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Increasing fracture incidence over 13 years in patients with rheumatoid arthritis from the IORRA cohort
Increasing fracture incidence over 13 years in patients with rheumatoid arthritis from the IORRA cohort
This study aimed to evaluate fracture incidence in patients with rheumatoid arthritis (RA) over 13 years in the I...
with menaquinone-7 improves bone biomechanics and microarchitecture in ovariectomized mice: preliminary study
with menaquinone-7 improves bone biomechanics and microarchitecture in ovariectomized mice: preliminary study
This study aimed to evaluate the effects of Limosilactobacillus reuteri (LR) and its combination with menaquinone-7 (MK-7;...
Non-contact electrical stimulation via a Vector-potential transformer promotes bone healing in drill-hole injury model
Non-contact electrical stimulation via a Vector-potential transformer promotes bone healing in drill-hole injury model
We investigated the effects of non-contact electrical stimulation via a Vector-potential (VP) transformer, a novel physica...
Masafumi Fukagawa, MD, PhD
Masafumi Fukagawa, MD, PhD
It is with profound sadness that we announce the passing of Professor Masafumi Fukaga...
Evaluation of the fracture prevention effects of teriparatide and alendronate in patients with frailty: a sub-analysis of the Japanese osteoporosis intervention trial-05
Evaluation of the fracture prevention effects of teriparatide and alendronate in patients with frailty: a sub-analysis of the Japanese osteoporosis intervention trial-05
The fracture prevention effects of teriparatide (TPTD) and alendronate (ALN) were evaluated in frail patients using data f...
Higher systemic immune-inflammation index associates with vertebral marrow proton density fat fraction in postmenopausal women
Higher systemic immune-inflammation index associates with vertebral marrow proton density fat fraction in postmenopausal women
The systemic immune-inflammation index (SII) may influence bone homeostasis through inflammatory modulation. Although bone...
Bisphosphonates with high bone-resorption-capacity promote osteonecrosis of the jaw development after tooth extraction in mice
Bisphosphonates with high bone-resorption-capacity promote osteonecrosis of the jaw development after tooth extraction in mice
Medication-Related Osteonecrosis of the Jaw (MRONJ) is a condition marked by osteonecrosis of the jaw bone and other sympt...
A scoring system and seven factors associated with certification for Japanese long-term care insurance in older people
A scoring system and seven factors associated with certification for Japanese long-term care insurance in older people
The increase in the older population is a serious concern in developed countries, and how to maintain independence of thes...
Spexin-induced MC3T3-E1 cell-derived exosomes enhance osteoblast differentiation
Spexin-induced MC3T3-E1 cell-derived exosomes enhance osteoblast differentiation
The roles of exosomes in osteoblast differentiation has been widely investigated. Low exosome production from donor cells ...
Locomotive syndrome and increased musculoskeletal disorder incidence in older adults: a prospective study
Locomotive syndrome and increased musculoskeletal disorder incidence in older adults: a prospective study
With the population aging, musculoskeletal disorders increasingly impair older adults’ quality of life and escalatin...
Deciphering the genetic interconnection between sarcopenia and osteoporosis: SCD1
Deciphering the genetic interconnection between sarcopenia and osteoporosis: SCD1
Sarcopenia is closely related to osteoporosis, but the causal direction of these associations remains unclear. This study ...
Increased complications of proximal femur fractures during the COVID-19 pandemic: a nationwide medical claims database study in Japan
Increased complications of proximal femur fractures during the COVID-19 pandemic: a nationwide medical claims database study in Japan
Coronavirus disease 2019 (COVID-19) is a worldwide pandemic, and mortality increases in elderly patients with comorbiditie...
Effects of introducing a new reimbursement scheme on pharmaceutical treatment for osteoporosis after hip fracture
Effects of introducing a new reimbursement scheme on pharmaceutical treatment for osteoporosis after hip fracture
Fracture Liaison Service (FLS) programs are beneficial for reducing the frequency of subsequent fractures and mortality in...
Postoperative risks of type 2 diabetes in elderly hip fracture patients: a propensity score-matched study
Postoperative risks of type 2 diabetes in elderly hip fracture patients: a propensity score-matched study
Type 2 diabetes is associated with an increased risk of fragility fractures, even in individuals with normal or high bone ...
Long-term assessment of quality of life in the older patients with fragility hip fracture
Long-term assessment of quality of life in the older patients with fragility hip fracture
Fragility hip fracture (FHF) has been frequently seen in trauma of older people, resulted in decreased mobility and a loss...
