Abbruzzese G, Morón-Oset J, Díaz-Castroverde S, García-Font N, Roncero C, López-Muñoz F, Marco Contelles JL, Oset-Gasque MJ (2020) Neuroprotection by phytoestrogens in the model of deprivation and resupply of oxygen and glucose in vitro: the contribution of autophagy and related signaling mechanisms. Antioxid (Basel) 9:545. https://doi.org/10.3390/antiox9060545

Article  CAS  Google Scholar 

Algoet M, Janssens S, Himmelreich U, Gsell W, Pusovnik M, Van den Eynde J, Oosterlinck W (2023) Myocardial ischemia-reperfusion injury and the influence of inflammation. Trends Cardiovasc Med 33:357–366. https://doi.org/10.1016/j.tcm.2022.02.005

Article  PubMed  CAS  Google Scholar 

Balaban RS, Nemoto S, Finkel T (2005) Mitochondria, oxidants, and aging. Cell 120:483–495. https://doi.org/10.1016/j.cell.2005.02.001

Article  PubMed  CAS  Google Scholar 

Barati A, Rahbar Saadat Y, Meybodi SM, Nouraei S, Moradi K, Kamrani Moghaddam F, Malekinejad Z, Hosseiniyan Khatibi SM, Zununi Vahed S, Bagheri Y (2023) Eplerenone reduces renal ischaemia/reperfusion injury by modulating klotho, NF-κB and SIRT1/SIRT3/PGC-1α signalling pathways. J Pharm Pharmacol 75:819–827. https://doi.org/10.1093/jpp/rgac054

Article  PubMed  CAS  Google Scholar 

Chen J, Ye X, Yan T, Zhang C, Yang XP, Cui X, Cui Y, Zacharek A, Roberts C, Liu X, Dai X, Lu M, Chopp M (2011) Adverse effects of bone marrow stromal cell treatment of stroke in diabetic rats. Stroke 42:3551–3558. https://doi.org/10.1161/STROKEAHA.111.627174

Article  PubMed  PubMed Central  Google Scholar 

Dai SH, Chen T, Wang YH, Zhu J, Luo P, Rao W, Yang YF, Fei Z, Jiang XF (2014) Sirt3 protects cortical neurons against oxidative stress via regulating mitochondrial Ca2 + and mitochondrial biogenesis. Int J Mol Sci 15:14591–14609. https://doi.org/10.3390/ijms150814591

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dasu MR, Devaraj S, Park S, Jialal I (2010) Increased toll-like receptor (TLR) activation and TLR ligands in recently diagnosed type 2 diabetic subjects. Diabetes Care 33:861–868. https://doi.org/10.2337/dc09-1799

Article  PubMed  PubMed Central  CAS  Google Scholar 

Desilles JP, Syvannarath V, Ollivier V, Journé C, Delbosc S, Ducroux C, Boisseau W, Louedec L, Di Meglio L, Loyau S, Jandrot-Perrus M, Potier L, Michel JB, Mazighi M, Ho-Tin-Noé B (2017) Exacerbation of thromboinflammation by hyperglycemia precipitates cerebral infarct growth and hemorrhagic transformation. Stroke 48:1932–1940. https://doi.org/10.1161/STROKEAHA.117.017080

Article  PubMed  Google Scholar 

Dong XL, Guan F, Xu SJ, Zhu LX, Zhang PP, Cheng AB, Liu TJ (2018) Influence of blood glucose level on the prognosis of patients with diabetes mellitus complicated with ischemic stroke. J Res Med Sci 23:10. https://doi.org/10.4103/1735-1995.223951

Article  PubMed  PubMed Central  CAS  Google Scholar 

Finkel T, Deng CX, Mostoslavsky R (2009) Recent progress in the biology and physiology of sirtuins. Nature 460:587–591. https://doi.org/10.1038/nature08197

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fluri F, Schuhmann MK, Kleinschnitz C (2015) Animal models of ischemic stroke and their application in clinical research. Drug Des Devel Ther 9:3445–3454. https://doi.org/10.2147/DDDT.S56071

Article  PubMed  PubMed Central  CAS  Google Scholar 

George MG, Fischer L, Koroshetz W, Bushnell C, Frankel M, Foltz J, Thorpe PG (2017) CDC grand rounds: public health strategies to prevent and treat strokes. MMWR Morb Mortal Wkly Rep 66:479–481. https://doi.org/10.15585/mmwr.mm6618a5

