Ni H, Liu C, Chen Y, Lu Y, Ji Y, Xiang M, et al. MGP regulates perivascular adipose-derived stem cells differentiation toward smooth muscle cells via BMP2/SMAD pathway enhancing neointimal formation. Cell Transplant. 2022;31:9636897221075748. https://doi.org/10.1177/09636897221075747.

Article  PubMed  Google Scholar 

Li TD, Zeng ZH. Adiponectin as a potential therapeutic target for the treatment of restenosis. Biomed Pharmacother. 2018;101:798–804. https://doi.org/10.1016/j.biopha.2018.03.003.

Article  CAS  PubMed  Google Scholar 

Antonopoulos AS, Sanna F, Sabharwal N, Thomas S, Oikonomou EK, Herdman L, et al. Detecting human coronary inflammation by imaging perivascular fat. Sci Transl Med. 2017;9:eaa12658. https://doi.org/10.1126/scitranslmed.aal2658.

Article  CAS  Google Scholar 

Cacanyiova S, Golas S, Zemancikova A, Majzunova M, Cebova M, Malinska H, et al. The vasoactive role of perivascular adipose tissue and the sulfide signaling pathway in a nonobese model of metabolic syndrome. Biomolecules. 2021;11(1):108. https://doi.org/10.3390/biom11010108.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan XX, Ruan CC, Liu XY, Kong LR, Ma Y, Wu QH, et al. Perivascular adipose tissue derived stromal cells contribute to vascular remodeling during aging. Aging Cell. 2019;18(4):e12969. https://doi.org/10.1111/acel.12969.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bogdanov L, Shishkova D, Mukhamadiyarov R, Velikanova E, Tsepokina A, Terekhov A, et al. Excessive adventitial and perivascular vascularisation correlates with vascular inflammation and intimal hyperplasia. Int J Mol Sci. 2022;23(20):12156. https://doi.org/10.3390/ijms232012156.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Watts SW, Flood ED, Garver H, Fink GD, Roccabianca S. A new function for perivascular adipose tissue (PVAT): assistance of arterial stress relaxation. Sci Rep. 2020;10(1):1807. https://doi.org/10.1038/s41598-020-58368-x.

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Zhu X, Zhang HW, Chen HN, Deng XJ, Tu YX, Jackson AO, et al. Perivascular adipose tissue dysfunction aggravates adventitial remodeling in obese mini pigs via NLRP3 inflammasome/IL-1 signaling pathway. Acta Pharmacol Sin. 2019;40(1):46–54. https://doi.org/10.1038/s41401-018-0068-9.

Article  CAS  PubMed  Google Scholar 

Hu J, Hu N, Hu T, Zhang J, Han D, Wang H. Associations between preprocedural carotid artery perivascular fat density and early in-stent restenosis after carotid artery stenting. Heliyon. 2023;9(6): e16220. https://doi.org/10.1016/j.heliyon.2023.e16220.

Article  PubMed  PubMed Central  Google Scholar 

Chang L, Garcia-Barrio MT, Chen YE. Perivascular adipose tissue regulates vascular function by targeting vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2020;40(5):1094–109. https://doi.org/10.1161/ATVBAHA.120.312464.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barcena AJR, Perez JVD, Liu O, Mu A, Heralde FM, Huang SY, et al. Localized perivascular therapeutic approaches to inhibit venous neointimal hyperplasia in arteriovenous fistula access for hemodialysis use. Biomolecules. 2022;12(10):1367. https://doi.org/10.3390/biom12101367.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhou Y, Dai C, Zhang B, Ge J. Adiponectin prevents restenosis through inhibiting cell proliferation in a rat vein graft model. Arq Bras Cardiol. 2021;117(6):1179–88. https://doi.org/10.36660/abc.20200761.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng CK, Ding H, Jiang M, Yin H, Gollasch M, Huang Y. Perivascular adipose tissue: fine-tuner of vascular redox status and inflammation. Redox Biol. 2023;62: 102683. https://doi.org/10.1016/j.redox.2023.102683.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Man AWC, Li H, Xia N. The role of sirtuin1 in regulating endothelial function, arterial remodeling and vascular aging. Front Physiol. 2019;10:1173. https://doi.org/10.3389/fphys.2019.01173.

