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Exploration of physical activity, sedentary behavior and insulin level among short sleepers
Exploration of physical activity, sedentary behavior and insulin level among short sleepers
BackgroundSufficient physical activity and sleep duration are essential for overall health. While one-third of the US popu...
Acupoint catgut embedding: a potential intervention strategy for obesity-related precocious puberty
Acupoint catgut embedding: a potential intervention strategy for obesity-related precocious puberty
IntroductionObesity-related precocious puberty is induced by obesity, and acupoint catgut embedding (ACE) therapy is known...
Targeting AMP-activated protein kinase in sepsis
Targeting AMP-activated protein kinase in sepsis
Sepsis is a global health challenge marked by limited clinical options and high mortality rates. AMP-activated protein kin...
Evidence of apoptosis as an early event leading to cyclophosphamide-induced primordial follicle depletion in a prepubertal mouse model
Evidence of apoptosis as an early event leading to cyclophosphamide-induced primordial follicle depletion in a prepubertal mouse model
IntroductionThe mechanisms leading to ovarian primordial follicle depletion following gonadotoxic chemotherapy with cyclop...
The associations of the triglyceride-glucose index and its combination with blood pressure on cardiovascular and all-cause mortality in hypertension: a national study
The associations of the triglyceride-glucose index and its combination with blood pressure on cardiovascular and all-cause mortality in hypertension: a national study
The triglyceride-glucose (TyG) index, a reliable surrogate biomarker of insulin resistance (IR), is highlighted recently a...
Enhanced joint pain in diabetic patients with knee osteoarthritis is associated with increased synovitis, synovial immune cell infiltration, and erythrocyte extravasation
Enhanced joint pain in diabetic patients with knee osteoarthritis is associated with increased synovitis, synovial immune cell infiltration, and erythrocyte extravasation
ObjectiveDiabetes mellitus (DM) is an important risk factor for the development of osteoarthritis (OA), increasing OA prog...
Tracing links between micronutrients and type 2 diabetes risk: the singular role of selenium
Tracing links between micronutrients and type 2 diabetes risk: the singular role of selenium
BackgroundType 2 diabetes (T2D) is a growing global health concern. While micronutrients are crucial for physiological fun...
Editorial: Molecular mechanisms underlying exercise-alleviated sarcopenic obesity
Sarcopenic obesity (SO), characterized by the concurrent decline in muscle mass and 9 function alongside an increase in bo...
Association of dietary and circulating antioxidant vitamins with metabolic syndrome: an observational and Mendelian randomization study
Association of dietary and circulating antioxidant vitamins with metabolic syndrome: an observational and Mendelian randomization study
AimsThe objective of this study was to investigate the associations of dietary and circulating antioxidant vitamins with m...
Obesity-related renal dysfunction: gender-specific influence of visceral adiposity and early impact of metabolic and bariatric surgery
Obesity-related renal dysfunction: gender-specific influence of visceral adiposity and early impact of metabolic and bariatric surgery
IntroductionRenal dysfunction is a recognized complication of obesity with an incompletely characterized pathophysiology. ...
Elevated non-HDL-C to HDL-C ratio as a marker for NAFLD and liver fibrosis risk: a cross-sectional analysis
Elevated non-HDL-C to HDL-C ratio as a marker for NAFLD and liver fibrosis risk: a cross-sectional analysis
BackgroundDyslipidemia is a known independent risk factor for Nonalcoholic fatty liver disease (NAFLD). However, the relat...
Effects of mesenchymal stromal cells and human recombinant Nerve Growth Factor delivered by bioengineered human corneal lenticule on an innovative model of diabetic retinopathy
Effects of mesenchymal stromal cells and human recombinant Nerve Growth Factor delivered by bioengineered human corneal lenticule on an innovative model of diabetic retinopathy
IntroductionDiabetic retinopathy (DR) is a microvascular complication of diabetes in which neurodegeneration has been rece...
Causal association between gastrointestinal diseases and coronary artery disease: a bidirectional Mendelian randomization study
Causal association between gastrointestinal diseases and coronary artery disease: a bidirectional Mendelian randomization study
BackgroundCoronary artery disease (CAD) has been a dominating reason of mortality globally due to its complexity of etiolo...
Opportunities for digitally-enabled personalization and decision support for pediatric growth hormone therapy
Opportunities for digitally-enabled personalization and decision support for pediatric growth hormone therapy
Smart technologies and connected health are providing opportunities for improved healthcare for chronic conditions. Accept...
