Mattson, C. L. et al. Trends and geographic patterns in drug and synthetic opioid overdose deaths—United States, 2013–2019. MMWR Morb. Mortal. Wkly. Rep. 70, 202–207 (2021).
PubMed PubMed Central Google Scholar
Gardner, E. A., McGrath, S. A., Dowling, D. & Bai, D. The opioid crisis: prevalence and markets of opioids. Forensic Sci. Rev. 34, 43–70 (2022).
Drug Overdose Deaths- NIDA. https://nida.nih.gov/research-topics/trends-statistics/overdose-death-rates.
CDC, National Center for Health Statistics, Office of Communication. U.S. Overdose Deaths In 2021 Increased Half as Much as in 2020—But Are Still Up 15%. cdc.gov https://www.cdc.gov/nchs/pressroom/nchs_press_releases/2022/202205.htm.
Matthes, H. W. et al. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature 383, 819–823 (1996).
James, A. & Williams, J. Basic opioid pharmacology—an update. Br. J. Pain. 14, 115–121 (2020).
PubMed PubMed Central Google Scholar
Volkow, N. D. & Wargo, E. M. Overdose prevention through medical treatment of opioid use disorders. Ann. Intern Med. 169, 190 (2018).
Volkow, N. D., Frieden, T. R., Hyde, P. S. & Cha, S. S. Medication-assisted therapies—tackling the opioid-overdose epidemic. N. Engl. J. Med. 370, 2063–2066 (2014).
Dickson-Gomez, J. et al. “You’re Not Supposed to be on it Forever”: medications to treat opioid use disorder (MOUD) related stigma among drug treatment providers and people who use opioids. Subst. Abus. 16, 117822182211038 (2022).
Madden, E. F., Prevedel, S., Light, T. & Sulzer, S. H. Intervention stigma toward medications for opioid use disorder: a systematic review. Subst. Use Misuse 56, 2181–2201 (2021).
Larochelle, M. R. et al. Medication for opioid use disorder after nonfatal opioid overdose and association with mortality: a cohort study. Ann. Intern. Med. 169, 137 (2018).
PubMed PubMed Central Google Scholar
Sullivan, L. E. & Fiellin, D. A. Narrative review: buprenorphine for opioid-dependent patients in office practice. Ann. Intern. Med. 148, 662 (2008).
PubMed PubMed Central Google Scholar
SAMHSA Medications for Opioid Use Disorder. https://store.samhsa.gov/sites/default/files/SAMHSA_Digital_Download/PEP21-02-01-002.pdf.
Yamamoto, A. et al. Association between homelessness and opioid overdose and opioid-related hospital admissions/emergency department visits. Soc. Sci. Med. 242, 112585 (2019).
PubMed PubMed Central Google Scholar
Bateman, J. T., Saunders, S. E. & Levitt, E. S. Understanding and countering opioid‐induced respiratory depression. Br. J. Pharmacol. bph.15580 https://doi.org/10.1111/bph.15580 (2021).
Eliza Wheeler, T., Stephen, J., Michael K. G., Peter J. D., Centers for Disease Control and Prevention (CDC). Opioid overdose prevention programs providing naloxone to laypersons—United States, 2014. MMWR Morb Mortal Wkly Rep. 64, 631-635 (2015).
Volkow, N. D. & Collins, F. S. The role of science in addressing the opioid crisis. N. Engl. J. Med. 377, 391–394 (2017).
Collins, F. S., Koroshetz, W. J. & Volkow, N. D. Helping to end addiction over the long-term: the research plan for the NIH HEAL initiative. JAMA 320, 129 (2018).
PubMed PubMed Central Google Scholar
Raleigh, M. D., Accetturo, C. & Pravetoni, M. Combining a candidate vaccine for opioid use disorders with extended-release naltrexone increases protection against oxycodone-induced behavioral effects and toxicity. J. Pharm. Exp. Ther. 374, 392–403 (2020).
Kimishima, A., Olson, M. E. & Janda, K. D. Investigations into the efficacy of multi-component cocaine vaccines. Bioorg. Med. Chem. Lett. 28, 2779–2783 (2018).
Stevens, M. W., Gunnell, M. G., Tawney, R. & Owens, S. M. Optimization of a methamphetamine conjugate vaccine for antibody production in mice. Int. Immunopharmacol. 35, 137–141 (2016).
CAS PubMed PubMed Central Google Scholar
Kosten, T. R. et al. Vaccine for cocaine dependence: a randomized double-blind placebo-controlled efficacy trial. Drug Alcohol Depend. 140, 42–47 (2014).
