Smart nanocarriers in triple-negative breast cancer: recent advances in targeting and translational application

Tagde P, Kulkarni GT, Mishra DK, Kesharwani P. Recent advances in folic acid engineered nanocarriers for treatment of breast cancer. J Drug Deliv Sci Technol. 2020. https://doi.org/10.1016/j.jddst.2020.101613.

Article  Google Scholar 

Stevenson JC, Farmer RDT. HRT and breast cancer: a million women ride again. Climacteric. 2020(3). https://doi.org/10.1080/13697137.2020.1735797.

Yin L, Duan JJ, Bian XW, Yu SC, BioMed Central Ltd. Triple-negative breast cancer molecular subtyping and treatment progress. Breast Cancer Res. 2020. https://doi.org/10.1186/s13058-020-01296-5.

Article  PubMed  PubMed Central  Google Scholar 

Bianchini G, Balko JM, Mayer IA, Sanders ME, Gianni L. Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease. Nat Rev Clin Oncol. 2016. https://doi.org/10.1038/nrclinonc.2016.66.

Article  PubMed  PubMed Central  Google Scholar 

Patra JK, BioMed Central Ltd. Nano based drug delivery systems: recent developments and future prospects. J Nanobiotechnol. 2018(1). https://doi.org/10.1186/s12951-018-0392-8.

Yang Y, Sun W, Royal Society of Chemistry. Recent advances in redox-responsive nanoparticles for combined cancer therapy. Nanoscale Adv. 2022. https://doi.org/10.1039/d2na00222a.

Article  PubMed  PubMed Central  Google Scholar 

Nag OK, Delehanty JB. Active cellular and subcellular targeting of nanoparticles for drug delivery. Pharmaceutics. 2019. https://doi.org/10.3390/pharmaceutics11100543.

Article  PubMed  PubMed Central  Google Scholar 

Sorasitthiyanukarn FN, Muangnoi C, Rojsitthisak P, Rojsitthisak P. Chitosan-alginate nanoparticles as effective oral carriers to improve the stability, bioavailability, and cytotoxicity of curcumin diethyl disuccinate. Carbohydr Polym. 2021. https://doi.org/10.1016/j.carbpol.2020.117426.

Article  PubMed  Google Scholar 

Salari N, et al. Hyaluronic acid-based drug nanocarriers as a novel drug delivery system for cancer chemotherapy: a systematic review. DARU J Pharm Sci. 2021. https://doi.org/10.1007/s40199-021-00416-6.

Article  Google Scholar 

Ye Z, Yuan J, Hong D, Xu P, Liu W. Multimodal diagnostic models and subtype analysis for neoadjuvant therapy in breast cancer. Front Immunol. 2025. https://doi.org/10.3389/fimmu.2025.1559200.

Article  PubMed  PubMed Central  Google Scholar 

Zagami P, Carey LA. Triple negative breast cancer: pitfalls and progress. NPJ Breast Cancer. 2022(1). https://doi.org/10.1038/s41523-022-00468-0.

Shokooh MK, Emami F, Jeong JH, Yook S. Bio-inspired and smart nanoparticles for triple negative breast cancer microenvironment. Pharmaceutics. 2021. https://doi.org/10.3390/pharmaceutics13020287.

Article  Google Scholar 

Bakker NAM, et al. Triple-negative breast cancer modifies the systemic immune landscape and alters neutrophil functionality. NPJ Breast Cancer. 2025. https://doi.org/10.1038/s41523-025-00721-2.

Article  PubMed  PubMed Central  Google Scholar 

Singh DD, Yadav DK. TNBC: potential targeting of multiple receptors for a therapeutic breakthrough, nanomedicine and immunotherapy. Biomedicines. 2021. https://doi.org/10.3390/biomedicines9080876.

Article  PubMed  PubMed Central  Google Scholar 

Ghassemifar V, et al. Harnessing nanotechnology to modulate hypoxic tumor microenvironments: enhanced strategies for oncological innovations. Biomed Pharmacother. 2025. https://doi.org/10.1016/j.biopha.2025.118543.

Article  PubMed  Google Scholar 

“breast-cancer-facts-and-figures-2024”.

Rahdari T, Mahdavimehr M, Ghafouri H, Ramezanpour S, Ehtesham S, Asghari SM. Advancing triple-negative breast cancer treatment through peptide decorated solid lipid nanoparticles for paclitaxel delivery. Sci Rep. 2025;15(1):6043. https://doi.org/10.1038/s41598-025-90107-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

X. Liu, F. He, and M. Liu, “New opportunities of stimulus-responsive smart nanocarriers in cancer therapy,” 2024, KeAi Communications Co. https://doi.org/10.1016/j.nanoms.2024.10.013.

Benderski K, Lammers T, Sofias AM. Analysis of multi-drug cancer nanomedicine. Nat Nanotechnol. 2025. https://doi.org/10.1038/s41565-025-01932-1.

Article  PubMed  PubMed Central  Google Scholar 

Sun L, et al. Smart nanoparticles for cancer therapy. Signal Transduct Target Ther. 2023(1). https://doi.org/10.1038/s41392-023-01642-x.

