Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health

Chouchani, E. T. & Kajimura, S. Metabolic adaptation and maladaptation in adipose tissue. Nat. Metab. 1, 189–200 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Fleck, S. J. Body composition of elite American athletes. Am. J. Sports Med. 11, 398–403 (1983).

Article  CAS  PubMed  Google Scholar 

Potter, A. W., Chin, G. C., Looney, D. P. & Friedl, K. E. Defining overweight and obesity by percent body fat instead of body mass index. J. Clin. Endocrinol. Metab. https://doi.org/10.1210/CLINEM/DGAE341 (2024).

Cohen, P. & Kajimura, S. The cellular and functional complexity of thermogenic fat. Nat. Rev. Mol. Cell Biol. 22, 393–409 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morigny, P., Boucher, J., Arner, P. & Langin, D. Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics. Nat. Rev. Endocrinol. 17, 276–295 (2021).

Article  CAS  PubMed  Google Scholar 

Ghaben, A. L. & Scherer, P. E. Adipogenesis and metabolic health. Nat. Rev. Mol. Cell Biol. 20, 242–258 (2019).

Article  CAS  PubMed  Google Scholar 

Karastergiou, K. & Fried, S. K. Multiple adipose depots increase cardiovascular risk via local and systemic effects. Curr. Atheroscler. Rep. 15, 361 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Marcelin, G., Silveira, A. L. M., Martins, L. B., Ferreira, A. V. M. & Clément, K. Deciphering the cellular interplays underlying obesity-induced adipose tissue fibrosis. J. Clin. Invest. 129, 4032–4040 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Klöting, N. et al. Insulin-sensitive obesity. Am. J. Physiol. Endocrinol. Metab. 299, E506–E515 (2010).

Article  PubMed  Google Scholar 

Pellegrinelli, V., Carobbio, S. & Vidal-Puig, A. Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues. Diabetologia 59, 1075–1088 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Favaretto, F., Bettini, S., Busetto, L., Milan, G. & Vettor, R. Adipogenic progenitors in different organs: pathophysiological implications. Rev. Endocr. Metab. Disord. 23, 71–85 (2022).

Article  CAS  PubMed  Google Scholar 

Rodbell, M. Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. J. Biol. Chem. 239, 375–380 (1964).

Article  CAS  PubMed  Google Scholar 

Hollenberg, C. H. & Vost, A. Regulation of DNA synthesis in fat cells and stromal elements from rat adipose tissue. J. Clin. Invest. 47, 2485–2498 (1968).

Article  CAS  PubMed Central  Google Scholar 

Ng, C. W., Poznanski, W. J., Borowiecki, M. & Reimer, G. Differences in growth in vitro of adipose cells from normal and obese patients. Nature 231, 445 (1971).

Article  CAS  PubMed  Google Scholar 

Van, R. L., Bayliss, C. E. & Roncari, D. A. Cytological and enzymological characterization of adult human adipocyte precursors in culture. J. Clin. Invest. 58, 699–704 (1976).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bjorntorp, P. et al. Isolation and characterization of cells from rat adipose tissue developing into adipocytes. J. Lipid Res. 19, 316–324 (1978).

Article  CAS  PubMed  Google Scholar 

Rodeheffer, M. S., Birsoy, K. & Friedman, J. M. Identification of white adipocyte progenitor cells in vivo. Cell 135, 240–249 (2008).

Article  CAS  PubMed  Google Scholar 

Marcelin, G. et al. A PDGFRα-mediated switch toward CD9high adipocyte progenitors controls obesity-induced adipose tissue fibrosis. Cell Metab. 25, 673–685 (2017).

Article  CAS  PubMed  Google Scholar 

Tang, W., Zeve, D., Seo, J., Jo, A. Y. & Graff, J. M. Thiazolidinediones regulate adipose lineage dynamics. Cell Metab. 14, 116–122 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang, W. et al. White fat progenitor cells reside in the adipose vasculature. Science 322, 583–586 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berry, R. & Rodeheffer, M. S. Characterization of the adipocyte cellular lineage in vivo. Nat. Cell Biol. 15, 302–308 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang, Y., Berry, D. C., Tang, W. & Graff, J. M. Independent stem cell lineages regulate adipose organogenesis and adipose homeostasis. Cell Rep. 9, 1007–1022 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, Q. A., Tao, C., Gupta, R. K. & Scherer, P. E. Tracking adipogenesis during white adipose tissue development, expansion and regeneration. Nat. Med. 19, 1338–1344 (2013).

Article  PubMed  PubMed Central  Google Scholar 

Rosenwald, M., Perdikari, A., Rülicke, T. & Wolfrum, C. Bi-directional interconversion of brite and white adipocytes. Nat. Cell Biol. 15, 659–667 (2013).

Article  CAS  PubMed  Google Scholar 

Guimarães-Camboa, N. et al. Pericytes of multiple organs do not behave as mesenchymal stem cells in vivo. Cell Stem Cell 20, 345–359.e5 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Vishvanath, L. et al. Pdgfrβ+ mural preadipocytes contribute to adipocyte hyperplasia induced by high-fat-diet feeding and prolonged cold exposure in adult mice. Cell Metab. 23, 350–359 (2016).

Article  CAS  PubMed  Google Scholar 

Shao, M. et al. De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity. Nat. Commun. 9, 890 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Emont, M. P. & Rosen, E. D. Exploring the heterogeneity of white adipose tissue in mouse and man. Curr. Opin. Genet. Dev. 80, 102045 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vijay, J. et al. Single-cell analysis of human adipose tissue identifies depot and disease specific cell types. Nat. Metab. 2, 97–109 (2020).

Article  PubMed  Google Scholar 

Sárvári, A. K. et al. Plasticity of epididymal adipose tissue in response to diet-induced obesity at single-nucleus resolution. Cell Metab. 33, 437–453.e5 (2021).

Article  PubMed  Google Scholar 

Hepler, C. et al. Identification of functionally distinct fibro-inflammatory and adipogenic stromal subpopulations in visceral adipose tissue of adult mice. Elife 7, e39636 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Merrick, D. et al. Identification of a mesenchymal progenitor cell hierarchy in adipose tissue. Science 364, eaav2501 (2019).

Article  CAS  PubMed 

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