Adams S, van der Laan LJ, Vernon-Wilson E, Renardel de Lavalette C, Dopp EA, Dijkstra CD, Simmons DL, van den Berg TK (1998) Signal-regulatory protein is selectively expressed by myeloid and neuronal cells. J Immunol 161:1853–1859
Article PubMed CAS Google Scholar
Arenas YM, Balzano T, Ivaylova G, Llansola M, Felipo V (2022) The S1PR2-CCL2-BDNF-TrkB pathway mediates neuroinflammation and motor incoordination in hyperammonaemia. Neuropathol Appl Neurobiol 48:e12799
Article PubMed CAS Google Scholar
Azcutia V, Bassil R, Herter JM, Engelbertsen D, Newton G, Autio A, Mayadas T, Lichtman AH, Khoury SJ, Parkos CA et al (2017) Defects in CD4 + T cell LFA-1 integrin-dependent adhesion and proliferation protect Cd47-/- mice from EAE. J Leukoc Biol 101:493–505
Article PubMed CAS Google Scholar
Baskaya MK, Dogan A, Rao AM, Dempsey RJ (2000) Neuroprotective effects of citicoline on brain edema and blood-brain barrier breakdown after traumatic brain injury. J Neurosurg 92:448–452
Article PubMed CAS Google Scholar
Bemeur C, Vaquero J, Desjardins P, Butterworth RF (2010) N-acetylcysteine attenuates cerebral complications of non-acetaminophen-induced acute liver failure in mice: antioxidant and anti-inflammatory mechanisms. Metab Brain Dis 25:241–249
Article PubMed CAS Google Scholar
Bernal W, Auzinger G, Dhawan A, Wendon J (2010) Acute liver failure. Lancet 376:190–201
Braissant O, Rackayova V, Pierzchala K, Grosse J, McLin VA, Cudalbu C (2019) Longitudinal neurometabolic changes in the hippocampus of a rat model of chronic hepatic encephalopathy. J Hepatol 71:505–515
Butterworth RF (2011) Hepatic encephalopathy: a central neuroinflammatory disorder? Hepatology 53:1372–1376
Cao C, Yu X, Liao Z, Zhu N, Huo H, Wang M, Ji G, She H, Luo Z, Yue S (2012) Hypertonic saline reduces lipopolysaccharide-induced mouse brain edema through inhibiting aquaporin 4 expression. Crit Care 16:R186
Article PubMed CAS Google Scholar
Cauli O, Rodrigo R, Piedrafita B, Boix J, Felipo V (2007) Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts. Hepatology 46:514–519
Article PubMed CAS Google Scholar
Frampton G, Invernizzi P, Bernuzzi F, Pae HY, Quinn M, Horvat D, Galindo C, Huang L, McMillin M, Cooper B et al (2012) Interleukin-6-driven progranulin expression increases cholangiocarcinoma growth by an akt-dependent mechanism. Gut 61:268–277
Article PubMed CAS Google Scholar
Fridman V, Galetta SL, Pruitt AA, Levine JM (2009) MRI findings associated with acute liver failure. Neurology 72:2130–2131
Ghantous L, Volman Y, Hefez R, Wald O, Stern E, Friehmann T, Chajut A, Bremer E, Elhalel MD, Rachmilewitz J (2023) The DNA damage response pathway regulates the expression of the immune checkpoint CD47. Commun Biol 6:245
Article PubMed PubMed Central CAS Google Scholar
Gheibihayat SM, Cabezas R, Nikiforov NG, Jamialahmadi T, Johnston TP, Sahebkar A (2021) CD47 in the brain and neurodegeneration: an update on the role in neuroinflammatory pathways. Molecules 26
Gorg B, Qvartskhava N, Bidmon HJ, Palomero-Gallagher N, Kircheis G, Zilles K, Haussinger D (2010) Oxidative stress markers in the brain of patients with cirrhosis and hepatic encephalopathy. Hepatology 52:256–265
Gugliandolo A, Pollastro F, Grassi G, Bramanti P, Mazzon E (2018) In vitro model of neuroinflammation: efficacy of cannabigerol, a non-psychoactive cannabinoid. Int J Mol Sci 19
