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Role of aberrant activated fibro/adipogenic progenitors and suppressed ferroptosis in disused skeletal muscle atrophy and fatty infiltration
Role of aberrant activated fibro/adipogenic progenitors and suppressed ferroptosis in disused skeletal muscle atrophy and fatty infiltration
Muscle fatty infiltration (MFI) was characterized by the pathological accumulation of fat within skeletal muscle tissue. P...
, , , and signature predicts melanoma immunotherapy response and survival
, , , and signature predicts melanoma immunotherapy response and survival
Melanoma poses a significant health concern due to its propensity to metastasize and its high mortality rate. Immunotherap...
Single intracerebroventricular TNFR2 agonist injection impacts remyelination in the cuprizone model
Single intracerebroventricular TNFR2 agonist injection impacts remyelination in the cuprizone model
The development of therapeutics that enhances the regeneration of myelin sheaths following demyelination is predicted to p...
Agreement between early-phase amyloid-PET and pulsed arterial spin labeling in a memory clinic cohort
Agreement between early-phase amyloid-PET and pulsed arterial spin labeling in a memory clinic cohort
Relative cerebral blood flow (rCBF), assessed using pulsed arterial spin labeling (pASL) MRI, and the standardized uptake ...
Targeting myeloid differentiation protein 2 ameliorates rheumatoid arthritis by inhibiting inflammation and ferroptosis via MAPK and NF-κB signaling pathways
Targeting myeloid differentiation protein 2 ameliorates rheumatoid arthritis by inhibiting inflammation and ferroptosis via MAPK and NF-κB signaling pathways
Myeloid differentiation protein 2 (MD2), a co-receptor of toll-like receptor 4 (TLR4) in the innate immune system, has eme...
The role of innate immunity triggered by HPV infection in promoting cervical lesions
The role of innate immunity triggered by HPV infection in promoting cervical lesions
Innate immunity is the immune system that organisms possess from birth. It is primarily responsible for the rapid, nonspec...
Patient-specific effects of metformin on the hepatic metabolism in adolescents with metabolic dysfunction-associated steatotic liver disease (MASLD)
Patient-specific effects of metformin on the hepatic metabolism in adolescents with metabolic dysfunction-associated steatotic liver disease (MASLD)
Metformin is a commonly prescribed antidiabetic drug that inhibits hepatic glucose production (HGP). Recent studies examin...
Tumor hypoxia shapes natural killer cell anticancer activities
Tumor hypoxia shapes natural killer cell anticancer activities
Tumor hypoxia, a hallmark of the tumor microenvironment (TME), profoundly impacts the antitumor functionality of immune ce...
Cerium oxide nanoparticles as potent inhibitors of ferroptosis: role of antioxidant activity and protein regulation
Cerium oxide nanoparticles as potent inhibitors of ferroptosis: role of antioxidant activity and protein regulation
Ferroptosis has been closely linked to the pathological processes of various diseases, making it a promising target for th...
A bioactive soluble recombinant mouse LIGHT promotes effective tumor immune cell infiltration delaying tumor growth
A bioactive soluble recombinant mouse LIGHT promotes effective tumor immune cell infiltration delaying tumor growth
The TNF family member LIGHT (TNFSF14) binds to two receptors, HVEM (TNFSFR14) and LTβR (TNFSFR3). HVEM functions as a...
Serum proteins and faecal microbiota as potential biomarkers in newly diagnosed, treatment-naïve inflammatory bowel disease and irritable bowel syndrome patients
Serum proteins and faecal microbiota as potential biomarkers in newly diagnosed, treatment-naïve inflammatory bowel disease and irritable bowel syndrome patients
Molecular biomarkers are valuable tools to predict the disease and determine its course. Several markers have been associa...
MicroRNA-100-5p in exosomes from human placental mesenchymal stem cells: a key modulator of anti-psoriatic effects through mTOR/S6 K1 pathway
MicroRNA-100-5p in exosomes from human placental mesenchymal stem cells: a key modulator of anti-psoriatic effects through mTOR/S6 K1 pathway
Exosomes from mesenchymal stem cells (MSCs) demonstrate therapeutic potential against psoriasis, primarily due to their an...
PCBP2 in gastrointestinal cancers: fundamental mechanism and clinical potential
PCBP2 in gastrointestinal cancers: fundamental mechanism and clinical potential
Poly(rC)-Binding Protein 2 (PCBP2) stands as a pivotal component within the PCBP family, renowned for its multifaceted rol...
Specialized pro-resolving mediators: key regulators in placental function and pregnancy complications
Specialized pro-resolving mediators: key regulators in placental function and pregnancy complications
Specialized pro-resolving mediators (SPMs) are bioactive lipids derived from essential fatty acids that play a key role in...