CAS PubMed PubMed Central Google Scholar
Cornuz, J. et al. A vaccine against nicotine for smoking cessation: a randomized controlled trial. PLoS One 3, e2547 (2008).
PubMed PubMed Central Google Scholar
Hatsukami, D. K. et al. Immunogenicity and smoking-cessation outcomes for a novel nicotine immunotherapeutic. Clin. Pharm. Ther. 89, 392–399 (2011).
Bonese, K. F., Wainer, B. H., Fitch, F. W., Rothberg, R. M. & Schuster, C. R. Changes in heroin self-administration by a rhesus monkey after morphine immunisation. Nature 252, 708–710 (1974).
Pravetoni, M. & Comer, S. D. Development of vaccines to treat opioid use disorders and reduce incidence of overdose. Neuropharmacology 158, 107662 (2019).
CAS PubMed PubMed Central Google Scholar
Alving, C. R., Matyas, G. R., Torres, O., Jalah, R. & Beck, Z. Adjuvants for vaccines to drugs of abuse and addiction. Vaccine 32, 5382–5389 (2014).
CAS PubMed PubMed Central Google Scholar
Shen, X. Y., Orson, F. M. & Kosten, T. R. Vaccines against drug abuse. Clin. Pharm. Ther. 91, 60–70 (2012).
Kimishima, A., Wenthur, C. J., Zhou, B. & Janda, K. D. An advance in prescription opioid vaccines: overdose mortality reduction and extraordinary alteration of drug half-life. ACS Chem. Biol. 12, 36–40 (2017).
Hamid, F. A. et al. Pre-clinical safety and toxicology profile of a candidate vaccine to treat oxycodone use disorder. Vaccine 40, 3244–3252 (2022).
CAS PubMed PubMed Central Google Scholar
Bremer, P. T. et al. Development of a clinically viable heroin vaccine. J. Am. Chem. Soc. 139, 8601–8611 (2017).
CAS PubMed PubMed Central Google Scholar
Belz, T. F. et al. Enhancement of a heroin vaccine through hapten deuteration. J. Am. Chem. Soc. 142, 13294–13298 (2020).
CAS PubMed PubMed Central Google Scholar
Hwang, C. S. et al. Heroin vaccine: using titer, affinity, and antinociception as metrics when examining sex and strain differences. Vaccine 37, 4155–4163 (2019).
CAS PubMed PubMed Central Google Scholar
Brisse, M., Vrba, S. M., Kirk, N., Liang, Y. & Ly, H. Emerging concepts and technologies in vaccine development. Front. Immunol. 11, 583077 (2020).
CAS PubMed PubMed Central Google Scholar
Baehr, C. et al. Preclinical efficacy and selectivity of vaccines targeting fentanyl, alfentanil, sufentanil, and acetylfentanyl in rats. ACS Omega 7, 16584–16592 (2022).
CAS PubMed PubMed Central Google Scholar
Stone, A. E. et al. Fentanyl conjugate vaccine by injected or mucosal delivery with dmLT or LTA1 adjuvants implicates IgA in protection from drug challenge. NPJ Vaccin. 6, 69 (2021).
Crouse, B. et al. Efficacy and selectivity of monovalent and bivalent vaccination strategies to protect against exposure to carfentanil, fentanyl, and their mixtures in rats. ACS Pharmacol. Transl. Sci. 5, 331–343 (2022).
CAS PubMed PubMed Central Google Scholar
Frietze, K. M., Peabody, D. S. & Chackerian, B. Engineering virus-like particles as vaccine platforms. Curr. Opin. Virol. 18, 44–49 (2016).
CAS PubMed PubMed Central Google Scholar
Chackerian, B., Lowy, D. R. & Schiller, J. T. Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies. J. Clin. Investig. 108, 415–423 (2001).
CAS PubMed PubMed Central Google Scholar
Collar, A. L., Linville, A. C., Core, S. B. & Frietze, K. M. Epitope-based vaccines against the chlamydia trachomatis major outer membrane protein variable domain 4 elicit protection in mice. Vaccines 10, 875 (2022).
CAS PubMed PubMed Central Google Scholar
Jelínková, L. et al. A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model. NPJ Vaccin. 7, 34 (2022).
Warner, N. L. & Frietze, K. M. Development of bacteriophage virus-like particle vaccines displaying conserved epitopes of dengue virus non-structural protein 1. Vaccines 9, 726 (2021).
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