Current status of the prediction for radio-iodine refractory thyroid cancer: a narrative review
Current status of the prediction for radio-iodine refractory thyroid cancer: a narrative review
It is well established that patients with the most differentiated thyroid cancers have a good prognosis, whereas when the ...
Systemic treatments for radioiodine-refractory thyroid cancers
Systemic treatments for radioiodine-refractory thyroid cancers
Differentiated thyroid cancers (DTCs) constitute the primary histological subtype within thyroid cancer. Due to DTCs’ dist...
Unveiling risk factors for post-COVID-19 syndrome development in people with type 2 diabetes
IntroductionApproximately 95% of people with diabetes worldwide have type 2 diabetes (T2D). A 3% increase in age-standardi...
Editorial: Advances in targeted therapy and biomarker research for endocrine-related cancers
The field of endocrine-related cancers is undergoing rapid transformation, fueled by significant strides in deciphering th...
Corrigendum: Gestational hypothyroxinemia induces ASD-like phenotypes in behavior, proinflammatory markers, and glutamatergic protein expression in mouse offspring of both sexes
Corrigendum: Gestational hypothyroxinemia induces ASD-like phenotypes in behavior, proinflammatory markers, and glutamater...
Editorial: Endocrine disruptors in gut endocrinology
Interactions between the endocrine system, gut microbiota, and endocrine disruptors are multifaceted study areas with sign...
Thyroid hormone levels and BMI-SDS changes in adolescents with obesity
Thyroid hormone levels and BMI-SDS changes in adolescents with obesity
BackgroundThyroid hormones play an important role in energy metabolism and weight control, explained mostly by inducing th...
Comparing pyrotinib with trastuzumab and pertuzumab with trastuzumab for HER2-positive metastatic breast cancer: a retrospective, multicenter analysis
Comparing pyrotinib with trastuzumab and pertuzumab with trastuzumab for HER2-positive metastatic breast cancer: a retrospective, multicenter analysis
ObjectivePyrotinib and pertuzumab are effective treatment options for HER2-positive metastatic breast cancer (HER2+ MBC). ...
Single-cell RNA-seq identified novel genes involved in primordial follicle formation
Single-cell RNA-seq identified novel genes involved in primordial follicle formation
IntroductionThe number of primordial follicles (PFs) in mammals determines the ovarian reserve, and impairment of primordi...
Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis
Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis
Obesity is a pathophysiological condition, dependent on body fat accumulation, that progressively induces systemic oxidati...
Protective role of perivascular adipose tissue in the cardiovascular system
Protective role of perivascular adipose tissue in the cardiovascular system
This review provides an overview of the key role played by perivascular adipose tissue (PVAT) in the protection of cardiov...
Arginine vasopressin injection rescues delayed oviposition in cyp19a1b-/- mutant female zebrafish
Arginine vasopressin injection rescues delayed oviposition in cyp19a1b-/- mutant female zebrafish
In zebrafish, estrogens produced in the ovaries via Cyp19a1a activity are required for both sexual differentiation of the ...
Association of trajectory of body shape index with all-cause and cause-specific mortality: 18 years follow-up
Association of trajectory of body shape index with all-cause and cause-specific mortality: 18 years follow-up
ObjectivesThe current study aimed to examine how the trajectory of a body shape index (ABSI) could predict mortality in a ...
Transcriptomic and lipid profiling analysis reveals a functional interplay between testosterone and growth hormone in hypothyroid liver
Transcriptomic and lipid profiling analysis reveals a functional interplay between testosterone and growth hormone in hypothyroid liver
Preclinical and clinical studies suggest that hypothyroidism might cause hepatic endocrine and metabolic disturbances with...
Estrobolome dysregulation is associated with altered immunometabolism in a mouse model of endometriosis
Estrobolome dysregulation is associated with altered immunometabolism in a mouse model of endometriosis
IntroductionEndometriosis is a painful disease that affects around 5% of women of reproductive age. In endometriosis, ecto...
Exploration and validation of key genes associated with early lymph node metastasis in thyroid carcinoma using weighted gene co-expression network analysis and machine learning
Exploration and validation of key genes associated with early lymph node metastasis in thyroid carcinoma using weighted gene co-expression network analysis and machine learning
BackgroundThyroid carcinoma (THCA), the most common endocrine neoplasm, typically exhibits an indolent behavior. However, ...
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