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Inverted H1 hemagglutinin nanoparticle vaccines protect mice against challenges with human H1N1 and bovine H5N1 influenza viruses
Inverted H1 hemagglutinin nanoparticle vaccines protect mice against challenges with human H1N1 and bovine H5N1 influenza viruses
Influenza is a global health concern, causing over 300,000 deaths worldwide annually. Current vaccines and natural infecti...
No compelling evidence that vaccination with streptococcus pyogenes group A carbohydrate elicits cross-reactive rheumatic fever autoantibodies
No compelling evidence that vaccination with streptococcus pyogenes group A carbohydrate elicits cross-reactive rheumatic fever autoantibodies
We reviewed 70 years of research defining the specificity of anti-group A carbohydrate (GAC) monoclonal and polyclon...
Aerosol and intranasal delivery of monoclonal antibodies to prevent transmission in pig influenza infection models
Aerosol and intranasal delivery of monoclonal antibodies to prevent transmission in pig influenza infection models
There is an urgent need for robust animal models to assess novel therapies that prevent the transmission of respiratory pa...
A system to rapidly develop a bunyavirus pseudotyped virus neutralisation assay for pandemic preparedness
A system to rapidly develop a bunyavirus pseudotyped virus neutralisation assay for pandemic preparedness
Several Bunyavirales families have been listed as being of high pandemic or epidemic risk by the WHO R&D Blueprint...
Recombinant AAV vaccine expressing PEDV S1 enhances immunity with superior neonatal protection
Recombinant AAV vaccine expressing PEDV S1 enhances immunity with superior neonatal protection
To address suboptimal antibody induction by commercial PEDV vaccines, we constructed a recombinant adeno-associated virus ...
More than half of shoulder vaccinations may end up in the subacromial space
More than half of shoulder vaccinations may end up in the subacromial space
Shoulder Injury Related to Vaccine Administration (SIRVA) can occur as subacromial bursitis, frozen shoulder, or tendinopa...
Rabies virus-vectored Lyme disease vaccine provides long-term protection against tick-transmitted Borrelia burgdorferi
Rabies virus-vectored Lyme disease vaccine provides long-term protection against tick-transmitted Borrelia burgdorferi
Lyme disease (LD) cases have doubled globally. LD is a tick-borne illness caused by the Borrelia burgdorferi sensu lato (B...
Helminth driven gut inflammation and microbial translocation associate with altered vaccine responses in rural Uganda
Helminth driven gut inflammation and microbial translocation associate with altered vaccine responses in rural Uganda
Vaccine responses are sometimes impaired in rural, low-income settings. Helminth-associated gut barrier dysfunction and mi...
Author Correction: Changes in vaccine attitudes and recommendations among US Healthcare Personnel during the COVID-19 pandemic
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Cytolytic γδ T-cells and IFNγ-producing CD4-lymphocytes characterise the early response to MTBVAC tuberculosis vaccine
Cytolytic γδ T-cells and IFNγ-producing CD4-lymphocytes characterise the early response to MTBVAC tuberculosis vaccine
Infection with Mycobacterium tuberculosis (Mtb) can produce a wide spectrum of clinical manifestations, ranging from activ...
Rapid development of attenuated IBV vaccine candidates through a versatile backbone applicable to variants
Rapid development of attenuated IBV vaccine candidates through a versatile backbone applicable to variants
The antigen variability of the infectious bronchitis virus (IBV) has hindered vaccine effectiveness and perpetuated its ep...
Two doses of Qβ virus like particle vaccines elicit protective antibodies against heroin and fentanyl
Two doses of Qβ virus like particle vaccines elicit protective antibodies against heroin and fentanyl
Opioid overdoses and opioid use disorder (OUD) are major public health concerns. Current treatment approaches for OUD have...
Modeling the impact of early vaccination in an influenza pandemic in the United States
Modeling the impact of early vaccination in an influenza pandemic in the United States
We modeled the impact of initiating one-dose influenza vaccination at 3 months vs 6 months after declaration of a pandemic...
RBD-depleted SARS-CoV-2 spike generates protective immunity in cynomolgus macaques
RBD-depleted SARS-CoV-2 spike generates protective immunity in cynomolgus macaques
The SARS-CoV-2 pandemic revealed the rapid evolution of circulating strains. This led to new variants carrying mostly muta...
