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TGR5 receptors in SF1-expressing neurons of the ventromedial hypothalamus regulate glucose homeostasis
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GDNF family receptor alpha-like (GFRAL) expression is restricted to the caudal brainstem
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LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK
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Cannabinoid type-1 receptors in CaMKII neurons drive impulsivity in pathological eating behavior.
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Bioenergetic adaptations of small intestinal epithelial cells reduce cell differentiation enhancing intestinal permeability in obese mice
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Metabolic plasticity in pancreatic cancer: The mitochondrial connection
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TMEM135 deficiency improves hepatic steatosis by suppressing CD36 in a SIRT1-dependent manner
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Epigenetic suppression of creatine kinase B in adipocytes links endoplasmic reticulum stress to obesity-associated inflammation
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Muscarinic acetylcholine type 1 receptor antagonism activates TRPM3 to augment mitochondrial function and drive axonal repair in adult sensory neurons
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Exercise-induced methylation of the Serhl2 promoter and implication for lipid metabolism in rat skeletal muscle
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Synthetic inhibition of SREBP2 and the mevalonate pathway blocks rhabdomyosarcoma tumor growth in vitro and in vivo and promotes chemosensitization
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Enhanced dynorphin expression and secretion in pancreatic beta-cells under hyperglycemic conditions
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Pre-operative DNA methylation marks as predictors of weight loss outcomes after sleeve gastrectomy
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Roles for Prlhr/GPR10 and Npffr2/GPR74 in feeding responses to PrRP
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Deficiency of the mitochondrial transporter SLC25A47 minimally impacts hepatic lipid metabolism in fasted and diet-induced obese mice
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SF1-specific deletion of the energy sensor AMPKγ2 induces obesity
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Increased cardiac myosin super-relaxation as an energy saving mechanism in hibernating grizzly bears
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Intrahepatic levels of microbiome-derived hippurate associates with improved metabolic dysfunction-associated steatotic liver disease
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Chronic GIPR agonism results in pancreatic islet GIPR functional desensitisation
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Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body
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Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis
Overexpression of ORMDL3 confers sexual dimorphism in diet-induced non-alcoholic steatohepatitis
Available online 9 December 2023, 101851Author links open overlay panel, , , , , , Highlights•High ORMDL3 overexpression i...
Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion
Intestinal SURF4 is essential for apolipoprotein transport and lipoprotein secretion
ObjectiveLipoprotein assembly and secretion in the small intestine are critical for dietary fat absorption. Surfeit locus ...
Farnesoid X receptor activation protects against renal fibrosis via modulation of β-catenin signaling
Farnesoid X receptor activation protects against renal fibrosis via modulation of β-catenin signaling
ObjectiveActivation of farnesoid X receptor (FXR), a bile acid nuclear receptor, may be implicated in the pathophysiology ...
Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co-ordinating insulin biosynthesis with secretory granule formation
Independent activation of CREB3L2 by glucose fills a regulatory gap in mouse β-cells by co-ordinating insulin biosynthesis with secretory granule formation
ObjectiveAlthough individual steps have been characterized, there is little understanding of the overall process whereby g...
Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes
Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes
KeywordsChREBPMycPvt1Beta cellsGlucose-mediated gene expressionChromatin conformation captureDNA loopingGlucose-stimulated...
Evaluation of long acting GLP1R/GCGR agonist in a DIO and biopsy-confirmed mouse model of NASH suggest a beneficial role of GLP-1/glucagon agonism in NASH patients.
Evaluation of long acting GLP1R/GCGR agonist in a DIO and biopsy-confirmed mouse model of NASH suggest a beneficial role of GLP-1/glucagon agonism in NASH patients.
The metabolic benefits of GLP-1 receptor (GLP-1R) agonists on glycemic and weight control are well established as therapy ...
Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
Inhibiting the endoplasmic reticulum stress response enhances the effect of doxorubicin by altering the lipid metabolism of liver cancer cells
Hepatocellular carcinoma (HCC) is characterized by a low and variable response to chemotherapeutic treatments. One contrib...
Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury
Tubular Mitochondrial Pyruvate Carrier Disruption Elicits Redox Adaptations that Protect from Acute Kidney Injury
Available online 4 December 2023, 101849Author links open overlay panel, , , , , , , , , , , , , , , , , Highlights•Severa...
Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib
Hepatic ChREBP orchestrates intrahepatic carbohydrate metabolism to limit hepatic glucose 6-phosphate and glycogen accumulation in a mouse model for acute Glycogen Storage Disease type Ib
ObjectiveCarbohydrate Response Element Binding Protein (ChREBP) is a glucose 6-phosphate (G6P)-sensitive transcription fac...
GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity
GPSM1 in POMC neurons impairs brown adipose tissue thermogenesis and provokes diet-induced obesity
ObjectiveG-protein-signaling modulator 1 (GPSM1) has been proved the potential role in brain tissues, however, whether GPS...
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