Bi J, Zhang C, Lu C, Mo C, Zeng J, Yao M, Jia B, Liu Z, Yuan P, Xu S (2024) Age-related bone diseases: role of inflammaging. J Autoimmun 143:103169

Article  CAS  PubMed  Google Scholar 

Kushioka J, Chow SKH, Toya M, Tsubosaka M, Shen H, Gao Q, Li X, Zhang N, Goodman SB (2023) Bone regeneration in inflammation with aging and cell-based immunomodulatory therapy. Inflamm Regen 43:29

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mazzaferro S, De Martini N, Rotondi S, Tartaglione L, Ureña-Torres P, Bover J, Pasquali M (2020) Bone, inflammation and chronic kidney disease. Clin Chim Acta 506:236–240

Article  CAS  PubMed  Google Scholar 

Huang Z, Xu Z, Wan R, Hu D, Huang Y (2023) Associations between blood inflammatory markers and bone mineral density and strength in the femoral neck: findings from the MIDUS II study. Sci Rep 13:10662

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen S, Sun X, Jin J, Zhou G, Li Z (2023) Association between inflammatory markers and bone mineral density: a cross-sectional study from NHANES 2007–2010. J Orthop Surg Res 18:305

Article  PubMed  PubMed Central  Google Scholar 

Koh JM, Khang YH, Jung CH, Bae S, Kim DJ, Chung YE, Kim GS (2005) Higher circulating hsCRP levels are associated with lower bone mineral density in healthy pre-and postmenopausal women: evidence for a link between systemic inflammation and osteoporosis. Osteoporos Int 16:1263–1271

Article  CAS  PubMed  Google Scholar 

Al Salmani A, Al Shidhani A, Al-Alawi NM, Al Sulaimi AA, Al-Hashemi MA (2022) Inflammatory markers as a predictor of postmenopausal osteoporosis: cross-sectional study from sultan qaboos university hospital. Sultan Qaboos Univ Med J 22:508–514

Article  PubMed  PubMed Central  Google Scholar 

Zhang J, Jiang J, Qin Y, Zhang Y, Wu Y, Xu H (2023) Systemic immune-inflammation index is associated with decreased bone mass density and osteoporosis in postmenopausal women but not in premenopausal women. Endocr Connect 12:e220461

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong Q, Wu J, Zhang H, Luo L, Wu W (2024) The causal role of circulating inflammatory markers in osteoporosis: a bidirectional Mendelian randomized study. Front Immunol 15:1412298

Article  CAS  PubMed  PubMed Central  Google Scholar 

Du YN, Chen YJ, Zhang HY, Wang X, Zhang ZF (2021) Inverse association between systemic immune-inflammation index and bone mineral density in postmenopausal women. Gynecol Endocrinol 37:650–654

Article  CAS  PubMed  Google Scholar 

Zhuo H, Zhou Z, Chen X, Song Z, Shang Q, Huang H, Xiao Y, Wang X, Chen H, Yan X, Zhang P (2024) Constructing and validating a predictive nomogram for osteoporosis risk among Chinese single-center male population using the systemic immune-inflammation index. Sci Rep 14:12637

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jin X, Wang Y, Wang H, Wang L, Huan B, Liu C (2024) Correlation study: bone density and circulating inflammatory markers in postmenopausal patients. Immun Inflamm Dis 12:e1365

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang S, Ni W (2023) High systemic immune-inflammation index is relevant to osteoporosis among middle-aged and older people: a cross-sectional study. Immun Inflamm Dis 11:e992

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu L, Xu Z, Li G, Wang Y, Li X, Shi X, Lin H, Chang S (2019) Marrow adiposity as an indicator for insulin resistance in postmenopausal women with newly diagnosed type 2 diabetes–an investigation by chemical shift-encoded water-fat MRI. Eur J Radiol 113:158–164

Article  PubMed  Google Scholar 

Marinelli Busilacchi E, Morsia E, Poloni A (2024) Bone marrow adipose tissue. Cells 13:724

Article  PubMed  PubMed Central  Google Scholar 

Aaron N, Costa S, Rosen CJ, Qiang L (2022) The implications of bone marrow adipose tissue on inflammaging. Front Endocrinol (Lausanne) 13:853765

