Buckley P (1985) Amplification of oesophageal sounds. Anaesthesia 40:712. https://doi.org/10.1111/j.1365-2044.1985.tb10977.x

Article  PubMed  CAS  Google Scholar 

Cai M, Guo Y, Wang S, Wei H, Sun S, Zhao G, Dong H (2017) Tanshinone IIA elicits neuroprotective effect through activating the nuclear factor erythroid 2-Related factor-dependent antioxidant response. Rejuven Res 20:286–297. https://doi.org/10.1089/rej.2016.1912

Article  CAS  Google Scholar 

Chen W, Li X, Guo S, Song N, Wang J, Jia L, Zhu A (2019) Tanshinone IIA harmonizes the crosstalk of autophagy and polarization in macrophages via miR-375/KLF4 pathway to attenuate atherosclerosis. Int Immunopharmacol 70:486–497. https://doi.org/10.1016/j.intimp.2019.02.054

Article  PubMed  CAS  Google Scholar 

Chi M, Lin Z, Lee C, Huang C, Peng K, Lin C, Lee H, Fang M, Chiang Y (2023) Tanshinone IIA suppresses burning incense-induced oxidative stress and inflammatory pathways in astrocytes. Ecotoxicol Environ Saf. https://doi.org/10.1016/j.ecoenv.2023.114987

Article  PubMed  Google Scholar 

Cui Y, Zhang Y, Zhao X, Shao L, Liu G, Sun C, Xu R, Zhang Z (2021) ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation. Brain Behav Immun 93:312–321. https://doi.org/10.1016/j.bbi.2021.01.003

Article  PubMed  CAS  Google Scholar 

Cui Y, Zhang Z, Lv M, Duan Z, Liu W, Gao J, Xu R, Wan Q (2024) Chromatin target of protein arginine methyltransferases alleviates cerebral ischemia/reperfusion-induced injury by regulating RNA alternative splicing. iScience 27:108688. https://doi.org/10.1016/j.isci.2023.108688

Article  PubMed  CAS  Google Scholar 

Dang R, Wang M, Li X, Wang H, Liu L, Wu Q, Zhao J, Ji P, Zhong L, Licinio J, Xie P (2022) Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway. J Neuroinflamm 19:41. https://doi.org/10.1186/s12974-022-02400-6

Article  CAS  Google Scholar 

Fan Z, Cai L, Wang S, Wang J, Chen B (2021) Baicalin prevents myocardial ischemia/reperfusion injury through inhibiting ACSL4 mediated ferroptosis. Front Pharmacol 12:628988. https://doi.org/10.3389/fphar.2021.628988

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fang X, Ding S, Du X, Wang J, Li X (2022) Ferroptosis-A novel mechanism with multifaceted actions on stroke. Front Neurol 13:881809. https://doi.org/10.3389/fneur.2022.881809

Article  PubMed  PubMed Central  Google Scholar 

Fededa J, Esk C, Mierzwa B, Stanyte R, Yuan S, Zheng H, Ebnet K, Yan W, Knoblich J, Gerlich D (2016) MicroRNA-34/449 controls mitotic spindle orientation during mammalian cortex development. EMBO J 35:2386–2398. https://doi.org/10.15252/embj.201694056

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gambardella G, Carissimo A, Chen A, Cutillo L, Nowakowski T, di Bernardo D, Blelloch R (2017) The impact of MicroRNAs on transcriptional heterogeneity and gene co-expression across single embryonic stem cells. Nat Commun 8:14126. https://doi.org/10.1038/ncomms14126

Article  PubMed  PubMed Central  CAS  Google Scholar 

Gao F, Zhang Y, Zhang Z, Fu L, Cao X, Zhang Y, Guo C, Yan X, Yang Q, Hu Y, Zhao X, Wang Y, Wu S, Ju G, Zheng M, Han H (2017) miR-342-5p regulates neural stem cell proliferation and differentiation downstream to Notch signaling in mice. Stem Cell Rep 8:1032–1045. https://doi.org/10.1016/j.stemcr.2017.02.017

Article  CAS  Google Scholar 

Guan Z, Chen J, Li X, Dong N (2020) Tanshinone IIA induces ferroptosis in gastric cancer cells through p53-mediated SLC7A11 down-regulation. Biosci Rep 40. https://doi.org/10.1042/bsr20201807

Guo Z, Yan M, Chen L, Fang P, Li Z, Wan Z, Cao S, Hou Z, Wei S, Li W, Zhang B (2018) Nrf2-dependent antioxidant response mediated the protective effect of tanshinone IIA on doxorubicin-induced cardiotoxicity. Exp Ther Med 16(4):3333–3344. https://doi.org/10.3892/etm.2018.6614

