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Rethinking brain body maps and phantom limbs
Rethinking brain body maps and phantom limbs
A study challenges previous assumptions that the brain’s body map undergoes reorganization after limb amputation, finding ...
Oligodendrocyte-targeted adeno-associated virus gene therapy for Canavan disease in children: a phase 1/2 trial
Oligodendrocyte-targeted adeno-associated virus gene therapy for Canavan disease in children: a phase 1/2 trial
This open-label phase 1/2 clinical study uses a novel recombinant vector, rAAV-Olig001, with selective tropism for oligode...
Macrovascular and microvascular outcomes of metabolic surgery versus GLP-1 receptor agonists in patients with diabetes and obesity
Macrovascular and microvascular outcomes of metabolic surgery versus GLP-1 receptor agonists in patients with diabetes and obesity
Both metabolic surgery and glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) improve cardiometabolic outcomes, but t...
Improving AI coaching with Gemini using real-world Fitbit data
Improving AI coaching with Gemini using real-world Fitbit data
We created and curated three benchmark datasets to assess large language model (LLM) performance on sleep and fitness task...
Time for the exposome to shape policy
For exposome research to make a difference, it must be diversified and translate into policies that protect health.
An implantable system to restore hemodynamic stability after spinal cord injury
An implantable system to restore hemodynamic stability after spinal cord injury
A spinal cord injury (SCI) causes immediate and sustained hemodynamic instability that threatens neurological recovery and...
The arts for disease prevention and health promotion: a systematic review
The arts for disease prevention and health promotion: a systematic review
Differences in risk factor exposure and access to prevention resources have led to unequal health outcomes for noncommunic...
Clinical implementation of an AI-based prediction model for decision support for patients undergoing colorectal cancer surgery
Clinical implementation of an AI-based prediction model for decision support for patients undergoing colorectal cancer surgery
Adverse outcomes after elective cancer surgery are a main contributor to decreased survival, poorer oncological outcomes a...
Author Correction: Mapping the effectiveness and risks of GLP-1 receptor agonists
Authors and AffiliationsClinical Epidemiology Center, Research and Development Service, VA St. Louis Health Care System, S...
Addressing maternal and infant health inequities requires improved birth record data collection
All authors are members or contributors to the American Heart Association’s Policy Research Advisory Group (PRAG), which p...
Author Correction: Single-dose suraxavir marboxil for acute uncomplicated influenza in adults and adolescents: a multicenter, randomized, double-blind, placebo-controlled phase 3 trial
These authors contributed equally: Yeming Wang, Hong Wang, Yu Zhang, Anlin Ma, Dong Liu.National Center for Respiratory Me...
Not the end of the road for macrophage therapy in liver cirrhosis
Not the end of the road for macrophage therapy in liver cirrhosis
A phase 2 trial of autologous macrophage therapy falls just short of meeting its primary endpoint of improving prognosis, ...
The medical crisis of war-injured children in Gaza and Lebanon
Israeli military operations have severely disrupted healthcare in Gaza and Lebanon, creating a humanitarian crisis with de...
Immunotherapy boosts responses in hormone receptor-positive breast cancers
Immunotherapy boosts responses in hormone receptor-positive breast cancers
The CheckMate-7FL and KEYNOTE-756 trials provide robust evidence for the efficacy of neoadjuvant chemo-immunotherapy in hi...
Bioaccumulation of microplastics in decedent human brains
Bioaccumulation of microplastics in decedent human brains
Rising global concentrations of environmental microplastics and nanoplastics (MNPs) drive concerns for human exposure and ...
Clinical applications of human organoids
Clinical applications of human organoids
Organoids are innovative three-dimensional and self-organizing cell cultures of various lineages that can be used to study...
Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial
Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial
In patients with chronic lymphocytic leukemia, Richter transformation (RT) reflects the development of an aggressive lymph...
Mosunetuzumab with polatuzumab vedotin in relapsed or refractory aggressive large B cell lymphoma: a phase 1b/2 trial
Mosunetuzumab with polatuzumab vedotin in relapsed or refractory aggressive large B cell lymphoma: a phase 1b/2 trial
Relapsed/refractory aggressive large B cell lymphoma (LBCL) remains an area of unmet need. Here we report the primary anal...
Injury-specific signals elicit plasticity in glial cells from patients with brain injury
Injury-specific signals elicit plasticity in glial cells from patients with brain injury
Glial cells influence brain function and disease progression. This study identifies signals that elicit hemorrhage-specifi...
Representative and equitable participant sampling in health research
Representative and equitable participant sampling in health research
Research participants often do not represent the target population for treatment. Systematic exclusion of particular group...
A toolkit for capturing a representative and equitable sample in health research
A toolkit for capturing a representative and equitable sample in health research
Research participants often do not represent the general population. Systematic exclusion of particular groups from resear...
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
The glial environment influences neurological disease progression, yet much of our knowledge still relies on preclinical a...
Meningioma risk stratification with a targeted gene-expression biomarker
Meningioma risk stratification with a targeted gene-expression biomarker
A validated biomarker risk score based on the expression of 34 genes improves risk stratification of patients with meningi...
11 clinical trials that will shape medicine in 2024
11 clinical trials that will shape medicine in 2024
Nature Medicine asks leading researchers to name their top clinical trial for 2024, from base editing and a vaccine agains...
Author Correction: Liquid biopsy epigenomic profiling for cancer subtyping
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USASylvan C. Baca, Ji-Heui Seo, Matthew P. David...
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial
Preclinical evidence has suggested an interplay between the androgen receptor, which largely drives the growth of prostate...
Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial
Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial
KRAS G12C mutation is prevalent in ~4% of colorectal cancer (CRC) and is associated with poor prognosis. Divarasib, a KRAS...
Durability of single-dose HPV vaccination in young Kenyan women: randomized controlled trial 3-year results
Durability of single-dose HPV vaccination in young Kenyan women: randomized controlled trial 3-year results
Cervical cancer burden is high where prophylactic vaccination and screening coverage are low. We demonstrated in a multice...
Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study
Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study
Converging evidence indicates that impairments in executive function and information-processing speed limit quality of lif...
Monitoring medical AI device adoption
Monitoring medical AI device adoption
The adoption of medical AI devices in clinical practice is still in its infancy, with uneven usage across procedures and l...
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