Peruzzo B, Pastor FE, Blazquez JL, Amat P, Rodriguez EM. Polarized endocytosis and transcytosis in the hypothalamic tanycytes of the rat. Cell Tissue Res. 2004;317(2):147–64.

Article  CAS  PubMed  Google Scholar 

Prevot V. Glial-neuronal-endothelial interactions are involved in the control of GnRH secretion. J Neuroendocrinol. 2002;14(3):247–55.

Article  CAS  PubMed  Google Scholar 

Rodriguez EM, Blazquez JL, Pastor FE, Pelaez B, Pena P, Peruzzo B, Amat P. Hypothalamic tanycytes: a key component of brain-endocrine interaction. Int Rev Cytol. 2005;247:89–164.

Article  CAS  PubMed  Google Scholar 

Kirst C, Skriabine S, Vieites-Prado A, Topilko T, Bertin P, Gerschenfeld G, et al. Mapping the Fine-Scale organization and plasticity of the brain vasculature. Cell. 2020;180(4):780–95. e25.

Article  CAS  PubMed  Google Scholar 

Chen B, Meseguer D, Renier N, Schneeberger M. Dynamic rewiring of neurovasculature in health and disease. Trends Mol Med. 2023;29(10):786–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen B, de Launoit E, Meseguer D, Garcia Caceres C, Eichmann A, Renier N, Schneeberger M. The interactions between energy homeostasis and neurovascular plasticity. Nat Rev Endocrinol. 2024;20(12):749–59.

Dakic T, Jevdjovic T, Lakic I, Djurasevic SF, Djordjevic J, Vujovic P. Food for thought: Short-Term fasting upregulates glucose transporters in neurons and endothelial cells, but not in astrocytes. Neurochem Res. 2019;44(2):388–99.

Article  CAS  PubMed  Google Scholar 

Langlet F, Levin BE, Luquet S, Mazzone M, Messina A, Dunn-Meynell AA, et al. Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting. Cell Metab. 2013;17(4):607–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Varela L, Suyama S, Huang Y, Shanabrough M, Tschop MH, Gao XB, et al. Endothelial HIF-1alpha enables hypothalamic glucose uptake to drive POMC neurons. Diabetes. 2017;66(6):1511–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nuzzaci D, Cansell C, Lienard F, Nedelec E, Ben Fradj S, Castel J, et al. Postprandial hyperglycemia stimulates neuroglial plasticity in hypothalamic POMC neurons after a balanced meal. Cell Rep. 2020;30(9):3067–78. e5.

Article  CAS  PubMed  Google Scholar 

Bakker W, Imbernon M, Salinas CG, Moro Chao DH, Hassouna R, Morel C, et al. Acute changes in systemic glycemia gate access and action of GLP-1R agonist on brain structures controlling energy homeostasis. Cell Rep. 2022;41(8):111698.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Porniece Kumar M, Cremer AL, Klemm P, Steuernagel L, Sundaram S, Jais A, et al. Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Nat Metab. 2021;3(12):1662–79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pasquettaz R, Kolotuev I, Rohrbach A, Gouelle C, Pellerin L, Langlet F. Peculiar protrusions along tanycyte processes face diverse neural and nonneural cell types in the hypothalamic parenchyma. J Comp Neurol. 2021;529(3):553–75.

Article  CAS  PubMed  Google Scholar 

Hofmann K, Lamberz C, Piotrowitz K, Offermann N, But D, Scheller A, et al. Tanycytes and a differential fatty acid metabolism in the hypothalamus. Glia. 2017;65(2):231–49.

Article  PubMed  Google Scholar 

Wang Y, Sabbagh MF, Gu X, Rattner A, Williams J, Nathans J. Beta-catenin signaling regulates barrier-specific gene expression in circumventricular organ and ocular vasculatures. Elife. 2019;8:e43257.

