Ng M, Gakidou E, Lo J, et al. Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021[J]. Lancet. 2025;405(10481):813–38. https://doi.org/10.1016/S0140-6736(25)00355-1.

Article  Google Scholar 

Zeng Q, Li N, Pan X-F, et al. Clinical management and treatment of obesity in China. Lancet Diabetes Endocrinol. 2021;9(6):393–405. https://doi.org/10.1016/S2213-8587(21)00047-4.

Article  PubMed  Google Scholar 

Anastasiou CA, Karfopoulou E, Yannakoulia M. Weight regaining: from statistics and behaviors to physiology and metabolism. Metabolism. 2015;64(11):1395–407. https://doi.org/10.1016/j.metabol.2015.08.006.

Article  CAS  PubMed  Google Scholar 

Nordmo M, Danielsen YS, Nordmo M. The challenge of keeping it off, a descriptive systematic review of high-quality, follow‐up studies of obesity treatments. Obes Rev. 2020;21(1):e12949. https://doi.org/10.1111/obr.12949.

Article  PubMed  Google Scholar 

Ji L, Mu Y, Chang C, et al. Perceptions, attitudes and barriers to effective obesity care among people living with obesity and healthcare professionals in China: The ACTION-China study. Diabetes Obes Metab. 2024;26(10):4694–704. https://doi.org/10.1111/dom.15837.

Article  PubMed  Google Scholar 

Sakers A, De Siqueira MK, Seale P, et al. Adipose-tissue plasticity in health and disease. Cell. 2022;185(3):419–46. https://doi.org/10.1016/j.cell.2021.12.016.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Baak MA, Mariman ECM. Mechanisms of weight regain after weight loss- the role of adipose tissue. Nat Rev Endocrinol. 2019;15(5):274–87. https://doi.org/10.1038/s41574-018-0148-4.

Article  PubMed  Google Scholar 

van Baak MA, Mariman ECM. Obesity-induced and weight-loss-induced physiological factors affecting weight regain. Nat Rev Endocrinol. 2023;19(11):655–70. https://doi.org/10.1038/s41574-023-00887-4.

Article  CAS  PubMed  Google Scholar 

Hinte LC, Castellano-Castillo D, Ghosh A, et al. Adipose tissue retains an epigenetic memory of obesity after weight loss. Nature. 2024;636(8042):457–65. https://doi.org/10.1038/s41586-024-08165-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Miranda AMA, McAllan L, Mazzei G, et al. Selective remodelling of the adipose niche in obesity and weight loss. Nature. 2025;644(8077):769–79. https://doi.org/10.1038/s41586-025-09233-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hasegawa Y. New perspectives on obesity-induced adipose tissue fibrosis and related clinical manifestations. Endocr J. 2022;69(7):739–48. https://doi.org/10.1507/endocrj.EJ22-0035.

Article  CAS  PubMed  Google Scholar 

Gliniak CM, Pedersen L, Scherer PE. Adipose tissue fibrosis: the unwanted houseguest invited by obesity. J Endocrinol. 2023;259(3):e230180. https://doi.org/10.1530/JOE-23-0180.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cheng B, Lu M, Jia Y, Xu F. Cellular mechanical intelligence. Adv Mech. 2025;55(2):340–77. https://doi.org/10.6052/1000-0992-24-028

Article  Google Scholar 

Yang C, Tibbitt MW, Basta L, et al. Mechanical memory and dosing influence stem cell fate. Nat Mater. 2014;13(6):645–52. https://doi.org/10.1038/nmat3889.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nasrollahi S, Walter C, Loza AJ, et al. Past matrix stiffness primes epithelial cells and regulates their future collective migration through a mechanical memory. Biomaterials. 2017;146:146–55. https://doi.org/10.1016/j.biomaterials.2017.09.012.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yui A, Oudin MJ. The rigidity connection: matrix stiffness and its impact on cancer progression. Cancer Res. 2024;84(7):958–60. https://doi.org/10.1158/0008-5472.CAN-24-0394.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng Y, Su X, Duan S. The stiffness of the extracellular matrix is a key factor in tumor progression. MedComm. 2024;5(9):e729. https://doi.org/10.1002/mco2.729.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huang L, Huhulea EN, Abraham E, et al. The role of artificial intelligence in obesity risk prediction and management: approaches, insights, and recommendations. Medicina. 2025;61(2):358. https://doi.org/10.3390/medicina61020358.

Article  PubMed  PubMed Central  Google Scholar 

Azmi S, Kunnathodi F, Alotaibi HF, et al. Harnessing artificial intelligence in obesity research and management: a comprehensive review. Diagnostics. 2025;15(3):396. https://doi.org/10.3390/diagnostics15030396.

Article  PubMed  PubMed Central  Google Scholar 

Singh B, Tawfik H. Machine Learning Approach for the Early Prediction of the Risk of Overweight and Obesity in Young People, in Computational Science – ICCS 2020. 2020. 523–535. https://doi.org/10.1007/978-3-030-50423-6_39

Bellini V, Valente M, Turetti M, et al. Current applications of artificial intelligence in bariatric surgery. Obes Surg. 2022;32(8):2717–33. https://doi.org/10.1007/s11695-022-06100-1.

Article  PubMed  PubMed Central  Google Scholar 

Coassolo L, Danneskiold-Samsøe NB, Nguyen Q, et al. Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide. Nature. 2025;641(8061):192–201. https://doi.org/10.1038/s41586-025-08683-y.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saux P, Bauvin P, Raverdy V, et al. Development and validation of an interpretable machine learning-based calculator for predicting 5-year weight trajectories after bariatric surgery: a multinational retrospective cohort SOPHIA study. Lancet Digit Health. 2023;5(10):e692–702. https://doi.org/10.1016/S2589-7500(23)00135-8.

Article  CAS  PubMed  Google Scholar 

Kawai T, Autieri MV, Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol. 2021;320(3):C375–91. https://doi.org/10.1152/ajpcell.00379.2020.

Article  CAS  PubMed  Google Scholar 

Fothergill E, Guo J, Howard L, et al. Persistent metabolic adaptation 6 years after “The Biggest Loser” competition. Obesity. 2016;24(8):1612–9. https://doi.org/10.1002/oby.21538.

Article  PubMed  PubMed Central  Google Scholar 

Mai K, Li L, Wiegand S, et al. An integrated understanding of the molecular mechanisms of how adipose tissue metabolism affects long-term body weight maintenance. Diabetes. 2019;68(1):57–65. https://doi.org/10.2337/db18-0440.

Article  CAS  PubMed  Google Scholar 

Hintze LJ, Mahmoodianfard S, Auguste CB, et al. Weight loss and appetite control in women. Curr Obes Rep. 2017;6(3):334–51. https://doi.org/10.1007/s13679-017-0273-8.

Article  PubMed  Google Scholar 

Morigny P, Boucher J, Arner P, et al. Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics. Nat Rev Endocrinol. 2021;17(5):276–95. https://doi.org/10.1038/s41574-021-00471-8.

Article  CAS  PubMed  Google Scholar 

Sun K, Tordjman J, Clément K, et al. Fibrosis and adipose tissue dysfunction. Cell Metab. 2013;18(4):470–7. https://doi.org/10.1016/j.cmet.2013.06.016.

Article  CAS  PubMed