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Antigen-specific Treg cells induce infectious tolerance
Antigen-specific Treg cells induce infectious tolerance
Regulatory T (Treg) cells can induce immune tolerance, making Treg cellular therapy a promising strategy to prevent autoim...
FDA fast-track approval of belzutifan is a milestone in rare cancer therapy
FDA fast-track approval of belzutifan is a milestone in rare cancer therapy
FDA approval of the selective HIF2α inhibitor belzutifan for advanced phaeochromocytoma and paraganglioma (PPGL) is a...
Twenty years of progress in type 1 diabetes mellitus
Twenty years of progress in type 1 diabetes mellitus
Future treatment targets for type 1 diabetes mellitus will be truly normal blood levels of glucose with a minimum of exoge...
Cardiometabolic and renal benefits of sodium–glucose cotransporter 2 inhibitors
Cardiometabolic and renal benefits of sodium–glucose cotransporter 2 inhibitors
The therapeutic scope of sodium–glucose cotransporter 2 (SGLT2) inhibitors has expanded beyond glycaemic regulation ...
Mechanisms of diabetic kidney disease and established and emerging treatments
Mechanisms of diabetic kidney disease and established and emerging treatments
Kidney disease is the leading cause of mortality in persons with diabetes mellitus. Diabetic kidney disease (DKD) typicall...
HDL metabolism and function in diabetes mellitus
HDL metabolism and function in diabetes mellitus
Epidemiological studies have identified an inverse association of high-density lipoprotein (HDL) cholesterol with cardiova...
Negative effects of ultra-processed foods beyond increasing calories
Negative effects of ultra-processed foods beyond increasing calories
As the popularity of ultra-processed foods (UPFs) grows in many places, so does the importance of research into the health...
Leptin and melanocortin signalling in the response to infection
Leptin and melanocortin signalling in the response to infection
The response to infection is an energy-demanding process that bolsters cell division and protein synthesis to overcome a r...
Illuminating the metabolic effects of circadian misalignment
Circadian misalignment affects physiology and metabolism and increases the risk of developing cardiometabolic disease. A p...
Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health
Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health
Adipose tissue demonstrates considerable plasticity and heterogeneity, enabling metabolic, cellular and structural adaptat...
Metabolic effects of gender-affirming hormone therapy
Metabolic effects of gender-affirming hormone therapy
As the field of gender-affirming hormone therapy (GAHT) evolves, research into how this type of treatment affects metaboli...
Management, biomarkers and prognosis in people developing endocrinopathies associated with immune checkpoint inhibitors
Management, biomarkers and prognosis in people developing endocrinopathies associated with immune checkpoint inhibitors
Immune-related adverse events (irAEs), including endocrine irAEs, can occur in response to cancer immunotherapy using immu...
Exploring the functions of the myokine feimin
Exploring the functions of the myokine feimin
Skeletal muscle produces a range of myokines, which have various effects throughout the body. Two new studies published in...
The effects of type 1 and type 2 diabetes mellitus on bone health in chronic kidney disease
The effects of type 1 and type 2 diabetes mellitus on bone health in chronic kidney disease
Fracture is an under-recognized but common complication of diabetes mellitus, with an incidence approaching twofold in typ...
Exercise exacerbates cardiac damage from high-fat, high-calorie feeding in mice
Exercise exacerbates cardiac damage from high-fat, high-calorie feeding in mice
Physical exercise is well known to help to prevent obesity and to benefit cardiometabolic health. A new study in Nature Co...
Hypoparathyroidism: diagnosis, management and emerging therapies
Hypoparathyroidism: diagnosis, management and emerging therapies
Hypoparathyroidism is characterized by inadequate parathyroid hormone (PTH) secretion or action and results in hypocalcaem...
Type 1 diabetes mellitus: a brave new world
Type 1 diabetes mellitus: a brave new world
One hundred years after the Nobel prize was bestowed on Banting and McLeod for the ‘discovery’ of insulin, we ...
Highlights from SfE BES 2023
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Advances in incretin-based therapeutics for obesity
The year 2023 brought reports of highly effective glucagon-like peptide 1 (GLP1) mono-agonists or combinations with amylin...
Harnessing the inflammatory processes in endometriosis
The pathophysiology of endometriosis is underpinned by a complex interplay of inflammatory processes that are responsible ...
Endocrinology in the multi-omics era
Endocrinology in the multi-omics era
Over the past decade, technological advances have enabled cost-efficient, high-throughput analysis of different types of o...
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
An individual’s nutritional status has a powerful effect on sexual maturation. Puberty onset is delayed in response ...
Genomic alterations in thyroid cancer: biological and clinical insights
Genomic alterations in thyroid cancer: biological and clinical insights
Tumours can arise from thyroid follicular cells if they acquire driver mutations that constitutively activate the MAPK sig...
GIP regulates body weight via GABAergic neurons
GIP regulates body weight via GABAergic neurons
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β-cells protected from T1DM by early senescence programme
β-cells protected from T1DM by early senescence programme
Pancreatic β-cells undergo high levels of cellular stress in the early stages of type 1 diabetes mellitus (T1DM), includin...
SGLT inhibitors: a serendipitous glycaemic tale
Competing interests S.A. declares no competing interests. I.L. has received gran...
The metabolic mythos of ketones
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How a common NAFLD genetic risk variant affects human metabolism
How a common NAFLD genetic risk variant affects human metabolism
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A new endometrial organoid: synthetically engineered matrix enhances epithelial–stromal interactions
A new endometrial organoid: synthetically engineered matrix enhances epithelial–stromal interactions
Over the past decade, the focus on modelling the human endometrium and its cyclical transformations has intensified, drive...
Macrophage and T cell networks in adipose tissue
Macrophage and T cell networks in adipose tissue
The signals and structure of the tissues in which leukocytes reside critically mould leukocyte function and development an...
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