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Lipocalin-2 deficiency attenuates kainic acid-induced hippocampal cell death in a high-fat diet-fed diabetic mice
Lipocalin-2 deficiency attenuates kainic acid-induced hippocampal cell death in a high-fat diet-fed diabetic mice
Metabolic dysfunctions such as obesity and diabetes predispose the brain to heightened excitotoxic vulnerability, aggravat...
Chronic social defeat stress accelerates lung cancer progression and induces hippocampal metabolic dysregulation in a duration-optimized comorbid model
Chronic social defeat stress accelerates lung cancer progression and induces hippocampal metabolic dysregulation in a duration-optimized comorbid model
Chronic social defeat stress (CSDS) is a commonly used mouse model of depression, yet lung cancer - CSDS combined model re...
Increased semaphorin, neuropilin, and plexin expression plays a role in recovery after traumatic brain injury
Increased semaphorin, neuropilin, and plexin expression plays a role in recovery after traumatic brain injury
One of the leading causes of death and disability globally, affecting people of all ages, is traumatic brain injury (TBI)....
Neuro-renin–angiotensin–aldosterone system axis in alzheimer’s disease: from molecular dysregulation to therapeutic redirection
Neuro-renin–angiotensin–aldosterone system axis in alzheimer’s disease: from molecular dysregulation to therapeutic redirection
Alzheimer's disease (AD) is characterized by progressive neurodegeneration marked by tau hyperphosphorylation, amyloid...
The role of gut dysbiosis in Parkinson’s disease: pathophysiology, epidemiology, and emerging therapeutic strategies
The role of gut dysbiosis in Parkinson’s disease: pathophysiology, epidemiology, and emerging therapeutic strategies
Parkinson’s disease (PD) is a prevalent neurodegenerative disorder characterized by the progressive loss of dopamine...
Human serum hypoxanthine as a biomarker to predict recurrent major depressive disorder: a cross-sectional metabolomic study
Human serum hypoxanthine as a biomarker to predict recurrent major depressive disorder: a cross-sectional metabolomic study
Major depressive disorder (MDD) is a multifactorial and highly recurrent illness. Patients are typically required to take ...
Environmental metals, prostaglandin pathways, and immune-mediated neuroinflammation in autism spectrum disorder: A secondary analysis of peripheral biomarker studies
Environmental metals, prostaglandin pathways, and immune-mediated neuroinflammation in autism spectrum disorder: A secondary analysis of peripheral biomarker studies
Autism spectrum disorder (ASD) shows peripheral signatures of inflammation, cellular stress, and immune dysregulation in s...
Intrathecal delivery of AAVrh10-mHexa combined with anti-inflammatory treatment reduces neuropathological markers and extends the lifespan of mice with early-onset Tay-Sachs disease
Intrathecal delivery of AAVrh10-mHexa combined with anti-inflammatory treatment reduces neuropathological markers and extends the lifespan of mice with early-onset Tay-Sachs disease
Tay-Sachs disease is a lysosomal storage disorder caused by mutations in the HEXA gene, which encodes the α-subunit o...
Kinetin mitigate neurodegenerative damage of Alzheimer induced by beta-amyloid in male rats by antioxidant and antithrombotic effects
Kinetin mitigate neurodegenerative damage of Alzheimer induced by beta-amyloid in male rats by antioxidant and antithrombotic effects
Alzheimer’s disease (AD) is a neurodegenerative disease that is charactrized by impaired memory and cognitive functi...
The relationship between gut microbiota and neurodegenerative diseases: a genetic and epigenetic perspective
The relationship between gut microbiota and neurodegenerative diseases: a genetic and epigenetic perspective
Gut microbiota (GM) is a complex and dynamic structure that can have a wide range of effects on human health. Studies in r...
Adiponectin in neuroinflammation and parkinson’s disease: A macromolecular and therapeutic perspective
Adiponectin in neuroinflammation and parkinson’s disease: A macromolecular and therapeutic perspective
Parkinson’s Disease (PD) is a neurodegenerative disorder that exacerbates over time and is the result of long-term n...
Post-translational modifications in alzheimer’s disease: proteome dynamics and emerging therapeutic strategies
Post-translational modifications in alzheimer’s disease: proteome dynamics and emerging therapeutic strategies
Alzheimer’s disease (AD) is a progressive neurodegenerative condition marked by the accumulation of amyloid-β (...
MiR-122 activates PI3K/Akt signaling to suppress microglial activation and ferroptosis in ischemic brain injury
MiR-122 activates PI3K/Akt signaling to suppress microglial activation and ferroptosis in ischemic brain injury
This study aimed to elucidate the neuroprotective effects of miR-122 in ischemic brain injury and its unique dual mechanis...
Role of insulin-like growth factor-1/2 and related signaling in parkinson’s disease
Role of insulin-like growth factor-1/2 and related signaling in parkinson’s disease
Parkinson’s disease (PD) is a chronically progressive neurodegenerative disorder primarily characterized by the dege...
Metabolic dysregulation in psychotic mania: longitudinal cardiometabolic changes with exploratory analyses of serum uric acid
Metabolic dysregulation in psychotic mania: longitudinal cardiometabolic changes with exploratory analyses of serum uric acid
Psychotic mania, a severe form of bipolar disorder, presents with elevated mood, hyperactivity, and psychotic symptoms. It...
reduces D-galactose-induced hepatic and cerebral oxidative damage in aging mice via the Nrf2/ARE pathway
reduces D-galactose-induced hepatic and cerebral oxidative damage in aging mice via the Nrf2/ARE pathway
The global aging population necessitates safe, multi-target strategies to combat age-related functional decline. Tu-Si-Zi-...