Hazell AS, Butterworth RF (1999) Hepatic encephalopathy: an update of pathophysiologic mechanisms. Proc Soc Exp Biol Med 222:99–112
Article PubMed CAS Google Scholar
Isenberg JS, Martin-Manso G, Maxhimer JB, Roberts DD (2009) Regulation of nitric oxide signalling by thrombospondin 1: implications for anti-angiogenic therapies. Nat Rev Cancer 9:182–194
Article PubMed PubMed Central CAS Google Scholar
Jefferson B, Ali M, Grant S, Frampton G, Ploof M, Andry S, DeMorrow S, McMillin M (2020) Thrombospondin-1 exacerbates acute liver failure and hepatic encephalopathy pathology in mice by activating transforming growth factor beta1. Am J Pathol 190:347–357
Article PubMed PubMed Central CAS Google Scholar
Jiang D, Burger CA, Akhanov V, Liang JH, Mackin RD, Albrecht NE, Andrade P, Schafer DP, Samuel MA (2022) Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina. Immunity 55:2318–2335e2317
Article PubMed PubMed Central CAS Google Scholar
Jin G, Tsuji K, Xing C, Yang YG, Wang X, Lo EH (2009) CD47 gene knockout protects against transient focal cerebral ischemia in mice. Exp Neurol 217:165–170
Article PubMed PubMed Central CAS Google Scholar
Jing C, Bian L, Wang M, Keep RF, Xi G, Hua Y (2019) Enhancement of hematoma clearance with CD47 blocking antibody in experimental intracerebral hemorrhage. Stroke 50:1539–1547
Article PubMed PubMed Central CAS Google Scholar
Kaur S, Roberts DD (2011) CD47 applies the brakes to angiogenesis via vascular endothelial growth factor receptor-2. Cell Cycle 10:10–12
Article PubMed CAS Google Scholar
Kaur S, Martin-Manso G, Pendrak ML, Garfield SH, Isenberg JS, Roberts DD (2010) Thrombospondin-1 inhibits VEGF receptor-2 signaling by disrupting its association with CD47. J Biol Chem 285:38923–38932
Article PubMed PubMed Central CAS Google Scholar
Kosenko E, Kaminsky Y, Kaminsky A, Valencia M, Lee L, Hermenegildo C, Felipo V (1997) Superoxide production and antioxidant enzymes in ammonia intoxication in rats. Free Radic Res 27:637–644
Article PubMed CAS Google Scholar
Lindberg FP, Bullard DC, Caver TE, Gresham HD, Beaudet AL, Brown EJ (1996) Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice. Science 274:795–798
Article PubMed CAS Google Scholar
Liu X, Pu Y, Cron K, Deng L, Kline J, Frazier WA, Xu H, Peng H, Fu YX, Xu MM (2015) CD47 blockade triggers T cell-mediated destruction of immunogenic tumors. Nat Med 21:1209–1215
Article PubMed PubMed Central CAS Google Scholar
Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402–408
Article PubMed CAS Google Scholar
Lopez-Dee Z, Pidcock K, Gutierrez LS (2011) Thrombospondin-1: multiple paths to inflammation. Mediators Inflamm 2011:296069
Article PubMed PubMed Central Google Scholar
Lorenz U (2009) SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels. Immunol Rev 228:342–359
Article PubMed PubMed Central Google Scholar
McMillin M, Frampton G, Thompson M, Galindo C, Standeford H, Whittington E, Alpini G, DeMorrow S (2014) Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation 11:121
Article PubMed PubMed Central Google Scholar
McMillin M, Frampton G, Tobin R, Dusio G, Smith J, Shin H, Newell-Rogers K, Grant S, DeMorrow S (2015) TGR5 signaling reduces neuroinflammation during hepatic encephalopathy. J Neurochem 135:565–576
Comments (0)