SCI Abstract

search
+
Development, in silico, in vitro, and in vivo evaluation of gatiserts: HME-based ophthalmic inserts for prolonged ocular delivery of gatifloxacin
Development, in silico, in vitro, and in vivo evaluation of gatiserts: HME-based ophthalmic inserts for prolonged ocular delivery of gatifloxacin
The objective of this study was to develop and characterize hot-melt extrusion (HME)-based gatifloxacin-loaded ophthalmic ...
Dual drug co-encapsulation into liposomes and liposome-derived nanosystems for improved synergistic treatment of skin diseases
Dual drug co-encapsulation into liposomes and liposome-derived nanosystems for improved synergistic treatment of skin diseases
Skin disorders impact nearly one-third of the global population, and represent the fourth most common cause of human disea...
Functional polysaccharide-based bioactive delivery systems for urinary and reproductive system therapeutics
Functional polysaccharide-based bioactive delivery systems for urinary and reproductive system therapeutics
Damage to lower genitourinary (GU) organs, which can lead to organ dysfunction and/or infertility, poses a significant thr...
Formulation and evaluation of probucol-LCA nanoparticles for supressing oxidative stress-related retinal degeneration
Formulation and evaluation of probucol-LCA nanoparticles for supressing oxidative stress-related retinal degeneration
Retinal degenerative diseases are a major cause of vision loss worldwide, with oxidative stress being a key pathological d...
Comparative review of translational approaches in lipid-based and water-based encapsulation strategies for coenzyme Q10
Comparative review of translational approaches in lipid-based and water-based encapsulation strategies for coenzyme Q10
The global coenzyme Q10 (CoQ10) market is expanding, driven by the increasing prevalence of chronic diseases, particularly...
Combining Leu-enkephalin nanomedicines with enkephalinase inhibitors: a promising painkiller strategy?
Combining Leu-enkephalin nanomedicines with enkephalinase inhibitors: a promising painkiller strategy?
This study investigates the potential of a novel nanomedicine approach relying on squalene nanoparticles of endogenous enk...
Development of sustained release injectable phospholipid-based phase transition gel matrixed with Piracetam and cannabidiol loaded nanoemulsion for amelioration of Alzheimer’s therapy
Development of sustained release injectable phospholipid-based phase transition gel matrixed with Piracetam and cannabidiol loaded nanoemulsion for amelioration of Alzheimer’s therapy
Alzheimer’s disease (AD) is an incurable neurological disorder and the primary cause of dementia globally, yet thera...
Ectoine as a multifunctional molecule: biotechnological production and pharmaceutical applications
Ectoine as a multifunctional molecule: biotechnological production and pharmaceutical applications
Traditional topical therapies can have considerable side effects, leading to the research for natural and biocompatible al...
Novel crystalline solid dispersions to improve the oral bioavailability and anti-liver cancer effect of Sorafenib
Novel crystalline solid dispersions to improve the oral bioavailability and anti-liver cancer effect of Sorafenib
This study investigates the interrelationships among drug loading, steric hindrance (Sh), defined as the spatial constrain...
Nanocarrier-based intranasal drug delivery for enhanced neurological disorders treatment
Nanocarrier-based intranasal drug delivery for enhanced neurological disorders treatment
The blood–brain barrier (BBB) represents a major obstacle in the treatment of neurological disorders. While it plays...
Smart nanocarriers in triple-negative breast cancer: recent advances in targeting and translational application
Smart nanocarriers in triple-negative breast cancer: recent advances in targeting and translational application
Breast cancer remains one of the most prevalent causes of cancer-related mortality worldwide. Triple-negative breast cance...
Precision engineering of anti-atherosclerotic herbal nanomedicine: from machine learning-aided active components screening to optimized metal-phenolic network codelivery
Precision engineering of anti-atherosclerotic herbal nanomedicine: from machine learning-aided active components screening to optimized metal-phenolic network codelivery
Atherosclerosis (AS), a chronic inflammatory disease linked to oxidative stress and lipid imbalance, remains a major cardi...
Oromucosal films for peptide delivery: formulation strategies using permeation enhancers and polymers
Oromucosal films for peptide delivery: formulation strategies using permeation enhancers and polymers
Buccal and sublingual mucosae offer highly vascularized, patient-acceptable routes for systemic peptide delivery, providin...
Formulation and characterization of exenatide-loaded PLGA microspheres prepared by coacervation
Formulation and characterization of exenatide-loaded PLGA microspheres prepared by coacervation
Bydureon® is a once-weekly injection of poly(lactide-co-glycolide) (PLGA) microspheres containing exenatide acetate, ...
Voriconazole nanosuspension-loaded ocular bilayer dissolving microneedle patch for the management of fungal keratitis
Voriconazole nanosuspension-loaded ocular bilayer dissolving microneedle patch for the management of fungal keratitis
Fungal keratitis (FK), caused by fungi like Aspergillus, Fusarium, and Candida, accounts for 20–60% of microbial ker...
