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Decoding Adipose Tissue Phenotypic Switching: From Mechanisms to Computational Drug Discovery
Decoding Adipose Tissue Phenotypic Switching: From Mechanisms to Computational Drug Discovery
This review aims to explore the therapeutic potential of brown adipose tissue (BAT) to combat obesity and associated metab...
Beyond the Scale: Setting Goals for Outcomes Beyond Weight in Evidence-based Obesity Treatment
Beyond the Scale: Setting Goals for Outcomes Beyond Weight in Evidence-based Obesity Treatment
As definitions of obesity evolve beyond a sole focus on weight, evidence-based obesity treatments may also benefit from a ...
Metabolic Flux Adaptations During GLP-1 Receptor Agonist Therapy: Redox Implications
Metabolic Flux Adaptations During GLP-1 Receptor Agonist Therapy: Redox Implications
GLP-1 receptor agonists (GLP-1RAs) have become central therapies for obesity and metabolic disease. Although these agents ...
Opportunities and Challenges for Precision Nutrition in Gestational Obesity Management
Opportunities and Challenges for Precision Nutrition in Gestational Obesity Management
This review summarizes current knowledge on precision nutrition in gestational obesity management and outlines priorities ...
Intelligence-driven Mechanomedicine for Weight Rebound in Obesity
Intelligence-driven Mechanomedicine for Weight Rebound in Obesity
This perspective aims to propose a mechanomedicine framework integrating the body’s intrinsic “mechanical inte...
Intersectionality in Weight Stigma Research: A Systematic Review of Empirical Evidence
Intersectionality in Weight Stigma Research: A Systematic Review of Empirical Evidence
Social stigma and discrimination based on body weight or size (weight stigma) contribute to inequities in healthcare acces...
Metabolic Dysfunction–Associated Steatotic Liver Disease and Respiratory Disorders: A Systematic Review of Clinical and Pathophysiological Associations
Metabolic Dysfunction–Associated Steatotic Liver Disease and Respiratory Disorders: A Systematic Review of Clinical and Pathophysiological Associations
Metabolic dysfunction–associated steatotic liver disease (MASLD) represents the hepatic manifestation of ectopic fat...
Prioritising Indicators for Large-scale Monitoring and Assessment of Food Environments for Public Health
Prioritising Indicators for Large-scale Monitoring and Assessment of Food Environments for Public Health
This study aimed to prioritise key indicators for monitoring and assessing the healthiness of food environments, including...
The Epidemiology of the Global Syndemic in Africa: New Evidence and Key Insights
The Epidemiology of the Global Syndemic in Africa: New Evidence and Key Insights
Over the past decade, Sub-Saharan Africa has entered a new phase in the evolution of the global syndemic of undernutrition...
Autophagy in Obesity and Type 2 Diabetes: Beyond the Protective Paradigm
Autophagy in Obesity and Type 2 Diabetes: Beyond the Protective Paradigm
This review examines the current evidence on autophagy dysregulation in obesity and type 2 diabetes mellitus (T2DM), with ...
Burden of Intrapancreatic Fat Deposition in Type 2 Diabetes and the Role of Obesity: A Systematic Review and Meta-Analysis
Burden of Intrapancreatic Fat Deposition in Type 2 Diabetes and the Role of Obesity: A Systematic Review and Meta-Analysis
Growing evidence supports a role for high intrapancreatic fat deposition (IPFD) in the pathogenesis of type 2 dia...
How Have Researchers Estimated the Impact of Excess Weight on Mortality? A Systematic Review
How Have Researchers Estimated the Impact of Excess Weight on Mortality? A Systematic Review
The aim of this review is to describe and reflect on the methodology of the studies that estimate the attributable mortali...
The Role of Fathers in the Intergenerational Transmission of Obesity
The Role of Fathers in the Intergenerational Transmission of Obesity
This narrative review aims to synthesize recent evidence demonstrating that paternal influences can significantly affect c...
Health Care Professionals’ Barriers and Facilitators for the Implementation of Lifestyle Interventions Targeting Weight Loss in Primary Care – A Systematic Review of Qualitative Studies
Health Care Professionals’ Barriers and Facilitators for the Implementation of Lifestyle Interventions Targeting Weight Loss in Primary Care – A Systematic Review of Qualitative Studies
This systematic review aims to investigate barriers and facilitators that Health Care Professionals (HCPs) experience duri...
Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure
Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure
Obesity stems from a chronic imbalance between energy intake and expenditure. Current therapeutic strategies primarily foc...
Effectiveness of Digital Tools on Lifestyle & Health-Related Outcomes Across the Full Continuum of the Maternal Journey: A Systematic Review
Effectiveness of Digital Tools on Lifestyle & Health-Related Outcomes Across the Full Continuum of the Maternal Journey: A Systematic Review
Maternal health is a global public health priority and a key determinant of generational and societal well-being. Healthy ...
