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Early weight loss, diabetes remission and long-term trajectory after diagnosis of type 2 diabetes: a retrospective study
Early weight loss, diabetes remission and long-term trajectory after diagnosis of type 2 diabetes: a retrospective study
Weight loss can improve glycaemic management in individuals with type 2 diabetes, but its long-term effects on remission, ...
Regulating islet stress responses through CD47 activation
Regulating islet stress responses through CD47 activation
Diabetes is a global health burden characterised by incremental beta cell loss. Islet transplantation is a recognised trea...
Immunotherapy with low-dose IL-2 attenuates vascular injury in mice with diabetic and neovascular retinopathy by restoring the balance between Foxp3 Tregs and CD8 T cells
Immunotherapy with low-dose IL-2 attenuates vascular injury in mice with diabetic and neovascular retinopathy by restoring the balance between Foxp3 Tregs and CD8 T cells
Diabetic retinopathy features damage to the retinal microvasculature that causes vessels to leak and proliferate and can l...
TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion
TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion
Diabetes is associated with the dysfunction of glucagon-producing pancreatic islet alpha cells, although the underlying me...
HEXA-FC protein therapy increases skeletal muscle glucose uptake and improves glycaemic control in mice with insulin resistance and in a mouse model of type 2 diabetes
HEXA-FC protein therapy increases skeletal muscle glucose uptake and improves glycaemic control in mice with insulin resistance and in a mouse model of type 2 diabetes
Type 2 diabetes is a chronic metabolic disorder characterised by insulin resistance and sustained hyperglycaemia, and is a...
Macular perfusion alterations in people with recent-onset diabetes and novel diabetes subtypes
Macular perfusion alterations in people with recent-onset diabetes and novel diabetes subtypes
Our aim was to detect early structural and functional changes in the macular capillaries using optical coherence tomograph...
Parent-of-origin effects in the life-course evolution of cardiometabolic traits
Parent-of-origin effects in the life-course evolution of cardiometabolic traits
Cardiometabolic traits are heritable, and some display parent-of-origin effects, which indicates preferential inheritance ...
The effect of once-weekly insulin icodec vs once-daily basal insulin on physical activity-attributed hypoglycaemia in type 2 diabetes: a post hoc analysis of ONWARDS 1–5
The effect of once-weekly insulin icodec vs once-daily basal insulin on physical activity-attributed hypoglycaemia in type 2 diabetes: a post hoc analysis of ONWARDS 1–5
Physical activity increases the risk of hypoglycaemia in individuals with type 2 diabetes when basal or basal-bolus insuli...
Clinical use of polygenic scores in type 2 diabetes: challenges and possibilities
Clinical use of polygenic scores in type 2 diabetes: challenges and possibilities
Resulting from a combination of genetic and environmental factors, type 2 diabetes is highly heterogeneous in manifestatio...
Cardiac remodelling, recognition memory deficits and accelerated ageing in a rat model of gestational diabetes
Cardiac remodelling, recognition memory deficits and accelerated ageing in a rat model of gestational diabetes
Women with prior gestational diabetes mellitus (GDM) have higher incidence of age-associated diseases, including type 2 di...
Metabolic effects of 3-hydroxybutyrate infusion in individuals with type 1 diabetes compared with healthy control participants: a randomised crossover trial showing intact feedback suppression of lipolysis
Metabolic effects of 3-hydroxybutyrate infusion in individuals with type 1 diabetes compared with healthy control participants: a randomised crossover trial showing intact feedback suppression of lipolysis
Diabetic ketoacidosis remains a severe complication in type 1 diabetes, arising from insufficient insulin levels and accel...
The genetics of low and high birthweight and their relationship with cardiometabolic disease
The genetics of low and high birthweight and their relationship with cardiometabolic disease
Low birthweight infants are at increased risk not only of mortality, but also of type 2 diabetes mellitus and CVD in later...
Alterations in cerebral perfusion and substrate metabolism in type 2 diabetes: interactions with -ε4
Alterations in cerebral perfusion and substrate metabolism in type 2 diabetes: interactions with -ε4
Epidemiological studies indicate that type 2 diabetes increases the risk for Alzheimer’s disease. Alterations in cer...
