Energy restriction inhibits β-catenin ubiquitination to improve ischemic stroke injury via USP18/SKP2 axis

Allen CL, Bayraktutan U (2009) Oxidative stress and its role in the pathogenesis of ischaemic stroke. Int J Stroke 4(6):461–470

Article  CAS  PubMed  Google Scholar 

Arumugam TV, Phillips TM, Cheng A, Morrell CH, Mattson MP, Wan R (2010) Age and energy intake interact to modify cell stress pathways and stroke outcome. Ann Neurol 67(1):41–52

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boehme AK, Esenwa C, Elkind MS (2017) Stroke risk factors, Genetics, and Prevention. Circ Res 120(3):472–495

Article  CAS  PubMed  PubMed Central  Google Scholar 

Camandola S, Mattson MP (2017) Brain metabolism in health, aging, and neurodegeneration. EMBO J 36(11):1474–1492

Article  CAS  PubMed  PubMed Central  Google Scholar 

Campbell BCV, Khatri P (2020) Stroke Lancet 396(10244):129–142

Article  PubMed  Google Scholar 

Candelario-Jalil E, Dijkhuizen RM, Magnus T (2020) Neuroinflammation, Stroke, blood-brain barrier dysfunction, and Imaging modalities. Stroke 53(5):1473–1486

Article  Google Scholar 

Cao G, Jiang N, Hu Y, Zhang Y, Wang G, Yin M, Ma X, Zhou K et al (2016) Ruscogenin attenuates Cerebral Ischemia-Induced blood-brain barrier dysfunction by suppressing TXNIP/NLRP3 inflammasome activation and the MAPK pathway. Int J Mol Sci 17(9):1418

Article  PubMed  PubMed Central  Google Scholar 

Deng L, Meng T, Chen L, Wei W, Wang P (2020) The role of ubiquitination in tumorigenesis and targeted drug discovery. Signal Transduct Target Ther 5(1):11

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dhawka L, Palfini V, Hambright E, Blanco I, Poon C, Kahl A, Resch U, Bhawal R et al (2023) Post-ischemic ubiquitination at the postsynaptic density reversibly influences the activity of ischemia-relevant kinases. bioRxiv [Preprint] 552860

Diao W, Guo Q, Zhu C, Song Y, Feng H, Cao Y, Du M, Chen H (2020) USP18 promotes cell proliferation and suppressed apoptosis in cervical cancer cells via activating AKT signaling pathway. BMC Cancer 20(1):741

Article  CAS  PubMed  PubMed Central  Google Scholar 

Donkor ES (2018) Stroke in the 21st Century: A Snapshot of the Burden, Epidemiology, and Quality of Life. Stroke Res Treat 2018:3238165

PubMed  PubMed Central  Google Scholar 

Fann DY, Santro T, Manzanero S, Widiapradja A, Cheng YL, Lee SY, Chunduri P, Jo DG et al (2014) Intermittent fasting attenuates inflammasome activity in ischemic stroke. Exp Neurol 257:114–119

Article  CAS  PubMed  Google Scholar 

Feigin VL, Nguyen G, Cercy K, Johnson CO, Alam T, Parmar PG, Abajobir AA, Abate KH et al (2018) Global, Regional, and Country-Specific Lifetime risks of Stroke, 1990 and 2016. N Engl J Med 379(25):2429–2437

Article  PubMed  PubMed Central  Google Scholar 

Gardener SL, Rainey-Smith SR (2018) The role of Nutrition in cognitive function and brain ageing in the Elderly. Curr Nutr Rep 7(3):139–149

Article  PubMed  Google Scholar 

Ge H, Zhang C, Yang Y, Chen W, Zhong J, Fang X, Jiang X, Tan L et al (2021) Ambroxol Upregulates Glucocerebrosidase expression to promote neural stem cells differentiation into neurons through Wnt/β-Catenin pathway after ischemic stroke. Front Mol Neurosci 13:596039

