Cao Q, Li Y-Y, He W-F, Zhang Z-Z, Zhou Q, Liu X, Shen Y, Huang T-T (2013) Interplay between microRNAs and the STAT3 signaling pathway in human cancers. Physiol Genomics 45:1206–1214. https://doi.org/10.1152/physiolgenomics.00122.2013

Article  CAS  PubMed  Google Scholar 

Cao Y, Wen J, Li Y, Chen W, Wu Y, Li J, Huang G (2019) Uric acid and sphingomyelin enhance autophagy in iPS cell-originated cardiomyocytes through lncRNA MEG3/miR-7-5p/EGFR axis. Artif Cells Nanomed Biotechnol 47:3774–3785. https://doi.org/10.1080/21691401.2019.1667817

Article  CAS  PubMed  Google Scholar 

Chen X-Q, Qiu K, Liu H, He Q, Bai J-H, Lu W (2019) Application and prospects of butylphthalide for the treatment of neurologic diseases. Chin Med J (Engl) 132:1467–1477. https://doi.org/10.1097/CM9.0000000000000289

Article  CAS  PubMed  Google Scholar 

Chen X, Deng S, Lei Q, He Q, Ren Y, Zhang Y, Nie J, Lu W (2020) miR-7-5p Affects Brain Edema After Intracerebral Hemorrhage and Its Possible Mechanism. Front Cell Dev Biol 8:598020. https://doi.org/10.3389/fcell.2020.598020

Article  PubMed  PubMed Central  Google Scholar 

Chu H, Yang X, Huang C, Gao Z, Tang Y, Dong Q (2017) Apelin-13 protects against ischemic blood-brain barrier damage through the effects of aquaporin-4. Cerebrovasc Dis 44:10–25. https://doi.org/10.1159/000460261

Article  CAS  PubMed  Google Scholar 

Crilly S, Withers SE, Allan SM, Parry-Jones AR, Kasher PR (2021) Revisiting promising preclinical intracerebral hemorrhage studies to highlight repurposable drugs for translation. Int J Stroke 16:123–136. https://doi.org/10.1177/1747493020972240

Article  PubMed  Google Scholar 

de Los G, Fayos Alonso I, Zujo L, Wiest I, Kodajova P, Timelthaler G, Edtmayer S, Zrimšek M, Kollmann S, Giordano C, Kothmayer M, Neubauer HA, Dey S, Schlederer M, Schmalzbauer BS, Limberger T, Probst C, Pusch O, Högler S, Tangermann S, Merkel O, Schiefer AI, Kornauth C, Prutsch N, Zimmerman M, Abraham B, Anagnostopoulos J, Quintanilla-Martinez L, Mathas S, Wolf P, Stoiber D, Staber PB, Egger G, Klapper W, Woessmann W, Look TA, Gunning P, Turner SD, Moriggl R, Lagger S, Kenner L (2022) PDGFRβ promotes oncogenic progression via STAT3/STAT5 hyperactivation in anaplastic large cell lymphoma. Mol Cancer 21:172. https://doi.org/10.1186/s12943-022-01640-7

Article  CAS  Google Scholar 

Fang M, Hou H, Feng B, Zhang T, Zhu X, Liu Z (2023) The neuroprotective effect of dl-3-n-butylphthalide on the brain with experimental intracerebral hemorrhage. Eur J Pharmacol 959:176105. https://doi.org/10.1016/j.ejphar.2023.176105

Article  CAS  PubMed  Google Scholar 

Freudlsperger C, Burnett JR, Friedman JA, Kannabiran VR, Chen Z, Van Waes C (2011) EGFR-PI3K-AKT-mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy. Expert Opin Ther Targets 15:63–74. https://doi.org/10.1517/14728222.2011.541440

Article  CAS  PubMed  Google Scholar 

Garbers C, Aparicio-Siegmund S, Rose-John S (2015) The IL-6/gp130/STAT3 signaling axis: recent advances towards specific inhibition. Curr Opin Immunol 34:75–82. https://doi.org/10.1016/j.coi.2015.02.008

Article  CAS  PubMed  Google Scholar 

Guo S, Song Z, He J, Yin G, Zhu J, Liu H, Yang L, Ji X, Xu X, Liu Z, Liu J (2022) Akt/Aquaporin-4 signaling aggravates neuropathic pain by activating astrocytes after spinal nerve ligation in rats. Neuroscience 482:116–131. https://doi.org/10.1016/j.neuroscience.2021.12.015

Article  CAS  PubMed  Google Scholar 

Huang L, Lan J, Tang J, Kang Y, Feng X, Wu L, Peng Y (2021) L-3-n-Butylphthalide improves synaptic and dendritic spine plasticity and ameliorates neurite pathology in Alzheimer’s disease mouse model and cultured hippocampal neurons. Mol Neurobiol 58:1260–1274. https://doi.org/10.1007/s12035-020-02183-y

Article  CAS  PubMed  Google Scholar 

Lee S-T, Chu K, Sinn D-I, Jung K-H, Kim E-H, Kim S-J, Kim J-M, Ko S-Y, Kim M, Roh J-K (2006) Erythropoietin reduces perihematomal inflammation and cell death with eNOS and STAT3 activations in experimental intracerebral hemorrhage. J Neurochem 96:1728–1739. https://doi.org/10.1111/j.1471-4159.2006.03697.x

