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Diverse combination of factors associated with the development of diabetic kidney disease among data-driven diabetes subtypes: analysis of the J-DREAMS registry
Diverse combination of factors associated with the development of diabetic kidney disease among data-driven diabetes subtypes: analysis of the J-DREAMS registry
Available methods for predicting the onset and progression of diabetic kidney disease (DKD) and end-stage kidney disease (...
Redosing of anti-CD3 antibodies in NOD mice with new-onset diabetes does not alter the effect of a single treatment course
Redosing of anti-CD3 antibodies in NOD mice with new-onset diabetes does not alter the effect of a single treatment course
Uncertainty exists regarding the effectiveness of redosing teplizumab, a humanised anti-CD3 monoclonal antibody, in indivi...
Comparative physiology and biomimetics in metabolic and environmental health: what can we learn from extreme animal phenotypes?
Comparative physiology and biomimetics in metabolic and environmental health: what can we learn from extreme animal phenotypes?
This review explores the remarkable metabolic adaptations of species that thrive in extreme environments, providing insigh...
Efficacy and safety of efsubaglutide alfa in individuals with type 2 diabetes (SUPER1): a randomised, double-blind, placebo-controlled, Phase IIb/III trial
Efficacy and safety of efsubaglutide alfa in individuals with type 2 diabetes (SUPER1): a randomised, double-blind, placebo-controlled, Phase IIb/III trial
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have become an important option in clinical use for type 2 diabetes d...
Time-dependent association between progression of arterial stiffness and risk of incident chronic kidney disease: a cohort study in China
Time-dependent association between progression of arterial stiffness and risk of incident chronic kidney disease: a cohort study in China
The relationship between the progression of arterial stiffness and the risk of chronic kidney disease (CKD) remains unclea...
Bridging the variant-to-function gap in type 2 diabetes: advances and challenges
Bridging the variant-to-function gap in type 2 diabetes: advances and challenges
Type 2 diabetes is a polygenic, heterogeneous disease affecting over 530 million individuals worldwide, a number projected...
CXCR3 expression on antigen-experienced B cells is systemically dysregulated in type 1 diabetes
CXCR3 expression on antigen-experienced B cells is systemically dysregulated in type 1 diabetes
The chemokine receptor C-X-C chemokine receptor type 3 (CXCR3) is a key chemoattractant molecule that facilitates...
Modelling the effects of human SUR1 R1420H variation on insulin secretory function using isogenic iPSC-derived pancreatic islets
Modelling the effects of human SUR1 R1420H variation on insulin secretory function using isogenic iPSC-derived pancreatic islets
An R1420H variation in sulfonylurea receptor 1 (SUR1), a subunit of the KATP channel, was previously identified in an Indi...
High incidence of eating disorders in individuals with type 2 diabetes and their association with cardiovascular and mortality risks
High incidence of eating disorders in individuals with type 2 diabetes and their association with cardiovascular and mortality risks
We examined the incidence of eating disorders (ED) in individuals with type 2 diabetes and their impact on all-cause morta...
Ketone supplementation dose-dependently lowers postprandial blood glucose, lipid and ghrelin levels in individuals with type 2 diabetes: a randomised crossover study
Ketone supplementation dose-dependently lowers postprandial blood glucose, lipid and ghrelin levels in individuals with type 2 diabetes: a randomised crossover study
Postprandial hyperglycaemia and hyperlipidaemia are independent risk factors for CVD in individuals with type 2 diabetes. ...
Defective autophagy and AMPK inactivation drive ferroptosis in diabetic kidney disease
Defective autophagy and AMPK inactivation drive ferroptosis in diabetic kidney disease
Ferroptosis, a regulated form of cell death characterised by excessive lipid peroxidation, plays a critical role in acute ...
Improving medication adherence in type 2 diabetes: strategies for better clinical and economic outcomes
Improving medication adherence in type 2 diabetes: strategies for better clinical and economic outcomes
Medication adherence is critical for optimal glycaemic management and the prevention of complications in type 2 diabetes m...
Placental expression of and diminished pancreatic beta cell function during pregnancy
Placental expression of and diminished pancreatic beta cell function during pregnancy
Pregnancy is characterised by augmented pancreatic beta cell function, which is impaired in gestational diabetes mellitus ...
Early weight loss, diabetes remission and long-term trajectory after diagnosis of type 2 diabetes: a retrospective study
Early weight loss, diabetes remission and long-term trajectory after diagnosis of type 2 diabetes: a retrospective study
Weight loss can improve glycaemic management in individuals with type 2 diabetes, but its long-term effects on remission, ...
Regulating islet stress responses through CD47 activation
Regulating islet stress responses through CD47 activation
Diabetes is a global health burden characterised by incremental beta cell loss. Islet transplantation is a recognised trea...
