Pardi N, Weissman D. Development of vaccines and antivirals for combating viral pandemics. Nat Biomed Eng. 2020;4(12):1128–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adamson CS, et al. Antiviral drug discovery: preparing for the next pandemic. Chem Soc Rev. 2021;50(6):3647–55.

Article  CAS  PubMed  Google Scholar 

Radoshitzky SR, et al. Expanded profiling of Remdesivir as a broad-spectrum antiviral and low potential for interaction with other medications in vitro. Sci Rep. 2023;13(1):3131.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Porter DP, et al. Remdesivir (GS-5734) Is Efficacious in Cynomolgus Macaques Infected With Marburg Virus. J Infect Dis. 2020;222(11):1894–901.

Article  CAS  PubMed  Google Scholar 

Lo MK, et al. Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge. Sci Trans Med. 2019;11(494):eaau9242.

Article  CAS  Google Scholar 

Mechineni A, et al. Remdesivir for the treatment of COVID 19: review of the pharmacological properties, safety and clinical effectiveness. Expert Opin Drug Saf. 2021;20(11):1299–307.

Article  CAS  PubMed  Google Scholar 

Saha A, et al. Probable Molecular Mechanism of Remdesivir for the Treatment of COVID-19: Need to Know More. Arch Med Res. 2020;51(6):585–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun D. Remdesivir for Treatment of COVID-19: Combination of Pulmonary and IV Administration May Offer Aditional Benefit. AAPS J. 2020;22(4):77.

Article  CAS  PubMed  Google Scholar 

Leegwater E, et al. Population Pharmacokinetics of Remdesivir and GS-441524 in Hospitalized COVID-19 Patients. Antimicrob Agents Chemother. 2022;66(6):e00254-e322.

Article  PubMed  PubMed Central  Google Scholar 

Sheahan TP, et al. Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV. Nat Commun. 2020;11(1):019–13940.

Article  Google Scholar 

Baldo BA. Immune- and Non-Immune-Mediated Adverse Effects of Monoclonal Antibody Therapy: A Survey of 110 Approved Antibodies. Antibodies. 2022;11(1):17. https://doi.org/10.3390/antib11010017.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sheahan TP, et al. Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses. Sci Transl Med. 2017;9(396):eaal3653. https://doi.org/10.1126/scitranslmed.aal3653.

FDA Approves First Treatment for COVID-19. 22/10/2020; Available from: https://www.fda.gov/news-events/press-announcements/fda-approves-first-treatment-covid-19.

Budi DS, et al. Remdesivir for pregnancy: A systematic review of antiviral therapy for COVID-19. Heliyon. 2022;8(1):08835.

Article  Google Scholar 

Solera JT, et al. Longitudinal outcomes of COVID-19 in solid organ transplant recipients from 2020 to 2023. Am J Transplant. 2024;24(7):1303–16.

Article  CAS  PubMed  Google Scholar 

Chang H-Y, et al. Safety and effectiveness of remdesivir in hospitalized patients with COVID-19 and severe renal impairment: experience at a large medical center. Ann Med. 2024;56(1):2361843.

Article  PubMed  PubMed Central  Google Scholar 

Khalil A, et al. Efficacy and Safety of Remdesivir in Hospitalized Pediatric COVID-19: A Retrospective Case-Controlled Study. Ther Clin Risk Manag. 2023;19:949–58.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Warren TK, et al. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016;531(7594):381–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bodmer BS, et al. Remdesivir inhibits the polymerases of the novel filoviruses Lloviu and Bombali virus. Antiviral Res. 2021;192:105120.

Article  CAS  PubMed  Google Scholar 

Konkolova E, et al. Remdesivir triphosphate can efficiently inhibit the RNA-dependent RNA polymerase from various flaviviruses. Antiviral Res. 2020;182:104899.

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Wit E, et al. Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection. Proc Natl Acad Sci U S A. 2020;117(12):6771–6.

Article  PubMed  PubMed Central  Google Scholar 

Beigel JH, et al. Remdesivir for the Treatment of Covid-19 - Final Report. N Engl J Med. 2020;383(19):1813–26.

Article  CAS  PubMed  Google Scholar 

Grein J, et al. Compassionate Use of Remdesivir for Patients with Severe Covid-19. N Engl J Med. 2020;382(24):2327–36.

Article  CAS  PubMed  Google Scholar 

Dubert M, et al. Case report study of the first five COVID-19 patients treated with remdesivir in France. Int J Infect Dis. 2020;98:290–3. https://doi.org/10.1016/j.ijid.2020.06.093.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Igbinosa I, et al. Use of remdesivir for pregnant patients with severe novel coronavirus disease 2019. Am J Obstet Gynecol. 2020;223(5):768–70. https://doi.org/10.1016/j.ajog.2020.08.001.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anderson J, et al. The use of convalescent plasma therapy and remdesivir in the successful management of a critically ill obstetric patient with novel coronavirus 2019 infection: A case report. Case Rep Womens Health. 2020;27:e00221. https://doi.org/10.1016/j.crwh.2020.e00221.

Article  PubMed  PubMed Central  Google Scholar 

Goldman DL, et al. Compassionate Use of Remdesivir in Children With Severe COVID-19. Pediatrics. 2021;147(5):2020–047803.

Article  Google Scholar 

Rivera DR, et al. Utilization of COVID-19 Treatments and Clinical Outcomes among Patients with Cancer: A COVID-19 and Cancer Consortium (CCC19) Cohort Study. Cancer Discov. 2020;10(10):1514–27.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Orf K, et al. Remdesivir during induction chemotherapy for newly diagnosed paediatric acute lymphoblastic leukaemia with concomitant SARS-CoV-2 infection. Br J Haematol. 2020;190(5):e274–6. https://doi.org/10.1111/bjh.17014.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, et al. Remdesivir inhibits the progression of glioblastoma by enhancing endoplasmic reticulum stress. Biomed Pharmacother. 2023;157(114037):22.

Google Scholar 

Lutz JD, et al. Physiologically-Based Pharmacokinetic Modeling of Remdesivir and Its Metabolites to Support Dose Selection for the Treatment of Pediatric Patients With COVID-19. Clin Pharmacol Ther. 2021;109(4):1116–24.

Article  CAS  PubMed  Google Scholar 

Deb S, Reeves AA. Simulation of Remdesivir Pharmacokinetics and Its Drug Interactions. J Pharm Pharm Sci. 2021;24:277–91.

Article  CAS  PubMed  Google Scholar 

Eryilmaz IE, et al. The cytotoxic and antitumoral effects of Remdesivir, an antiviral RdRp inhibitor, on different cancer cells in vitro. Mol Cell Toxicol. 2023;20(3):649–60.

Article