Article  CAS  PubMed  Google Scholar 

Li W, Wei D, Zhu Z, Xie X, Zhan S, Zhang R, Zhang G, Huang L (2020) Dl-3-n-Butylphthalide alleviates hippocampal neuron damage in chronic cerebral hypoperfusion via regulation of the CNTF/CNTFRα/JAK2/STAT3 signaling pathways. Front Aging Neurosci 12:587403. https://doi.org/10.3389/fnagi.2020.587403

Article  CAS  PubMed  Google Scholar 

Liu Z, Wang H, Shi X, Li L, Zhou M, Ding H, Yang Y, Li X, Ding K (2017) DL-3-n-Butylphthalide (NBP) provides neuroprotection in the mice models after traumatic brain injury via Nrf2-ARE signaling pathway. Neurochem Res 42:1375–1386. https://doi.org/10.1007/s11064-017-2186-z

Article  CAS  PubMed  Google Scholar 

Liu Y, Xu Q, Deng F, Zheng Z, Luo J, Wang P, Zhou J, Lu X, Zhang L, Chen Z, Zhang Q, Chen Q, Zuo D (2023) HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway. J Exp Clin Cancer Res 42:38. https://doi.org/10.1186/s13046-023-02609-0

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu S, Li W, Liang L, Zhou Y, Li Y (2024) The regulatory relationship between transcription factor STAT3 and noncoding RNA. Cell Mol Biol Lett 29:4. https://doi.org/10.1186/s11658-023-00521-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Niu X-L, Jiang X, Xu G-D, Zheng G-M, Tang Z-P, Yin N, Li X-Q, Yang Y-Y, Lv P-Y (2019) DL-3-n-butylphthalide alleviates vascular cognitive impairment by regulating endoplasmic reticulum stress and the Shh/Ptch1 signaling-pathway in rats. J Cell Physiol 234:12604–12614. https://doi.org/10.1002/jcp.27332

Article  CAS  PubMed  Google Scholar 

Niu F, Sharma A, Wang Z, Feng L, Muresanu DF, Sahib S, Tian ZR, Lafuente JV, Buzoianu AD, Castellani RJ, Nozari A, Patnaik R, Wiklund L, Sharma HS (2020) Co-administration of TiO2-nanowired dl-3-n-butylphthalide (dl-NBP) and mesenchymal stem cells enhanced neuroprotection in Parkinson’s disease exacerbated by concussive head injury. Prog Brain Res 258:101–155. https://doi.org/10.1016/bs.pbr.2020.09.011

Article  PubMed  Google Scholar 

Qiu K, Deng S, Liu H, You H, Lei Q, Lu W (2019) Effect of butylphthalide on blood-brain barrier after cerebral hemorrhage in SD rats and the mechanisms. Zhong Nan Da Xue Xue Bao Yi Xue Ban 44:1321–1329. https://doi.org/10.11817/j.issn.1672-7347.2019.190017

Article  PubMed  Google Scholar 

Shrivastava K, Llovera G, Recasens M, Chertoff M, Giménez-Llort L, Gonzalez B, Acarin L (2013) Temporal expression of cytokines and signal transducer and activator of transcription factor 3 activation after neonatal hypoxia/ischemia in mice. Dev Neurosci 35:212–225. https://doi.org/10.1159/000348432

Article  CAS  PubMed  Google Scholar 

Tang G, Yang G-Y (2016) Aquaporin-4: a potential therapeutic target for cerebral edema. Int J Mol Sci 17:1413. https://doi.org/10.3390/ijms17101413

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang Z, Xu T, Li Y, Fei W, Yang G, Hong Y (2020) Inhibition of CRY2 by STAT3/miRNA-7–5p promotes osteoblast differentiation through upregulation of CLOCK/BMAL1/P300 expression. Mol Ther Nucleic Acids 19:865–876. https://doi.org/10.1016/j.omtn.2019.12.020

Article  CAS  PubMed  Google Scholar 

Tu E, Chen Q, Tan L, Wand Y (2020) Dl-3-n-Butylphthalide promotes neovascularization and neurological recovery in a rat model of intracerebral hemorrhage. BMC Neurosci 21(1):24. https://doi.org/10.1186/s12868-020-00575-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang B, Cui Z, Zhong Z, Sun Y, Sun Q, Yang G, Bian L (2015) Curcumin attenuates brain edema in mice with intracerebral hemorrhage through inhibition of AQP4 and AQP9 expression. Acta Pharmacol Sin 36:939. https://doi.org/10.1038/aps.2015.47

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang A, Jia B, Zhang X, Huo X, Chen J, Gui L, Cai Y, Guo Z, Han Y, Peng Z, Jing P, Chen Y, Liu Y, Yang Y, Wang F, Sun Z, Li T, Sun H, Yuan H, Shao H, Gao L, Zhang P, Wang F, Cao X, Shi W, Li C, Yang J, Zhang H, Wang F, Deng J, Liu Y, Deng W, Song C, Chen H, He L, Zhao H, Li X, Yang H, Zhou Z, Wang Y, Miao Z, BAST Investigators (2023) Efficacy and Safety of Butylphthalide in Patients With Acute Ischemic Stroke: a Randomized Clinical Trial. JAMA Neurol 80:851–859. https://doi.org/10.1001/jamaneurol.2023.1871

Article  PubMed