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mPEG-PLA micelles for nose-to-brain delivery of crizotinib-heptamethine cyanine dye conjugate for potential treatment of glioblastoma
mPEG-PLA micelles for nose-to-brain delivery of crizotinib-heptamethine cyanine dye conjugate for potential treatment of glioblastoma
Glioblastoma (GBM) is one of the most challenging tumours to treat, with considerable intra- and inter-tumoral heterogenei...
Bortezomib-loaded hybrid liposome inducing pyroptosis for targeted therapy against colorectal cancer
Bortezomib-loaded hybrid liposome inducing pyroptosis for targeted therapy against colorectal cancer
Colorectal cancer (CRC) is a highly invasive malignant tumor. At present, the combination of surgery with chemotherapy con...
Minoxidil cyclodextrin inclusion complex-loaded microemulsions and transfersomes for androgen alopecia treatment: a comparative study
Minoxidil cyclodextrin inclusion complex-loaded microemulsions and transfersomes for androgen alopecia treatment: a comparative study
Our MXD/SCD@TF designed by the combination of transfersome and inclusion technology was obviously superior to commercial 2...
Protamine nanocapsules as gene delivery carriers for the treatment of intraocular tumors
Protamine nanocapsules as gene delivery carriers for the treatment of intraocular tumors
Uveal melanoma is the most common primary intraocular tumor in adults that appears mainly in the choroid, ciliary body, or...
Preparation, characterisation, and testing of reservoir-based implantable devices loaded with tizanidine and lidocaine
Preparation, characterisation, and testing of reservoir-based implantable devices loaded with tizanidine and lidocaine
Multiple sclerosis is a chronic neuroimmunological disorder that causes progressive disability, primarily in young adults....
Enhancing vaccine stability in transdermal microneedle platforms
Enhancing vaccine stability in transdermal microneedle platforms
Micron-scale needles, so-called microneedles (MNs) offer a minimally invasive, nearly painless, and user-friendly method f...
Dynamics of nanoparticles in a 3D breathing lung-on-a-chip
Dynamics of nanoparticles in a 3D breathing lung-on-a-chip
The"Breathing Lung-on-a-Chip,"a novel microfluidic device featuring a stretchable membrane, replicates the natur...
Unlocking the potential of remdesivir: innovative approaches to drug delivery
Unlocking the potential of remdesivir: innovative approaches to drug delivery
Given the recurrent waves of COVID-19 and the emergence of new viral infections, optimizing the potential of remdesivir as...
Biodegradable multifunctional hyaluronic acid hydrogel microneedle band-aids for accelerating skin wound healing
Biodegradable multifunctional hyaluronic acid hydrogel microneedle band-aids for accelerating skin wound healing
Wound healing for various diseases and wounds such as diabetes and burns remains a major biomedical challenge. Conventiona...
Effective approaches in conquering chemoresistance of glioblastoma: potential for nanoformulations
Effective approaches in conquering chemoresistance of glioblastoma: potential for nanoformulations
Glioblastoma Multiforme is an aggressive and complex cancer affecting mostly elderly patients above the age of 60&nbsp...
Sex-specific formulations of doxazosin mesylate via direct powder extrusion 3D printing
Sex-specific formulations of doxazosin mesylate via direct powder extrusion 3D printing
Males and females are known to exhibit significant differences in drug pharmacokinetics and pharmacodynamics, which are st...
Development of silver-based hybrid nanoparticles loaded with eEF2 K-siRNA and quercetin against triple-negative breast cancer
Development of silver-based hybrid nanoparticles loaded with eEF2 K-siRNA and quercetin against triple-negative breast cancer
Breast cancer is the most common cancer among women, with approximately 2.3 million new cases globally. Triple-negative br...
Emerging nano-derived therapy for the treatment of dementia: a comprehensive review
Emerging nano-derived therapy for the treatment of dementia: a comprehensive review
Dementia includes a variety of neurodegenerative diseases that affect and target the brain’s fundamental cognitive f...
Oral peptide drug delivery: design of SEDDS providing a protective effect against intestinal membrane-bound enzymes
Oral peptide drug delivery: design of SEDDS providing a protective effect against intestinal membrane-bound enzymes
This study presents an emerging approach for oral peptide drug delivery by designing self-emulsifying drug delivery system...
Formulation and clinical translation of inhalable nanomedicines for the treatment and prevention of pulmonary infectious diseases
Formulation and clinical translation of inhalable nanomedicines for the treatment and prevention of pulmonary infectious diseases
Pulmonary infections caused by bacteria, viruses and fungi are a significant global health issue. Inhalation therapies are...
