Li CW, Yu K, Shyh-Chang N, Jiang Z, Liu T, Ma S et al (2022) Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review. J Cachexia Sarcopenia Muscle 13(2):781–794

Article  CAS  PubMed  PubMed Central  Google Scholar 

Walston JD (2012) Sarcopenia in older adults. Curr Opin Rheumatol 24(6):623–627

Article  PubMed  PubMed Central  Google Scholar 

Wu H, Ballantyne CM (2017) Skeletal muscle inflammation and insulin resistance in obesity. J Clin Investig 127(1):43–54

Article  PubMed  PubMed Central  Google Scholar 

Linge J, Ekstedt M, Dahlqvist LO (2021) Adverse muscle composition is linked to poor functional performance and metabolic comorbidities in NAFLD. JHEP Rep: Innov Hepatol 3(1):100197

Article  Google Scholar 

Albano D, Messina C, Vitale J, Sconfienza LM (2020) Imaging of sarcopenia: old evidence and new insights. Eur Radiol 30(4):2199–2208

Article  PubMed  Google Scholar 

Zhu Y, Hu Y, Pan Y, Li M, Niu Y, Zhang T et al (2024) Fatty infiltration in the musculoskeletal system: pathological mechanisms and clinical implications. Front Endocrinol 15:1406046

Article  Google Scholar 

Molina T, Fabre P, Dumont NA (2021) Fibro-adipogenic progenitors in skeletal muscle homeostasis, regeneration and diseases. Open Biol 11(12):210110

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen W, You W, Valencak TG, Shan T (2022) Bidirectional roles of skeletal muscle fibro-adipogenic progenitors in homeostasis and disease. Ageing Res Rev 80:101682

Article  PubMed  Google Scholar 

Jiang X, Stockwell BR, Conrad M (2021) Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol 22(4):266–282

Article  PubMed  PubMed Central  Google Scholar 

Liu J, Kang R, Tang D (2022) Signaling pathways and defense mechanisms of ferroptosis. FEBS J 289(22):7038–7050

Article  CAS  PubMed  Google Scholar 

Li P, Jiang M, Li K, Li H, Zhou Y, Xiao X et al (2021) Glutathione peroxidase 4-regulated neutrophil ferroptosis induces systemic autoimmunity. Nat Immunol 22(9):1107–1117

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song X, Long D (2020) Nrf2 and ferroptosis: a new research direction for neurodegenerative diseases. Front Neurosci 14:267

Article  PubMed  PubMed Central  Google Scholar 

Zhao L, Zhou X, Xie F, Zhang L, Yan H, Huang J et al (2022) Ferroptosis in cancer and cancer immunotherapy. Cancer Commun (London, England) 42(2):88–116

Article  PubMed Central  Google Scholar 

Cai W, Liu L, Shi X, Liu Y, Wang J, Fang X et al (2023) Alox15/15-HpETE aggravates myocardial ischemia-reperfusion injury by promoting cardiomyocyte ferroptosis. Circulation 147(19):1444–1460

Article  CAS  PubMed  Google Scholar 

Liang D, Minikes AM, Jiang X (2022) Ferroptosis at the intersection of lipid metabolism and cellular signaling. Mol Cell 82(12):2215–2227

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li D, Li Y (2020) The interaction between ferroptosis and lipid metabolism in cancer. Signal Transduct Target Ther 5(1):108

Article  PubMed  PubMed Central  Google Scholar 

Cai L, Shi L, Peng Z, Sun Y, Chen J (2023) Ageing of skeletal muscle extracellular matrix and mitochondria: finding a potential link. Ann Med 55(2):2240707

Article  PubMed  PubMed Central  Google Scholar 

Zhang S, Sun Z, Jiang X, Lu Z, Ding L, Li C et al (2022) Ferroptosis increases obesity: crosstalk between adipocytes and the neuroimmune system. Front Immunol 13:1049936

