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NKX6.1 expression is linked to successful pancreatic islet transplantation
NKX6.1 expression is linked to successful pancreatic islet transplantation
For people with type 1 diabetes mellitus, pancreatic islet transplantation can lead to long-term improvements in insulin s...
Causes of sarcopenia and frailty in people taking GLP1RAs
Causes of sarcopenia and frailty in people taking GLP1RAs
Medications based on glucagon-like peptide 1 pathways are an efficient drug treatment for people with obesity, often elici...
Neurokinin receptor antagonists for vasomotor symptoms: from KNDy neurons to clinical translation
Neurokinin receptor antagonists for vasomotor symptoms: from KNDy neurons to clinical translation
Vasomotor symptoms (VMS), including hot flushes and night sweats, affect approximately 70% of people experiencing menopaus...
The effect of hypoglycaemia on neurodevelopment: insights from congenital hyperinsulinism
The effect of hypoglycaemia on neurodevelopment: insights from congenital hyperinsulinism
Infants exposed to hypoglycaemia are at risk of neuroglycopenia and long-term neurodisability. Individuals with congenital...
Precision medicine in low-income settings and small island developing states
Precision medicine in low-income settings and small island developing states
Precision medicine tailors prevention, diagnosis and treatment of cardiometabolic diseases to individual genetic, environm...
Pathophysiology, diagnosis and management of secondary osteoporosis
Pathophysiology, diagnosis and management of secondary osteoporosis
Age-related decline in sex hormones is the most frequent cause of primary osteoporosis; however, secondary causes contribu...
Highlights from SfE BES 2026
This March, more than 1,000 endocrinologists convened in Harrogate, UK, for the annual meeting of the Society for Endocrin...
Clinical obesity in Asian people: bridging the gap between adiposity and disease
Clinical obesity in Asian people: bridging the gap between adiposity and disease
This Perspective argues for a reconceptualization of clinical obesity in Asian populations, moving beyond BMI-centric defi...
Antigen-specific Treg cells induce infectious tolerance
Antigen-specific Treg cells induce infectious tolerance
Regulatory T (Treg) cells can induce immune tolerance, making Treg cellular therapy a promising strategy to prevent autoim...
FDA fast-track approval of belzutifan is a milestone in rare cancer therapy
FDA fast-track approval of belzutifan is a milestone in rare cancer therapy
FDA approval of the selective HIF2α inhibitor belzutifan for advanced phaeochromocytoma and paraganglioma (PPGL) is a...
Twenty years of progress in type 1 diabetes mellitus
Twenty years of progress in type 1 diabetes mellitus
Future treatment targets for type 1 diabetes mellitus will be truly normal blood levels of glucose with a minimum of exoge...
Cardiometabolic and renal benefits of sodium–glucose cotransporter 2 inhibitors
Cardiometabolic and renal benefits of sodium–glucose cotransporter 2 inhibitors
The therapeutic scope of sodium–glucose cotransporter 2 (SGLT2) inhibitors has expanded beyond glycaemic regulation ...
Mechanisms of diabetic kidney disease and established and emerging treatments
Mechanisms of diabetic kidney disease and established and emerging treatments
Kidney disease is the leading cause of mortality in persons with diabetes mellitus. Diabetic kidney disease (DKD) typicall...
HDL metabolism and function in diabetes mellitus
HDL metabolism and function in diabetes mellitus
Epidemiological studies have identified an inverse association of high-density lipoprotein (HDL) cholesterol with cardiova...
Negative effects of ultra-processed foods beyond increasing calories
Negative effects of ultra-processed foods beyond increasing calories
As the popularity of ultra-processed foods (UPFs) grows in many places, so does the importance of research into the health...
Leptin and melanocortin signalling in the response to infection
Leptin and melanocortin signalling in the response to infection
The response to infection is an energy-demanding process that bolsters cell division and protein synthesis to overcome a r...
Illuminating the metabolic effects of circadian misalignment
Circadian misalignment affects physiology and metabolism and increases the risk of developing cardiometabolic disease. A p...
Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health
Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health
Adipose tissue demonstrates considerable plasticity and heterogeneity, enabling metabolic, cellular and structural adaptat...
Metabolic effects of gender-affirming hormone therapy
Metabolic effects of gender-affirming hormone therapy
As the field of gender-affirming hormone therapy (GAHT) evolves, research into how this type of treatment affects metaboli...
Management, biomarkers and prognosis in people developing endocrinopathies associated with immune checkpoint inhibitors
Management, biomarkers and prognosis in people developing endocrinopathies associated with immune checkpoint inhibitors
Immune-related adverse events (irAEs), including endocrine irAEs, can occur in response to cancer immunotherapy using immu...
Exploring the functions of the myokine feimin
Exploring the functions of the myokine feimin
Skeletal muscle produces a range of myokines, which have various effects throughout the body. Two new studies published in...
The effects of type 1 and type 2 diabetes mellitus on bone health in chronic kidney disease
The effects of type 1 and type 2 diabetes mellitus on bone health in chronic kidney disease
Fracture is an under-recognized but common complication of diabetes mellitus, with an incidence approaching twofold in typ...
Exercise exacerbates cardiac damage from high-fat, high-calorie feeding in mice
Exercise exacerbates cardiac damage from high-fat, high-calorie feeding in mice
Physical exercise is well known to help to prevent obesity and to benefit cardiometabolic health. A new study in Nature Co...
Hypoparathyroidism: diagnosis, management and emerging therapies
Hypoparathyroidism: diagnosis, management and emerging therapies
Hypoparathyroidism is characterized by inadequate parathyroid hormone (PTH) secretion or action and results in hypocalcaem...
Type 1 diabetes mellitus: a brave new world
Type 1 diabetes mellitus: a brave new world
One hundred years after the Nobel prize was bestowed on Banting and McLeod for the ‘discovery’ of insulin, we ...
Highlights from SfE BES 2023
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Advances in incretin-based therapeutics for obesity
The year 2023 brought reports of highly effective glucagon-like peptide 1 (GLP1) mono-agonists or combinations with amylin...
Harnessing the inflammatory processes in endometriosis
The pathophysiology of endometriosis is underpinned by a complex interplay of inflammatory processes that are responsible ...
Endocrinology in the multi-omics era
Endocrinology in the multi-omics era
Over the past decade, technological advances have enabled cost-efficient, high-throughput analysis of different types of o...
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
An individual’s nutritional status has a powerful effect on sexual maturation. Puberty onset is delayed in response ...
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