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Early postnatal growth predictors of catch-up growth in term small-for-gestational-age infants: a nationwide propensity-score–matched study
Early postnatal growth predictors of catch-up growth in term small-for-gestational-age infants: a nationwide propensity-score–matched study
BackgroundInfants born small for gestational age (SGA) are at risk for impaired growth and metabolic complications. Howeve...
One-year changes in body composition and phase angle during feminizing gender-affirming hormone therapy: a longitudinal and comparative study
BackgroundGender dysphoria (GD) refers to the clinically significant distress or discomfort that may arise from a marked i...
Beyond the triglyceride-glucose index, the cholesterol- high-density lipoprotein -glucose index as a superior predictor for diabetes risk in patients with major adverse cardiovascular events: dual evidence from the CHARLS database and real-world data
BackgroundTo compare the predictive value of the cholesterol-high-density lipoprotein-glucose (CHG) index versus the trigl...
Knowledge, attitudes, and practices of patients with chronic kidney disease toward osteosarcopenia
ObjectiveTo investigate the knowledge, attitudes, and practices of patients with chronic kidney disease regarding osteosar...
Analysis of the association between history of gestational diabetes mellitus and hypertensive disorders in a subsequent pregnancy: a retrospective cohort study
AimTo investigate the association between history of gestational diabetes mellitus (GDM) and the risk of hypertensive diso...
Emulating the LEADER trial in China: a regulatory science case study on non-interventional research
IntroductionIntegrating real-world evidence (RWE) into regulatory decision-making requires validation against pivotal rand...
Daixie recipe ameliorates diet-induced MASH in mice via activating PI3K/AKT and Keap1/Nrf2 signaling
BackgroundMetabolic dysfunction-associated steatohepatitis (MASH) is a highly prevalent liver disease that can progress to...
Metabolic-associated steatotic liver disease in children and adolescents: a scoping review and narrative synthesis of epidemiology, risk factors, and screening approaches with emerging implications for sub-Saharan Africa
BackgroundMetabolic-Associated Steatotic Liver Disease (MASLD) is recognized as one of the most common chronic liver disea...
Assessing the association of FIB-4 index with diabetic kidney disease in patients with diabetes mellitus: a cross-sectional and retrospective study utilizing NHANES and clinical data
AimTo evaluate the cross-sectional of the FIB-4 index with the prevalence of diabetic kidney disease (DKD) and the deterio...
Life activities of elderly patients with operated nonfunctional pituitary adenoma
AimTo evaluate the clinical findings of nonfunctional pituitary adenomas in the geriatric population, functional status, c...
Placental monoamine oxidase A. activity in pregnancies complicated by maternal overweight/obesity and gestational diabetes mellitus
IntroductionThe human placenta is a major site of metabolic transformation, synthesizing and catabolizing a wide range of ...
Gender differences in diabetes knowledge, glycemic control, and cardiovascular risk among adults with type 2 diabetes: a cross-sectional study
BackgroundGender differences in diabetes knowledge, glycemic control, and cardiovascular risk remain an important public h...
Salivary microbiota signatures of periodontitis are associated with CGM-derived short-term glycaemic control in adults with type 1 diabetes: a pilot study
AimsPeriodontitis is common in type 1 diabetes (T1D), yet its relationship with short-term glycaemic control remains uncle...
The ovulation trigger method affects gonadotropin concentrations and gonadotropin receptor expression during final oocyte maturation in women
IntroductionHuman chorionic gonadotropin (hCG) and gonadotropin-releasing hormone agonist (GnRHa) are widely used for fina...
Comparative outcomes of day 4 versus day 5 embryo transfers by fertilization method
ObjectiveThe aim of this retrospective cohort study was to evaluate the clinical and neonatal outcomes between day 4 and d...
Depression comorbidity in children and adolescents with type 2 diabetes mellitus: a systematic review and meta-analysis
BackgroundDepression is a frequent psychological comorbidity among youth with type 2 diabetes mellitus (T2DM), yet reporte...
