Abdul Muneer PM, Alikunju S, Szlachetka AM, Haorah J (2012) The mechanisms of cerebral vascular dysfunction and neuroinflammation by MMP-mediated degradation of VEGFR-2 in alcohol ingestion. Arterioscler Thromb Vasc Biol 32:1167–1177. https://doi.org/10.1161/atvbaha.112.247668

Article  PubMed Central  CAS  Google Scholar 

Appunni S, Gupta D, Rubens M, Ramamoorthy V, Singh HN, Swarup V (2021) Deregulated protein kinases: friend and foe in ischemic stroke. Mol Neurobiol 58:6471–6489. https://doi.org/10.1007/s12035-021-02563-y

Article  PubMed  CAS  Google Scholar 

Chi OZ, Hunter C, Liu X, Tan T, Weiss HR (2008) Effects of VEGF on the blood-brain barrier disruption caused by hyperosmolarity. Pharmacology 82:187–192. https://doi.org/10.1159/000151433

Article  PubMed  CAS  Google Scholar 

Dijkhuizen RM (2011) Advances in MRI-Based detection of cerebrovascular changes after experimental traumatic brain injury. Transl Stroke Res 2:524–532. https://doi.org/10.1007/s12975-011-0130-0

Article  PubMed  PubMed Central  CAS  Google Scholar 

Fan Y, Lan L, Zheng L, Ji X, Lin J, Zeng J, Huang R, Sun J (2015) Spontaneous white matter lesion in brain of stroke-prone renovascular hypertensive rats: a study from MRI, pathology and behavior. Metab Brain Dis 30:1479–1486. https://doi.org/10.1007/s11011-015-9722-9

Article  PubMed  Google Scholar 

Gao XX, Li XH, Zhang QF, Zhu M, Guo YX, Deng KP, Zhang GM, Wang F (2018) Effects of l-arginine on endometrial microvessel density in nutrient-restricted Hu sheep. Theriogenology 119:252–258. https://doi.org/10.1016/j.theriogenology.2018.07.017

Article  PubMed  CAS  Google Scholar 

Guan J, Darb-Esfahani S, Richter R, Taube ET, Ruscito I, Mahner S, Woelber L, Prieske K, Concin N, Vergote I, Van Nieuwenhuysen E, Achimas-Cadariu P, Glajzer J, Woopen H, Stanske M, Kulbe H, Denkert C, Sehouli J, Braicu EI (2019) Vascular endothelial growth factor receptor 2 (VEGFR2) correlates with long-term survival in patients with advanced high-grade serous ovarian cancer (HGSOC): a study from the Tumor Bank Ovarian Cancer (TOC) Consortium. J Cancer Res Clin Oncol 145:1063–1073. https://doi.org/10.1007/s00432-019-02877-4

Article  PubMed  CAS  Google Scholar 

Hannawi Y, Ewees MG, Moore JT, Zweier JL (2022) Characterizing CD38 expression and enzymatic activity in the brain of spontaneously hypertensive stroke-prone rats. Front Pharmacol 13:881708. https://doi.org/10.3389/fphar.2022.881708

Article  PubMed  PubMed Central  CAS  Google Scholar 

Harauz G, Boggs JM (2013) Myelin management by the 18.5-kDa and 21.5-kDa classic myelin basic protein isoforms. J Neurochem 125:334–361. https://doi.org/10.1111/jnc.12195

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hou W, Xue Y, Tang W, Pan H, Xu M, Li X, Bi S, Shen Y, Qian Y, Yu Y (2019) Evaluation of Tumor Hypoxia in C6 glioma rat model with dynamic contrast-enhanced magnetic resonance imaging. Acad Radiol 26:e224–e232. https://doi.org/10.1016/j.acra.2018.09.011

Article  PubMed  Google Scholar 

Ji X, Tian L, Niu S, Yao S, Qu C (2022) Trimethylamine N-oxide promotes demyelination in spontaneous hypertension rats through enhancing pyroptosis of oligodendrocytes. Front Aging Neurosci 14:963876. https://doi.org/10.3389/fnagi.2022.963876

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kassner A, Thornhill R (2011) Measuring the integrity of the human blood-brain barrier using magnetic resonance imaging. Methods Mol Biol 686:229–245. https://doi.org/10.1007/978-1-60761-938-3_10

Article  PubMed  CAS  Google Scholar 

Kimura M, Miyahara K, Yamasaki M, Uchida N (2022) Comparison of vascular endothelial growth factor/vascular endothelial growth factor receptor 2 expression and its relationship to tumor cell proliferation in canine epithelial and mesenchymal tumors. J Vet Med Sci 84:133–141. https://doi.org/10.1292/jvms.21-0388

Article  PubMed  CAS  Google Scholar 

Kitamura A, Saito S, Maki T, Oishi N, Ayaki T, Hattori Y, Yamamoto Y, Urushitani M, Kalaria RN, Fukuyama H, Horsburgh K, Takahashi R, Ihara M (2016) Gradual cerebral hypoperfusion in spontaneously hypertensive rats induces slowly evolving white matter abnormalities and impairs working memory. J Cereb Blood Flow Metab 36:1592–1602. https://doi.org/10.1177/0271678x15606717