Article  PubMed  PubMed Central  Google Scholar 

Shi H, Goo B, Kim D, Kress TC, Ogbi M, Mintz J, et al. Perivascular adipose tissue promotes vascular dysfunction in murine lupus. Front Immunol. 2023;14:1095034. https://doi.org/10.3389/fimmu.2023.1095034.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bahnson ES, Havelka GE, Koo NC, Jiang Q, Kibbe MR. Periadventitial adipose tissue modulates the effect of PROLI/NO on neointimal hyperplasia. J Surg Res. 2016;205(2):440–5. https://doi.org/10.1016/j.jss.2016.06.074.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mori Y, Terasaki M, Hiromura M, Saito T, Kushima H, Koshibu M, et al. Luseogliflozin attenuates neointimal hyperplasia after wire injury in high-fat diet-fed mice via inhibition of perivascular adipose tissue remodeling. Cardiovasc Diabetol. 2019;18:143. https://doi.org/10.1186/s12933-019-0947-5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sena CM, Pereira A, Fernandes R, Letra L, Seiça RM. Adiponectin improves endothelial function in mesenteric arteries of rats fed a high-fat diet: role of perivascular adipose tissue. Br J Pharmacol. 2017;174(20):3514–26. https://doi.org/10.1111/bph.13756.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nakladal D, Sijbesma JWA, Visser LM, Tietge UJF, Slart RHJA, Deelman LE, et al. Perivascular adipose tissue-derived nitric oxide compensates endothelial dysfunction in aged pre-atherosclerotic apolipoprotein E-deficient rats. Vascul Pharmacol. 2022;142: 106945. https://doi.org/10.1016/j.vph.2021.106945.

Article  CAS  PubMed  Google Scholar 

Qin B, Li Z, Zhou H, Liu Y, Wu H, Wang Z. The predictive value of the perivascular adipose tissue CT fat attenuation index for coronary in-stent restenosis. Front Cardiovasc Med. 2022;9: 822308. https://doi.org/10.3389/fcvm.2022.822308.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ji Y, Ma Y, Shen J, Ni H, Lu Y, Zhang Y, et al. TBX20 contributes to balancing the differentiation of perivascular adipose-derived stem cells to vascular lineages and neointimal hyperplasia. Front Cell Dev Biol. 2021;9: 662704. https://doi.org/10.3389/fcell.2021.662704.

Article  PubMed  PubMed Central  Google Scholar 

Adachi Y, Ueda K, Nomura S, Ito K, Katoh M, Katagiri M, et al. Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling. Nat Commun. 2022;13(1):5117. https://doi.org/10.1038/s41467-022-32658-6.

Article  CAS  PubMed  PubMed Central  ADS  Google Scholar 

Miron TR, Flood ED, Tykocki NR, Thompson JM, Watts SW. Identification of Piezo1 channels in perivascular adipose tissue (PVAT) and their potential role in vascular function. Pharmacol Res. 2022;175: 105995. https://doi.org/10.1016/j.phrs.2021.105995.

Article  CAS  PubMed  Google Scholar 

Tian Z, Miyata K, Tazume H, Sakaguchi H, Kadomatsu T, Horio E, et al. Perivascular adipose tissue-secreted angiopoietin-like protein 2 (Angptl2) accelerates neointimal hyperplasia after endovascular injury. J Mol Cell Cardiol. 2013;57:1–12. https://doi.org/10.1016/j.yjmcc.2013.01.004.

Article  CAS  PubMed  Google Scholar 

Tan N, Dey D, Marwick TH, Nerlekar N. Pericoronary adipose tissue as a marker of cardiovascular risk: JACC review topic of the week. J Am Coll Cardiol. 2023;81(9):913–23. https://doi.org/10.1016/j.jacc.2022.12.021.

Article  CAS  PubMed  Google Scholar 

Sanders WG, Li H, Zhuplatov I, He Y, Kim SE, Cheung AK, et al. Autologous fat transplants to deliver glitazone and adiponectin for vasculoprotection. J Control Release. 2017;264:237–46. https://doi.org/10.1016/j.jconrel.2017.08.036.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xia N, Reifenberg G, Schirra C, Li H. The involvement of sirtuin 1 dysfunction in high-fat diet-induced vascular dysfunction in mice. Antioxidants. 2022;11(3):541. https://doi.org/10.3390/antiox11030541.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shirasu T, Yodsanit N, Xie X, Zhao Y, Wang Y, Xie R, et al. An adventitial painting modality of local drug delivery to abate intimal hyperplasia. Biomaterials. 2021;275: 120968. https://doi.org/10.1016/j.biomaterials.2021.120968.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moussi K, Haneef AA, Alsiary RA, Diallo EM, Boone MA, Abu-Araki H, et al. A microneedles balloon catheter for endovascular drug delivery. Adv Mater Technol. 2021;6(8):1–9. https://doi.org/10.1002/admt.202170046.

Article  Google Scholar 

Cawich I, Armstrong EJ, George JC, Golzar J, Shishehbor MH, Razavi M, et al. Temsirolimus adventitial delivery to improve ANGiographic outcomes below the knee. J Endovasc Ther. 2022;15266028221131459 https://doi.org/10.1177/15266028221131459.

Applewhite B, Gupta A, Wei Y, Yang X, Martinez L, Rojas MG, et al. Periadventitial β-aminopropionitrile-loaded nanofibers reduce fibrosis and improve arteriovenous fistula remodeling in rats. Front Cardiovasc Med. 2023;10:1124106. https://doi.org/10.3389/fcvm.2023.1124106.

Article  CAS  PubMed