What is the appropriate antibiotic administration to prevent MRONJ development after tooth extraction?
What is the appropriate antibiotic administration to prevent MRONJ development after tooth extraction?
There are no established guidelines for antibiotic administration to prevent the development of medication related-osteone...
Safety and effectiveness of risedronate in Paget’s disease of bone: postmarketing surveillance study in Japan
Safety and effectiveness of risedronate in Paget’s disease of bone: postmarketing surveillance study in Japan
We conducted an all-case postmarketing surveillance study between 2008 and 2017 to evaluate the safety and effectiveness o...
Effectiveness of romosozumab in patients with osteoporosis at high fracture risk: a Japanese real-world study
Effectiveness of romosozumab in patients with osteoporosis at high fracture risk: a Japanese real-world study
To describe the real-world use of romosozumab in Japan, we conducted a chart review of > 1000 Japanese ...
Medication-related osteonecrosis of the lower jaw without osteolysis on computed tomography images
Medication-related osteonecrosis of the lower jaw without osteolysis on computed tomography images
Surgery is the standard treatment for medication-related osteonecrosis of the jaw (MRONJ). This study reviewed patients wi...
Psoas muscle area is associated with prognosis in elderly patients with hip fracture
Psoas muscle area is associated with prognosis in elderly patients with hip fracture
Sarcopenia is a key predictor of prognosis in patients with hip fractures. This study utilized computed tomography (CT) sc...
Bone mineral density and body mass composition measurements in premenopausal anorexic patients: the impact of lean body mass
Bone mineral density and body mass composition measurements in premenopausal anorexic patients: the impact of lean body mass
Evaluating bone density and body composition by dual-energy x-ray absorptiometry (DXA) and analyzing their relationships a...
Association of chronic liver disease with bone diseases and muscle weakness
Association of chronic liver disease with bone diseases and muscle weakness
The liver is a vital organ involved in nutrient metabolism, hormone regulation, immunity, cytokine production, and gut hom...
Secondary fracture and mortality risk with very high fracture risk osteoporosis and proximal femoral fracture
Secondary fracture and mortality risk with very high fracture risk osteoporosis and proximal femoral fracture
We aimed to investigate secondary fracture and mortality rates, and risk factors in patients with proximal femoral fractur...
Inherited Fanconi renotubular syndromes: unveiling the intricacies of hypophosphatemic rickets/osteomalacia
Inherited Fanconi renotubular syndromes: unveiling the intricacies of hypophosphatemic rickets/osteomalacia
Fanconi renotubular syndromes (FRTS) are a rare group of inherited phosphaturic disorders with limited Indian as well as g...
Zinc improves Denosumab and eldecalcitol efficacy for bone mineral density in patients with hypozincemia
Zinc improves Denosumab and eldecalcitol efficacy for bone mineral density in patients with hypozincemia
We aimed to investigate the effects of zinc deficiency and zinc medication in osteoporosis patients undergoing denosumab (...
Bone–fat linkage via interleukin-11 in response to mechanical loading
Bone–fat linkage via interleukin-11 in response to mechanical loading
Positive regulators of bone formation, such as mechanical loading and PTH, stimulate and negative regulators, such as agin...
The impact of chronic obstructive pulmonary disease on bone strength
The impact of chronic obstructive pulmonary disease on bone strength
Chronic obstructive pulmonary disease (COPD) is a lifestyle-related disease that develops in middle-aged and older adults,...
Histomorphometric analysis of patients with femoral neck fracture and 25-hydroxyvitamin D deficiency: a cross-sectional study
Histomorphometric analysis of patients with femoral neck fracture and 25-hydroxyvitamin D deficiency: a cross-sectional study
Vitamin D deficiency causes osteoporosis, bone mineralization disorders, and osteomalacia. Osteomalacia is diagnosed using...
Effects of acute- and long-term aerobic exercises at different intensities on bone in mice
Effects of acute- and long-term aerobic exercises at different intensities on bone in mice
Exercise intensity determines the benefits of aerobic exercise. Our objectives were, in aerobic exercise at different inte...
Inhibition of cysteine protease disturbs the topological relationship between bone resorption and formation in vitro
Inhibition of cysteine protease disturbs the topological relationship between bone resorption and formation in vitro
Osteoporosis is a global health issue. Bisphosphonates that are commonly used to treat osteoporosis suppress both bone res...
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