Article  PubMed  PubMed Central  CAS  Google Scholar 

Guo C, Cao X, Zhang Y, Yue K, Han J, Yan H, Han H, Zheng M (2023) Exosome-mediated Inhibition of microRNA-449a promotes the amplification of mouse retinal progenitor cells and enhances their transplantation in retinal degeneration mouse models. Mol Therapy Nucleic Acids 31:763–778. https://doi.org/10.1016/j.omtn.2023.02.015

Article  PubMed  CAS  Google Scholar 

He L, Liu Y, Wang K, Li C, Zhang W, Li Z, Huang X, Xiong Y (2021) Tanshinone IIA protects human coronary artery endothelial cells from ferroptosis by activating the NRF2 pathway. Biochem Biophys Res Commun 575:1–7. https://doi.org/10.1016/j.bbrc.2021.08.067

Article  PubMed  CAS  Google Scholar 

Herpich F, Rincon F (2020) Management of acute ischemic stroke. Crit Care Med 48:1654–1663. https://doi.org/10.1097/ccm.0000000000004597

Article  PubMed  PubMed Central  Google Scholar 

Ji B, Zhou F, Han L, Yang J, Fan H, Li S, Li J, Zhang X, Wang X, Chen X, Xu Y (2017) Sodium Tanshinone IIA sulfonate enhances effectiveness Rt-PA treatment in acute ischemic stroke patients associated with ameliorating Blood-Brain barrier damage. Translational Stroke Res 8:334–340. https://doi.org/10.1007/s12975-017-0526-6

Article  CAS  Google Scholar 

Jin F, Jin L, Wei B, Li X, Li R, Liu W, Guo S, Fan H, Duan C (2024) miR-96-5p alleviates cerebral ischemia-reperfusion injury in mice by inhibiting pyroptosis via downregulating caspase 1. Exp Neurol 374:114676. https://doi.org/10.1016/j.expneurol.2024.114676

Article  PubMed  CAS  Google Scholar 

Li Z, Zhang S, Cao L, Li W, Ye Y, Shi Z, Wang Z, Sun L, Wang J, Jia L, Wang W (2018) Cx37Tanshinone IIA and Astragaloside IV promote the angiogenesis of mesenchymal stem cell-derived endothelial cell-like cells via upregulation of, and. Exp Ther Med 15:1847–1854. https://doi.org/10.3892/etm.2017.5636

Article  PubMed  CAS  Google Scholar 

Li J, Cao F, Yin H, Huang Z, Lin Z, Mao N, Sun B, Wang G (2020) Ferroptosis: past, present and future. Cell Death Dis 11:88. https://doi.org/10.1038/s41419-020-2298-2

Article  PubMed  PubMed Central  Google Scholar 

Li C, Sun G, Chen B, Xu L, Ye Y, He J, Bao Z, Zhao P, Miao Z, Zhao L, Hu J, You Y, Liu N, Chao H, Ji J (2021a) Nuclear receptor coactivator 4-mediated ferritinophagy contributes to cerebral ischemia-induced ferroptosis in ischemic stroke. Pharmacol Res 174:105933. https://doi.org/10.1016/j.phrs.2021.105933

Article  PubMed  CAS  Google Scholar 

Li G, Li X, Dong J, Han Y (2021b) Electroacupuncture ameliorates cerebral ischemic injury by inhibiting ferroptosis. Front Neurol 12:619043. https://doi.org/10.3389/fneur.2021.619043

Article  PubMed  PubMed Central  Google Scholar 

Liang D, Minikes A, Jiang X (2022) Ferroptosis at the intersection of lipid metabolism and cellular signaling. Mol Cell 82:2215–2227. https://doi.org/10.1016/j.molcel.2022.03.022

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu Y, Tong C, Tang Y, Cong P, Liu Y, Shi X, Shi L, Zhao Y, Jin H, Li J, Hou M (2020) Tanshinone IIA alleviates blast-induced inflammation, oxidative stress and apoptosis in mice partly by inhibiting the PI3K/Akt/FoxO1 signaling pathway. Free Radic Biol Med 152:52–60. https://doi.org/10.1016/j.freeradbiomed.2020.02.032

Article  PubMed  CAS  Google Scholar 

Liu L, Cao Q, Gao W, Li B, Xia Z, Zhao B (2021) Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway. Aging 13:16105–16123. https://doi.org/10.18632/aging.203137

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu H, Zhao Z, Yan M, Zhang Q, Jiang T, Xue J (2023) Calycosin decreases cerebral ischemia/reperfusion injury by suppressing ACSL4-dependent ferroptosis. Arch Biochem Biophys 734. https://doi.org/10.1016/j.abb.2022.109488

Mens M, Ghanbari M (2018) Cell cycle regulation of stem cells by MicroRNAs. Stem Cell Rev Rep 14:309–322. https://doi.org/10.1007/s12015-018-9808-y

Article  PubMed  CAS  Google Scholar 

Morton J, Andersson I,