Deciphering the genetic interconnection between sarcopenia and osteoporosis: SCD1

Saykali B, Mathiah N, Nahaboo W, Racu ML, Hammou L, Defrance M, Migeotte I (2019) Distinct mesoderm migration phenotypes in extra-embryonic and embryonic regions of the early mouse embryo. Elife 8 https://doi.org/10.7554/eLife.42434

Bettis T, Kim BJ, Hamrick MW (2018) Impact of muscle atrophy on bone metabolism and bone strength: implications for muscle-bone crosstalk with aging and disuse. Osteoporos Int 29:1713–1720. https://doi.org/10.1007/s00198-018-4570-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosenberg IH (1997) Sarcopenia: origins and clinical relevance. J Nutr 127:990s-s991. https://doi.org/10.1093/jn/127.5.990S. (in English)

Article  CAS  PubMed  Google Scholar 

Paintin J, Cooper C, Dennison E (2018) Osteosarcopenia. Br J Hospital Med (London, England: 2005) 79:253–258 (in English). https://doi.org/10.12968/hmed.2018.79.5.253

Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M (2019) Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48:16–31. https://doi.org/10.1093/ageing/afy169. (in English)

Article  PubMed  Google Scholar 

Reid IR (2020) A broader strategy for osteoporosis interventions. Nat Rev Endocrinol 16:333–339. https://doi.org/10.1038/s41574-020-0339-7. (in English)

Article  PubMed  Google Scholar 

Chinese Medical Association Osteoporosis and Bone Mineral Disorders Branch (2019) Results of the epidemiological survey of osteoporosis in China and the “healthy bones” special action campaign released. Chin J Osteoporosis Bone Mineral Metabolic Disorders 12: 317–318. https://doi.org/10.3969/j.issn.1674-2591.2019.04.001

Fujiwara S, Zhao X, Teoh C, Jaffe DH, Taguchi Y (2019) Disease burden of fractures among patients with osteoporosis in Japan: health-related quality of life, work productivity and activity impairment, healthcare resource utilization, and economic costs. J Bone Miner Metab 37:307–318. https://doi.org/10.1007/s00774-018-0916-1. (in English)

Article  PubMed  Google Scholar 

Clynes MA, Gregson CL, Bruyère O, Cooper C, Dennison EM (2021) Osteosarcopenia: where osteoporosis and sarcopenia collide. Rheumatology (Oxford) 60:529–537. https://doi.org/10.1093/rheumatology/keaa755. (in English)

Article  CAS  PubMed  Google Scholar 

Kirk B, Zanker J, Duque G (2020) Osteosarcopenia: epidemiology, diagnosis, and treatment-facts and numbers. J Cachexia Sarcopenia Muscle 11:609–618. https://doi.org/10.1002/jcsm.12567. (in English)

Article  PubMed  PubMed Central  Google Scholar 

Girgis CM, Mokbel N, Digirolamo DJ (2014) Therapies for musculoskeletal disease: can we treat two birds with one stone? Curr Osteoporos Rep 12:142–153. https://doi.org/10.1007/s11914-014-0204-5. (in English)

Article  PubMed  PubMed Central  Google Scholar 

Yu X, Sun S, Zhang S, Hao Q, Zhu B, Teng Y, Long Q, Li S, Lv Y, Yue Q, Lu S, Teng Z (2022) A pooled analysis of the association between sarcopenia and osteoporosis. Medicine (Baltimore) 101:e31692. https://doi.org/10.1097/md.0000000000031692. (in English)

Article  CAS  PubMed  Google Scholar 

Hata R, Miyamoto K, Abe Y, Sasaki T, Oguma Y, Tajima T, Arai Y, Matsumoto M, Nakamura M, Kanaji A, Miyamoto T (2023) Osteoporosis and sarcopenia are associated with each other and reduced IGF1 levels are a risk for both diseases in the very old elderly. Bone 166:116570. https://doi.org/10.1016/j.bone.2022.116570. (in English)

Article  CAS  PubMed  Google Scholar 

Kirk B, Phu S, Brennan-Olsen SL, Bani Hassan E, Duque G (2020) Associations between osteoporosis, the severity of sarcopenia and fragility fractures in community-dwelling older adults. Eur Geriatr Med 11:443–450. https://doi.org/10.1007/s41999-020-00301-6. (in English)

