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Modeling the Hemodynamic Impact of Y-incision Aortic Annular Enlargements on Aortic Valve Replacement and Valve-in-Valve Procedures
Modeling the Hemodynamic Impact of Y-incision Aortic Annular Enlargements on Aortic Valve Replacement and Valve-in-Valve Procedures
Y-incision aortic annular enlargement (Y-AAE) with surgical aortic valve replacement (SAVR) may improve outflow tract hemo...
Hypoxia/reoxygenation-induced Glycolysis Mediates Myocardial Ischemia–reperfusion Injury Through Promoting the Lactylation of GPX4
Hypoxia/reoxygenation-induced Glycolysis Mediates Myocardial Ischemia–reperfusion Injury Through Promoting the Lactylation of GPX4
Myocardial ischemia–reperfusion injury (MIRI) is an injury mechanism of myocardial infarction, related to ferroptosi...
Evaluation of Positive Patients Evaluated in a Tertiary Genetic Heart Rhythm Clinic
Evaluation of Positive Patients Evaluated in a Tertiary Genetic Heart Rhythm Clinic
Genetic variants in CACNA1C are associated with several cardiac and neurologic conditions. We conducted ...
Exosomal miRNAs: A New Frontier in Cardiovascular Disease Diagnosis and Treatment
Exosomal miRNAs: A New Frontier in Cardiovascular Disease Diagnosis and Treatment
Exosomes are small vesicles secreted by a variety of cells surrounded by a lipid bilayer membrane and containing a variety...
Distinct Myocardial Remodelling Profiles in Athletes: A Comparative Analysis Across Sporting Disciplines
Distinct Myocardial Remodelling Profiles in Athletes: A Comparative Analysis Across Sporting Disciplines
Despite being recognized for over a century, the athlete's heart (AH) a result of intense and regular physical trainin...
The Individual and Joint Associations of Systolic Blood Pressure Variability and Arterial Stiffness with Cardiovascular Disease: A Prospective Cohort Study
The Individual and Joint Associations of Systolic Blood Pressure Variability and Arterial Stiffness with Cardiovascular Disease: A Prospective Cohort Study
Systolic blood pressure variability (SBPV) and arterial stiffness index (ASI) are risk factors for cardiovascular diseases...
Circulating Extracellular Vesicles Predict Complications after Cardiac Surgery
Circulating Extracellular Vesicles Predict Complications after Cardiac Surgery
Cardiac surgery with cardiopulmonary bypass (CPB) may lead to many postoperative complications. However, many complication...
Investigating the Therapeutic Potential of miRNA-137-3p/383-5p/PGC-1α Signalling Nexus Against Cardiac Hypertrophy
Investigating the Therapeutic Potential of miRNA-137-3p/383-5p/PGC-1α Signalling Nexus Against Cardiac Hypertrophy
Pathological growth of cardiomyocytes known as cardiac hypertrophy (CH). Differential expressions of miRNAs have an immens...
Development of a Nomogram Model to Predict the Risk of Postoperative Delirium in Cardiac Surgery Patients
Development of a Nomogram Model to Predict the Risk of Postoperative Delirium in Cardiac Surgery Patients
Postoperative delirium (POD) is a common and severe complication following cardiac surgery, with an incidence of about 65%...
Correlation Between NLR to Albumin Ratio and 90-day Prognosis After Treatment for Acute Ischemic Stroke
Correlation Between NLR to Albumin Ratio and 90-day Prognosis After Treatment for Acute Ischemic Stroke
The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in relation to albumin levels for acute ischemic s...
The Immediate Cardiovascular and Mitochondrial Response in Ischemic Cardiogenic Shock
The Immediate Cardiovascular and Mitochondrial Response in Ischemic Cardiogenic Shock
The acute pathophysiological changes after myocardial ischemia complicated by cardiogenic shock (CS) remain poorly defined...
Mydgf Enhances Cardiac Angiogenesis by Upregulating FGF1
Mydgf Enhances Cardiac Angiogenesis by Upregulating FGF1
Following myocardial infarction (MI), endothelial cell proliferation drives neovascularization to support cardiac regenera...
Small Interfering RNA (siRNA) for Cardiorenal Disease: Mechanistic Insights from Preclinical and Clinical Studies
Small Interfering RNA (siRNA) for Cardiorenal Disease: Mechanistic Insights from Preclinical and Clinical Studies
Small Interfering RNA (siRNA) is a class of double-stranded, noncoding RNA that silences pathogenic mRNA through the proce...
Intracoronary Stenting and Restenosis – Randomized Trial of Drug-Eluting Stent Implantation or Drug-Coated Balloon Angioplasty According to Neointima Morphology in Drug-Eluting Stent REstenosis 5: Rationale and Design of the ISAR-DESIRE 5 Trial
Intracoronary Stenting and Restenosis – Randomized Trial of Drug-Eluting Stent Implantation or Drug-Coated Balloon Angioplasty According to Neointima Morphology in Drug-Eluting Stent REstenosis 5: Rationale and Design of the ISAR-DESIRE 5 Trial
In-stent restenosis (ISR) is the leading cause of revascularization failure, occurring in up to 10% of patients within 10&...
Acetyl-CoA Short-Chain Synthetase-2 Regulates Myocardial Ischemia/Reperfusion Injury by Targeting Histone Acetylation
Acetyl-CoA Short-Chain Synthetase-2 Regulates Myocardial Ischemia/Reperfusion Injury by Targeting Histone Acetylation
Myocardial infarction (MI) remains a leading cause of mortality, and although reperfusion therapy is essential for myocard...
