Ahmed S, Karim MM, Ross AG, Hossain MS, Clemens JD, Sumiya MK, Phru CS, Rahman M, Zaman K, Somani J, Yasmin R, Hasnat MA, Kabir A, Aziz AB, Khan WA (2021) A five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness. Int J Infect Dis 103:214–216. https://doi.org/10.1016/j.ijid.2020.11.191

Article  CAS  PubMed  Google Scholar 

Ali BH (1990) The effect of ivermectin on some haematological indices in rabbits: influence of vitamin K treatment. Clin Exp Pharmacol Physiol 17(10):735–738. https://doi.org/10.1111/j.1440-1681.1990.tb01273.x

Article  CAS  PubMed  Google Scholar 

Andries M, Van Damme P, Robberecht W, Van Den Bosch L (2007) Ivermectin inhibits AMPA receptor-mediated excitotoxicity in cultured motor neurons and extends the life span of a transgenic mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 25(1):8–16. https://doi.org/10.1016/j.nbd.2006.08.018

Article  CAS  PubMed  Google Scholar 

Aryannejad A, Tabary M, Noroozi N, Mashinchi B, Iranshahi S, Tavangar SM, Mohammad Jafari R, Rashidian A, Dehpour AR (2022) Anti-inflammatory Effects of Ivermectin in the Treatment of Acetic Acid-Induced Colitis in Rats: Involvement of GABA B Receptors. Dig Dis Sci 67(8):3672–3682. https://doi.org/10.1007/s10620-021-07258-x

Article  CAS  PubMed  Google Scholar 

Attar A, Liu T, Chan W-TC, Hayes J, Nejad M, Lei K, Bitan G (2013) A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer’s disease. PLoS One 8(11):e80355. https://doi.org/10.1371/journal.pone.0080355

Article  CAS  PubMed  PubMed Central  Google Scholar 

Babataheri S, Malekinejad H, Mosarrezaii A, Soraya H (2023) Pre-treatment or post-treatment with hydroxychloroquine demonstrates neuroprotective effects in cerebral ischemia/reperfusion. Fundam Clin Pharmacol 37(3):589–598. https://doi.org/10.1111/fcp.12856

Article  CAS  PubMed  Google Scholar 

Bramante CT, Huling JD, Tignanelli CJ, Buse JB, Liebovitz DM, Nicklas JM, Cohen K, Puskarich MA, Belani HK, Proper JL, Siegel LK, Klatt NR, Odde DJ, Luke DG, Anderson B, Karger AB, Ingraham NE, Hartman KM, Rao V, Hagen AA, Patel B, Fenno SL, Avula N, Reddy NV, Erickson SM, Lindberg S, Fricton R, Lee S, Zaman A, Saveraid HG, Tordsen WJ, Pullen MF, Biros M, Sherwood NE, Thompson JL, Boulware DR, Murray TA, COVID-OUT Trial Team (2022) Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19. N Engl J Med 387(7):599–610. https://doi.org/10.1056/nejmoa2201662

Article  CAS  PubMed  PubMed Central  Google Scholar 

da Silva WAM, Guimarães ATB, Montalvão MF, Mendes BO, Rodrigues ASL, Malafaia G (2018) The chronic exposure to abamectin causes spatial memory deficit and depressive behavior in mice. Chemosphere 194:523–533. https://doi.org/10.1016/j.chemosphere.2017.12.028

Article  CAS  PubMed  Google Scholar 

Davis JA, Paylor R, McDonald MP, Libbey M, Ligler A, Bryant K, Crawley JN (1999) Behavioral effects of ivermectin in mice. Lab Anim Sci 49(3):288–296

CAS  PubMed  Google Scholar 

Della-Morte D, Guadagni F, Palmirotta R, Testa G, Caso V, Paciaroni M, Abete P, Rengo F, Ferroni P, Sacco RL, Rundek T (2012) Genetics of ischemic stroke, stroke-related risk factors, stroke precursors and treatments. Pharmacogenomics 13(5):595–613. https://doi.org/10.2217/pgs.12.14

Article  CAS  PubMed  Google Scholar 

Denorme F, Portier I, Rustad JL, Cody MJ, de Araujo CV, Hoki C, Alexander MD, Grandhi R, Dyer MR, Neal MD, Majersik JJ, Yost CC, Campbell RA (2022) Neutrophil extracellular traps regulate ischemic stroke brain injury. J Clin Invest 16:132(10). https://doi.org/10.1172/jci154225

Doyle KP, Simon RP, Stenzel-Poore MP (2008) Mechanisms of ischemic brain damage. Neuropharmacology 55(3):310–318. https://doi.org/10.1016/j.neuropharm.2008.01.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Durukan A, Tatlisumak T (2007) Acute ischemic stroke: overview of major experimental rodent models, pathophysiology, and therapy of focal cerebral ischemia. Pharmacol Biochem Behav 87(1):179–197. https://doi.org/10.1016/j.pbb.2007.04.015