Article  PubMed  PubMed Central  Google Scholar 

Gerhart-Hines Z, Rodgers JT, Bare O, Lerin C, Kim SH, Mostoslavsky R, Alt FW, Wu Z, Puigserver P (2007) Metabolic control of muscle mitochondrial function and fatty acid oxidation through SIRT1/PGC-1alpha. EMBO J 26:1913–1923. https://doi.org/10.1038/sj.emboj.7601633

Article  PubMed  PubMed Central  CAS  Google Scholar 

Han D, Wang J, Ma S, Chen Y, Cao F (2017) SIRT1 as a promising novel therapeutic target for myocardial ischemia reperfusion injury and cardiometabolic disease. Curr Drug Targets 18:1746–1753. https://doi.org/10.2174/1389450116666150630110529

Article  PubMed  CAS  Google Scholar 

Han Y, Sun W, Ren D, Zhang J, He Z, Fedorova J, Sun X, Han F, Li J (2020) SIRT1 agonism modulates cardiac NLRP3 inflammasome through pyruvate dehydrogenase during ischemia and reperfusion. Redox Biol 34:101538. https://doi.org/10.1016/j.redox.2020.101538

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hei C, Zhou Y, Zhang C, Gao F, Cao M, Yuan S, Qin Y, Li PA, Yang X (2023) Rapamycin ameliorates brain damage and maintains mitochondrial dynamic balance in diabetic rats subjected to middle cerebral artery occlusion. Metab Brain Dis 38:409–418. https://doi.org/10.1007/s11011-022-01020-6

Article  PubMed  CAS  Google Scholar 

Houtkooper RH, Pirinen E, Auwerx J (2012) Sirtuins as regulators of metabolism and healthspan. Nat Rev Mol Cell Biol 13:225–238. https://doi.org/10.1038/nrm3293

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hsu CP, Zhai P, Yamamoto T, Maejima Y, Matsushima S, Hariharan N, Shao D, Takagi H, Oka S, Sadoshima J (2010) Silent information regulator 1 protects the heart from ischemia/reperfusion. Circulation 122:2170–2182. https://doi.org/10.1161/CIRCULATIONAHA.110.958033

Article  PubMed  PubMed Central  Google Scholar 

Huang DD, Wei XH, Mu HN, Pan CS, Li Q, Hu BH, Chang X, Yan L, Fan JY, Liu YY, Luo JY, Han JY (2019) Total Salvianolic acid injection prevents ischemia/reperfusion-induced myocardial injury via antioxidant mechanism involving mitochondrial respiratory chain through the upregulation of sirtuin1 and Sirtuin3. Shock 51:745–756. https://doi.org/10.1097/SHK.0000000000001185

Article  PubMed  PubMed Central  CAS  Google Scholar 

Imai S, Armstrong CM, Kaeberlein M, Guarente L (2000) Transcriptional Silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403:795–800. https://doi.org/10.1038/35001622

Article  PubMed  CAS  Google Scholar 

Jamali-Raeufy N, Kardgar S, Baluchnejadmojarad T, Roghani M, Goudarzi M (2019) Troxerutin exerts neuroprotection against lipopolysaccharide (LPS) induced oxidative stress and neuroinflammation through targeting SIRT1/SIRT3 signaling pathway. Metab Brain Dis 34:1505–1513. https://doi.org/10.1007/s11011-019-00454-9

Article  PubMed  CAS  Google Scholar 

Juliana C, Fernandes-Alnemri T, Kang S, Farias A, Qin F, Alnemri ES (2012) Non-transcriptional priming and deubiquitination regulate NLRP3 inflammasome activation. J Biol Chem 287:36617–36622. https://doi.org/10.1074/jbc.M112.407130

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kelly DP, Scarpulla RC (2004) Transcriptional regulatory circuits controlling mitochondrial biogenesis and function. Genes Dev 18:357–368. https://doi.org/10.1101/gad.1177604

Article  PubMed  CAS  Google Scholar 

King GL (2008) The role of inflammatory cytokines in diabetes and its complications. J Periodontol 79:1527–1534. https://doi.org/10.1902/jop.2008.080246

Article  PubMed  CAS  Google Scholar 

Kong X, Wang R, Xue Y, Liu X, Zhang H, Chen Y, Fang F, Chang Y (2010) Sirtuin 3, a new target of PGC-1alpha, plays an important role in the suppression of ROS and mitochondrial biogenesis. PLoS ONE 5:e11707. https://doi.org/10.1371/journal.pone.0011707

Article  PubMed  PubMed Central  CAS  Google Scholar 

Krinock MJ, Singhal NS (2021) Diabetes, stroke, and neuroresilience: looking beyond hyperglycemia. Ann N Y Acad Sci 1495:78–98. https://doi.org/10.1111/nyas.14583

Article  PubMed