Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM, Barengo NC, Beaton AZ, Benjamin EJ, Benziger CP et al (2020) Global burden of cardiovascular diseases and risk factors, 1990–2019: update from the GBD 2019 study. J Am Coll Cardiol 76(25):2982–3021
Article PubMed PubMed Central Google Scholar
Ma ZG, Yuan YP, Wu HM, Zhang X, Tang QZ (2018) Cardiac fibrosis: new insights into the pathogenesis. Int J Biol Sci 14(12):1645–1657
Article CAS PubMed PubMed Central Google Scholar
Rossi VA, Gruebler M, Monzo L, Galluzzo A, Beltrami M (2023) The different pathways of epicardial adipose tissue across the heart failure phenotypes: from pathophysiology to therapeutic target. Int J Mol Sci 24(7). https://doi.org/10.3390/ijms24076838
Yang CD, Quan JW, Tay GP, Feng S, Yuan H, Amuti A, Tang SY, Wu XR, Yuan RS, Lu L et al (2024) Epicardial adipose tissue volume and density are associated with heart failure with improved ejection fraction. Cardiovasc Diabetol 23(1):283
Article PubMed PubMed Central Google Scholar
Zhu D, Zhang Z, Zhao J, Liu D, Gan L, Lau WB, Xie D, Meng Z, Yao P, Tsukuda J et al (2022) Targeting adiponectin receptor 1 phosphorylation against ischemic heart failure. Circ Res 131(2):e34–e50
Article CAS PubMed PubMed Central Google Scholar
Zhou Z, Liu C, Xu S, Wang J, Guo F, Duan S, Deng Q, Sun J, Yu F, Zhou Y et al (2022) Metabolism regulator adiponectin prevents cardiac remodeling and ventricular arrhythmias via sympathetic modulation in a myocardial infarction model. Basic Res Cardiol 117(1):34
Article CAS PubMed Google Scholar
Aprigliano G, Scuteri L, Iafelice I, Li Volsi L, Cuko B, Palloshi A, Pisani M, Bonizzato S, Bianchi M, Morici N (2015) Epicardial adipose tissue thickness and acute coronary syndrome: a matter of how much or how? Int J Cardiol 199:8–9
Si Y, Fan W, Sun L (2020) A review of the relationship between CTRP family and coronary artery disease. Curr Atheroscler Rep 22(6):22
Article CAS PubMed PubMed Central Google Scholar
Schaffler A, Buechler C (2012) CTRP family: linking immunity to metabolism. Trends Endocrinol Metab 23(4):194–204
Liu Y, Wei C, Ding Z, Xing E, Zhao Z, Shi F, Tian Y, Zhang Y, Fan W, Sun L (2022) Role of serum C1q/TNF-related protein family levels in patients with acute coronary syndrome. Front Cardiovasc Med 9:967918
Article CAS PubMed PubMed Central Google Scholar
Li Q, Wang L, Tan W, Peng Z, Luo Y, Zhang Y, Zhang G, Na D, Jin P, Shi T et al (2011) Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-kappaB pathways and promotes cell survival in human cancer cells. Cancer Lett 308(2):203–214
Article CAS PubMed Google Scholar
Shanaki M, Shabani P, Goudarzi A, Omidifar A, Bashash D, Emamgholipour S (2020) The C1q/TNF-related proteins (CTRPs) in pathogenesis of obesity-related metabolic disorders: focus on type 2 diabetes and cardiovascular diseases. Life Sci 256:117913
Article CAS PubMed Google Scholar
Kishore U, Gaboriaud C, Waters P, Shrive AK, Greenhough TJ, Reid KB, Sim RB, Arlaud GJ (2004) C1q and tumor necrosis factor superfamily: modularity and versatility. Trends Immunol 25(10):551–561
Article CAS PubMed Google Scholar
Seldin MM, Tan SY, Wong GW (2014) Metabolic function of the CTRP family of hormones. Rev Endocr Metab Disord 15(2):111–123
Article CAS PubMed PubMed Central Google Scholar
Zhang H, Zhang-Sun Z-y, Xue C-x, Li X-y, Ren J, Jiang Y-t, Liu T, Yao H-r, Zhang J, Gou T-t et al (2022) CTRP family in diseases associated with inflammation and metabolism: molecular mechanisms and clinical implication. Acta Pharmacol Sin 44(4):710–725