The translational journey of cancer nanomedicines: biological and entrepreneurial lessons learned
The translational journey of cancer nanomedicines: biological and entrepreneurial lessons learned
Despite exhaustive investments, the breakthrough potential of nanomedicines (NM) is not yet realized. Whilst Doxil and cov...
S.C. delivery of ultra-high concentration (up to 500 mg/mL) protein microparticle suspensions: pharmacokinetics, efficacy, biodistribution, and immunogenicity
S.C. delivery of ultra-high concentration (up to 500 mg/mL) protein microparticle suspensions: pharmacokinetics, efficacy, biodistribution, and immunogenicity
A shift towards the subcutaneous (S.C.) delivery of protein therapeutics is enabling patient-centric at-home self-administ...
Buccal application of microneedles coated with an optimized hydrogel containing naproxen and dexamethasone
Buccal application of microneedles coated with an optimized hydrogel containing naproxen and dexamethasone
Inflammation and impaired bone regeneration are major challenges in oral and maxillofacial surgery, necessitating the deve...
Design, optimization, and evaluation for a long-time-released transdermal microneedle delivery system containing estradiol
Design, optimization, and evaluation for a long-time-released transdermal microneedle delivery system containing estradiol
Transdermal drug delivery systems (TDDS) have drawbacks such as poor absorption, low blood concentration, and delayed effe...
Multicellular tumor spheroid model to study the multifaceted role of tumor-associated macrophages in PDAC
Multicellular tumor spheroid model to study the multifaceted role of tumor-associated macrophages in PDAC
While considerable efforts have been made to develop new therapies, progress in the treatment of pancreatic cancer has so ...
Enhancing transmucosal delivery of CBD through nanoemulsion: in vitro and in vivo studies
Enhancing transmucosal delivery of CBD through nanoemulsion: in vitro and in vivo studies
Cannabidiol (CBD) has gained significant attention as a complementary and alternative medicine due to its promising therap...
Optimized gravity-driven intranasal drop administration delivers significant doses to the ostiomeatal complex and maxillary sinus
Optimized gravity-driven intranasal drop administration delivers significant doses to the ostiomeatal complex and maxillary sinus
Chronic and allergic rhinosinusitis impacts approximately 12% of the global population. Challenges in rhinosinusitis treat...
Retraction Note: Co-delivery of doxorubicin and SIS3 by folate-targeted polymeric micelles for overcoming tumor multidrug resistance
Retraction Note: Co-delivery of doxorubicin and SIS3 by folate-targeted polymeric micelles for overcoming tumor multidrug resistance
Cite this articleWang, S., Tan, X., Zhou, Q. et al. Retraction Note: Co-delivery of doxorubicin and SIS3 by folate-targete...
Clopidogrel-loaded vascular grafts prepared using digital light processing 3D printing
Clopidogrel-loaded vascular grafts prepared using digital light processing 3D printing
The leading cause of death worldwide and a significant factor in decreased quality of life are the cardiovascular diseases...
Dual delivery systems combining nanocrystals and dissolving microneedles for improved local vaginal delivery of fluconazole
Dual delivery systems combining nanocrystals and dissolving microneedles for improved local vaginal delivery of fluconazole
Fluconazole (FLZ) has been widely used in the treatment of infection caused by Candida albicans, including the treatment o...
Unravelling the role of microneedles in drug delivery: Principle, perspectives, and practices
Unravelling the role of microneedles in drug delivery: Principle, perspectives, and practices
In recent year, the research of transdermal drug delivery systems has got substantial attention towards the development of...
Aqueous remote loading of model cationic peptides in uncapped poly(lactide-co-glycolide) microspheres for long-term controlled release
Aqueous remote loading of model cationic peptides in uncapped poly(lactide-co-glycolide) microspheres for long-term controlled release
Remote loading microencapsulation of peptides into polymer microspheres without organic solvent represents a promising alt...
Freeze-drying revolution: unleashing the potential of lyophilization in advancing drug delivery systems
Freeze-drying revolution: unleashing the potential of lyophilization in advancing drug delivery systems
Lyophilization also known as freeze-drying is a technique that has been employed to enhance the long-term durability of na...
Raloxifene encapsulated spanlastic nanogel for the prevention of bone fracture risk via transdermal administration: Pharmacokinetic and efficacy study in animal model
Raloxifene encapsulated spanlastic nanogel for the prevention of bone fracture risk via transdermal administration: Pharmacokinetic and efficacy study in animal model
This research work is to evaluate spanlastic-loaded raloxifene (RLX) nanogel administration via the transdermal route to a...
3D printing injectable microbeads using a composite liposomal ink for local treatment of peritoneal diseases
3D printing injectable microbeads using a composite liposomal ink for local treatment of peritoneal diseases
The peritoneal cavity offers an attractive administration route for challenging-to-treat diseases, such as peritoneal carc...
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