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The history of an effective, specific and sensitive diagnostic test: the GHRH test in clinical practice
The history of an effective, specific and sensitive diagnostic test: the GHRH test in clinical practice
Growth hormone (GH) secretion is pulsatile, entropic, and nycthemeral and is mainly controlled by the hypothalamus through...
Effects of growth hormone-releasing hormone deficiency in mice beyond growth
Effects of growth hormone-releasing hormone deficiency in mice beyond growth
This paper provides a critical overview on GHRH and its deficiency, discussing its multiple roles in both central and peri...
The radiologic spectrum of neuroendocrine tumors in emergent care
The radiologic spectrum of neuroendocrine tumors in emergent care
Neuroendocrine tumors (NETs) are a diverse group of neoplasms whose prevalence is increasing globally, primarily due to ad...
Poor muscle quality: A hidden and detrimental health condition in obesity
Poor muscle quality: A hidden and detrimental health condition in obesity
Poor muscle quality (MQ) is a hidden health condition in obesity, commonly disregarded and underdiagnosed, associated with...
Update on regulation of GHRH and its actions on GH secretion in health and disease
Update on regulation of GHRH and its actions on GH secretion in health and disease
This review focuses on our current understanding of how growth hormone releasing hormone (GHRH): 1) stimulates GH release ...
Pituitary adenomas: biology, nomenclature and clinical classification
Pituitary adenomas: biology, nomenclature and clinical classification
An ‘adenoma’ is a benign neoplasm composed of epithelial tissue, and has been standard nomenclature for primar...
Growth hormone-releasing hormone signaling and manifestations within the cardiovascular system
Growth hormone-releasing hormone signaling and manifestations within the cardiovascular system
Growth hormone (GH)-releasing hormone (GHRH), a hypothalamic peptide initially characterized for its role in GH regulation...
The differential diagnosis of adrenocortical tumors: systematic review of Ki-67 and IGF2 and meta-analysis of Ki-67
The differential diagnosis of adrenocortical tumors: systematic review of Ki-67 and IGF2 and meta-analysis of Ki-67
Distinguishing benign from malignant adrenocortical tumors (ACT) is not always easy, particularly for tumors with unclear ...
The role of tissue oxygenation in obesity-related cardiometabolic complications
The role of tissue oxygenation in obesity-related cardiometabolic complications
Obesity is a complex, multifactorial, chronic disease that acts as a gateway to a range of other diseases. Evidence from r...
Meal replacements on obesity and leptin: a systematic review and meta-analysis
Meal replacements on obesity and leptin: a systematic review and meta-analysis
The global prevalence of obesity and overweight is a significant concern in the field of public health. Numerous intervent...
Vitamin D and hip protectors in osteosarcopenia: a combined hip fracture preventing approach
Vitamin D and hip protectors in osteosarcopenia: a combined hip fracture preventing approach
Osteosarcopenia is an emerging clinical condition highly prevalent in the older people. Affected subjects due to their int...
Role of HOXA10 in pathologies of the endometrium
Role of HOXA10 in pathologies of the endometrium
HOXA10 belongs to the homeobox gene family and is essential for uterine biogenesis, endometrial receptivity, embryo implan...
Clinical research progress on β-cell dysfunction in T2DM development in the Chinese population
Clinical research progress on β-cell dysfunction in T2DM development in the Chinese population
The prevalence of type-2 diabetes mellitus (T2DM) has increased over 10-fold in the past 40 years in China, which now has ...
No longer to be ignored: Hypophosphatemia following intravenous iron administration
No longer to be ignored: Hypophosphatemia following intravenous iron administration
Intravenous iron supplementation is increasingly used to safely and effectively correct iron deficiency anemia, but some f...
Role of CaMKII in diabetes induced vascular injury and its interaction with anti-diabetes therapy
Role of CaMKII in diabetes induced vascular injury and its interaction with anti-diabetes therapy
Diabetes mellitus is a metabolic disorder denoted by chronic hyperglycemia that drives maladaptive structural changes and ...
New findings on brain actions of growth hormone and potential clinical implications
New findings on brain actions of growth hormone and potential clinical implications
Growth hormone (GH) is secreted by somatotropic cells of the anterior pituitary gland. The classical effects of GH compris...
Association between protein undernutrition and diabetes: Molecular implications in the reduction of insulin secretion
Association between protein undernutrition and diabetes: Molecular implications in the reduction of insulin secretion
Undernutrition is still a recurring nutritional problem in low and middle-income countries. It is directly associated with...
Efficacy and tolerability of somatostatin analogues according to gender in patients with neuroendocrine tumors
Efficacy and tolerability of somatostatin analogues according to gender in patients with neuroendocrine tumors
As the incidence of neuroendocrine tumors has been rising, gender differences in epidemiology and clinical behavior have e...
An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications
An update on the secretory functions of brown, white, and beige adipose tissue: Towards therapeutic applications
Adipose tissue, including white adipose tissue (WAT), brown adipose tissue (BAT), and beige adipose tissue, is vital in mo...
Potential therapeutic strategies for osteoarthritis via CRISPR/Cas9 mediated gene editing
Potential therapeutic strategies for osteoarthritis via CRISPR/Cas9 mediated gene editing
Osteoarthritis (OA) is an incapacitating and one of the most common physically degenerative conditions with an assorted et...
New insights in thyroid diagnosis and treatment
New insights in thyroid diagnosis and treatment
The prevalence of thyroid disease continues to rise. As a consequence, the research in the thyroid field has significantly...
Epigenetic programming for obesity and noncommunicable disease: From womb to tomb
Epigenetic programming for obesity and noncommunicable disease: From womb to tomb
Several epidemiological, clinical and experimental studies in recent decades have shown the relationship between exposure ...
Dynamic risk assessment in patients with differentiated thyroid cancer
Dynamic risk assessment in patients with differentiated thyroid cancer
The current approach for patients with differentiated thyroid carcinoma should be individualized according to the risk of ...
Current practice in intermediate risk differentiated thyroid cancer – a review
Current practice in intermediate risk differentiated thyroid cancer – a review
Although the overall prognosis for differentiated thyroid cancer (DTC) is excellent, a subset of patients will experience ...
Clinical and molecular impact of concurrent thyroid autoimmune disease and thyroid cancer: From the bench to bedside
Clinical and molecular impact of concurrent thyroid autoimmune disease and thyroid cancer: From the bench to bedside
The recent incorporation of immune checkpoint inhibitors targeting the PD-1 (programmed cell death receptor 1) and CTLA-4 ...