Type 5 diabetes mellitus: nutritional-imprinted β-cell insufficiency, diagnostic gaps, and emerging therapeutic strategies
Historical descriptions of malnutrition-related diabetes mellitus (MRDM) have regained attention in contemporary discourse...
Associations of C-reactive protein, triglyceride–glucose index, and the C-reactive protein–triglyceride glucose index with multistate trajectories in the cardiovascular–renal–diabetes cluster
ObjectiveTo investigate the associations of C-reactive protein (CRP), triglyceride–glucose (TyG) index, and their composit...
From the perspective of prolactin: a view on obesity
The physiological roles of prolactin extend beyond its classical functions in reproductive regulation. Emerging evidence i...
Diabetes and postoperative cognitive dysfunction and delirium in adults: mechanisms, biomarkers, and clinical management
Postoperative cognitive dysfunction (POCD) and postoperative delirium (POD) are common perioperative neurocognitive disord...
Exploration of physical activity, sedentary behavior and insulin level among short sleepers
Exploration of physical activity, sedentary behavior and insulin level among short sleepers
BackgroundSufficient physical activity and sleep duration are essential for overall health. While one-third of the US popu...
Acupoint catgut embedding: a potential intervention strategy for obesity-related precocious puberty
Acupoint catgut embedding: a potential intervention strategy for obesity-related precocious puberty
IntroductionObesity-related precocious puberty is induced by obesity, and acupoint catgut embedding (ACE) therapy is known...
Targeting AMP-activated protein kinase in sepsis
Targeting AMP-activated protein kinase in sepsis
Sepsis is a global health challenge marked by limited clinical options and high mortality rates. AMP-activated protein kin...
Evidence of apoptosis as an early event leading to cyclophosphamide-induced primordial follicle depletion in a prepubertal mouse model
Evidence of apoptosis as an early event leading to cyclophosphamide-induced primordial follicle depletion in a prepubertal mouse model
IntroductionThe mechanisms leading to ovarian primordial follicle depletion following gonadotoxic chemotherapy with cyclop...
The associations of the triglyceride-glucose index and its combination with blood pressure on cardiovascular and all-cause mortality in hypertension: a national study
The associations of the triglyceride-glucose index and its combination with blood pressure on cardiovascular and all-cause mortality in hypertension: a national study
The triglyceride-glucose (TyG) index, a reliable surrogate biomarker of insulin resistance (IR), is highlighted recently a...
Enhanced joint pain in diabetic patients with knee osteoarthritis is associated with increased synovitis, synovial immune cell infiltration, and erythrocyte extravasation
Enhanced joint pain in diabetic patients with knee osteoarthritis is associated with increased synovitis, synovial immune cell infiltration, and erythrocyte extravasation
ObjectiveDiabetes mellitus (DM) is an important risk factor for the development of osteoarthritis (OA), increasing OA prog...
Tracing links between micronutrients and type 2 diabetes risk: the singular role of selenium
Tracing links between micronutrients and type 2 diabetes risk: the singular role of selenium
BackgroundType 2 diabetes (T2D) is a growing global health concern. While micronutrients are crucial for physiological fun...
Editorial: Molecular mechanisms underlying exercise-alleviated sarcopenic obesity
Sarcopenic obesity (SO), characterized by the concurrent decline in muscle mass and 9 function alongside an increase in bo...
Association of dietary and circulating antioxidant vitamins with metabolic syndrome: an observational and Mendelian randomization study
Association of dietary and circulating antioxidant vitamins with metabolic syndrome: an observational and Mendelian randomization study
AimsThe objective of this study was to investigate the associations of dietary and circulating antioxidant vitamins with m...
Obesity-related renal dysfunction: gender-specific influence of visceral adiposity and early impact of metabolic and bariatric surgery
Obesity-related renal dysfunction: gender-specific influence of visceral adiposity and early impact of metabolic and bariatric surgery
IntroductionRenal dysfunction is a recognized complication of obesity with an incompletely characterized pathophysiology. ...
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