Impact of frameshift extension variant on auditory function and development
Impact of frameshift extension variant on auditory function and development
The HOMER2 gene, crucial for synaptic signaling and calcium homeostasis in the auditory system, is linked to sensorineural...
Selenium and selenoproteins: key regulators of ferroptosis and therapeutic targets in cancer
Selenium and selenoproteins: key regulators of ferroptosis and therapeutic targets in cancer
The interplay between selenium (Se) metabolism and ferroptosis presents a compelling area of study in cancer biology. This...
TIPE2: a novel regulatory factor for cardiovascular-related diseases
TIPE2: a novel regulatory factor for cardiovascular-related diseases
Tumor necrosis factor-α-inducible protein 8-like 2 (TIPE2) is a novel regulatory factor involved in innate and adapti...
ATF4 in proximal tubules modulates kidney function and modifies the metabolome
ATF4 in proximal tubules modulates kidney function and modifies the metabolome
Activating transcription factor 4 (ATF4) is a transcription factor that mediates the response to stress at the cellular, t...
The molecular landscape of glioblastoma-associated epilepsy
The molecular landscape of glioblastoma-associated epilepsy
Glioblastoma (GBM) is the most prevalent and aggressive primary brain tumor. Tumor-associated epilepsy is a clinical chall...
Unveiling the roles of CTRP family in cardiac remodeling
Unveiling the roles of CTRP family in cardiac remodeling
The C1q/TNF-related protein family (CTRPs), a group of adipokines sharing structural homology with adiponectin (APN), have...
Correction to: Evaluation of EpCAM-specific exosomal lncRNAs as potential diagnostic biomarkers for lung cancer using droplet digital PCR
Correction to: Evaluation of EpCAM-specific exosomal lncRNAs as potential diagnostic biomarkers for lung cancer using droplet digital PCR
Department of Thoracic Surgery, The Affiliated Hospital of Medical School of Ningbo University, 247 Renmin Road, Ningbo, 3...
The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates EN1 expression by modulating DNA methylation and E2F6 binding
The osteoporosis susceptibility SNP rs188303909 at 2q14.2 regulates EN1 expression by modulating DNA methylation and E2F6 binding
EN1 encodes a homeodomain-containing transcription factor and is a determinant of bone density and fracture. Previous powe...
FDA-approved disulfiram as a novel treatment for aggressive leukemia
FDA-approved disulfiram as a novel treatment for aggressive leukemia
Acute leukemia continues to be a major cause of death from disease worldwide and current chemotherapeutic agents are assoc...
Current knowledge of bone-derived factor osteocalcin: its role in the management and treatment of diabetes mellitus, osteoporosis, osteopetrosis and inflammatory joint diseases
Current knowledge of bone-derived factor osteocalcin: its role in the management and treatment of diabetes mellitus, osteoporosis, osteopetrosis and inflammatory joint diseases
Osteocalcin (OC) is the most abundant non-collagenous and osteoblast-secreted protein in bone. It consists of two forms su...
Systemic and local effect of oxidative stress on recurrent aphthous stomatitis: systematic review
Systemic and local effect of oxidative stress on recurrent aphthous stomatitis: systematic review
Recurrent aphthous stomatitis (RAS) is a chronic and recurrent inflammatory disease of the mouth. It is characterised by t...
Novel high-yield potato protease inhibitor panels block a wide array of proteases involved in viral infection and crucial tissue damage
Novel high-yield potato protease inhibitor panels block a wide array of proteases involved in viral infection and crucial tissue damage
Viruses critically rely on various proteases to ensure host cell entry and replication. In response to viral infection, th...
Altered expression of Sialyl Lewis X in experimental models of Parkinson’s disease
Altered expression of Sialyl Lewis X in experimental models of Parkinson’s disease
The mechanisms underlying neurodegeneration in Parkinson’s disease (PD) are still not fully understood. Glycosylatio...
Spinal cord abnormal autophagy and mitochondria energy metabolism are modified by swim training in SOD1-G93A mice
Spinal cord abnormal autophagy and mitochondria energy metabolism are modified by swim training in SOD1-G93A mice
Amyotrophic lateral sclerosis (ALS) may result from the dysfunctions of various mechanisms such as protein accumulation, m...
Etiopathogenesis of medication-related osteonecrosis of the jaws: a review
Etiopathogenesis of medication-related osteonecrosis of the jaws: a review
This study compiles the main hypotheses involved in the etiopathogenesis of medication-related osteonecrosis of the jaw (M...
Traumatic brain injury-induced disruption of the circadian clock
Traumatic brain injury-induced disruption of the circadian clock
Disturbances in the circadian rhythm have been reported in patients following traumatic brain injury (TBI). However, the r...
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