Author Correction: A Rift Valley fever mRNA vaccine elicits strong immune responses in mice and rhesus macaques
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Healthy ageing: Herpes zoster infection and the role of zoster vaccination
Healthy ageing: Herpes zoster infection and the role of zoster vaccination
Populations are ageing worldwide, with considerable time lived in ill-health, putting upwards pressure on healthcare budge...
BA.5 bivalent booster vaccination enhances neutralization of XBB.1.5, XBB.1.16 and XBB.1.9 variants in patients with lung cancer
BA.5 bivalent booster vaccination enhances neutralization of XBB.1.5, XBB.1.16 and XBB.1.9 variants in patients with lung cancer
This study reports that most patients with NSCLC had a significant increase in the nAb response to the currently circulati...
Ischemic stroke after COVID-19 bivalent vaccine administration in patients aged 65 years and older in the United States
Ischemic stroke after COVID-19 bivalent vaccine administration in patients aged 65 years and older in the United States
The Centers for Disease Control and Prevention announced in January 2023 a potential connection between administration of ...
The effect of dosage on the protective efficacy of whole-sporozoite formulations for immunization against malaria
The effect of dosage on the protective efficacy of whole-sporozoite formulations for immunization against malaria
Immunization with Plasmodium sporozoites, either attenuated or administered under the cover of an antimalarial drug, can i...
Enhancing anti-viral neutralization response to immunization with HIV-1 envelope glycoprotein immunogens
Enhancing anti-viral neutralization response to immunization with HIV-1 envelope glycoprotein immunogens
An effective human immunodeficiency virus type I (HIV-1) vaccine that robustly elicits broadly neutralizing antibodies (bn...
Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques
Conjugation of HIV-1 envelope to hepatitis B surface antigen alters vaccine responses in rhesus macaques
An effective HIV-1 vaccine remains a critical unmet need for ending the AIDS epidemic. Vaccine trials conducted to date ha...
Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants
Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants
We compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circula...
Outlook of pandemic preparedness in a post-COVID-19 world
Outlook of pandemic preparedness in a post-COVID-19 world
The COVID-19 pandemic was met with rapid, unprecedented global collaboration and action. Even still, the public health, so...
Polyethylene glycol (PEG)-associated immune responses triggered by clinically relevant lipid nanoparticles in rats
Polyethylene glycol (PEG)-associated immune responses triggered by clinically relevant lipid nanoparticles in rats
With the large-scale vaccination of lipid nanoparticles (LNP)-based COVID-19 mRNA vaccines, elucidating the potential poly...
Advancements in Rift Valley fever vaccines: a historical overview and prospects for next generation candidates
Advancements in Rift Valley fever vaccines: a historical overview and prospects for next generation candidates
Rift Valley fever (RVF) is a zoonotic viral disease transmitted by mosquitoes and causes abortion storms, fetal malformati...
Both chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection
Both chimpanzee adenovirus-vectored and DNA vaccines induced long-term immunity against Nipah virus infection
Nipah virus (NiV) is a highly lethal zoonotic paramyxovirus that poses a severe threat to humans due to its high morbidity...
Identification of the flavivirus conserved residues in the envelope protein hinge region for the rational design of a candidate West Nile live-attenuated vaccine
Identification of the flavivirus conserved residues in the envelope protein hinge region for the rational design of a candidate West Nile live-attenuated vaccine
The flavivirus envelope protein is a class II fusion protein that drives flavivirus-cell membrane fusion. The membrane fus...
IL6 suppresses vaccine responses in neonates by enhancing IL2 activity on T follicular helper cells
IL6 suppresses vaccine responses in neonates by enhancing IL2 activity on T follicular helper cells
The inability of neonates to develop CD4+FoxP3-CXCR5hiPD-1hi T follicular helper (TFH) cells contributes to their weak vac...
Prediction of long-term humoral response induced by the two-dose heterologous Ad26.ZEBOV, MVA-BN-Filo vaccine against Ebola
Prediction of long-term humoral response induced by the two-dose heterologous Ad26.ZEBOV, MVA-BN-Filo vaccine against Ebola
The persistence of the long-term immune response induced by the heterologous Ad26.ZEBOV, MVA-BN-Filo two-dose vaccination ...
Immunogenic arenavirus vector SIV vaccine reduces setpoint viral load in SIV-challenged rhesus monkeys
Immunogenic arenavirus vector SIV vaccine reduces setpoint viral load in SIV-challenged rhesus monkeys
HIV affects more than 38 million people worldwide. Although HIV can be effectively treated by lifelong combination antiret...
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