Bolam KA, Van Uffelen JGZ, Taaffe DR (2013) The effect of physical exercise on bone density in middle-aged and older men: a systematic review. Osteoporos Int 24:2749–2762. https://doi.org/10.1007/s00198-013-2346-1

Article  CAS  PubMed  Google Scholar 

Ma D, Wu L, He Z (2013) Effects of walking on the preservation of bone mineral density in perimenopausal and postmenopausal women: a systematic review and meta-analysis. Menopause 20:1216–1226. https://doi.org/10.1097/gme.0000000000000100

Article  PubMed  Google Scholar 

Davidović Cvetko E, Nešić N, Matić A et al (2022) Effects of 8-week increment aerobic exercise program on bone metabolism and body composition in young non-athletes. Eur J Appl Physiol 122:1019–1034. https://doi.org/10.1007/s00421-022-04900-y

Article  CAS  PubMed  Google Scholar 

Burrows M (2007) Exercise and bone mineral accrual in children and adolescents. J Sport Sci Med 6:305–312

Google Scholar 

Khan K, McKay HA, Haapasalo H et al (2000) Does childhood and adolescence provide a unique opportunity for exercise to strengthen the skeleton? J Sci Med Sport 3:150–164. https://doi.org/10.1016/S1440-2440(00)80077-8

Article  CAS  PubMed  Google Scholar 

Benedetti MG, Furlini G, Zati A, Mauro GL (2018) The effectiveness of physical exercise on bone density in osteoporotic patients. Biomed Res Int. https://doi.org/10.1155/2018/4840531

Article  PubMed  PubMed Central  Google Scholar 

Olmedillas H, González-Agüero A, Moreno LA et al (2013) Is bone tissue really affected by swimming? A systematic review. BMC Med 10:168. https://doi.org/10.1371/journal.pone.0070119

Article  CAS  Google Scholar 

Kistler-Fischbacher M, Weeks BK, Beck BR (2021) The effect of exercise intensity on bone in postmenopausal women (part 2): a meta-analysis. Bone 143:115697. https://doi.org/10.1016/j.bone.2020.115697

Article  PubMed  Google Scholar 

Bennell KL, Malcolm SA, Thomas SA et al (1996) Risk factors for stress fractures in track and field athletes: a twelve- month prospective study. Am J Sports Med 24:810–818. https://doi.org/10.1177/036354659602400617

Article  CAS  PubMed  Google Scholar 

Herbert AJ, Williams AG, Hennis PJ et al (2019) The interactions of physical activity, exercise and genetics and their associations with bone mineral density: implications for injury risk in elite athletes. Eur J Appl Physiol 119:29–47. https://doi.org/10.1007/s00421-018-4007-8

Article  PubMed  Google Scholar 

Guillemant J, Accarie C, Peres G, Guillemant S (2004) Acute effects of an oral calcium load on markers of bone metabolism during endurance cycling exercise in male Athletes. Calcif Tissue Int 74:407–414. https://doi.org/10.1007/s00223-003-0070-0

Article  CAS  PubMed  Google Scholar 

Scott JPR, Sale C, Greeves JP et al (2010) The effect of training status on the metabolic response of bone to an acute bout of exhaustive treadmill running. J Clin Endocrinol Metab 95:3918–3925. https://doi.org/10.1210/jc.2009-2516

Article  CAS  PubMed  Google Scholar 

Dolan E, Varley I, Ackerman KE et al (2020) The bone metabolic response to exercise and nutrition. Exerc Sport Sci Rev 48:49–58. https://doi.org/10.1249/JES.0000000000000215

Article  PubMed  Google Scholar 

Gardinier JD, Al-Omaishi S, Morris MD, Kohn DH (2016) PTH signaling mediates perilacunar remodeling during exercise. Matrix Biol 52–54:162–175. https://doi.org/10.1016/j.matbio.2016.02.010

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Z, Gao J, Gong H (2019) Effects of treadmill with different intensities on bone quality and muscle properties in adult rats. Biomed Eng Online 18:1–18. https://doi.org/10.1186/s12938-019-0728-0

Article  Google Scholar 

Latza J, Otte M, Lindner T et al (2020) Interval training is not superior to endurance training with respect to bone accrual of ovariectomized mice. Front Physiol. https://doi.org/10.3389/fphys.2020.01096

Article  PubMed  PubMed Central  Google Scholar 

Scott JPR, Sale C, Greeves JP et al (2011) The role of exercise intensity in the bone metabolic response to an acute bout of weight-bearing exercise. J Appl Physiol 110:423–432. https://doi.org/10.1152/japplphysiol.00764.2010

Article  CAS  PubMed  Google Scholar 

Chen X, Li L, Guo J et al (2016) Treadmill running exercise prevents senile osteoporosis and upregulates the Wnt signaling pathway in SAMP6 mice. Oncotarget. https://doi.org/10.18632/oncotarget.12125