Tryptophan metabolism alterations in neurological and psychiatric diseases: Molecular mechanisms and pharmacological targets
Tryptophan metabolism alterations in neurological and psychiatric diseases: Molecular mechanisms and pharmacological targets
Tryptophan (TRP) is an essential amino acid required for protein synthesis. It undergoes an extensive and complex metaboli...
Elucidating the pharmacological mechanism of Yangming-Kaixin-Yizhi formula in inhibiting neuronal ferroptosis via Nrf2 in Alzheimer’s disease: a study combining network pharmacology, transcriptomics, and experimental validation
Elucidating the pharmacological mechanism of Yangming-Kaixin-Yizhi formula in inhibiting neuronal ferroptosis via Nrf2 in Alzheimer’s disease: a study combining network pharmacology, transcriptomics, and experimental validation
Ferroptosis is considered to be an important pathological driver of Alzheimer’s disease (AD), and inhibiting neurona...
Amino acid patterns predict white matter integrity measures in the brain in patients across the Alzheimer’s disease continuum
Amino acid patterns predict white matter integrity measures in the brain in patients across the Alzheimer’s disease continuum
Alzheimer’s disease (AD), the leading cause of dementia, poses a growing global health challenge due to its rising p...
Cola acuminata extract’s inhibition of NLRP3 inflammasome in THP-1 cells as a potential treatment option for Parkinson’s disease
Cola acuminata extract’s inhibition of NLRP3 inflammasome in THP-1 cells as a potential treatment option for Parkinson’s disease
Neuroinflammation has been described as one of the multiple clinical manifestations of Parkinson’s and AlzheimerR...
Rice bran extract attenuates cognitive impairment by enhancing pancreatic β-cell insulin secretion in STZ-induced diabetic rats targeting the PPARγ/PDX1 pathway
Rice bran extract attenuates cognitive impairment by enhancing pancreatic β-cell insulin secretion in STZ-induced diabetic rats targeting the PPARγ/PDX1 pathway
Type I diabetes (T1D), also known as juvenile diabetes, is an autoimmune disease that causes gradual destruction of pancre...
Metabolomic analysis of blood spots in a Chinese cohort with autism spectrum disorders: a pilot study
Metabolomic analysis of blood spots in a Chinese cohort with autism spectrum disorders: a pilot study
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a strong genetic component that is becoming increasin...
Differential effects of industrial and ruminant trans fatty acids on appetitive memory
Differential effects of industrial and ruminant trans fatty acids on appetitive memory
Trans-fatty acids (TFAs) are categorized into industrial TFAs (iTFAs) and ruminant TFAs (rTFAs). TFAs intakes over 48&...
Tanshinone IIA inhibits neuronal ferroptosis and relieves cerebral ischemia‒reperfusion injury by regulating miR-449a/ACSL4
Tanshinone IIA inhibits neuronal ferroptosis and relieves cerebral ischemia‒reperfusion injury by regulating miR-449a/ACSL4
Cerebral ischemia‒reperfusion injury (CI/RI) plays a significant role in the initiation of ischemic stroke. This stu...
An analysis of the therapeutic efficacy and underlying mechanisms of combining lycopene with dental pulp stem cells to ameliorate alzheimer’s disease in rats
An analysis of the therapeutic efficacy and underlying mechanisms of combining lycopene with dental pulp stem cells to ameliorate alzheimer’s disease in rats
The choroid plexus (CP), which is responsible for forming the blood-cerebrospinal fluid barrier, contributes to the modula...
Ivermectin’s neuroprotective effects decrease with prolonged use after cerebral ischemia/reperfusion
Ivermectin’s neuroprotective effects decrease with prolonged use after cerebral ischemia/reperfusion
Ivermectin (IVM), the recipient of the 2015 Nobel Prize, is an FDA-approved drug for a variety of parasitic diseases in an...
Association between traumatic brain injury and risk of developing infections in the central nervous system and periphery
Association between traumatic brain injury and risk of developing infections in the central nervous system and periphery
Traumatic brain injury (TBI) is defined as structural damage or physiological disruption of brain function resulting from ...
Mechanisms of SIRT1/SIRT3-mediated reduction of mitochondrial regeneration and inflammatory response in diabetic cerebral ischemia-reperfusion injury
Mechanisms of SIRT1/SIRT3-mediated reduction of mitochondrial regeneration and inflammatory response in diabetic cerebral ischemia-reperfusion injury
This study investigates the specific mechanisms by which SIRT1/SIRT3 modulates the reduction of mitochondrial regeneration...
Neuroprotective efficacy of in Cadmium-induced neurotoxicity: involvement of antioxidant defense, anti-inflammatory, dopaminergic, and cholinergic systems
Neuroprotective efficacy of in Cadmium-induced neurotoxicity: involvement of antioxidant defense, anti-inflammatory, dopaminergic, and cholinergic systems
The incidence of neurotoxicity has been rising recently due to increase exposure to toxic compounds such as Cadmium (Cd). ...
Mechanistic study of butylphthalide in alleviating cerebral Edema after intracerebral Hemorrhage by regulating miR-7-5p expression
Mechanistic study of butylphthalide in alleviating cerebral Edema after intracerebral Hemorrhage by regulating miR-7-5p expression
To investigate the mechanisms by which butylphthalide (NBP) alleviates cerebral edema after intracerebral hemorrhage (ICH)...
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