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From a bispecific monoclonal antibody to gene therapy: A new era in the treatment of hemophilia A
The treatment of hemophilia A has progressed amazingly in recent years. Emicizumab, a bispecific-humanized monoclonal anti...
Complete revascularization of multivessel coronary artery disease in patients with ST elevation acute coronary syndrome - for whom and when? A comprehensive review
Atherosclerosis is the most common cause of coronary steno-occlusive disease and acute myocardial infarction is the leadin...
Blood urea nitrogen - independent marker of mortality in sepsis
Background. This retrospective study examines the relationship between admission Blood Urea Nitrogen (BUN) levels and clin...
Cerebrospinal fluid neurofilament light chains and CXCL13 as predictive factors for clinical course of multiple sclerosis
Aim. The aim of this study was to identify whether NfL and CXCL13 cerebrospinal fluid (CSF) concentrations at diagnostic l...
Detection of galanin receptors in the spinal cord in experimental autoimmune encephalomyelitis
Aims. The neuropeptide galanin is a widely distributed neurotransmitter/neuromodulator that regulates a variety of physiol...
Differentiated modulation of signaling molecules AMPK and SIRT1 in experimentally drug-induced hepatocyte injury
Aim. Currently available medicines have little to offer in terms of supporting the regeneration of injured hepatic cells. ...
Global DNA methylation and increased DNMT3A expression in multiple myeloma patients
Aims. The aim of this study was to compare the expression profile of selected DNA methyltransferases and global DNA methyl...
Administration of mucolytic solution before upper endoscopy - double-blind, monocentric, randomized study
Aims. Sufficient visibility of the mucosa during upper endoscopy is crucial for successful diagnosis, especially for early...
Total thyroidectomy can still remain the method of choice in some Bethesda III cases
Background. The latest WHO classification of tumours of endocrine organs defines new units of borderline thyroid tumours (...
Periradicular corticosteroid infiltration for radicular pain - comparison of Diprophos and Depomedrone and ozone effects
Objectives. To determine the treatment effect of corticosteroids in periradicular therapy (PRT) for radicular pain and to ...
Diabetic macular edema treatment with subthreshold micropulse laser - five-year long monitoring
Aim. The objective of this study was to evaluate the efficacy of diabetic macular edema (DME) therapy using subthreshold m...
Floppy iris syndrome associated with specific medication intake: A narrative review
Intraoperative floppy iris syndrome (IFIS) is a cataract surgery complication that remains a challenge for eye surgeons. I...
Is high accuracy of Vesical Imaging-Reporting and Data System (VI-RADS) sufficient for its implementation in the urological practice?
Aims. Currently, the only method used to differentiate between MIBC and NMIBC is transurethral resection of the bladder tu...
Letter to the Editor Regarding: "Modern diagnostic and therapeutic approaches in familial maculopathy with reference to North Carolina macular dystrophy" by Jana Nekolova et al.
Small, K.W. (2023). Letter to the Editor Regarding: "Modern diagnostic and therapeutic approaches in familial maculop...
Tension pneumopericardium in a polytrauma patient
Introduction. Tension pneumopericardium is a life-threatening condition, manifesting most commonly as hemodynamic instabil...
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