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou D, Lu P, Mo X, Yang B, Chen T, Yao Y et al (2023) Ferroptosis and metabolic syndrome and complications: association, mechanism, and translational applications. Front Endocrinol 14:1248934

Article  Google Scholar 

Wu Y, Wu Y, Yang Y, Yu J, Wu J, Liao Z et al (2022) Lysyl oxidase-like 2 inhibitor rescues D-galactose-induced skeletal muscle fibrosis. Aging Cell 21(7):e13659

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu W, Lv S, Wang X, Song C, Xi C, Yan J (2025) Ferrostatin-1 inhibits osteoclast differentiation and prevents osteoporosis by suppressing lipid peroxidation. J Orthop Surg Res 20(1):117

Article  PubMed  PubMed Central  Google Scholar 

Flor-Rufino C, Barrachina-Igual J, Pérez-Ros P, Pablos-Monzó A, Sanz-Requena R, Martínez-Arnau FM (2023) Fat infiltration and muscle hydration improve after high-intensity resistance training in women with sarcopenia. A randomized clinical trial. Maturitas 168:29–36

Article  CAS  PubMed  Google Scholar 

Zhang KZ, Li JW, Xu JS, Shen ZK, Lin YS, Zhao C et al (2024) RBP4 promotes denervation-induced muscle atrophy through STRA6-dependent pathway. J Cachexia Sarcopenia Muscle 15(4):1601–1615

Article  PubMed  PubMed Central  Google Scholar 

Yin K, Zhang C, Deng Z, Wei X, Xiang T, Yang C et al (2024) FAPs orchestrate homeostasis of muscle physiology and pathophysiology. FASEB J: Off Publ Fed Am Soc Exp Biol 38(24):e70234

Article  CAS  Google Scholar 

Iio R, Manaka T, Takada N, Orita K, Nakazawa K, Hirakawa Y et al (2023) Parathyroid hormone inhibits fatty infiltration and muscle atrophy after rotator cuff tear by browning of fibroadipogenic progenitors in a rodent model. Am J Sports Med 51(12):3251–3260

Article  PubMed  Google Scholar 

Wang K, Yang J, An Y, Wang J, Tan S, Xu H et al (2024) MST1/2 regulates fibro/adipogenic progenitor fate decisions in skeletal muscle regeneration. Stem Cell Rep 19(4):501–514

Article  CAS  Google Scholar 

Hogarth MW, Kurukunda MP, Ismat K, Uapinyoying P, Jaiswal JK (2025) Exploring the therapeutic potential of fibroadipogenic progenitors in muscle disease. J Neuromuscul Dis 12(1):22143602241298544

PubMed  PubMed Central  Google Scholar 

Xu Z, Wu J, Li Y, Zhou J, Zhang Y, Qiao M et al (2024) A single-cell atlas of porcine skeletal muscle reveals mechanisms that regulate intramuscular adipogenesis. Int J Mol Sci 25(23):12935. https://doi.org/10.3390/ijms252312935

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pagano AF, Arc-Chagnaud C, Brioche T, Chopard A, Py G (2019) Muscle resting and TGF-β inhibitor treatment prevent fatty infiltration following skeletal muscle injury. Cell Physiol Biochem 53(1):62–75

Article  CAS  PubMed  Google Scholar 

Madaro L, Passafaro M, Sala D, Etxaniz U, Lugarini F, Proietti D et al (2018) Denervation-activated STAT3-IL-6 signalling in fibro-adipogenic progenitors promotes myofibres atrophy and fibrosis. Nat Cell Biol 20(8):917–927

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pryce BR, Oles A, Talbert EE, Romeo MJ, Vaena S, Sharma S et al (2024) Muscle inflammation is regulated by NF-κB from multiple cells to control distinct states of wasting in cancer cachexia. Cell Rep 43(11):114925

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun Y, Xu Z, You W, Zhou Y, Nong Q, Chen W et al (2024) Lipidomics and single-cell RNA sequencing reveal lipid and cell dynamics of porcine glycerol-injured skeletal muscle regeneration model. Life Sci 350:122742

Article