Live tissue microbiota and bacterial translocation: mechanisms and translational perspectives in cardiometabolic diseases

Powell-Wiley TM, Poirier CP, Burke VCLE, Després JP, Gordon-Larsen P, Lavie CJ, et al. Obes Cardiovasc Disease Circ. 2021;143(21):e984–1010.

Google Scholar 

Aggarwal N, Kitano S, Puah GRY, Kittelmann S, Hwang IY, Chang MW. Microbiome and human health: current Understanding, Engineering, and enabling technologies. Chem Rev. 2022;123(1):31–72.

Article  PubMed  PubMed Central  Google Scholar 

Maciel-Fiuza MF, Muller GC, Campos DMS, do, Socorro Silva Costa P, Peruzzo J, Bonamigo RR, et al. Role of gut microbiota in infectious and inflammatory diseases. Front Microbiol. 2023;14:1098386. https://doi.org/10.3389/fmicb.2023.1098386

Article  PubMed  PubMed Central  Google Scholar 

Hou K, Wu ZX, Chen XY, Wang JQ, Zhang D, Xiao C, et al. Microbiota in health and diseases. Signal Transduct Target Ther. 2022;7(1):135.

Article  PubMed  PubMed Central  Google Scholar 

Petersen C, Round JL. Defining dysbiosis and its influence on host immunity and disease. Cell Microbiol 2014;16(7):1024–33.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berg RD. Bacterial translocation from the Gastrointestinal tract. Adv Exp Med Biol. 1999;473:11–30.

Article  CAS  PubMed  Google Scholar 

Wasim R, Sumaiya null, Ahmad A, Anwar A, Salman A. Microbial imbalance in the gut: a new frontier in rheumatoid arthritis research. Inflammopharmacol. 2025;33(5):2277–91.

Article  Google Scholar 

Wang C, Li Q, Ren J. Microbiota-Immune interaction in the pathogenesis of Gut-Derived infection. Front Immunol. 2019;10:1873.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Radaic A, Kapila YL. The oralome and its dysbiosis: new insights into oral microbiome-host interactions. Comput Struct Biotechnol J. 2021;19:1335–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ciesielska A, Matyjek M, Kwiatkowska K. TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling. Cell Mol Life Sci. 2021;78(4):1233–61.

Article  CAS  PubMed  Google Scholar 

Salguero MV, Al-Obaide MAI, Singh R, Siepmann T, Vasylyeva TL. Dysbiosis of Gram-negative gut microbiota and the associated serum lipopolysaccharide exacerbates inflammation in type 2 diabetic patients with chronic kidney disease. Exp Ther Med. 2019;18(5):3461–9.

CAS  PubMed  PubMed Central  Google Scholar 

Mazgaeen L, Gurung P. Recent advances in lipopolysaccharide recognition systems. Int J Mol Sci. 2020;21(2):379.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghosh S, Whitley CS, Haribabu B, Jala VR. Regulation of intestinal barrier function by microbial metabolites. Cell Mol Gastroenterol Hepatol. 2021;11(5):1463–82.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ghosh SS, Wang J, Yannie PJ, Ghosh S. Intestinal barrier Dysfunction, LPS Translocation, and disease development. J Endocr Soc. 2020;4(2):bvz039.

Article  PubMed  PubMed Central  Google Scholar 

de Jongh CA, de Vries TJ, Bikker FJ, Gibbs S, Krom BP. Mechanisms of Porphyromonas gingivalis to translocate over the oral mucosa and other tissue barriers. J Oral Microbiol. 2023;15(1):2205291.

Article  PubMed  PubMed Central  Google Scholar 

Lê S, Cecchin-Albertoni C, Thomas C, Kemoun P, Minty M, Blasco-Baque V. oct. The role of dysbiotic oral microbiota in cardiometabolic diseases: a narrative Review. Diagnostics (Basel). 2023;13(20):3184.

