Exploration of Imatinib involved in amyloidogenesis as a common foundation for type-2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD)

Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121–126. https://doi.org/10.1016/s0076-6879(84)05016-3

Article  CAS  PubMed  Google Scholar 

Aguilar Diaz De Leon J, Borges CR (2020) Evaluation of oxidative stress in biological samples using the thiobarbituric acid reactive substances assay. J vis Exp. https://doi.org/10.3791/61122

Article  PubMed  Google Scholar 

Ali SK, Ali RH (2022) Effects of antidiabetic agents on Alzheimer’s disease biomarkers in experimentally induced hyperglycemic rat model by streptozocin. PLoS ONE 17:e0271138. https://doi.org/10.1371/journal.pone.0271138

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arrieta-Cruz I, Knight CM, Gutiérrez-Juárez R (2015) Acute exposure of the mediobasal hypothalamus to amyloid-β25-35 perturbs hepatic glucose metabolism. J Alzheimers Dis 46:843–848. https://doi.org/10.3233/JAD-131865

Article  CAS  PubMed  Google Scholar 

Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882–888

CAS  PubMed  Google Scholar 

Bhargava SK, Singh TG, Mannan A et al (2022a) Pharmacological evaluation of Thuja occidentalis for the attenuation of nephropathy in streptozotocin-induced diabetes rats. Obesity Medicine 31:100391. https://doi.org/10.1016/j.obmed.2022.100391

Article  Google Scholar 

Bhargava SK, Singh TG, Mannan A et al (2022b) Pharmacological evaluation of Thuja occidentalis for the attenuation of neuropathy via AGEs and TNF-α inhibition in diabetic neuropathic rats. Environ Sci Pollut Res Int 29:60542–60557. https://doi.org/10.1007/s11356-022-20106-3

Article  CAS  PubMed  Google Scholar 

Cai Y, Liu J, Wang B et al (2022) Microglia in the neuroinflammatory pathogenesis of Alzheimer’s disease and related therapeutic targets. Front Immunol 13:856376. https://doi.org/10.3389/fimmu.2022.856376

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chien M-Y, Ku Y-H, Chang J-M et al (2016) Effects of herbal mixture extracts on obesity in rats fed a high-fat diet. J Food Drug Anal 24:594–601. https://doi.org/10.1016/j.jfda.2016.01.012

Article  PubMed  PubMed Central  Google Scholar 

de la Monte SM (2012) Contributions of brain insulin resistance and deficiency in amyloid-related neurodegeneration in Alzheimer’s disease. Drugs 72:49–66. https://doi.org/10.2165/11597760-000000000-00000

Article  PubMed  PubMed Central  Google Scholar 

Feldman EL, Nave K-A, Jensen TS, Bennett DLH (2017) New horizons in diabetic neuropathy: mechanisms, bioenergetics, and pain. Neuron 93:1296–1313. https://doi.org/10.1016/j.neuron.2017.02.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Furman BL (2021) Streptozotocin-induced diabetic models in mice and rats. Curr Protocol 1:e78. https://doi.org/10.1002/cpz1.78

Article  CAS  Google Scholar 

Garg N, Mannan A, Mohan M, Singh TG (2025) Therapeutic efficacy of hydroalcoholic extract of Euphorbia prostrata Aiton in NAD-STZ-induced diabetic nephropathy: a multifaceted intervention targeting oxidative stress and inflammation. Obes Med 54:100579. https://doi.org/10.1016/j.obmed.2024.100579

Article  Google Scholar 

Gonfloni S, Maiani E, Di Bartolomeo C et al (2012) Oxidative stress, DNA damage, and c-Abl signaling: at the crossroad in neurodegenerative diseases? Int J Cell Biol 2012:683097. https://doi.org/10.1155/2012/683097

Article  CAS  PubMed  PubMed Central  Google Scholar 

González-Martín A, Moyano T, Gutiérrez DA et al (2021) c-Abl regulates a synaptic plasticity-related transcriptional program involved in memory and learning. Prog Neurobiol 205:102122. https://doi.org/10.1016/j.pneurobio.2021.102122

