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Rethinking triage for febrile children in low-resource settings
Rethinking triage for febrile children in low-resource settings
Integrating clinical data with simple physiological measures or biomarkers improves triage of febrile children and could r...
Brazilian elimination of mother-to-child HIV transmission: lessons for large-scale global health systems
In 2025, Brazil became the first country with a population exceeding 100 million to achieve validation of the elimination ...
Early kidney risk prediction in APOL1 high-risk genotype carriers
Early kidney risk prediction in APOL1 high-risk genotype carriers
A nine-protein plasma signature is predictive of kidney events and mortality in individuals with a high-risk APOL1 genotyp...
An international and independent scientific foundation for AI governance
An international and independent scientific foundation for AI governance
This Comment was written by B.A.M. and was submitted for publication with the permission of the panel’s secretariat, on be...
Autonomous pathology research using agentic AI shows potential in oncology
Autonomous pathology research using agentic AI shows potential in oncology
The agentic artificial intelligence tool SPARK is able to reproduce pathology-based reasoning and produce biological hypot...
Author Correction: Benralizumab versus placebo for hypereosinophilic syndrome: a randomized, placebo-controlled phase 3 trial
A full list of members and their affiliations appears in the Supplementary Information.Division of Pediatric Allergy, Immu...
Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals
The American Heart Association’s PREVENT equations estimate risk of total cardiovascular disease (CVD), atherosclero...
ChatGPT Health triage advice falls short in key cases
ChatGPT Health triage advice falls short in key cases
ChatGPT Health showed high accuracy for moderately urgent conditions but frequently overtriaged mild cases and undertriage...
Rethinking brain body maps and phantom limbs
Rethinking brain body maps and phantom limbs
A study challenges previous assumptions that the brain’s body map undergoes reorganization after limb amputation, finding ...
Oligodendrocyte-targeted adeno-associated virus gene therapy for Canavan disease in children: a phase 1/2 trial
Oligodendrocyte-targeted adeno-associated virus gene therapy for Canavan disease in children: a phase 1/2 trial
This open-label phase 1/2 clinical study uses a novel recombinant vector, rAAV-Olig001, with selective tropism for oligode...
Macrovascular and microvascular outcomes of metabolic surgery versus GLP-1 receptor agonists in patients with diabetes and obesity
Macrovascular and microvascular outcomes of metabolic surgery versus GLP-1 receptor agonists in patients with diabetes and obesity
Both metabolic surgery and glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) improve cardiometabolic outcomes, but t...
Improving AI coaching with Gemini using real-world Fitbit data
Improving AI coaching with Gemini using real-world Fitbit data
We created and curated three benchmark datasets to assess large language model (LLM) performance on sleep and fitness task...
Time for the exposome to shape policy
For exposome research to make a difference, it must be diversified and translate into policies that protect health.
An implantable system to restore hemodynamic stability after spinal cord injury
An implantable system to restore hemodynamic stability after spinal cord injury
A spinal cord injury (SCI) causes immediate and sustained hemodynamic instability that threatens neurological recovery and...
The arts for disease prevention and health promotion: a systematic review
The arts for disease prevention and health promotion: a systematic review
Differences in risk factor exposure and access to prevention resources have led to unequal health outcomes for noncommunic...
Clinical implementation of an AI-based prediction model for decision support for patients undergoing colorectal cancer surgery
Clinical implementation of an AI-based prediction model for decision support for patients undergoing colorectal cancer surgery
Adverse outcomes after elective cancer surgery are a main contributor to decreased survival, poorer oncological outcomes a...
Author Correction: Mapping the effectiveness and risks of GLP-1 receptor agonists
Authors and AffiliationsClinical Epidemiology Center, Research and Development Service, VA St. Louis Health Care System, S...
Addressing maternal and infant health inequities requires improved birth record data collection
All authors are members or contributors to the American Heart Association’s Policy Research Advisory Group (PRAG), which p...
Author Correction: Single-dose suraxavir marboxil for acute uncomplicated influenza in adults and adolescents: a multicenter, randomized, double-blind, placebo-controlled phase 3 trial
These authors contributed equally: Yeming Wang, Hong Wang, Yu Zhang, Anlin Ma, Dong Liu.National Center for Respiratory Me...
Not the end of the road for macrophage therapy in liver cirrhosis
Not the end of the road for macrophage therapy in liver cirrhosis
A phase 2 trial of autologous macrophage therapy falls just short of meeting its primary endpoint of improving prognosis, ...
The medical crisis of war-injured children in Gaza and Lebanon
Israeli military operations have severely disrupted healthcare in Gaza and Lebanon, creating a humanitarian crisis with de...
Immunotherapy boosts responses in hormone receptor-positive breast cancers
Immunotherapy boosts responses in hormone receptor-positive breast cancers
The CheckMate-7FL and KEYNOTE-756 trials provide robust evidence for the efficacy of neoadjuvant chemo-immunotherapy in hi...
Bioaccumulation of microplastics in decedent human brains
Bioaccumulation of microplastics in decedent human brains
Rising global concentrations of environmental microplastics and nanoplastics (MNPs) drive concerns for human exposure and ...
Clinical applications of human organoids
Clinical applications of human organoids
Organoids are innovative three-dimensional and self-organizing cell cultures of various lineages that can be used to study...
Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial
Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial
In patients with chronic lymphocytic leukemia, Richter transformation (RT) reflects the development of an aggressive lymph...
Mosunetuzumab with polatuzumab vedotin in relapsed or refractory aggressive large B cell lymphoma: a phase 1b/2 trial
Mosunetuzumab with polatuzumab vedotin in relapsed or refractory aggressive large B cell lymphoma: a phase 1b/2 trial
Relapsed/refractory aggressive large B cell lymphoma (LBCL) remains an area of unmet need. Here we report the primary anal...
Injury-specific signals elicit plasticity in glial cells from patients with brain injury
Injury-specific signals elicit plasticity in glial cells from patients with brain injury
Glial cells influence brain function and disease progression. This study identifies signals that elicit hemorrhage-specifi...
Representative and equitable participant sampling in health research
Representative and equitable participant sampling in health research
Research participants often do not represent the target population for treatment. Systematic exclusion of particular group...
A toolkit for capturing a representative and equitable sample in health research
A toolkit for capturing a representative and equitable sample in health research
Research participants often do not represent the general population. Systematic exclusion of particular groups from resear...
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
The glial environment influences neurological disease progression, yet much of our knowledge still relies on preclinical a...
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