Nguyen LNM, et al. The mechanisms of nanoparticle delivery to solid tumours. Nat Rev Bioeng. 2024;2(3):201–13. https://doi.org/10.1038/s44222-024-00154-9.

Article  CAS  Google Scholar 

Rasmussen MK, Pedersen JN, Marie R. Size and surface charge characterization of nanoparticles with a salt gradient. Nat Commun. 2020. https://doi.org/10.1038/s41467-020-15889-3.

Article  PubMed  PubMed Central  Google Scholar 

Anjum S, et al. Enhancing therapeutic efficacy: sustained delivery of 5-fluorouracil (5-FU) via thiolated chitosan nanoparticles targeting CD44 in triple-negative breast cancer. Sci Rep. 2024. https://doi.org/10.1038/s41598-024-55900-1.

Article  PubMed  PubMed Central  Google Scholar 

Scialla S, et al. Targeted treatment of triple-negative-breast cancer through pH-triggered tumour associated macrophages using smart theranostic nanoformulations. Int J Pharm. 2023. https://doi.org/10.1016/j.ijpharm.2022.122575.

Article  PubMed  Google Scholar 

Ghasemi Z, Maleki A, Jafari T. A review of multimodule stimuli-responsive chitosan-incorporated lipid-based micro/nanocarriers for drug delivery in cancer therapy: promises, outlooks, and prospects. Int J Biol Macromol. 2025. https://doi.org/10.1016/j.ijbiomac.2025.144587.

Article  PubMed  Google Scholar 

Alum EU, Nwuruku OA, Ugwu OPC, Uti DE, Alum BN, Edwin N. Harnessing nature: plant-derived nanocarriers for targeted drug delivery in cancer therapy. Phytomedicine Plus. 2025. https://doi.org/10.1016/j.phyplu.2025.100828.

Article  Google Scholar 

Wu W, Pu Y, Shi J. Nanomedicine-enabled chemotherapy-based synergetic cancer treatments. J Nanobiotechnol. 2022(1). https://doi.org/10.1186/s12951-021-01181-z.

Yang Y, Zeng W, Huang P, Zeng X, Mei L. Smart materials for drug delivery and cancer therapy. VIEW. 2021. https://doi.org/10.1002/VIW.20200042.

Article  PubMed  Google Scholar 

Zhang H, Yu N, Chen Y, Yan K, Wang X. Cationic liposome codelivering PI3K pathway regulator improves the response of BRCA1-deficient breast cancer cells to PARP1 inhibition. J Cell Biochem. 2019;120(8):13037–45. https://doi.org/10.1002/jcb.28574.

Article  CAS  PubMed  Google Scholar 

M. Alavi and M. Hamidi, “Passive and active targeting in cancer therapy by liposomes and lipid nanoparticles,” 2019, De Gruyter. https://doi.org/10.1515/dmpt-2018-0032.

Zhao M, feng Ding X, yu Shen J, ping Zhang X, wen Ding X, Xu B. Use of liposomal doxorubicin for adjuvant chemotherapy of breast cancer in clinical practice. J Zhejiang Univ-Sci B. 2017. https://doi.org/10.1631/jzus.B1600303.

Article  PubMed  PubMed Central  Google Scholar 

Pattni BS, Chupin VV, Torchilin VP. New developments in liposomal drug delivery. Chem Rev. 2015. https://doi.org/10.1021/acs.chemrev.5b00046.

Article  PubMed  Google Scholar 

Akbarzadeh A, et al. Liposome: classification, preparation, and applications. Nanoscale Res Lett. 2013. https://doi.org/10.1186/1556-276X-8-102.

Article  PubMed  PubMed Central  Google Scholar 

H. Pandey, R. Rani, and V. Agarwal, “Liposome and their applications in cancer therapy,” Brazilian Archives of Biology and Technology, vol. 59, 2016, https://doi.org/10.1590/1678-4324-2016150477.

Yang B, ping Song B, Shankar S, Guller A, Deng W. Recent advances in liposome formulations for breast cancer therapeutics. Cell Mol Life Sci. 2021(13). https://doi.org/10.1007/s00018-021-03850-6.

Wu D, Si M, Xue HY, Wong HL. Nanomedicine applications in the treatment of breast cancer: current state of the art. Int J Nanomedicine. 2017. https://doi.org/10.2147/IJN.S123437.

Article  PubMed  PubMed Central  Google Scholar 

Panagi M, et al. Polymeric micelles effectively reprogram the tumor microenvironment to potentiate nano-immunotherapy in mouse breast cancer models. Nat Commun. 2022. https://doi.org/10.1038/s41467-022-34744-1.

Article  PubMed  PubMed Central  Google Scholar 

Cagel M, et al. Polymeric mixed micelles as nanomedicines: achievements and perspectives. Eur J Pharm Biopharm. 2017. https://doi.org/10.1016/j.ejpb.2016.12.019.

Article  PubMed  Google Scholar 

Comments (0)

No login
gif