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The role of ferroptosis in renal cell carcinoma: molecular mechanisms and therapeutic implications
The role of ferroptosis in renal cell carcinoma: molecular mechanisms and therapeutic implications
Of the numerous regulatory cell death mechanisms, ferroptosis has emerged as a pivotal player in the pathobiology of renal...
Spil-mediated sEH overexpression contributes to the senescence of alveolar epithelial cells during pulmonary fibrosis in mice
Spil-mediated sEH overexpression contributes to the senescence of alveolar epithelial cells during pulmonary fibrosis in mice
Alveolar epithelial cell (AEC) senescence is a crucial driver of pulmonary fibrosis (PF). Epoxyeicosatrienoic acids (EETs)...
The ApoA5–Cidec axis: keeping fibrosis and MASLD at bay
The ApoA5–Cidec axis: keeping fibrosis and MASLD at bay
Li C, Dongjie Y, Xiaowen W et al (2025) ApoA5-CIDEC axis regulates hepatic lipid metabolism, inflammation, and fibrosis in...
Measuring Neural Factor X Pathway Activity in Rodent Glioma Cell Culture and Brain Slices
Measuring Neural Factor X Pathway Activity in Rodent Glioma Cell Culture and Brain Slices
Coagulation factor X (FX) plays a significant role in neuroinflammation and is considered a promising target for therapeut...
Longitudinal analysis in -het female mice reveals atypical nociceptive behaviours
Longitudinal analysis in -het female mice reveals atypical nociceptive behaviours
Rett Syndrome (RTT), a neurodevelopmental disorder predominantly affecting females, is characterised by evolving symptoms ...
cGAS-STING signaling pathway in MASLD and liver fibrosis
cGAS-STING signaling pathway in MASLD and liver fibrosis
In metabolic dysfunction-associated steatotic liver disease (MASLD), lipid accumulation and inflammatory stimulation lead ...
E2F7 targets S100A2 to suppress CD8T cell activity in lung adenocarcinoma by regulating glutamine metabolism
E2F7 targets S100A2 to suppress CD8T cell activity in lung adenocarcinoma by regulating glutamine metabolism
Malignant cells within the tumor microenvironment have developed numerous strategies to resist the CD8+T cell-driven immun...
Identification of cryptic KMT2A-PTD and other novel fusion genes by transcriptome sequencing alters molecular risk stratification in AML-NK
Identification of cryptic KMT2A-PTD and other novel fusion genes by transcriptome sequencing alters molecular risk stratification in AML-NK
Acute myeloid leukaemia with normal karyotype (AML-NK) is a cytogenetically cryptic yet heterogeneous clinical subgroup th...
Combined targeting poly (ADP-ribose) polymerase and receptor tyrosine kinase inhibits ovarian clear cell carcinoma progression through disrupted ribosome biogenesis
Combined targeting poly (ADP-ribose) polymerase and receptor tyrosine kinase inhibits ovarian clear cell carcinoma progression through disrupted ribosome biogenesis
OCCC has extremely poor prognosis. ARID1A mutation-related chromatin remodeling errors are key molecular features of OCCC....
Alcohol induces sorafenib resistance in hepatocellular carcinoma: A translational study
Alcohol induces sorafenib resistance in hepatocellular carcinoma: A translational study
Alcohol is a major cause of hepatocellular carcinoma (HCC), accounting for 30% of cases worldwide. Sorafenib, a tyrosine k...
Temozolomide increases the generation of cell heterogeneity in ERK activity in glioma cells
Temozolomide increases the generation of cell heterogeneity in ERK activity in glioma cells
ERK activity governs diverse cellular responses and has significant implications in cancer biology and treatment. Cellular...
DAPL1 is activated by Np63 and GRα and regulates lipid metabolism
DAPL1 is activated by Np63 and GRα and regulates lipid metabolism
Non-small cell lung cancer (NSCLC) accounts for about 80% of all lung cancer occurrences and is divided into largely Adeno...
Prosaposin in CNS health and disease, metabolic stress and exercise adaptation
Prosaposin in CNS health and disease, metabolic stress and exercise adaptation
Prosaposin (PSAP), a highly conserved lysosomal protein and precursor of saposins A–D, has emerged as a key regulato...
Liver specific-inhibition of LPCAT3 ameliorates metabolic dysfunction-associated steatotic liver disease
Liver specific-inhibition of LPCAT3 ameliorates metabolic dysfunction-associated steatotic liver disease
The membrane unsaturation in the liver is associated with abnormal biosynthesis and accumulation of cholesterol and trigly...
Integrated regulation of ferroptosis in prostate cancer covering mechanisms, resistance, and translational opportunities
Integrated regulation of ferroptosis in prostate cancer covering mechanisms, resistance, and translational opportunities
Ferroptosis, an iron dependent form of regulated cell death driven by lipid peroxidation, has emerged as a pivotal process...