Update on Hypothalamic Inflammation and Gliosis: Expanding Evidence of Relevance Beyond Obesity
Update on Hypothalamic Inflammation and Gliosis: Expanding Evidence of Relevance Beyond Obesity
To evaluate the role of hypothalamic inflammation and gliosis in human obesity pathogenesis and other disease processes in...
Nutritional Strategies for Battling Obesity-Linked Liver Disease: the Role of Medical Nutritional Therapy in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management
Nutritional Strategies for Battling Obesity-Linked Liver Disease: the Role of Medical Nutritional Therapy in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) Management
This narrative review explores the role of Medical Nutritional Therapy (MNT) in managing Metabolic-Associated Steatotic Li...
Updates on Methods for Body Composition Analysis: Implications for Clinical Practice
Updates on Methods for Body Composition Analysis: Implications for Clinical Practice
Recent technological advances have introduced novel methods for measuring body composition, each with unique benefits and ...
Bone Marrow Adipocytes as Novel Regulators of Metabolic Homeostasis: Clinical Consequences of Bone Marrow Adiposity
Bone Marrow Adipocytes as Novel Regulators of Metabolic Homeostasis: Clinical Consequences of Bone Marrow Adiposity
Bone marrow adipose tissue is a distinctive fat depot located within the skeleton, with the potential to influence both lo...
New Frontiers: Umbilical Cord Mesenchymal Stem Cells Uncover Developmental Roots and Biological Underpinnings of Obesity Susceptibility
New Frontiers: Umbilical Cord Mesenchymal Stem Cells Uncover Developmental Roots and Biological Underpinnings of Obesity Susceptibility
To review evidence supporting human umbilical cord mesenchymal stem cells (UC-MSC) as an innovative model system advancing...
Hallmarks of Appetite: A Comprehensive Review of Hunger, Appetite, Satiation, and Satiety
Hallmarks of Appetite: A Comprehensive Review of Hunger, Appetite, Satiation, and Satiety
The present review describes the available literature on the physiologic mechanisms that modulate hunger, appetite, satiat...
Defining Hyperphagia for Improved Diagnosis and Management of MC4R Pathway–Associated Disease: A Roundtable Summary
Defining Hyperphagia for Improved Diagnosis and Management of MC4R Pathway–Associated Disease: A Roundtable Summary
Hyperphagia is a condition associated with rare obesity-related diseases, presenting as a pathologic, insatiable hunger ac...
Optimal Bilio-Pancreatic Limb (BPL) Length in One Anastomosis Gastric Bypass (OAGB) Surgery
Optimal Bilio-Pancreatic Limb (BPL) Length in One Anastomosis Gastric Bypass (OAGB) Surgery
One Anastomosis Gastric Bypass (OAGB) is a modification of Mason’s loop bypass procedure, which has become a well-es...
Is There a Need to Reassess Protein Intake Recommendations Following Metabolic Bariatric Surgery?
Is There a Need to Reassess Protein Intake Recommendations Following Metabolic Bariatric Surgery?
Protein intake is recognized as a key nutritional factor crucial for optimizing Metabolic Bariatric Surgery (MBS) outcomes...
Current Clinical Practice Guidelines for Nutritional Screening Before and After Sleeve Gastrectomy and Roux-En-Y Gastric Bypass: A Scoping Review
Current Clinical Practice Guidelines for Nutritional Screening Before and After Sleeve Gastrectomy and Roux-En-Y Gastric Bypass: A Scoping Review
Long-term data indicate that patients who underwent metabolic bariatric surgery have a higher risk of developing nutrition...
Time Restricted Eating: A Valuable Alternative to Calorie Restriction for Addressing Obesity?
Time Restricted Eating: A Valuable Alternative to Calorie Restriction for Addressing Obesity?
In this review, we summarize the molecular effects of time-restricted eating (TRE) and its possible role in appetite regul...
The Impact of Novel Medications for Obesity on Weight Stigma and Societal Attitudes: A Narrative Review
The Impact of Novel Medications for Obesity on Weight Stigma and Societal Attitudes: A Narrative Review
This narrative review examines the potential implications of the expanded use of novel medications for obesity, particular...
Circadian Disruption and the Risk of Developing Obesity
Circadian Disruption and the Risk of Developing Obesity
This review summarizes recent evidence for a role of the clock in adipose tissue physiology and the impact of circadian de...
The Interplay of Genetic Predisposition, Circadian Misalignment, and Metabolic Regulation in Obesity
The Interplay of Genetic Predisposition, Circadian Misalignment, and Metabolic Regulation in Obesity
This review explores the complex interplay between genetic predispositions to obesity, circadian rhythms, metabolic regula...
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