Adenosine and guanosine-based oligonucleotides-loaded PLGA nanoparticles attenuates progression of surgically induced osteoarthritis
Adenosine and guanosine-based oligonucleotides-loaded PLGA nanoparticles attenuates progression of surgically induced osteoarthritis
A potent anti-inflammatory adenosine–guanosine-based oligonucleotide was identified by screening a large library abo...
Functional and therapeutic effects of Glabrescione B delivery by liposomes on Hedgehog-dependent tumors
Functional and therapeutic effects of Glabrescione B delivery by liposomes on Hedgehog-dependent tumors
Aberrant Hedgehog (HH) signaling pathway is responsible of tumorigenesis of medulloblastoma (MB) and basal cell carcinoma ...
Topical delivery of Lidocaine using spicules for local anesthesia
Topical delivery of Lidocaine using spicules for local anesthesia
Topical anesthesia offers a painless alternative to injections but is limited by the low skin permeability of local anesth...
Rational design of anticancer multidrug nanosystems and their adaptation for glioblastoma treatment
Rational design of anticancer multidrug nanosystems and their adaptation for glioblastoma treatment
Multidrug nanosystems emerged as an innovation in anticancer therapy, addressing key limitations of conventional mono- and...
mPEG-PLA micelles for nose-to-brain delivery of crizotinib-heptamethine cyanine dye conjugate for potential treatment of glioblastoma
mPEG-PLA micelles for nose-to-brain delivery of crizotinib-heptamethine cyanine dye conjugate for potential treatment of glioblastoma
Glioblastoma (GBM) is one of the most challenging tumours to treat, with considerable intra- and inter-tumoral heterogenei...
Bortezomib-loaded hybrid liposome inducing pyroptosis for targeted therapy against colorectal cancer
Bortezomib-loaded hybrid liposome inducing pyroptosis for targeted therapy against colorectal cancer
Colorectal cancer (CRC) is a highly invasive malignant tumor. At present, the combination of surgery with chemotherapy con...
Minoxidil cyclodextrin inclusion complex-loaded microemulsions and transfersomes for androgen alopecia treatment: a comparative study
Minoxidil cyclodextrin inclusion complex-loaded microemulsions and transfersomes for androgen alopecia treatment: a comparative study
Our MXD/SCD@TF designed by the combination of transfersome and inclusion technology was obviously superior to commercial 2...
Protamine nanocapsules as gene delivery carriers for the treatment of intraocular tumors
Protamine nanocapsules as gene delivery carriers for the treatment of intraocular tumors
Uveal melanoma is the most common primary intraocular tumor in adults that appears mainly in the choroid, ciliary body, or...
Preparation, characterisation, and testing of reservoir-based implantable devices loaded with tizanidine and lidocaine
Preparation, characterisation, and testing of reservoir-based implantable devices loaded with tizanidine and lidocaine
Multiple sclerosis is a chronic neuroimmunological disorder that causes progressive disability, primarily in young adults....
Enhancing vaccine stability in transdermal microneedle platforms
Enhancing vaccine stability in transdermal microneedle platforms
Micron-scale needles, so-called microneedles (MNs) offer a minimally invasive, nearly painless, and user-friendly method f...
Dynamics of nanoparticles in a 3D breathing lung-on-a-chip
Dynamics of nanoparticles in a 3D breathing lung-on-a-chip
The"Breathing Lung-on-a-Chip,"a novel microfluidic device featuring a stretchable membrane, replicates the natur...
Unlocking the potential of remdesivir: innovative approaches to drug delivery
Unlocking the potential of remdesivir: innovative approaches to drug delivery
Given the recurrent waves of COVID-19 and the emergence of new viral infections, optimizing the potential of remdesivir as...
Biodegradable multifunctional hyaluronic acid hydrogel microneedle band-aids for accelerating skin wound healing
Biodegradable multifunctional hyaluronic acid hydrogel microneedle band-aids for accelerating skin wound healing
Wound healing for various diseases and wounds such as diabetes and burns remains a major biomedical challenge. Conventiona...
Effective approaches in conquering chemoresistance of glioblastoma: potential for nanoformulations
Effective approaches in conquering chemoresistance of glioblastoma: potential for nanoformulations
Glioblastoma Multiforme is an aggressive and complex cancer affecting mostly elderly patients above the age of 60&nbsp...
Sex-specific formulations of doxazosin mesylate via direct powder extrusion 3D printing
Sex-specific formulations of doxazosin mesylate via direct powder extrusion 3D printing
Males and females are known to exhibit significant differences in drug pharmacokinetics and pharmacodynamics, which are st...
Load More
format_indent_increase