Chouchani, E. T. & Kajimura, S. Metabolic adaptation and maladaptation in adipose tissue. Nat. Metab. 1, 189–200 (2019).
Article PubMed PubMed Central Google Scholar
Fleck, S. J. Body composition of elite American athletes. Am. J. Sports Med. 11, 398–403 (1983).
Article CAS PubMed Google Scholar
Potter, A. W., Chin, G. C., Looney, D. P. & Friedl, K. E. Defining overweight and obesity by percent body fat instead of body mass index. J. Clin. Endocrinol. Metab. https://doi.org/10.1210/CLINEM/DGAE341 (2024).
Cohen, P. & Kajimura, S. The cellular and functional complexity of thermogenic fat. Nat. Rev. Mol. Cell Biol. 22, 393–409 (2021).
Article CAS PubMed PubMed Central Google Scholar
Morigny, P., Boucher, J., Arner, P. & Langin, D. Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics. Nat. Rev. Endocrinol. 17, 276–295 (2021).
Article CAS PubMed Google Scholar
Ghaben, A. L. & Scherer, P. E. Adipogenesis and metabolic health. Nat. Rev. Mol. Cell Biol. 20, 242–258 (2019).
Article CAS PubMed Google Scholar
Karastergiou, K. & Fried, S. K. Multiple adipose depots increase cardiovascular risk via local and systemic effects. Curr. Atheroscler. Rep. 15, 361 (2013).
Article PubMed PubMed Central Google Scholar
Marcelin, G., Silveira, A. L. M., Martins, L. B., Ferreira, A. V. M. & Clément, K. Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis. J. Clin. Invest. 129, 4032–4040 (2019).
Article PubMed PubMed Central Google Scholar
Klöting, N. et al. Insulin-sensitive obesity. Am. J. Physiol. Endocrinol. Metab. 299, E506–E515 (2010).
Pellegrinelli, V., Carobbio, S. & Vidal-Puig, A. Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues. Diabetologia 59, 1075–1088 (2016).
Article CAS PubMed PubMed Central Google Scholar
Favaretto, F., Bettini, S., Busetto, L., Milan, G. & Vettor, R. Adipogenic progenitors in different organs: pathophysiological implications. Rev. Endocr. Metab. Disord. 23, 71–85 (2022).
Article CAS PubMed Google Scholar
Rodbell, M. Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. J. Biol. Chem. 239, 375–380 (1964).
Article CAS PubMed Google Scholar
Hollenberg, C. H. & Vost, A. Regulation of DNA synthesis in fat cells and stromal elements from rat adipose tissue. J. Clin. Invest. 47, 2485–2498 (1968).
Article CAS PubMed Central Google Scholar
Ng, C. W., Poznanski, W. J., Borowiecki, M. & Reimer, G. Differences in growth in vitro of adipose cells from normal and obese patients. Nature 231, 445 (1971).
Article CAS PubMed Google Scholar
Van, R. L., Bayliss, C. E. & Roncari, D. A. Cytological and enzymological characterization of adult human adipocyte precursors in culture. J. Clin. Invest. 58, 699–704 (1976).
Article CAS PubMed PubMed Central Google Scholar
Bjorntorp, P. et al. Isolation and characterization of cells from rat adipose tissue developing into adipocytes. J. Lipid Res. 19, 316–324 (1978).
Article CAS PubMed Google Scholar
Rodeheffer, M. S., Birsoy, K. & Friedman, J. M. Identification of white adipocyte progenitor cells in vivo. Cell 135, 240–249 (2008).
Article CAS PubMed Google Scholar
Marcelin, G. et al. A PDGFRα-mediated switch toward CD9high adipocyte progenitors controls obesity-induced adipose tissue fibrosis. Cell Metab. 25, 673–685 (2017).
Article CAS PubMed Google Scholar
Tang, W., Zeve, D., Seo, J., Jo, A. Y. & Graff, J. M. Thiazolidinediones regulate adipose lineage dynamics. Cell Metab. 14, 116–122 (2011).
Article CAS PubMed PubMed Central Google Scholar
Tang, W. et al. White fat progenitor cells reside in the adipose vasculature. Science 322, 583–586 (2008).
Article CAS PubMed PubMed Central Google Scholar
Berry, R. & Rodeheffer, M. S. Characterization of the adipocyte cellular lineage in vivo. Nat. Cell Biol. 15, 302–308 (2013).
Article CAS PubMed PubMed Central Google Scholar
Jiang, Y., Berry, D. C., Tang, W. & Graff, J. M. Independent stem cell lineages regulate adipose organogenesis and adipose homeostasis. Cell Rep. 9, 1007–1022 (2014).
Article CAS PubMed PubMed Central Google Scholar
Wang, Q. A., Tao, C., Gupta, R. K. & Scherer, P. E. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat. Med. 19, 1338–1344 (2013).
Article PubMed PubMed Central Google Scholar
Rosenwald, M., Perdikari, A., Rülicke, T. & Wolfrum, C. Bi-directional interconversion of brite and white adipocytes. Nat. Cell Biol. 15, 659–667 (2013).
Article CAS PubMed Google Scholar
Guimarães-Camboa, N. et al. Pericytes of multiple organs do not behave as mesenchymal stem cells in vivo. Cell Stem Cell 20, 345–359.e5 (2017).
Article PubMed PubMed Central Google Scholar
Vishvanath, L. et al. Pdgfrβ+ mural preadipocytes contribute to adipocyte hyperplasia induced by high-fat-diet feeding and prolonged cold exposure in adult mice. Cell Metab. 23, 350–359 (2016).
Article CAS PubMed Google Scholar
Shao, M. et al. De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity. Nat. Commun. 9, 890 (2018).
Article PubMed PubMed Central Google Scholar
Emont, M. P. & Rosen, E. D. Exploring the heterogeneity of white adipose tissue in mouse and man. Curr. Opin. Genet. Dev. 80, 102045 (2023).
Article CAS PubMed PubMed Central Google Scholar
Vijay, J. et al. Single-cell analysis of human adipose tissue identifies depot and disease specific cell types. Nat. Metab. 2, 97–109 (2020).
Sárvári, A. K. et al. Plasticity of epididymal adipose tissue in response to diet-induced obesity at single-nucleus resolution. Cell Metab. 33, 437–453.e5 (2021).
Hepler, C. et al. Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice. Elife 7, e39636 (2018).
Article PubMed PubMed Central Google Scholar
Merrick, D. et al. Identification of a mesenchymal progenitor cell hierarchy in adipose tissue. Science 364, eaav2501 (2019).
Comments (0)