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Illuminating the metabolic effects of circadian misalignment
Circadian misalignment affects physiology and metabolism and increases the risk of developing cardiometabolic disease. A p...
Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health
Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health
Adipose tissue demonstrates considerable plasticity and heterogeneity, enabling metabolic, cellular and structural adaptat...
Metabolic effects of gender-affirming hormone therapy
Metabolic effects of gender-affirming hormone therapy
As the field of gender-affirming hormone therapy (GAHT) evolves, research into how this type of treatment affects metaboli...
Management, biomarkers and prognosis in people developing endocrinopathies associated with immune checkpoint inhibitors
Management, biomarkers and prognosis in people developing endocrinopathies associated with immune checkpoint inhibitors
Immune-related adverse events (irAEs), including endocrine irAEs, can occur in response to cancer immunotherapy using immu...
Exploring the functions of the myokine feimin
Exploring the functions of the myokine feimin
Skeletal muscle produces a range of myokines, which have various effects throughout the body. Two new studies published in...
The effects of type 1 and type 2 diabetes mellitus on bone health in chronic kidney disease
The effects of type 1 and type 2 diabetes mellitus on bone health in chronic kidney disease
Fracture is an under-recognized but common complication of diabetes mellitus, with an incidence approaching twofold in typ...
Exercise exacerbates cardiac damage from high-fat, high-calorie feeding in mice
Exercise exacerbates cardiac damage from high-fat, high-calorie feeding in mice
Physical exercise is well known to help to prevent obesity and to benefit cardiometabolic health. A new study in Nature Co...
Hypoparathyroidism: diagnosis, management and emerging therapies
Hypoparathyroidism: diagnosis, management and emerging therapies
Hypoparathyroidism is characterized by inadequate parathyroid hormone (PTH) secretion or action and results in hypocalcaem...
Type 1 diabetes mellitus: a brave new world
Type 1 diabetes mellitus: a brave new world
One hundred years after the Nobel prize was bestowed on Banting and McLeod for the ‘discovery’ of insulin, we ...
Highlights from SfE BES 2023
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Advances in incretin-based therapeutics for obesity
The year 2023 brought reports of highly effective glucagon-like peptide 1 (GLP1) mono-agonists or combinations with amylin...
Harnessing the inflammatory processes in endometriosis
The pathophysiology of endometriosis is underpinned by a complex interplay of inflammatory processes that are responsible ...
Endocrinology in the multi-omics era
Endocrinology in the multi-omics era
Over the past decade, technological advances have enabled cost-efficient, high-throughput analysis of different types of o...
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
An individual’s nutritional status has a powerful effect on sexual maturation. Puberty onset is delayed in response ...
Genomic alterations in thyroid cancer: biological and clinical insights
Genomic alterations in thyroid cancer: biological and clinical insights
Tumours can arise from thyroid follicular cells if they acquire driver mutations that constitutively activate the MAPK sig...
GIP regulates body weight via GABAergic neurons
GIP regulates body weight via GABAergic neurons
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β-cells protected from T1DM by early senescence programme
β-cells protected from T1DM by early senescence programme
Pancreatic β-cells undergo high levels of cellular stress in the early stages of type 1 diabetes mellitus (T1DM), includin...
SGLT inhibitors: a serendipitous glycaemic tale
Competing interests S.A. declares no competing interests. I.L. has received gran...
The metabolic mythos of ketones
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How a common NAFLD genetic risk variant affects human metabolism
How a common NAFLD genetic risk variant affects human metabolism
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A new endometrial organoid: synthetically engineered matrix enhances epithelial–stromal interactions
A new endometrial organoid: synthetically engineered matrix enhances epithelial–stromal interactions
Over the past decade, the focus on modelling the human endometrium and its cyclical transformations has intensified, drive...
Macrophage and T cell networks in adipose tissue
Macrophage and T cell networks in adipose tissue
The signals and structure of the tissues in which leukocytes reside critically mould leukocyte function and development an...
Antivirals in the treatment of new-onset T1DM
Antivirals in the treatment of new-onset T1DM
The pathogenesis of type 1 diabetes mellitus (T1DM) involves genetic and environmental factors. However, the process is co...
Health equity in endocrinology
Health equity is when every person can achieve their full potential for health and wellbeing. In this Viewpoint, global ex...
The ageing thyroid: implications for longevity and patient care
The ageing thyroid: implications for longevity and patient care
Thyroid hormones have vital roles in development, growth and energy metabolism. Within the past two decades, disturbances ...
Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and pancreatic β-cell dysfunct...
Metabolic elasticity — a new trait associated with health?
Metabolic elasticity — a new trait associated with health?
A recent study by Zhou and colleagues proposed that low metabolic elasticity and gene elasticity are involved in the metab...
Immune cell population prevents weight regain
Immune cell population prevents weight regain
Weight regain after weight loss is a common problem that can increase the risk of metabolic disease. A new study in Cell M...
Stem cell-derived islet therapy: is this the end of the beginning?
Stem cell-derived islet therapy: is this the end of the beginning?
The debut of stem cell-derived islets in the clinic for glycaemic control in patients with type 1 diabetes mellitus has ga...