Zhou Y, Wang Y, Tischfield M, Williams J, Smallwood PM, Rattner A, et al. Canonical WNT signaling components in vascular development and barrier formation. J Clin Invest. 2014;124(9):3825–46.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Valenzuela CF, Kazlauskas A, Weiner JL. Roles of platelet-derived growth factor in the developing and mature nervous systems. Brain Res Brain Res Rev. 1997;24(1):77–89.

Article  CAS  PubMed  Google Scholar 

Vanlandewijck M, He L, Mae MA, Andrae J, Ando K, Del Gaudio F, et al. A molecular atlas of cell types and zonation in the brain vasculature. Nature. 2018;554(7693):475–80.

Article  CAS  PubMed  Google Scholar 

Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev. 1999;79(4):1283–316.

Article  CAS  PubMed  Google Scholar 

Duan L, Zhang XD, Miao WY, Sun YJ, Xiong G, Wu Q, et al. PDGFRbeta cells rapidly relay inflammatory signal from the circulatory system to neurons via chemokine CCL2. Neuron. 2018;100(1):183–e2008.

Article  CAS  PubMed  Google Scholar 

Okekawa A, Wada T, Onogi Y, Takeda Y, Miyazawa Y, Sasahara M, et al. Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity. Mol Med. 2024;30(1):21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garcia-Caceres C, Quarta C, Varela L, Gao Y, Gruber T, Legutko B, et al. Astrocytic insulin signaling couples brain glucose uptake with nutrient availability. Cell. 2016;166(4):867–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gruber T, Pan C, Contreras RE, Wiedemann T, Morgan DA, Skowronski AA, et al. Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension. Cell Metab. 2021;33(6):1155–e7010.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morita S, Ukai S, Miyata S. VEGF-dependent continuous angiogenesis in the median eminence of adult mice. Eur J Neurosci. 2013;37(4):508–18.

Article  CAS  PubMed  Google Scholar 

Kuczynski-Noyau L, Karmann S, Alberton P, Martinez-Corral I, Nampoothiri S, Sauve F, et al. A plastic Aggrecan barrier modulated by peripheral energy state gates metabolic signal access to arcuate neurons. Nat Commun. 2024;15(1):6701.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schaeffer M, Langlet F, Lafont C, Molino F, Hodson DJ, Roux T, et al. Rapid sensing of Circulating Ghrelin by hypothalamic appetite-modifying neurons. Proc Natl Acad Sci U S A. 2013;110(4):1512–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Campbell JN, Macosko EZ, Fenselau H, Pers TH, Lyubetskaya A, Tenen D, et al. A molecular census of arcuate hypothalamus and median eminence cell types. Nat Neurosci. 2017;20(3):484–96.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Romano N, Lafont C, Campos P, Guillou A, Fiordelisio T, Hodson DJ et al. Median eminence blood flow influences food intake by regulating Ghrelin access to the metabolic brain. JCI Insight. 2023;8(3):e165763.

Kohnke S, Buller S, Nuzzaci D, Ridley K, Lam B, Pivonkova H, et al. Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence. Cell Rep. 2021;36(2):109362.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Buller S, Staricoff EO, Riches C, Tsang A, Josipovic M, Ikemura K et al. Adult oligodendrogenesis gates arcuate neuronal glucose sensing through remodelling of the blood-hypothalamus barrier via ADAMTS4. bioRxiv. 2024:2024.09.10.612227.

Takahashi H, Takata F, Matsumoto J, Machida T, Yamauchi A, Dohgu S, Kataoka Y. Brain pericyte-derived soluble factors enhance insulin sensitivity in GT1-7 hypothalamic neurons. Biochem Biophys Res Commun. 2015;457(4):532–7.

Article  CAS  PubMed  Google Scholar 

Butiaeva LI, Slutzki T, Swick HE, Bourguignon C, Robins SC, Liu X, et al. Leptin receptor-expressing pericytes mediate access of hypothalamic feeding centers to Circulating leptin. Cell Metab. 2021;33(7):1433–48. e5.

Article  CAS