Article  PubMed  Google Scholar 

Polineni S, Resulaj M, Faje AT, Meenaghan E, Bredella MA, Bouxsein M, Lee H, MacDougald OA, Klibanski A, Fazeli PK (2020) Red and white blood cell counts are associated with bone marrow adipose tissue, bone mineral density, and bone microarchitecture in premenopausal women. J Bone Miner Res 35:1031–1039

Article  CAS  PubMed  Google Scholar 

Li X, Zuo X, Lu L, Xu R, Wang Y, Chang S, Wang Y, Luo P, Li G (2024) Vertebral marrow fat fraction is associated with circulating RANKL in postmenopausal females. Front Endocrinol (Lausanne) 15:1442046

Article  PubMed  Google Scholar 

Li G, Xu Z, Gu H, Li X, Yuan W, Chang S, Fan J, Calimente H, Hu J (2017) Comparison of chemical shift-encoded water–fat MRI and MR spectroscopy in quantification of marrow fat in postmenopausal females. J Magn Reson Imaging 45:66–73

Article  PubMed  Google Scholar 

Leonhardt Y, Ketschau J, Ruschke S, Gassert FT, Glanz L, Feuerriegel GC, Gassert FG, Baum T, Kirschke JS, Braren RF, Schwaiger BJ (2022) Associations of incidental vertebral fractures and longitudinal changes of MR–based proton density fat fraction and T2* measurements of vertebral bone marrow. Front Endocrinol (Lausanne) 13:1046547

Article  PubMed  Google Scholar 

Jackaman C, Tomay F, Duong L, Razak NBA, Pixley FJ, Metharom P, Nelson DJ (2017) Aging and cancer: the role of macrophages and neutrophils. Ageing Res Rev 36:105–116

Article  CAS  PubMed  Google Scholar 

Pang WW, Price EA, Sahoo D, Beerman I, Maloney WJ, Rossi DJ, Schrier SL, Weissman IL (2011) Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci USA 108:20012–20017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yahata T, Takanashi T, Muguruma Y, Ibrahim AA, Matsuzawa H, Uno T, Sheng Y, Onizuka M, Ito M, Kato S, Ando K (2011) Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells. Blood 118:2941–2950

Article  CAS  PubMed  Google Scholar 

Caputa G, Castoldi A, Pearce EJ (2019) Metabolic adaptations of tissue-resident immune cells. Nat Immunol 20:793–801

Article  CAS  PubMed  Google Scholar 

Tuljapurkar SR, McGuire TR, Brusnahan SK, Jackson JD, Garvin KL, Kessinger MA, Lane JT, O’Kane BJ, Sharp JG (2011) Changes in human bone marrow fat content associated with changes in hematopoietic stem cell numbers and cytokine levels with aging. J Anat 219:574–581

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brusnahan SK, McGuire TR, Jackson JD, Lane JT, Garvin KL, O’kane BJ, Berger AM, Tuljapurkar SR, Kessinger MA, Sharp JG (2010) Human blood and marrow side population stem cell and stro-1 positive bone marrow stromal cell numbers decline with age, with an increase in quality of surviving stem cells: correlation with cytokines. Mech Ageing Dev 131:718–722

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fang H, Zhang H, Wang Z, Zhou Z, Li Y, Lu L (2020) Systemic immune-inflammation index acts as a novel diagnostic biomarker for postmenopausal osteoporosis and could predict the risk of osteoporotic fracture. J Clin Lab Anal 34:e23016

Article  PubMed  Google Scholar 

Chen Y, Yu J, Shi L, Han S, Chen J, Sheng Z, Deng M, Jin X, Zhang Z (2023) Systemic inflammation markers associated with bone mineral density in perimenopausal and postmenopausal women. J Inflamm Res 16:297–309

Article  PubMed  PubMed Central  Google Scholar 

Fischer V, Haffner-Luntzer M (2022) Interaction between bone and immune cells: Implications for postmenopausal osteoporosis. Semin Cell Dev Biol 123:14–21

Article  PubMed