Ethics approval and consent to participate

All in vivo experiments conducted in this study followed the protocols approved by the Institutional Welfare Ethics Committee at Xiamen University Laboratory Animal Center (XMULAC20170258). The clinical trial was conducted by Xiang 'an Hospital of Xiamen University approved by Medical Ethics Committee of Xiamen University (Registration Site: https://www.chictr.org.cn/showproj.html?proj=250187, Registration number: ChiCTR2400092111, Ethic Number: XAHLL2024039).

Consent for publication

We confirm that this manuscript is original, has not been published before, and is not currently under consideration for publication elsewhere. All authors have approved the final version and agree to transfer copyright to the journal upon acceptance.

Competing interests

This work was supported by Marinesharp Therapeutics CoLtd. M.C. is a shareholder and scientific advisor to Marinesharp Therapeutics. S.Y. is a shareholder to Marinesharp Therapeutics.

Disclosure

Prof. Dr. Ming Chen reports that two patents, ZL 201610267764.6 and US 10,555,896 B2, have been issued, and that one patent, CN202510113546.6, is pending.