Article  PubMed  PubMed Central  Google Scholar 

Zhang L, Chen X, Wu J et al (2017) The effects of different intensities of exercise and active vitamin D on mouse bone mass and bone strength. J Bone Miner Metab 35:265–277. https://doi.org/10.1007/s00774-016-0764-9

Article  CAS  PubMed  Google Scholar 

Troib A, Guterman M, Rabkin R et al (2016) Endurance exercise and growth hormone improve bone formation in young and growth-retarded chronic kidney disease rats. Nephrol Dial Transplant 31:1270–1279. https://doi.org/10.1093/ndt/gfv373

Article  CAS  PubMed  Google Scholar 

Friedman MA, Bailey AM, Rondon MJ et al (2016) Calcium- and phosphorus-supplemented diet increases bone mass after short-term exercise and increases bone mass and structural strength after long-term exercise in adult mice. PLoS One 11:1–21. https://doi.org/10.1371/journal.pone.0151995

Article  CAS  Google Scholar 

Chang X, Xu S, Zhang H (2022) Regulation of bone health through physical exercise: mechanisms and types. Front Endocrinol (Lausanne) 13:1–13. https://doi.org/10.3389/fendo.2022.1029475

Article  CAS  Google Scholar 

Li J, Xue J, Jing Y et al (2019) SOST deficiency aggravates osteoarthritis in mice by promoting sclerosis of subchondral bone. Biomed Res Int. https://doi.org/10.1155/2019/7623562

Article  PubMed  PubMed Central  ADS  Google Scholar 

Galea GL, Lanyon LE, Price JS (2017) Sclerostin’s role in bone’s adaptive response to mechanical loading. Bone 96:38–44. https://doi.org/10.1016/j.bone.2016.10.008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin C, Jiang X, Dai Z et al (2009) Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/β-catenin signaling. J Bone Miner Res 24:1651–1661. https://doi.org/10.1359/jbmr.090411

Article  CAS  PubMed  Google Scholar 

Schefer V, Talan MI (1996) Oxygen consumption in adult and aged C57BL/6J mice during acute treadmill exercise of different intensity. Exp Gerontol 31:387–392. https://doi.org/10.1016/0531-5565(95)02032-2

Article  CAS  PubMed  Google Scholar 

Fernando P, Bonen A, Hoffman-Goetz L (1993) Predicting submaximal oxygen consumption during treadmill running in mice. Can J Physiol Pharmacol 71:854–857. https://doi.org/10.1139/y93-128

Article  CAS  PubMed  Google Scholar 

Kawamoto T (2003) Use of a new adhesive film for the preparation of multi-purpose fresh-frozen sections from hard tissues, whole-animals, insects and plants. Arch Histol Cytol 66:123–143

Article  PubMed  Google Scholar 

Komori T (2019) Regulation of proliferation, differentiation and functions of osteoblasts by runx2. Int J Mol Sci. https://doi.org/10.3390/ijms20071694

Article  PubMed  PubMed Central  Google Scholar 

Wada T, Nakashima T, Hiroshi N, Penninger JM (2006) RANKL-RANK signaling in osteoclastogenesis and bone disease. Trends Mol Med 12:17–25. https://doi.org/10.1016/j.molmed.2005.11.007

Article  CAS  PubMed  Google Scholar 

Kaneguchi A, Ozawa J, Kawamata S, Yamaoka K (2017) Development of arthrogenic joint contracture as a result of pathological changes in remobilized rat knees. J Orthop Res 35:1414–1423. https://doi.org/10.1002/jor.23419

Article  CAS  PubMed  Google Scholar 

Inoue S, Hatakeyama J, Aoki H et al (2021) Utilization of mechanical stress to treat osteoporosis: the effects of electrical stimulation, radial extracorporeal shock wave, and ultrasound on experimental osteoporosis in ovariectomized rats. Calcif Tissue Int 109:215–229. https://doi.org/10.1007/s00223-021-00831-6

Article  CAS  PubMed  Google Scholar 

Herberg S, Kondrikova G, Hussein KA et al (2014) Total body irradiation is permissive for mesenchymal stem cell-mediated new bone formation following local transplantation. Tissue Eng Part A 20:3212–3227. https://doi.org/10.1089/ten.tea.2013.0663

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wallace IJ, Pagnotti GM, Rubin-Sigler J et al (2015) Focal enhancement of the skeleton to exercise correlates with responsivity of bone marrow mesenchymal stem cells rather than peak external forces. J Exp Biol 218:3002–3009. https://doi.org/10.1242/jeb.118729

Article  PubMed  PubMed Central  Google Scholar 

Hammond MA, Laine TJ, Berman AG, Wallace JM (2016) Treadmill exercise improves fracture toughness and indentation modulus without altering the nanoscale morphology of collagen in mice. PLoS One. https://doi.org/10.1371/journal.pone.0163273