Immunotherapy with low-dose IL-2 attenuates vascular injury in mice with diabetic and neovascular retinopathy by restoring the balance between Foxp3 Tregs and CD8 T cells
Immunotherapy with low-dose IL-2 attenuates vascular injury in mice with diabetic and neovascular retinopathy by restoring the balance between Foxp3 Tregs and CD8 T cells
Diabetic retinopathy features damage to the retinal microvasculature that causes vessels to leak and proliferate and can l...
TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion
TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion
Diabetes is associated with the dysfunction of glucagon-producing pancreatic islet alpha cells, although the underlying me...
HEXA-FC protein therapy increases skeletal muscle glucose uptake and improves glycaemic control in mice with insulin resistance and in a mouse model of type 2 diabetes
HEXA-FC protein therapy increases skeletal muscle glucose uptake and improves glycaemic control in mice with insulin resistance and in a mouse model of type 2 diabetes
Type 2 diabetes is a chronic metabolic disorder characterised by insulin resistance and sustained hyperglycaemia, and is a...
Macular perfusion alterations in people with recent-onset diabetes and novel diabetes subtypes
Macular perfusion alterations in people with recent-onset diabetes and novel diabetes subtypes
Our aim was to detect early structural and functional changes in the macular capillaries using optical coherence tomograph...
Parent-of-origin effects in the life-course evolution of cardiometabolic traits
Parent-of-origin effects in the life-course evolution of cardiometabolic traits
Cardiometabolic traits are heritable, and some display parent-of-origin effects, which indicates preferential inheritance ...
The effect of once-weekly insulin icodec vs once-daily basal insulin on physical activity-attributed hypoglycaemia in type 2 diabetes: a post hoc analysis of ONWARDS 1–5
The effect of once-weekly insulin icodec vs once-daily basal insulin on physical activity-attributed hypoglycaemia in type 2 diabetes: a post hoc analysis of ONWARDS 1–5
Physical activity increases the risk of hypoglycaemia in individuals with type 2 diabetes when basal or basal-bolus insuli...
Clinical use of polygenic scores in type 2 diabetes: challenges and possibilities
Clinical use of polygenic scores in type 2 diabetes: challenges and possibilities
Resulting from a combination of genetic and environmental factors, type 2 diabetes is highly heterogeneous in manifestatio...
Cardiac remodelling, recognition memory deficits and accelerated ageing in a rat model of gestational diabetes
Cardiac remodelling, recognition memory deficits and accelerated ageing in a rat model of gestational diabetes
Women with prior gestational diabetes mellitus (GDM) have higher incidence of age-associated diseases, including type 2 di...
Metabolic effects of 3-hydroxybutyrate infusion in individuals with type 1 diabetes compared with healthy control participants: a randomised crossover trial showing intact feedback suppression of lipolysis
Metabolic effects of 3-hydroxybutyrate infusion in individuals with type 1 diabetes compared with healthy control participants: a randomised crossover trial showing intact feedback suppression of lipolysis
Diabetic ketoacidosis remains a severe complication in type 1 diabetes, arising from insufficient insulin levels and accel...
The genetics of low and high birthweight and their relationship with cardiometabolic disease
The genetics of low and high birthweight and their relationship with cardiometabolic disease
Low birthweight infants are at increased risk not only of mortality, but also of type 2 diabetes mellitus and CVD in later...
Alterations in cerebral perfusion and substrate metabolism in type 2 diabetes: interactions with -ε4
Alterations in cerebral perfusion and substrate metabolism in type 2 diabetes: interactions with -ε4
Epidemiological studies indicate that type 2 diabetes increases the risk for Alzheimer’s disease. Alterations in cer...
Exercise-induced meteorin-like protein protects human pancreatic beta cells from cytokine-induced apoptosis
Exercise-induced meteorin-like protein protects human pancreatic beta cells from cytokine-induced apoptosis
Inflammation-driven pancreatic beta cell death is a hallmark of type 1 diabetes progression. We have previously shown that...
Diabetes and natural and man-made disasters: prevention, preparation, response and recovery
Diabetes and natural and man-made disasters: prevention, preparation, response and recovery
Both the global prevalence of diabetes and the frequency of natural and man-made disasters are increasing. Of all chronic ...
The relationship between shrunken pore syndrome and all-cause mortality in people with type 2 diabetes and normal renal function: the Fremantle Diabetes Study Phase II
The relationship between shrunken pore syndrome and all-cause mortality in people with type 2 diabetes and normal renal function: the Fremantle Diabetes Study Phase II
Estimated GFRs utilising creatinine- (eGFRcreat) or cystatin C-based (eGFRcyst) equations can generate discrepant results ...
Correction to: Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice
Correction to: Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice
Department of Nutrition, University of California Davis, 3135 Meyer Hall, Davis, CA, 95616, USAYannan Xi, Siming Liu, Ahme...
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