Spinal fluid antibody profile against bacteria demonstrates intrathecal antibody production in demyelinating diseases
Spinal fluid antibody profile against bacteria demonstrates intrathecal antibody production in demyelinating diseases
This study follows work establishing multiple sclerosis (MS) microbial candidates from RNA sequencing of human brain sampl...
Galectin-9 potentiates salivary gland damage by inducing ferroptosis in Sjogren’s disease
Galectin-9 potentiates salivary gland damage by inducing ferroptosis in Sjogren’s disease
Sjögren’s disease (SjD), a systemic autoimmune disease, is characterized by exocrine glandular damage and hypof...
Bystander effects in photodynamic therapy-treated tumors involve spatiotemporally extended ferroptosis
Bystander effects in photodynamic therapy-treated tumors involve spatiotemporally extended ferroptosis
The tumor bystander effect describes the ability of cells sustaining therapeutic treatment damage to transmit distress sig...
Role of aberrant activated fibro/adipogenic progenitors and suppressed ferroptosis in disused skeletal muscle atrophy and fatty infiltration
Role of aberrant activated fibro/adipogenic progenitors and suppressed ferroptosis in disused skeletal muscle atrophy and fatty infiltration
Muscle fatty infiltration (MFI) was characterized by the pathological accumulation of fat within skeletal muscle tissue. P...
, , , and signature predicts melanoma immunotherapy response and survival
, , , and signature predicts melanoma immunotherapy response and survival
Melanoma poses a significant health concern due to its propensity to metastasize and its high mortality rate. Immunotherap...
Single intracerebroventricular TNFR2 agonist injection impacts remyelination in the cuprizone model
Single intracerebroventricular TNFR2 agonist injection impacts remyelination in the cuprizone model
The development of therapeutics that enhances the regeneration of myelin sheaths following demyelination is predicted to p...
Agreement between early-phase amyloid-PET and pulsed arterial spin labeling in a memory clinic cohort
Agreement between early-phase amyloid-PET and pulsed arterial spin labeling in a memory clinic cohort
Relative cerebral blood flow (rCBF), assessed using pulsed arterial spin labeling (pASL) MRI, and the standardized uptake ...
Targeting myeloid differentiation protein 2 ameliorates rheumatoid arthritis by inhibiting inflammation and ferroptosis via MAPK and NF-κB signaling pathways
Targeting myeloid differentiation protein 2 ameliorates rheumatoid arthritis by inhibiting inflammation and ferroptosis via MAPK and NF-κB signaling pathways
Myeloid differentiation protein 2 (MD2), a co-receptor of toll-like receptor 4 (TLR4) in the innate immune system, has eme...
The role of innate immunity triggered by HPV infection in promoting cervical lesions
The role of innate immunity triggered by HPV infection in promoting cervical lesions
Innate immunity is the immune system that organisms possess from birth. It is primarily responsible for the rapid, nonspec...
Patient-specific effects of metformin on the hepatic metabolism in adolescents with metabolic dysfunction-associated steatotic liver disease (MASLD)
Patient-specific effects of metformin on the hepatic metabolism in adolescents with metabolic dysfunction-associated steatotic liver disease (MASLD)
Metformin is a commonly prescribed antidiabetic drug that inhibits hepatic glucose production (HGP). Recent studies examin...
Tumor hypoxia shapes natural killer cell anticancer activities
Tumor hypoxia shapes natural killer cell anticancer activities
Tumor hypoxia, a hallmark of the tumor microenvironment (TME), profoundly impacts the antitumor functionality of immune ce...
Cerium oxide nanoparticles as potent inhibitors of ferroptosis: role of antioxidant activity and protein regulation
Cerium oxide nanoparticles as potent inhibitors of ferroptosis: role of antioxidant activity and protein regulation
Ferroptosis has been closely linked to the pathological processes of various diseases, making it a promising target for th...
A bioactive soluble recombinant mouse LIGHT promotes effective tumor immune cell infiltration delaying tumor growth
A bioactive soluble recombinant mouse LIGHT promotes effective tumor immune cell infiltration delaying tumor growth
The TNF family member LIGHT (TNFSF14) binds to two receptors, HVEM (TNFSFR14) and LTβR (TNFSFR3). HVEM functions as a...
Serum proteins and faecal microbiota as potential biomarkers in newly diagnosed, treatment-naïve inflammatory bowel disease and irritable bowel syndrome patients
Serum proteins and faecal microbiota as potential biomarkers in newly diagnosed, treatment-naïve inflammatory bowel disease and irritable bowel syndrome patients
Molecular biomarkers are valuable tools to predict the disease and determine its course. Several markers have been associa...
MicroRNA-100-5p in exosomes from human placental mesenchymal stem cells: a key modulator of anti-psoriatic effects through mTOR/S6 K1 pathway
MicroRNA-100-5p in exosomes from human placental mesenchymal stem cells: a key modulator of anti-psoriatic effects through mTOR/S6 K1 pathway
Exosomes from mesenchymal stem cells (MSCs) demonstrate therapeutic potential against psoriasis, primarily due to their an...
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