Article  PubMed  PubMed Central  Google Scholar 

Greene AE, Todorova MT, McGowan R, Seyfried TN (2001) Caloric restriction inhibits seizure susceptibility in epileptic EL mice by reducing blood glucose. Epilepsia 42(11):1371–1378

Article  CAS  PubMed  Google Scholar 

Gudden J, Arias Vasquez A, Bloemendaal M (2021) The effects of intermittent fasting on brain and cognitive function. Nutrients 13(9):3166

Article  PubMed  PubMed Central  Google Scholar 

Honke N, Shaabani N, Zhang DE, Hardt C, Lang KS (2016) Multiple functions of USP18. Cell Death Dis 7(11):e2444

Article  PubMed  PubMed Central  Google Scholar 

Hursting SD, Lavigne JA, Berrigan D, Perkins SN, Barrett JC (2003) Calorie restriction, aging, and cancer prevention: mechanisms of action and applicability to humans. Annu Rev Med 54:131–152

Article  CAS  PubMed  Google Scholar 

Katan M, Luft A (2018) Global Burden of Stroke. Semin Neurol 38(2):208–211

Article  PubMed  Google Scholar 

Kim J, Kang SW, Mallilankaraman K, Baik SH, Lim JC, Balaganapathy P, She DT, Lok KZ et al (2018) Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke. Hum Mol Genet 27(9):1497–1513

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kunz A, Dirnagl U, Mergenthaler P (2010) Acute pathophysiological processes after ischaemic and traumatic brain injury. Best Pract Res Clin Anaesthesiol 24(4):495–509

Article  CAS  PubMed  Google Scholar 

Li C, Du L, Ren Y, Liu X, Jiao Q, Cui D, Wen M, Wang C et al (2019) SKP2 promotes breast cancer tumorigenesis and radiation tolerance through PDCD4 ubiquitination. J Exp Clin Cancer Res 38(1):76

Article  PubMed  PubMed Central  Google Scholar 

Li H, Luo Y, Liu P, Liu P, Hua W, Zhang Y, Zhang L, Li Z et al (2021) Exosomes containing miR-451a is involved in the protective effect of cerebral ischemic preconditioning against cerebral ischemia and reperfusion injury. CNS Neurosci Ther 27(5):564–576

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Lu Y, Chen Z, Liu X, Hu W, Zheng L, Chen Y, Kurie JM et al (2021) The ubiquitin-specific peptidase USP18 promotes lipolysis, fatty acid oxidation, and Lung Cancer Growth. Mol Cancer Res 19(4):667–677

Article  CAS  PubMed  Google Scholar 

Manzanero S, Gelderblom M, Magnus T, Arumugam TV (2011) Calorie restriction and stroke. Exp Transl Stroke Med 3:8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Manzanero S, Erion JR, Santro T, Steyn FJ, Chen C, Arumugam TV, Stranahan AM (2014) Intermittent fasting attenuates increases in neurogenesis after ischemia and reperfusion and improves recovery. J Cereb Blood Flow Metab 34(5):897–905

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mattson MP, Wan R (2005) Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems. J Nutr Biochem 16(3):129–137

Article  CAS  PubMed  Google Scholar 

Pan Q, Li K, Xue L, Cheng X, Zhou Q (2022) MiR-641 exacerbates the progression of ischemic stroke through the MCL-1/Wnt/β-Catenin pathway. Clin Lab 68(8)

Paul S, Candelario-Jalil E (2021) Emerging neuroprotective strategies for the treatment of ischemic stroke: an overview of clinical and preclinical studies. Exp Neurol 335:113518

Article  CAS  PubMed  Google Scholar 

Qin C, Yang S, Chu YH, Zhang H, Pang XW, Chen L, Zhou LQ, Chen M et al (2022) Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther 7(1):215

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh S, Anshita D, Ravichandiran V (2021) MCP-1: function, regulation, and involvement in disease. Int Immunopharmacol 101(Pt B):107598

Singh V, Kaur R, Kumari P, Pasricha C, Singh R (2023) ICAM-1 and VCAM-1: gatekeepers in various inflammatory and cardiovascular disorders. Clin Chim Acta 548:117487

Article  CAS  PubMed 

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