Article  CAS  PubMed  Google Scholar 

Gornall AG, Bardawill CJ, David MM (1949) Determination of serum proteins by means of the biuret reaction. J Biol Chem 177:751–766

CAS  PubMed  Google Scholar 

Gottschalk S, Anderson N, Hainz C et al (2004) Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells. Clin Cancer Res 10:6661–6668. https://doi.org/10.1158/1078-0432.CCR-04-0039

Article  CAS  PubMed  Google Scholar 

Grieb P (2016) Intracerebroventricular streptozotocin injections as a model of Alzheimer’s disease: in search of a relevant mechanism. Mol Neurobiol 53:1741–1752. https://doi.org/10.1007/s12035-015-9132-3

Article  CAS  PubMed  Google Scholar 

Güemes A, Georgiou P (2018) Review of the role of the nervous system in glucose homoeostasis and future perspectives towards the management of diabetes. Bioelectron Med 4:9. https://doi.org/10.1186/s42234-018-0009-4

Article  PubMed  PubMed Central  Google Scholar 

Guo T, Zhang D, Zeng Y et al (2020) Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease. Mol Neurodegener 15:40. https://doi.org/10.1186/s13024-020-00391-7

Article  PubMed  PubMed Central  Google Scholar 

Gutierrez DA, Vargas LM, Chandia-Cristi A et al (2019) c-Abl deficiency provides synaptic resiliency against Aβ-oligomers. Front Cell Neurosci 13:526. https://doi.org/10.3389/fncel.2019.00526

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gutiérrez DA, Chandía-Cristi A, Yáñez MJ et al (2022) c-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases. Neural Regen Res 18:237–243. https://doi.org/10.4103/1673-5374.346540

Article  CAS  PubMed Central  Google Scholar 

Hamzé R, Delangre E, Tolu S et al (2022) Type 2 diabetes mellitus and Alzheimer’s disease: shared molecular mechanisms and potential common therapeutic targets. Int J Mol Sci 23:15287. https://doi.org/10.3390/ijms232315287

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iheagwam FN, Iheagwam OT, Onuoha MK et al (2022) Terminalia catappa aqueous leaf extract reverses insulin resistance, improves glucose transport and activates PI3K/AKT signalling in high fat/streptozotocin-induced diabetic rats. Sci Rep 12:10711. https://doi.org/10.1038/s41598-022-15114-9

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jump DB (2011) Fatty acid regulation of hepatic lipid metabolism. Curr Opin Clin Nutr Metab Care 14:115–120. https://doi.org/10.1097/MCO.0b013e328342991c

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karunakaran U, Elumalai S, Moon JS, Won KC (2022) c-Abl tyrosine kinase inhibition attenuate oxidative stress-induced pancreatic β-Cell dysfunction via glutathione antioxidant system. Transl Res 249:74–87. https://doi.org/10.1016/j.trsl.2022.06.007

Article  CAS  PubMed  Google Scholar 

Kaur N, Kishore L, Farooq SA et al (2023) Cucurbita pepo seeds improve peripheral neuropathy in diabetic rats by modulating the inflammation and oxidative stress in rats. Environ Sci Pollut Res Int. https://doi.org/10.1007/s11356-023-28339-6

Article  PubMed  PubMed Central  Google Scholar 

Kelliny S, Deng I, Zhou X-F, Bobrovskaya L (2023) Chapter 2 - Sporadic Alzheimer’s disease animal model using streptozotocin and APP/PS1 mice. In: Martin CR, Patel VB, Preedy VR (eds) Handbook of Animal Models in Neurological Disorders. Academic Press, pp 17–30

Google Scholar 

Kim H-G (2019) Cognitive dysfunctions in individuals with diabetes mellitus. Yeungnam Univ J Med 36:183–191. https://doi.org/10.12701/yujm.2019.00255

Article  PubMed  PubMed Central  Google Scholar 

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