P.B. is supported by the National Institute for Health and Care Research (NIHR) Exeter Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. J.M.E.M. has received grants from the State Research Funding for university-level health research funding, Kuopio University Hospital and Wellbeing Service County of North Savo, and postdoctoral research funding from the Foundation for Pediatric Research. S.E.F. has a Wellcome Trust Senior Research Fellowship (grant number 223187/Z/21/Z).