Exercise-induced meteorin-like protein protects human pancreatic beta cells from cytokine-induced apoptosis
Exercise-induced meteorin-like protein protects human pancreatic beta cells from cytokine-induced apoptosis
Inflammation-driven pancreatic beta cell death is a hallmark of type 1 diabetes progression. We have previously shown that...
Diabetes and natural and man-made disasters: prevention, preparation, response and recovery
Diabetes and natural and man-made disasters: prevention, preparation, response and recovery
Both the global prevalence of diabetes and the frequency of natural and man-made disasters are increasing. Of all chronic ...
The relationship between shrunken pore syndrome and all-cause mortality in people with type 2 diabetes and normal renal function: the Fremantle Diabetes Study Phase II
The relationship between shrunken pore syndrome and all-cause mortality in people with type 2 diabetes and normal renal function: the Fremantle Diabetes Study Phase II
Estimated GFRs utilising creatinine- (eGFRcreat) or cystatin C-based (eGFRcyst) equations can generate discrepant results ...
Correction to: Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice
Correction to: Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice
Department of Nutrition, University of California Davis, 3135 Meyer Hall, Davis, CA, 95616, USAYannan Xi, Siming Liu, Ahme...
ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis
ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis
The brain is a major consumer of glucose as an energy source and regulates systemic glucose as well as energy balance. Alt...
A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab
A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab
We hypothesised that islet beta cell antigen presentation in the gut along with a tolerising cytokine would lead to antige...
Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial
Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial
Hypomagnesaemia has been associated with insulin resistance and an increased risk of type 2 diabetes. Whether magnesium su...
Paediatric diabetes subtypes in a consanguineous population: a single-centre cohort study from Kurdistan, Iraq
Paediatric diabetes subtypes in a consanguineous population: a single-centre cohort study from Kurdistan, Iraq
Monogenic diabetes is estimated to account for 1–6% of paediatric diabetes cases in primarily non-consanguineous pop...
Chronic kidney disease in type 1 diabetes: translation of novel type 2 diabetes therapeutics to individuals with type 1 diabetes
Chronic kidney disease in type 1 diabetes: translation of novel type 2 diabetes therapeutics to individuals with type 1 diabetes
Current management of chronic kidney disease (CKD) in type 1 diabetes centres on glycaemic control, renin–angiotensi...
Correction to: Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation
Correction to: Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Using race as a social construct when looking at differences in racial associations between non‑alcoholic fatty liver disease and type 2 diabetes. Reply to Rollin FG, Washington C, Fluker S-A [letter]
Using race as a social construct when looking at differences in racial associations between non‑alcoholic fatty liver disease and type 2 diabetes. Reply to Rollin FG, Washington C, Fluker S-A [letter]
Authors’ relationships and activities The authors declare that there are n...
Sex influences health: reporting on female characteristics should be mandatory in exercise and physical activity-related diabetes research
Sex influences health: reporting on female characteristics should be mandatory in exercise and physical activity-related diabetes research
Augustana Faculty, University of Alberta, Camrose, AB, CanadaJane E. YardleyAlberta Diabetes Institute, University of Albe...
Novel time-resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation
Novel time-resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation
Glucagon-expressing pancreatic alpha cells have attracted much attention for their plasticity to transdifferentiate into i...
Female sex is a risk factor for painful diabetic peripheral neuropathy: the EURODIAB prospective diabetes complications study
Female sex is a risk factor for painful diabetic peripheral neuropathy: the EURODIAB prospective diabetes complications study
While the risk factors for diabetic peripheral neuropathy (DPN) are now well recognised, the risk factors for painful DPN ...
Correction to: Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition
Correction to: Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition
Effect of maternal low protein diet on the expression of insulin signalling molecules in epididymal WAT of 14-month-old ma...
Multi-omic prediction of incident type 2 diabetes
Multi-omic prediction of incident type 2 diabetes
The identification of people who are at high risk of developing type 2 diabetes is a key part of population-level preventi...
The metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT)
The metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT)
High-throughput metabolomics technologies in a variety of study designs have demonstrated a consistent metabolomic signatu...
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