Identification of Prognostic Factors for Sepsis or Septic Shock Patients with Cardiac Dysfunction
Identification of Prognostic Factors for Sepsis or Septic Shock Patients with Cardiac Dysfunction
Myocardial markers and inflammatory factors have been identified as risk factors for the development of sepsis-induced car...
A Molecular Perspective on the Intricate Interplay Among Exosomes, Bioenergetic Metabolism, and the Pathogenesis of Diabetic Cardiomyopathy
A Molecular Perspective on the Intricate Interplay Among Exosomes, Bioenergetic Metabolism, and the Pathogenesis of Diabetic Cardiomyopathy
Diabetic cardiomyopathy (DCM), defined as cardiac impairment resulting from the development of diabetes mellitus, has emer...
Recent Insights Into Targeting Interleukin-27 in Coronary Artery Disease
Recent Insights Into Targeting Interleukin-27 in Coronary Artery Disease
Coronary artery disease (CAD) is increasingly recognized as a chronic inflammatory condition. Interleukin-27 (IL-27), a cy...
Ferroptosis Related Serum Gpx4 Correlates to Severity of Coronary Artery Stenosis, and in-Stent Restenosis in Patients
Ferroptosis Related Serum Gpx4 Correlates to Severity of Coronary Artery Stenosis, and in-Stent Restenosis in Patients
This study aimed to explore the association between serum ferritin and glutathione peroxidase 4 (Gpx4), markers of ferropt...
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway
Lipoamide Attenuates Hypertensive Myocardial Hypertrophy Through PI3K/Akt-Mediated Nrf2 Signaling Pathway
The process of myocardial hypertrophy in hypertension can lead to excessive activation of oxidative stress. Lipoamide (ALM...
CD137 Signaling Mediates Pulmonary Artery Endothelial Cell Proliferation Under Hypoxia By Regulating Mitochondrial Dynamics
CD137 Signaling Mediates Pulmonary Artery Endothelial Cell Proliferation Under Hypoxia By Regulating Mitochondrial Dynamics
Altered mitochondrial dynamics affect pulmonary artery endothelial cells (PAECs) proliferation, contributing to the develo...
Changes in Cardiac Electrical Biomarker in Response to Coronary Arterial Occlusion: An Experimental Observation
Changes in Cardiac Electrical Biomarker in Response to Coronary Arterial Occlusion: An Experimental Observation
Cardiac electrical biomarker (CEB), an indicator of ischaemia-induced change in myocyte polarity, has been proposed for di...
Exploration of the Potential Biomarker FNDC5 for Discriminating Heart Failure in Patients with Coronary Atherosclerosis
Exploration of the Potential Biomarker FNDC5 for Discriminating Heart Failure in Patients with Coronary Atherosclerosis
Coronary atherosclerosis leading to ischemic artery disease is one of the etiological factors to develop heart failure (HF...
Transplantation of Human Embryonic Stem Cell–Derived Pericyte-Like Cells Transduced with Basic Fibroblast Growth Factor Promotes Angiogenic Recovery in Mice with Severe Chronic Hindlimb Ischemia
Transplantation of Human Embryonic Stem Cell–Derived Pericyte-Like Cells Transduced with Basic Fibroblast Growth Factor Promotes Angiogenic Recovery in Mice with Severe Chronic Hindlimb Ischemia
Critical limb ischemia (CLI) is a state of severe peripheral artery disease, with no effective treatment. Cell therapy has...
Percutaneous Alginate Hydrogel Endomyocardial Injection with a Novel Dedicated Catheter Delivery System: An Animal Feasibility Study
Percutaneous Alginate Hydrogel Endomyocardial Injection with a Novel Dedicated Catheter Delivery System: An Animal Feasibility Study
The objective of this preclinical study was to evaluate the feasibility and safety of transcatheter endocardial alginate h...
Circulating Proteome Analysis Identifies Reduced Inflammation After Initiation of Hemodynamic Support with Either Veno-Arterial Extracorporeal Membrane Oxygenation or Impella in Patients with Cardiogenic Shock
Circulating Proteome Analysis Identifies Reduced Inflammation After Initiation of Hemodynamic Support with Either Veno-Arterial Extracorporeal Membrane Oxygenation or Impella in Patients with Cardiogenic Shock
In-hospital mortality associated with cardiogenic shock (CS) remains high despite the use of percutaneous assist devices. ...
Allograft Model of Aortic Arch Segment Grafting to Abdominal Aorta Through End-to-Side Anastomosis in Mice
Allograft Model of Aortic Arch Segment Grafting to Abdominal Aorta Through End-to-Side Anastomosis in Mice
The mouse aortic transplantation model is a valuable tool for investigating the mechanisms of atherosclerosis regression, ...
Impact of Perivascular Adipose Tissue on Neointimal Formation Following Endovascular Placement
Impact of Perivascular Adipose Tissue on Neointimal Formation Following Endovascular Placement
Following the placement of endovascular implants, perivascular adipose tissue (PVAT) becomes an early sensor of vascular i...
PPARγ Agonist Rosiglitazone and Antagonist GW9662: Antihypertensive Effects on Chronic Intermittent Hypoxia-Induced Hypertension in Rats
PPARγ Agonist Rosiglitazone and Antagonist GW9662: Antihypertensive Effects on Chronic Intermittent Hypoxia-Induced Hypertension in Rats
The increased incidence of hypertension associated with obstructive sleep apnea (OSA) presents significant physical, psych...
Association Between Automated 3D Measurement of Coronary Luminal Narrowing and Risk of Future Myocardial Infarction
Association Between Automated 3D Measurement of Coronary Luminal Narrowing and Risk of Future Myocardial Infarction
This study focuses on identifying anatomical markers with predictive capacity for long-term myocardial infarction (MI) in ...
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