N, Tsujikawa K (2016) The miR-130 family promotes cell migration and invasion in bladder cancer through FAK and Akt phosphorylation by regulating PTEN. Sci Rep 6:20574. https://doi.org/10.1038/srep20574

Article  CAS  PubMed  PubMed Central  Google Scholar 

Exposito F, Redrado M, Houry M, Hastings K, Molero-Abraham M, Lozano T, Solorzano JL, Sanz-Ortega J, Adradas V, Amat R, Redin E, Leon S, Legarra N, Garcia J, Serrano D, Valencia K, Robles-Oteiza C, Foggetti G, Otegui N, Felip E, Lasarte JJ, Paz-Ares L, Zugazagoitia J, Politi K, Montuenga L, Calvo A (2023) PTEN loss confers resistance to anti-PD-1 therapy in non-small cell lung cancer by increasing tumor infiltration of regulatory T cells. Cancer Res 83:2513–2526. https://doi.org/10.1158/0008-5472.Can-22-3023

Article  CAS  PubMed  Google Scholar 

Ge X, Li M, Yin J, Shi Z, Fu Y, Zhao N, Chen H, Meng L, Li X, Hu Z, Zhao X, Guo H, Qian X (2022) Fumarate inhibits PTEN to promote tumorigenesis and therapeutic resistance of type2 papillary renal cell carcinoma. Mol Cell 82:1249-1260.e7. https://doi.org/10.1016/j.molcel.2022.01.029

Article  CAS  PubMed  Google Scholar 

Guo Q, Lu L, Liao Y, Wang X, Zhang Y, Liu Y, Huang S, Sun H, Li Z, Zhao L (2018) Influence of c-Src on hypoxic resistance to paclitaxel in human ovarian cancer cells and reversal of FV-429. Cell Death Dis 8:e3178. https://doi.org/10.1038/cddis.2017.367

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ho JN, Byun SS, Kim D, Ryu H, Lee S (2024) Dasatinib induces apoptosis and autophagy by suppressing the PI3K/Akt/mTOR pathway in bladder cancer cells. Investig Clin Urol 65:593–602. https://doi.org/10.4111/icu.20240250

Article  PubMed  PubMed Central  Google Scholar 

Hu C, Zhou H, Liu Y, Huang J, Liu W, Zhang Q, Tang Q, Sheng F, Li G, Zhang R (2019) ROCK1 promotes migration and invasion of non-small-cell lung cancer cells through the PTEN/PI3K/FAK pathway. Int J Oncol 55:833–844. https://doi.org/10.3892/ijo.2019.4864

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang YW, Chen C, Xu MM, Li JD, Xiao J, Zhu XF (2013) Expression of c-Src and phospho-Src in epithelial ovarian carcinoma. Mol Cell Biochem 376:73–79. https://doi.org/10.1007/s11010-012-1550-1

Article  CAS  PubMed  Google Scholar 

Ismail R, Rashid R, Andrabi K, Parray FQ, Besina S, Shah MA, Ul Hussain M (2014) Pathological implications of Cx43 down-regulation in human colon cancer. Asian Pac J Cancer Prev 15:2987–2991. https://doi.org/10.7314/apjcp.2014.15.7.2987

Article  PubMed  Google Scholar 

Kao WH, Liao LZ, Chen YA, Lo UG, Pong RC, Hernandez E, Chen MC, Teng CJ, Wang HY, Tsai SC, Kapur P, Lai CH, Hsieh JT, Lin H (2024) SPHK1 promotes bladder cancer metastasis via PD-L2/c-Src/FAK signaling cascade. Cell Death Dis 15:678. https://doi.org/10.1038/s41419-024-07044-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kazan JM, El-Saghir J, Saliba J, Shaito A, Jalaleddine N, El-Hajjar L, Al-Ghadban S, Yehia L, Zibara K, El-Sabban M (2019) Cx43 expression correlates with breast cancer metastasis in MDA-MB-231 cells in vitro, in a mouse xenograft model and in human breast cancer tissues. Cancers (Basel). https://doi.org/10.3390/cancers11040460

Article  PubMed  PubMed Central  Google Scholar 

Li K, Li GD, Sun LY, Li XQ (2018) PTEN and SHIP: impact on lymphatic metastasis in breast cancer. J Cancer Res Ther 14:S937-s941. https://doi.org/10.4103/0973-1482.193894

Article  CAS  PubMed  Google Scholar 

Li F, Zhao S, Guo T, Li J, Gu C (2019) The nutritional cytokine leptin promotes NSCLC by activating the PI3K/AKT and MAPK/ERK pathways in NSCLC cells in a paracrine manner. BioMed Res Int 2019:2585743. https://doi.org/10.1155/2019/2585743

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Z, Li Y, Liu L, Zhang C, Li X (2024) Multiple programmed cell death patterns and immune landscapes in bladder cancer: evidence based on machine learning and multi-cohorts. Environ Toxicol 39:1780–1801. https://doi.org/10.1002/tox.24066

Article  CAS  PubMed  Google Scholar 

Liu S, Zhao Y, Liu H, Zhao X, Shen X (2021) miR-301-3p directly regulates Cx43 to mediate the development of gastric cancer. J Int Med Res 49:3000605211033185. https://doi.org/10.1177/03000605211033185

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y, Dai M, Yang P, Cao L, Lu L (2022) Src-homology domain 2 containing protein tyrosine phosphatase-1 (SHP-1) directly binds to proto-oncogene tyrosine-protein kinase Src (c-Src) and promotes the transcriptional activation of connexin 43 (Cx43). Bioengineered 13:13534–13543. https://doi.org/10.1080/21655979.2022.2079252

Article  CAS  PubMed  PubMed Central  Google Scholar 

McCutcheon S, Spray DC (2022) Glioblastoma-astrocyte connexin 43 gap junctions promote tumor invasion. Mol Cancer Res 20:319–331. https://doi.org/10.1158/1541-7786.Mcr-21-0199

Article  CAS  PubMed  Google Scholar 

Paštar V, Lozić M, Kelam N, Filipović N, Bernard B, Katsuyama Y, Vukojević K (2021) Connexin expression is altered in liver development of Yotari (dab1 -/-) mice. Int J Mol Sci. https://doi.org/10.3390/ijms221910712

Article  PubMed 

Comments (0)

No login
gif