Article  CAS  PubMed  Google Scholar 

Formiga FR, Leblanc R, de Souza Rebouças J, Farias LP, de Oliveira RN, Pena L (2021) Ivermectin: an award-winning drug with expected antiviral activity against COVID-19. J Control Release 329:758–761. https://doi.org/10.1016/j.jconrel.2020.10.009

Article  CAS  PubMed  Google Scholar 

Gaston LW, Brooks JE, Blumenthal HJ, Miller CE (1971) A study of blood coagulation following an acute stroke. Stroke 2(1):81–87. https://doi.org/10.1161/01.str.2.1.81

Article  CAS  PubMed  Google Scholar 

Gedar Totuk ÖM, Güzel ŞE, Ekici H, Kumandaş A, Emre Aydıngöz S, Yılmaz EÇ, Kırdan T, Midi A (2020) Effects of Algan Hemostatic Agent on bleeding time in a rat tail hemorrhage model. Ulus Travma Acil Cerrahi Derg 26(6):853–858. https://doi.org/10.14744/tjtes.2020.50384

Article  PubMed  Google Scholar 

George-Gay B, Parker K (2003) Understanding the complete blood count with differential. J Perianesth Nurs 18(2):96–117. https://doi.org/10.1053/jpan.2003.50013

Article  PubMed  Google Scholar 

Guo Q, Ma M, Yu H, Han Y, Zhang D (2023) Dexmedetomidine enables copper homeostasis in cerebral ischemia/reperfusion via ferredoxin 1. Ann Med 55(1):2209735. https://doi.org/10.1080/07853890.2023.2209735

Article  CAS  PubMed  PubMed Central  Google Scholar 

Han SJ, Lovaszi M, Kim M, D’Agati V, Haskó G, Lee HT (2020) P2X4 receptor exacerbates ischemic AKI and induces renal proximal tubular NLRP3 inflammasome signaling. FASEB J 34(4):5465–5482. https://doi.org/10.1096/fj.201903287R

Article  CAS  PubMed  Google Scholar 

Heidary F, Gharebaghi R (2020) Ivermectin: a systematic review from antiviral effects to COVID-19 complementary regimen. J Antibiot (Tokyo) 73(9):593–602. https://doi.org/10.1038/s41429-020-0336-z

Article  CAS  PubMed  Google Scholar 

Jickling GC, Liu D, Ander BP, Stamova B, Zhan X, Sharp FR (2015) Targeting neutrophils in ischemic stroke: translational insights from experimental studies. J Cereb Blood Flow Metab 35(6):888–901. https://doi.org/10.1038/jcbfm.2015.45

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kamal AH, Tefferi A, Pruthi RK (2007) How to interpret and pursue an abnormal prothrombin time, activated partial thromboplastin time, and bleeding time in adults. Mayo Clin Proc 82(7):864–873. https://doi.org/10.4065/82.7.864

Article  CAS  PubMed  Google Scholar 

Kamat PK, Kalani A, Metreveli N, Tyagi SC, Tyagi N (2015) A possible molecular mechanism of hearing loss during cerebral ischemia in mice. Can J Physiol Pharmacol 93(7):505–516. https://doi.org/10.1139/cjpp-2014-0489

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karimipour M, Zarghani SS, Milani MM, Soraya H (2018) Pre-treatment with metformin in comparison with post-treatment reduces cerebral ischemia reperfusion induced injuries in rats. Bull Emerg Trauma 6(2):115. https://doi.org/10.29252/beat-060205

Article  PubMed  PubMed Central  Google Scholar 

Lakhan SE, Kirchgessner A, Hofer M (2009) Inflammatory mechanisms in ischemic stroke: therapeutic approaches. J Transl Med 7:97. https://doi.org/10.1186/1479-5876-7-97

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee NT, Selan C, Chia JSJ, Sturgeon SA, Wright DK, Zamani A, Pereira M, Nandurkar HH, Sashindranath M (2020) Characterization of a novel model of global forebrain ischaemia-reperfusion injury in mice and comparison with focal ischaemic and haemorrhagic stroke. Sci Rep 10(1):18170. https://doi.org/10.1038/s41598-020-75034-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li G, Cao X, Liao J, Wei Y (2023) Pharmacokinetics of tenvermectin in swine, a novel antiparasitic drug candidate-comparison with ivermectin. Vet Med Sci 9(3):1211–1216. https://doi.org/10.1002/vms3.1085

Article  CAS  PubMed  PubMed Central