Article PubMed PubMed Central Google Scholar
Kishore U, Reid KB (2000) C1q: structure, function, and receptors. Immunopharmacology 49(1–2):159–170
Article CAS PubMed Google Scholar
Seldin MM, Peterson JM, Byerly MS, Wei Z, Wong GW (2012) Myonectin (CTRP15), a novel myokine that links skeletal muscle to systemic lipid homeostasis. J Biol Chem 287(15):11968–11980
Article CAS PubMed PubMed Central Google Scholar
Jeon JH, Kim KY, Kim JH, Baek A, Cho H, Lee YH, Kim JW, Kim D, Han SH, Lim JS et al (2008) A novel adipokine CTRP1 stimulates aldosterone production. FASEB J 22(5):1502–1511
Article CAS PubMed Google Scholar
Xin Y, Lyu X, Wang C, Fu Y, Zhang S, Tian C, Li Q, Zhang D (2014) Elevated circulating levels of CTRP1, a novel adipokine, in diabetic patients. Endocr J 61(9):841–847
Article CAS PubMed Google Scholar
Su Z, Tian S, Liang W (2019) Circulating CTRP1 levels are increased and associated with the STOD in essential hypertension in Chinese patients. Cardiovasc Ther 2019:4183781
Article PubMed PubMed Central Google Scholar
Lasser G, Guchhait P, Ellsworth JL, Sheppard P, Lewis K, Bishop P, Cruz MA, Lopez JA, Fruebis J (2006) C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen. Blood 107(2):423–430
Article CAS PubMed Google Scholar
van Hinsbergh VW, Eringa EC (2016) C1q/TNF-related protein 1: a novel link between visceral fat and athero-inflammation. Eur Heart J 37(22):1772–1774
Davis KE, Scherer PE (2008) Adiponectin: no longer the lone soul in the fight against insulin resistance? Biochem J 416(2):e7-9
Article CAS PubMed Google Scholar
Ye M, Wu QH, Yang K, Luo Y (2022) C1q/TNF-related protein-2 improved angiogenesis to protect myocardial function during ischaemia-reperfusion. Diab Vasc Dis Res 19(6):14791641221137356
Article CAS PubMed PubMed Central Google Scholar
Peterson JM, Seldin MM, Tan SY, Wong GW (2014) CTRP2 overexpression improves insulin and lipid tolerance in diet-induced obese mice. PLoS ONE 9(2):e88535
Article PubMed PubMed Central Google Scholar
Petersen PS, Wolf RM, Lei X, Peterson JM, Wong GW (2016) Immunomodulatory roles of CTRP3 in endotoxemia and metabolic stress. Physiological Reports 4(5). https://doi.org/10.14814/phy2.12735
Li Y, Ozment T, Wright GL, Peterson JM (2016) Identification of putative receptors for the movel adipokine CTRP3 using ligand-receptor capture technology. PLoS ONE 11(10):e0164593
Article PubMed PubMed Central Google Scholar
Li X, Jiang L, Yang M, Wu Y-w, Sun S-x, Sun J-z (2014) CTRP3 modulates the expression and secretion of adipokines in 3T3-L1 adipocytes. Endocr J 61(12):1153–1162
Article CAS PubMed Google Scholar
Peterson JM, Seldin MM, Wei Z, Aja S, Wong GW (2013) CTRP3 attenuates diet-induced hepatic steatosis by regulating triglyceride metabolism. Am J Physiol Gastrointest Liver Physiol 305(3):G214–G224
Article CAS PubMed PubMed Central Google Scholar
Li Y, Wright GL, Peterson JM (2017) C1q/TNF-related protein 3 (CTRP3) function and regulation. Compr Physiol 7(3):863–878
Article PubMed PubMed Central Google Scholar
Cao L, Deng J, Chen W, He M, Zhao N, Huang H, Ling L, Li Q, Zhu X, Wang L (2023) CTRP4/interleukin-6 receptor signaling ameliorates autoimmune encephalomyelitis by suppressing Th17 cell differentiation. J Clin Invest 134(4). https://doi.org/10.1172/JCI168384
Sarver DC, Stewart AN, Rodriguez S, Little HC, Aja S, Wong GW (2020) Loss of CTRP4 alters adiposity and food intake behaviors in obese mice. Am J Physiol Endocrinol Metab 319(6):E1084–E1100
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