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Pregnancy-associated thyroid disorders: the role of genetic, epigenetic, and oxidative stress factors
Pregnancy-associated thyroid disorders: the role of genetic, epigenetic, and oxidative stress factors
Thyroid inflammation during pregnancy, particularly Hashimoto’s thyroiditis (HT) and postpartum thyroiditis (PPT), h...
Mechanisms of exercise in preventing cardiovascular diseases: Insights from gut microbiota characteristics in pathological states of cardiovascular diseases
Mechanisms of exercise in preventing cardiovascular diseases: Insights from gut microbiota characteristics in pathological states of cardiovascular diseases
Cardiovascular diseases (CVD) are major lethal diseases worldwide. Imbalance of gut microbiota (GM) homeostasis affects th...
Pathophysiological insights into asprosin: an emerging adipokine in reproductive health
Pathophysiological insights into asprosin: an emerging adipokine in reproductive health
Asprosin is a versatile protein hormone primarily produced by white adipose tissue (WAT). When secreted into the bloodstre...
Lights or shadows, a promising future for positron emission tomography in pituitary tumors: a systematic review
Lights or shadows, a promising future for positron emission tomography in pituitary tumors: a systematic review
The diagnosis of pituitary adenomas (PAs), also called pituitary tumors or neuroendocrine tumors (PitNETs) currently invol...
Exploring obesity phenotypes: a longitudinal perspective
Exploring obesity phenotypes: a longitudinal perspective
Traditional reliance on Body Mass Index (BMI) as a diagnostic tool for obesity is increasingly challenged due to its inabi...
Association between continuous glucose monitoring metrics and cardiovascular autonomic neuropathy in diabetic patients: a systematic review
Association between continuous glucose monitoring metrics and cardiovascular autonomic neuropathy in diabetic patients: a systematic review
Cardiovascular autonomic neuropathy (CAN) is a serious and prevalent complication of diabetes, linked to significant morbi...
Neurovascular plasticity as a modulator of hypothalamic function
Neurovascular plasticity as a modulator of hypothalamic function
The hypothalamus, located at the most ventral part of the brain, is the central regulator of homeostatic processes such as...
Sexual dimorphism in the development and function of the melanocortin system
Sexual dimorphism in the development and function of the melanocortin system
The melanocortin system is fundamental for the regulation of whole-body energy homeostasis. This system consists of pro-op...
Targeted therapeutic strategies as alternative and sustainable treatment options for obesity-induced steatohepatitis
Targeted therapeutic strategies as alternative and sustainable treatment options for obesity-induced steatohepatitis
The development of metabolic dysfunction-associated steatotic liver disease (MASLD), and its progression to metabolic dysf...
Hyperphagia in rare melanocortin-4 receptor pathway diseases: therapeutic options and assessing treatment response
Hyperphagia in rare melanocortin-4 receptor pathway diseases: therapeutic options and assessing treatment response
Hyperphagia is a hallmark of both congenital and acquired rare melanocortin-4 receptor (MC4R) pathway diseases. Currently,...
BBSome: An essential component of hypothalamic regulation of energy homeostasis
BBSome: An essential component of hypothalamic regulation of energy homeostasis
The BBSome is a protein complex composed of eight Bardet-Biedl syndrome (BBS) proteins. Although the BBSome is best known ...
Body mass index and body composition changes in transgender people undergoing gender-affirming hormone therapy: a systematic review and meta-analysis
Body mass index and body composition changes in transgender people undergoing gender-affirming hormone therapy: a systematic review and meta-analysis
Gender-affirming hormone therapy (GAHT) uses sex steroid hormones to induce desired physical changes, improving the qualit...
Emerging evidence and potential avenues to achieve durable outcomes in patients with obesity: the confluence of nutrition, and Microbiome on body composition
Emerging evidence and potential avenues to achieve durable outcomes in patients with obesity: the confluence of nutrition, and Microbiome on body composition
Obesity is a global health concern that impacts health, quality of life, and longevity in affected individuals. Comorbid c...
Endocrine and metabolic consequences of childhood-onset craniopharyngioma during the transition age: A literature review by the TALENT study group
Endocrine and metabolic consequences of childhood-onset craniopharyngioma during the transition age: A literature review by the TALENT study group
Craniopharyngiomas are frequently diagnosed during childhood and adolescence, crucial periods for physical and psychosocia...