Article  PubMed  CAS  Google Scholar 

Lange C, Storkebaum E, de Almodóvar CR, Dewerchin M, Carmeliet P (2016) Vascular endothelial growth factor: a neurovascular target in neurological diseases. Nat Rev Neurol 12:439–454. https://doi.org/10.1038/nrneurol.2016.88

Li X, Zhu H, Sun X, Zuo F, Lei J, Wang Z, Bao X, Wang R (2016) Human neural stem cell transplantation rescues cognitive defects in APP/PS1 model of Alzheimer’s disease by enhancing neuronal connectivity and metabolic activity. Front Aging Neurosci 8:282. https://doi.org/10.3389/fnagi.2016.00282

Article  PubMed  PubMed Central  CAS  Google Scholar 

Li J, Yu J, Ma H, Yang N, Li L, Zheng DD, Wu MX, Zhao ZL, Qi HY (2017) Intranasal pretreatment with Z-Ligustilide, the Main Volatile Component of Rhizoma Chuanxiong, confers Prophylaxis against Cerebral Ischemia via Nrf2 and HSP70 Signaling pathways. J Agric Food Chem 65:1533–1542. https://doi.org/10.1021/acs.jafc.6b04979

Article  PubMed  CAS  Google Scholar 

Li CC, Chen WX, Wang J, Xia M, Jia ZC, Guo C, Tang XQ, Li MX, Yin Y, Liu X, Feng H (2020) Nicotinamide riboside rescues angiotensin II-induced cerebral small vessel disease in mice. CNS Neurosci Ther 26:438–447. https://doi.org/10.1111/cns.13276

Article  PubMed  PubMed Central  CAS  Google Scholar 

Liu H, Chen S, Huang C, Zheng Q, Ye Y, Ye Z, Lyu G (2021a) Longitudinal changes in knee joint synovial vascularity in a rabbit model of rheumatoid arthritis: quantification using power Doppler Ultrasound and contrast-enhanced Ultrasound. Ultrasound Med Biol 47:2430–2441. https://doi.org/10.1016/j.ultrasmedbio.2021.03.012

Article  PubMed  Google Scholar 

Liu N, Xue Y, Tang J, Zhang M, Ren X, Fu J (2021b) The dynamic change of phenotypic markers of smooth muscle cells in an animal model of cerebral small vessel disease. Microvasc Res 133:104061. https://doi.org/10.1016/j.mvr.2020.104061

Article  PubMed  CAS  Google Scholar 

Liu N, Tang J, Xue Y, Mok V, Zhang M, Ren X, Wang Y, Fu J (2022) EP3 receptor Deficiency improves vascular remodeling and cognitive impairment in Cerebral Small Vessel Disease. Aging Dis 13:313–328. https://doi.org/10.14336/ad.2021.0627

Article  PubMed  PubMed Central  Google Scholar 

Marchi N, Lerner-Natoli M (2013) Cerebrovascular remodeling and epilepsy. Neuroscientist 19:304–312. https://doi.org/10.1177/1073858412462747

Article  PubMed  CAS  Google Scholar 

Matin N, Fisher C, Lansdell TA, Hammock BD, Yang J, Jackson WF, Dorrance AM (2021) Soluble epoxide hydrolase inhibition improves cognitive function and parenchymal artery dilation in a hypertensive model of chronic cerebral hypoperfusion. Microcirculation 28:e12653. https://doi.org/10.1111/micc.12653

Article  PubMed  CAS  Google Scholar 

Matsuno H, Tsuchimine S, O’Hashi K, Sakai K, Hattori K, Hidese S, Nakajima S, Chiba S, Yoshimura A, Fukuzato N, Kando M, Tatsumi M, Ogawa S, Ichinohe N, Kunugi H, Sohya K (2022) Association between vascular endothelial growth factor-mediated blood-brain barrier dysfunction and stress-induced depression. Mol Psychiatry 27:3822–3832. https://doi.org/10.1038/s41380-022-01618-3

Article  PubMed  CAS  Google Scholar 

Morin-Brureau M, Rigau V, Lerner-Natoli M (2012) Why and how to target angiogenesis in focal epilepsies. Epilepsia 53(Suppl 6):64–68. https://doi.org/10.1111/j.1528-1167.2012.03705.x

Article  PubMed  CAS  Google Scholar 

Pantoni L (2010) Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol 9:689–701. https://doi.org/10.1016/s1474-4422(10)70104-6

Article  PubMed  Google Scholar 

Raja R, Rosenberg GA, Caprihan A (2018) MRI measurements of blood-brain barrier function in dementia: a review of recent studies. Neuropharmacology 134:259–271. https://doi.org/10.1016/j.neuropharm.2017.10.034

Article  PubMed  CAS