Article  PubMed  Google Scholar 

Petermann-Rocha F, Ferguson LD, Gray SR, Rodríguez-Gómez I, Sattar N, Siebert S, Ho FK, Pell JP, Celis-Morales C (2021) Association of sarcopenia with incident osteoporosis: a prospective study of 168,682 UK biobank participants. J Cachexia Sarcopenia Muscle 12:1179–1188. https://doi.org/10.1002/jcsm.12757. (in English)

Article  PubMed  PubMed Central  Google Scholar 

Migliavacca E, Tay SKH, Patel HP, Sonntag T, Civiletto G et al (2019) Mitochondrial oxidative capacity and NAD(+) biosynthesis are reduced in human sarcopenia across ethnicities. Nat Commun 10:5808. https://doi.org/10.1038/s41467-019-13694-1. (in English)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bowden J, Davey Smith G, Burgess S (2015) Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol 44:512–525. https://doi.org/10.1093/ije/dyv080. (in English)

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Davey Smith G, Haycock PC, Burgess S (2016) Consistent estimation in Mendelian randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol 40:304–314. https://doi.org/10.1002/gepi.21965. (in English)

Article  PubMed  PubMed Central  Google Scholar 

Burgess S, Scott RA, Timpson NJ, Davey Smith G, Thompson SG (2015) Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors. Eur J Epidemiol 30:543–552. https://doi.org/10.1007/s10654-015-0011-z. (in English)

Article  PubMed  PubMed Central  Google Scholar 

Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V et al (2018) The MR-Base platform supports systematic causal inference across the human phenome. Elife 7 (in English). https://doi.org/10.7554/eLife.34408

Hartwig FP, Davey Smith G, Bowden J (2017) Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption. Int J Epidemiol 46:1985–1998. https://doi.org/10.1093/ije/dyx102. (in English)

Article  PubMed  PubMed Central  Google Scholar 

Qin Q, Zhao L, Ren A, Li W, Ma R, Peng Q, Luo S (2023) Systemic lupus erythematosus is causally associated with hypothyroidism, but not hyperthyroidism: a Mendelian randomization study. Front Immunol 14:1125415. https://doi.org/10.3389/fimmu.2023.1125415. (in English)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davey Smith G, Hemani G (2014) Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet 23:R89-98. https://doi.org/10.1093/hmg/ddu328. (in English)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cui Z, Feng H, He B, He J, Tian Y (2021) Relationship between serum amino acid levels and bone mineral density: a Mendelian randomization study. Front Endocrinol (Lausanne) 12:763538. https://doi.org/10.3389/fendo.2021.763538. (in English)

Article  PubMed  Google Scholar 

Karasik D, Kiel DP (2008) Genetics of the musculoskeletal system: a pleiotropic approach. J Bone Miner Res 23:788–802. https://doi.org/10.1359/jbmr.080218. (in English)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun Q, Xing X, Wang H, Wan K, Fan R, Liu C, Wang Y, Wu W, Wang Y, Wang R (2024) SCD1 is the critical signaling hub to mediate metabolic diseases: mechanism and the development of its inhibitors. Biomed Pharmacother 170:115586. https://doi.org/10.1016/j.biopha.2023.115586. (in English)

Article  CAS  PubMed  Google Scholar 

Paton CM, Ntambi JM (2009) Biochemical and physiological function of stearoyl-CoA desaturase. Am J Physiol Endocrinol Metab 297:E28-37. https://doi.org/10.1152/ajpendo.90897.2008. (in English)

Article  CAS  PubMed  Google Scholar 

Mauvoisin D, Mounier C (2011) Hormonal and nutritional regulation of SCD1 gene expression. Biochimie 93:78–86. https://doi.org/10.1016/j.biochi.2010.08.001. (in English)

Article  CAS  PubMed  Google Scholar 

Ascenzi F, De Vitis C, Maugeri-Saccà M, Napoli C, Ciliberto G, Mancini R (2021) SCD1, autophagy and cancer: implications for therapy. J Exp Clin Cancer Res 40:265. https://doi.org/10.1186/s13046-021-02067-6. (in English)

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al AM, Syed DN, Ntambi JM (2017) Insights into Stearoyl-CoA desaturase-1 regulation of systemic metabolism. Trends Endocrinol Metab 28:831–842. https://doi.org/10.1016/j.tem.2017.10.003. (in English)

Article  CAS  Google Scholar 

Comments (0)

No login
gif