Trends in gestational diabetes prevalence in China from 1990 to 2024: a systematic review and meta-analysis
Trends in gestational diabetes prevalence in China from 1990 to 2024: a systematic review and meta-analysis
This study examines the 34-year trends in gestational diabetes mellitus (GDM) prevalence in China, analyzing diagnostic sh...
Management of cushing’s syndrome in patients with adrenocortical cancer: state of the art and future perspectives
Management of cushing’s syndrome in patients with adrenocortical cancer: state of the art and future perspectives
Adrenocortical cancers (ACCs) are rare tumours, with up to 50% of cases associated with hypercortisolism. Cortisol-secreti...
Body composition changes across a spectrum of hypothyroidism severity - a systematic review and meta-analysis
Body composition changes across a spectrum of hypothyroidism severity - a systematic review and meta-analysis
This systematic review and meta-analysis aimed to investigate the impact of clinical hypothyroidism (CH) and subclinical h...
Emerging role of AgRP neurons as integrators of metabolic, sensory and environmental cues in the control of energy homeostasis
Emerging role of AgRP neurons as integrators of metabolic, sensory and environmental cues in the control of energy homeostasis
The regulation of energy homeostasis is an essential function of every living organism. In mammals a complex interplay of ...
The history of an effective, specific and sensitive diagnostic test: the GHRH test in clinical practice
The history of an effective, specific and sensitive diagnostic test: the GHRH test in clinical practice
Growth hormone (GH) secretion is pulsatile, entropic, and nycthemeral and is mainly controlled by the hypothalamus through...
Effects of growth hormone-releasing hormone deficiency in mice beyond growth
Effects of growth hormone-releasing hormone deficiency in mice beyond growth
This paper provides a critical overview on GHRH and its deficiency, discussing its multiple roles in both central and peri...
The radiologic spectrum of neuroendocrine tumors in emergent care
The radiologic spectrum of neuroendocrine tumors in emergent care
Neuroendocrine tumors (NETs) are a diverse group of neoplasms whose prevalence is increasing globally, primarily due to ad...
Poor muscle quality: A hidden and detrimental health condition in obesity
Poor muscle quality: A hidden and detrimental health condition in obesity
Poor muscle quality (MQ) is a hidden health condition in obesity, commonly disregarded and underdiagnosed, associated with...
Update on regulation of GHRH and its actions on GH secretion in health and disease
Update on regulation of GHRH and its actions on GH secretion in health and disease
This review focuses on our current understanding of how growth hormone releasing hormone (GHRH): 1) stimulates GH release ...
Pituitary adenomas: biology, nomenclature and clinical classification
Pituitary adenomas: biology, nomenclature and clinical classification
An ‘adenoma’ is a benign neoplasm composed of epithelial tissue, and has been standard nomenclature for primar...
Exploring the relationship between glycemic variability and muscle dysfunction in adults with diabetes: A systematic review
Exploring the relationship between glycemic variability and muscle dysfunction in adults with diabetes: A systematic review
This review is to systematically explore the relationship between muscle dysfunction and diabetes in adults, and to examin...
Growth hormone-releasing hormone signaling and manifestations within the cardiovascular system
Growth hormone-releasing hormone signaling and manifestations within the cardiovascular system
Growth hormone (GH)-releasing hormone (GHRH), a hypothalamic peptide initially characterized for its role in GH regulation...
The differential diagnosis of adrenocortical tumors: systematic review of Ki-67 and IGF2 and meta-analysis of Ki-67
The differential diagnosis of adrenocortical tumors: systematic review of Ki-67 and IGF2 and meta-analysis of Ki-67
Distinguishing benign from malignant adrenocortical tumors (ACT) is not always easy, particularly for tumors with unclear ...
The role of tissue oxygenation in obesity-related cardiometabolic complications
The role of tissue oxygenation in obesity-related cardiometabolic complications
Obesity is a complex, multifactorial, chronic disease that acts as a gateway to a range of other diseases. Evidence from r...
Meal replacements on obesity and leptin: a systematic review and meta-analysis
Meal replacements on obesity and leptin: a systematic review and meta-analysis
The global prevalence of obesity and overweight is a significant concern in the field of public health. Numerous intervent...
Meal replacement therapy for obesity and diabetes remission: efficacy assessment and considerations of barriers and facilitators to adherence among U.S. individuals with low economic resources
Meal replacement therapy for obesity and diabetes remission: efficacy assessment and considerations of barriers and facilitators to adherence among U.S. individuals with low economic resources
Individuals in the United States with lower economic resources face a disproportionate burden of obesity and co-morbid con...
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