Article  PubMed  PubMed Central  Google Scholar 

Shayista H, Prasad MNN, Raj SN, Ranjini HK, Manju K, Baker S. Mechanistic overview of gut microbiota and mucosal pathogens with respect to cardiovascular diseases. Microbe. 2024;5:100160.

Article  Google Scholar 

Hou K, Wu ZX, Chen XY, Wang JQ, Zhang D, Xiao C, et al. Microbiota in health and diseases. Sig Transduct Target Ther. 2022;7(1):1–28.

Article  Google Scholar 

Chakaroun RM, Massier L, Kovacs P, Gut, Microbiome. Intestinal Permeability, and tissue bacteria in metabolic disease: perpetrators or bystanders? Nutr. 2020;12(4):1082.

CAS  Google Scholar 

Anhê FF, Barra NG, Cavallari JF, Henriksbo BD, Schertzer JD. Metabolic endotoxemia is dictated by the type of lipopolysaccharide. Cell Rep. 2021;36(11):109691.

Article  PubMed  Google Scholar 

Amar J, Chabo C, Waget A, Klopp P, Vachoux C, Bermúdez-Humarán LG, et al. Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Mol Med. 2011;3(9):559–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Minty M, Germain A, Sun J, Kaglan G, Servant F, Lelouvier B, et al. Identifying the location-dependent adipose tissue bacterial DNA signatures in obese patients that predict body weight loss. Gut Microbes. 2025;17(1):2439105.

Article  PubMed  Google Scholar 

Fakhoury HMA, Kvietys PR, AlKattan W, Anouti FA, Elahi MA, Karras SN, et al. Vitamin D and intestinal homeostasis: Barrier, microbiota, and immune modulation. J Steroid Biochem Mol Biology. 2020;200:105663.

Article  CAS  Google Scholar 

Yue R, Wei X, Zhao J, Zhou Z, Zhong W. Essential role of IFN-γ in regulating gut antimicrobial peptides and microbiota to protect against Alcohol-Induced bacterial translocation and hepatic inflammation in mice. Front Physiol. 2021;11:629141. https://doi.org/10.3389/fphys.2020.629141

Article  PubMed  PubMed Central  Google Scholar 

Proietti M, Del Buono A, Pagliaro G, Del Buono R, Di Rienzo C. The intestinal permeability syndrome, Celiac disease, gluten sensitivity, autistic spectrum, Mycotoxins and immunological tolerance. Mediterr J Nutr Metab. 2013;6(2):99–104.

Article  Google Scholar 

Belkaid Y, Hand T. Role of the microbiota in immunity and inflammation. Cell. 2014;157(1):121–41.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vancamelbeke M, Vermeire S. The intestinal barrier: a fundamental role in health and disease. Expert Rev Gastroenterol Hepatol. 2017;11(9):821–34.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinez KB, Leone V, Chang EB. Western diets, gut dysbiosis, and metabolic diseases: are they linked? Gut Microbes. 2017;8(2):130–42.

Article  PubMed  PubMed Central  Google Scholar 

Kang GG, Trevaskis NL, Murphy AJ, Febbraio MA. Diet-induced gut dysbiosis and inflammation: Key drivers of obesity-driven NASH. iScience. 2022;26(1):105905.

Article  PubMed  PubMed Central  Google Scholar 

Gilbert J, Blaser MJ, Caporaso JG, Jansson J, Lynch SV, Knight R. Current understanding of the human microbiome. Nat Med. 2018;24(4):392–400.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lynch SV, Pedersen O. The human intestinal Microbiome in health and disease. N Engl J Med. 2016;375(24):2369–79.

Article  CAS  PubMed  Google Scholar 

Parada Venegas D, De la Fuente MK, Landskron G, González MJ, Quera R, Dijkstra G, et al. Short chain fatty acids (SCFAs)-Mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases. Front Immunol. 2019;10:277.

Article  PubMed  PubMed Central 

Comments (0)

No login
gif